DE1208036B - Herstellung von Arzneimittel-Aerosolen - Google Patents

Herstellung von Arzneimittel-Aerosolen

Info

Publication number
DE1208036B
DE1208036B DEB74324A DEB0074324A DE1208036B DE 1208036 B DE1208036 B DE 1208036B DE B74324 A DEB74324 A DE B74324A DE B0074324 A DEB0074324 A DE B0074324A DE 1208036 B DE1208036 B DE 1208036B
Authority
DE
Germany
Prior art keywords
particle size
microns
preparation
manufacture
propellant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEB74324A
Other languages
German (de)
English (en)
Inventor
Philip Saxton Hartley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BENGER LAB Ltd
HOLMES CHAPEL
Original Assignee
BENGER LAB Ltd
HOLMES CHAPEL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BENGER LAB Ltd, HOLMES CHAPEL filed Critical BENGER LAB Ltd
Publication of DE1208036B publication Critical patent/DE1208036B/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/141—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant specially adapted for specific contents or propellants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DEB74324A 1962-11-30 1963-11-19 Herstellung von Arzneimittel-Aerosolen Pending DE1208036B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45282/62A GB1063512A (en) 1962-11-30 1962-11-30 Aerosols

Publications (1)

Publication Number Publication Date
DE1208036B true DE1208036B (de) 1965-12-30

Family

ID=10436603

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB74324A Pending DE1208036B (de) 1962-11-30 1963-11-19 Herstellung von Arzneimittel-Aerosolen

Country Status (6)

Country Link
US (1) US3560607A (enrdf_load_stackoverflow)
BE (1) BE654599A (enrdf_load_stackoverflow)
DE (1) DE1208036B (enrdf_load_stackoverflow)
FR (1) FR3384M (enrdf_load_stackoverflow)
GB (1) GB1063512A (enrdf_load_stackoverflow)
NL (1) NL144832B (enrdf_load_stackoverflow)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US6932962B1 (en) 1994-12-22 2005-08-23 Astrazeneca Ab Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405598A (en) * 1976-01-30 1983-09-20 Fisons, Limited Composition for treating asthma
FI770215A7 (enrdf_load_stackoverflow) * 1976-01-30 1977-07-31 Fisons Ltd
DE2750090A1 (de) * 1976-11-19 1978-06-01 Sandoz Ag Neue verabreichungsformen fuer organische verbindungen
US4352789A (en) * 1980-03-17 1982-10-05 Minnesota Mining And Manufacturing Company Aerosol compositions containing finely divided solid materials
US4897256A (en) * 1986-11-25 1990-01-30 Abbott Laboratories LHRH analog formulations
GB8921222D0 (en) * 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
GB9200148D0 (en) * 1992-01-06 1992-02-26 Minnesota Mining & Mfg Aerosol valves
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US20070122353A1 (en) * 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
WO2002094239A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of diphenhydramine through an inhalation route
WO2002094242A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US6737043B2 (en) * 2001-05-24 2004-05-18 Alexza Molecula Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
WO2002094216A2 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of stimulants through an inhalation route
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
JP2005503425A (ja) * 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
WO2003057188A1 (en) * 2001-11-21 2003-07-17 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US8003080B2 (en) 2002-05-13 2011-08-23 Alexza Pharmaceuticals, Inc. Delivery of drug amines through an inhalation route
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US8288372B2 (en) * 2002-11-26 2012-10-16 Alexza Pharmaceuticals, Inc. Method for treating headache with loxapine
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
CA2507158A1 (en) * 2002-11-26 2004-06-10 Alexza Molecular Delivery Corporation Treatment of headache with antipsychotics delivered by inhalation
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625334B9 (en) 2003-05-21 2012-07-25 Alexza Pharmaceuticals, Inc. Percussively ignited self-contained heating unit
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
US7581540B2 (en) * 2004-08-12 2009-09-01 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
JP2021511893A (ja) 2018-02-02 2021-05-13 アレクザ・ファーマシューティカルズ・インコーポレイテッドＡｌｅｘｚａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 電気式凝縮エアロゾル装置
US20220160656A1 (en) 2019-03-22 2022-05-26 Dbbh, Llc Intranasally administered antihistamines and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US6932962B1 (en) 1994-12-22 2005-08-23 Astrazeneca Ab Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides

Also Published As

Publication number Publication date
NL144832B (nl) 1975-02-17
GB1063512A (en) 1967-03-30
US3560607A (en) 1971-02-02
NL6412459A (enrdf_load_stackoverflow) 1966-04-27
FR3384M (fr) 1965-06-21
BE654599A (enrdf_load_stackoverflow) 1965-04-20

Similar Documents

Publication Publication Date Title
DE1208036B (de) Herstellung von Arzneimittel-Aerosolen
DE69132407T2 (de) Aerosol arzneiformulierungen
DE4434629C1 (de) Zusammensetzungen zur Behandlung von IRDS und ARDS
DE3230743C2 (de) Als Aerosol versprühbare Masse und Verfahren zu deren Herstellung
DE69303004T2 (de) Aerosolventil
DE69001573T2 (de) Zusammensetzungen zur herstellung von in dosisformen aktiven vitaminen d3 sowie verfahren zur herstellung stabiler, in dosisformen aktiver vitamine d3 unter deren verwendung.
DE2709229A1 (de) Aerosoltreibmittel
DE68919642T2 (de) Arzneimittel.
DE4132176C2 (de) Dosieraerosole mit Isobutan als Treibmittel
DE2504331A1 (de) Heptaminol-5'-adenosinmonophosphat und dessen therapeutische verwendung
WO1993015715A1 (de) Asthma oder pulmonal-aerosolzubereitungen mit lecithin
DE3852717T2 (de) Zusammensetzung für die Prophylaxe von Pneumocystis-carinii-Pneumonie.
EP0707798A1 (de) Verfahren zur Herstellung von Futtermitteln, die pharmakologisch wirksame Substanzen enthalten
DE1617610A1 (de) Nasenspray-Praeparat
DE1114613B (de) Verfahren zum Herstellen von in Behaeltern, insbesondere Spruehbehaeltern, aus Kunststoffen verpackten fluessigen kosmetischen Praeparaten, die aetherische OEle enthalten, welche den Kunststoff des Behaelters angreifen
DE2137857B2 (de) Verfahren zur Herstellung pulvriger transpirationshemmender Komplexverbindungen, dadurch erhaltene Verfahrensprodukte und transpirationshemmende Pulver-Aerosol-Präparate
DE4325658C2 (de) Verfahren zur Herstellung von Futtermitteln, die pharmakologisch wirksame Substanzen enthalten
DE69105663T2 (de) Behälter für reaktive pharmazeutische Produkte.
DE69200794T2 (de) Verwendung von 4,9,11-Trien-Steroiden in Zusammensetzungen für Truthühner.
DE2151706B1 (en) Tantalum-contg x-ray contrast agents - in aerosol form for bronchography
EP1575559B1 (de) Dosieraerosole mit lecithin als oberflächenaktiver substanz
DE969562C (de) Verfahren zur Herstellung von Camphersulfonaten aromatischer Alkanolamine
DE2831419A1 (de) Dispersion oder suspension aus lecithin oder einem sorbitan- oder sorbit-ester in treibmittel 12
AT402895B (de) Verfahren zur herstellung einer flüssigen pharmazeutischenzusammensetzung für die nasale verabreichung eines calcitonins als nasaler spray
DE666745C (de) Verfahren zur Herstellung von Emanation, Riechstoffe, Arzneimittel u. dgl. enthaltenden Emulsionen, Salben, Pulvern und aehnlichen Koerpern