DE1545922A1 - Verfahren zur Herstellung von Cephalosporinderivaten - Google Patents

Verfahren zur Herstellung von Cephalosporinderivaten

Info

Publication number
DE1545922A1
DE1545922A1 DE19641545922 DE1545922A DE1545922A1 DE 1545922 A1 DE1545922 A1 DE 1545922A1 DE 19641545922 DE19641545922 DE 19641545922 DE 1545922 A DE1545922 A DE 1545922A DE 1545922 A1 DE1545922 A1 DE 1545922A1
Authority
DE
Germany
Prior art keywords
carboxylate
ceph
ylmethyl
pyridinium
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19641545922
Other languages
German (de)
English (en)
Inventor
Stephen Eardley
Wall Wilfred Frank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of DE1545922A1 publication Critical patent/DE1545922A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/42—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an araliphatic carboxylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
DE19641545922 1963-03-27 1964-03-26 Verfahren zur Herstellung von Cephalosporinderivaten Pending DE1545922A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1214363A GB1082943A (en) 1963-03-27 1963-03-27 Derivatives of 7-aminocephalosporanic acid
GB2128563 1963-05-28

Publications (1)

Publication Number Publication Date
DE1545922A1 true DE1545922A1 (de) 1969-12-11

Family

ID=26248814

Family Applications (2)

Application Number Title Priority Date Filing Date
DEG40208A Pending DE1228264B (de) 1963-03-27 1964-03-26 Verfahren zur Herstellung von Derivaten der 7-Phenylacetamidocephalosporansaeure vom C-Typ
DE19641545922 Pending DE1545922A1 (de) 1963-03-27 1964-03-26 Verfahren zur Herstellung von Cephalosporinderivaten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DEG40208A Pending DE1228264B (de) 1963-03-27 1964-03-26 Verfahren zur Herstellung von Derivaten der 7-Phenylacetamidocephalosporansaeure vom C-Typ

Country Status (7)

Country Link
AT (1) AT266312B (zh)
BE (1) BE645869A (zh)
CH (1) CH531004A (zh)
DE (2) DE1228264B (zh)
FR (1) FR4200M (zh)
GB (1) GB1082943A (zh)
NL (1) NL6403230A (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1476981A (en) * 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
KR100891720B1 (ko) * 2007-09-13 2009-04-03 전남대학교산학협력단 식물병에 대한 저항성을 유도하는 슈도모나스 클로로라피스ｏ6 유래 4-카바모일페닐아세트산 및 그의 용도
GB201818410D0 (en) * 2018-11-12 2018-12-26 Imperial Innovations Ltd Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1298904A (fr) * 1959-03-16 1962-07-20 Nat Res Dev Procédé de préparation de composés de céphalosporine
AT232645B (de) * 1960-01-20 1964-03-25 Nat Res Dev Verfahren zur Herstellung von Derivaten der 7-Aminocephalosporansäure u. ähnl. Verbindungen
NO122749B (zh) * 1961-06-08 1971-08-09 Lilly Co Eli

Also Published As

Publication number Publication date
BE645869A (zh) 1964-09-28
NL6403230A (zh) 1964-09-28
FR4200M (zh) 1966-06-06
CH531004A (de) 1972-11-30
AT266312B (de) 1968-11-11
GB1082943A (en) 1967-09-13
DE1228264B (de) 1966-11-10

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