DE1930118A1 - Neue Cephalosporinverbindungen und Verfahren zu ihrer Herstellung - Google Patents

Neue Cephalosporinverbindungen und Verfahren zu ihrer Herstellung

Info

Publication number
DE1930118A1
DE1930118A1 DE19691930118 DE1930118A DE1930118A1 DE 1930118 A1 DE1930118 A1 DE 1930118A1 DE 19691930118 DE19691930118 DE 19691930118 DE 1930118 A DE1930118 A DE 1930118A DE 1930118 A1 DE1930118 A1 DE 1930118A1
Authority
DE
Germany
Prior art keywords
group
acid
carboxylic acid
compound
proton
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19691930118
Other languages
German (de)
English (en)
Inventor
Clark John Colin
Long Alan Gibson
Gregory Gordon Jan
James Kennedy
Cowley Brian Richard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of DE1930118A1 publication Critical patent/DE1930118A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
DE19691930118 1968-06-14 1969-06-13 Neue Cephalosporinverbindungen und Verfahren zu ihrer Herstellung Pending DE1930118A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28528/68A GB1279402A (en) 1968-06-14 1968-06-14 Improvements in or relating to cephalosporin derivatives

Publications (1)

Publication Number Publication Date
DE1930118A1 true DE1930118A1 (de) 1969-12-18

Family

ID=10277067

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19691930118 Pending DE1930118A1 (de) 1968-06-14 1969-06-13 Neue Cephalosporinverbindungen und Verfahren zu ihrer Herstellung

Country Status (9)

Country Link
US (1) US3647788A (enrdf_load_stackoverflow)
AT (2) AT306231B (enrdf_load_stackoverflow)
BE (1) BE734533A (enrdf_load_stackoverflow)
DE (1) DE1930118A1 (enrdf_load_stackoverflow)
FR (1) FR2010920A1 (enrdf_load_stackoverflow)
GB (1) GB1279402A (enrdf_load_stackoverflow)
IE (1) IE33997B1 (enrdf_load_stackoverflow)
NL (1) NL6909100A (enrdf_load_stackoverflow)
ZA (1) ZA694201B (enrdf_load_stackoverflow)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759570A (fr) * 1969-11-28 1971-05-27 Ciba Geigy Derives de l'acide 7-cyanacetylamino-cephalosporanique et procede pour leur preparation
JPS4948559B1 (enrdf_load_stackoverflow) * 1970-11-10 1974-12-21
JPS5248996B1 (enrdf_load_stackoverflow) * 1971-01-29 1977-12-14 Glaxo Lab Ltd
US3932393A (en) * 1971-02-25 1976-01-13 Eli Lilly And Company 3-Methylenecephalosporins and process for production thereof
AU468437B2 (en) * 1971-03-09 1976-01-15 Takeda Chemical Industries, Ltd Cephalosporin derivatives
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US3939266A (en) * 1972-05-03 1976-02-17 Smithkline Corporation Substituted sulfonylacetamido cephalosporins
US3865819A (en) * 1972-05-03 1975-02-11 Smithkline Corp Substituted sulfonylacetamido cephalosporins
US3943131A (en) * 1972-07-20 1976-03-09 Smithkline Corporation Trifluoromethylmercaptoacetamidocephalosporins
US3897422A (en) * 1973-03-05 1975-07-29 Squibb & Sons Inc {8 (Azidomethyl)thio{9 acetylcephalosporins
FI771866A7 (enrdf_load_stackoverflow) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
FR2570702B1 (fr) * 1984-09-27 1987-01-09 Sanofi Sa Derives des cephalosporines, procedes d'obtention et leur application a titre d'antibiotiques
EP1379531A2 (en) 2001-04-19 2004-01-14 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives

Also Published As

Publication number Publication date
IE33997L (en) 1969-12-14
FR2010920A1 (enrdf_load_stackoverflow) 1970-02-20
AT312798B (de) 1974-01-25
US3647788A (en) 1972-03-07
AT306231B (de) 1973-03-26
BE734533A (enrdf_load_stackoverflow) 1969-12-15
IE33997B1 (en) 1975-01-08
ZA694201B (en) 1971-01-27
GB1279402A (en) 1972-06-28
NL6909100A (enrdf_load_stackoverflow) 1969-12-16

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