DE1806867A1 - Verfahren zur Herstellung substituierter 4-Hydroxypyrimidine - Google Patents
Verfahren zur Herstellung substituierter 4-HydroxypyrimidineInfo
- Publication number
- DE1806867A1 DE1806867A1 DE19681806867 DE1806867A DE1806867A1 DE 1806867 A1 DE1806867 A1 DE 1806867A1 DE 19681806867 DE19681806867 DE 19681806867 DE 1806867 A DE1806867 A DE 1806867A DE 1806867 A1 DE1806867 A1 DE 1806867A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- substituted
- preparation
- reacted
- ammonium chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
!91O ;)<ί.ΐ-.--:-:Λ
-t-
R - CH2 - CO - NH2
Dimethylformamid· dimethylacetal
1. HtC
CH
0 C
CH CH
GH
NH4ClZHH3
II,
CH,
! + 2 HN
.-"—OH \
CH,
009822/1882
Claims (1)
- PatentansprücheVerfahren zur Herstellung substituierter 4-Hydroxy pyrimidine der FormelCr-R
•OHin der E für die Eeete-OH, -COOR1 und steht, wobei R1 und R« gleiche oder verschiedene Alkylreste bis zu 4 C-Atomen bedeuten? dadurch gekennzeichnet, daß ein Säurearaid der FormelR - CH2 - 00 - 2worin R die angegebenen Reste bedeutet, mit Dimethyl« formamid, vorzugsweise Bimethylformamiddimethylacetal zu einer Verbindung der FormelR1 CH C GH RC M Nr rumgesetzt, diese mit wäßriger Ammonchloridlösung zur Reaktion gebracht und das Endprodukt isoliert wird ο2ο Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß das Molverhältnia Säureamid zu Dimethylformamid dimethylacetal 1:2 bis 1:4, vorzugsweise 1 i 3 bis 1 : 4 beträgt«,M 7 „0098 22/1882. ©AD ORIGINAL3» Verfahren nach Anepraoh 1, dadurch gekennzeichnet, daß die wäßrige Amnonohloridlößung noch freies Ammoniak enthält.0098 22/1882
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1806867A DE1806867C3 (de) | 1968-11-04 | 1968-11-04 | Verfahren zur Herstellung substituierter 4-Hydroxy pyrimidine |
BE741096D BE741096A (de) | 1968-11-04 | 1969-10-31 | |
GB53473/69A GB1244075A (en) | 1968-11-04 | 1969-10-31 | Improvements in or relating to pyrimidine derivatives |
FR6937686A FR2022515A1 (de) | 1968-11-04 | 1969-11-03 | |
CH1638869A CH521971A (de) | 1968-11-04 | 1969-11-04 | Verfahren zur Herstellung substituierter 4-Hydroxypyrimidine |
US00874077A US3798220A (en) | 1968-11-04 | 1969-11-04 | Process for preparing 4-hydroxy 5-substituted pyrimidines and products obtained |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1806867A DE1806867C3 (de) | 1968-11-04 | 1968-11-04 | Verfahren zur Herstellung substituierter 4-Hydroxy pyrimidine |
Publications (3)
Publication Number | Publication Date |
---|---|
DE1806867A1 true DE1806867A1 (de) | 1970-05-27 |
DE1806867B2 DE1806867B2 (de) | 1973-12-20 |
DE1806867C3 DE1806867C3 (de) | 1974-07-18 |
Family
ID=5712328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1806867A Expired DE1806867C3 (de) | 1968-11-04 | 1968-11-04 | Verfahren zur Herstellung substituierter 4-Hydroxy pyrimidine |
Country Status (6)
Country | Link |
---|---|
US (1) | US3798220A (de) |
BE (1) | BE741096A (de) |
CH (1) | CH521971A (de) |
DE (1) | DE1806867C3 (de) |
FR (1) | FR2022515A1 (de) |
GB (1) | GB1244075A (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998030549A1 (de) * | 1997-01-13 | 1998-07-16 | Lonza Ag | Verfahren zur herstellung von substituierten pyrimidinderivaten |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2348213A1 (fr) * | 1976-04-16 | 1977-11-10 | Bellon Labor Sa Roger | Procede pour la preparation de l'ethoxycarbonyl-6 ethyl-8 methoxy-2 oxo-5 dihydro-5,8 pyrido(2,3-d) pyrimidine |
DE2907773A1 (de) * | 1979-02-28 | 1980-09-11 | Consortium Elektrochem Ind | Verfahren zur herstellung von diazinon |
BRPI0811309B1 (pt) | 2007-05-09 | 2022-03-03 | The Brigham And Women's Hospital, Inc. | Métodos in vitro para avaliar uma responsividade do gene apo(a) em uma amostra de ácido nucleico de um indivíduo humano ao tratamento com ácido acetilsalicílico para reduzir o risco de um evento cardiovascular futuro |
-
1968
- 1968-11-04 DE DE1806867A patent/DE1806867C3/de not_active Expired
-
1969
- 1969-10-31 GB GB53473/69A patent/GB1244075A/en not_active Expired
- 1969-10-31 BE BE741096D patent/BE741096A/xx unknown
- 1969-11-03 FR FR6937686A patent/FR2022515A1/fr not_active Withdrawn
- 1969-11-04 US US00874077A patent/US3798220A/en not_active Expired - Lifetime
- 1969-11-04 CH CH1638869A patent/CH521971A/de not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998030549A1 (de) * | 1997-01-13 | 1998-07-16 | Lonza Ag | Verfahren zur herstellung von substituierten pyrimidinderivaten |
US6114527A (en) * | 1997-01-13 | 2000-09-05 | Lonza Ag | Process for preparing substituted pyrimidine derivatives |
Also Published As
Publication number | Publication date |
---|---|
US3798220A (en) | 1974-03-19 |
CH521971A (de) | 1972-04-30 |
BE741096A (de) | 1970-04-01 |
DE1806867C3 (de) | 1974-07-18 |
FR2022515A1 (de) | 1970-07-31 |
GB1244075A (en) | 1971-08-25 |
DE1806867B2 (de) | 1973-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SH | Request for examination between 03.10.1968 and 22.04.1971 | ||
C3 | Grant after two publication steps (3rd publication) |