DE112018000451B4 - Verfahren zur Herstellung einer vernetzten Polyethylenimin-Beschichtung und Verwendung einer vernetzten Polyethylenimin-Beschichtung - Google Patents
Verfahren zur Herstellung einer vernetzten Polyethylenimin-Beschichtung und Verwendung einer vernetzten Polyethylenimin-Beschichtung Download PDFInfo
- Publication number
- DE112018000451B4 DE112018000451B4 DE112018000451.1T DE112018000451T DE112018000451B4 DE 112018000451 B4 DE112018000451 B4 DE 112018000451B4 DE 112018000451 T DE112018000451 T DE 112018000451T DE 112018000451 B4 DE112018000451 B4 DE 112018000451B4
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- bpei
- layer
- coating
- glyoxal
- negatively charged
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Images
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| US15/474,330 US10563069B2 (en) | 2017-03-30 | 2017-03-30 | Prevention of biofilm formation |
| US15/474,330 | 2017-03-30 | ||
| PCT/IB2018/052075 WO2018178859A1 (en) | 2017-03-30 | 2018-03-27 | Prevention of biofilm formation |
Publications (2)
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| DE112018000451T5 DE112018000451T5 (de) | 2019-10-10 |
| DE112018000451B4 true DE112018000451B4 (de) | 2021-12-02 |
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| DE112018000451.1T Active DE112018000451B4 (de) | 2017-03-30 | 2018-03-27 | Verfahren zur Herstellung einer vernetzten Polyethylenimin-Beschichtung und Verwendung einer vernetzten Polyethylenimin-Beschichtung |
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| JP (1) | JP7212436B2 (enExample) |
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| DE (1) | DE112018000451B4 (enExample) |
| GB (1) | GB2575000B (enExample) |
| WO (1) | WO2018178859A1 (enExample) |
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| US10238110B2 (en) | 2016-11-29 | 2019-03-26 | Houssam BOULOUSSA | Ready-to-use storable methanolic solution of a biocompatible and biocidal polyvinylpyridine polymer |
| US10563069B2 (en) * | 2017-03-30 | 2020-02-18 | International Business Machines Corporation | Prevention of biofilm formation |
| US10507267B2 (en) | 2017-04-25 | 2019-12-17 | International Business Machines Corporation | Highly hydrophobic antifouling coatings for implantable medical devices |
| US10745586B2 (en) | 2017-08-08 | 2020-08-18 | International Business Machines Corporation | Fluorinated networks for anti-fouling surfaces |
| US10696849B2 (en) * | 2017-08-08 | 2020-06-30 | International Business Machines Corporation | Tailorable surface topology for antifouling coatings |
| JP7649675B2 (ja) * | 2021-03-31 | 2025-03-21 | 日華化学株式会社 | 抗菌・抗ウイルス剤組成物、物品、及び物品の製造方法 |
| JP2023043519A (ja) * | 2021-09-16 | 2023-03-29 | 株式会社ユポ・コーポレーション | 抗菌シート |
| CN117126604B (zh) * | 2023-08-14 | 2025-10-31 | 中国科学院海洋研究所 | 一种表面带负电的透明自润滑有机硅杂化防污涂层及其制备方法 |
| DE102023127620A1 (de) | 2023-10-10 | 2025-04-10 | epitome GmbH | Vorrichtung zum Durchführen von Intraoralscans |
| CN117899367B (zh) * | 2024-01-29 | 2024-10-18 | 深圳市美林医疗科技有限公司 | 一种安全除颤穿戴装置及使用方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030194504A1 (en) | 1999-10-19 | 2003-10-16 | Alexander Bilyk | Preparation of functional polymeric surface |
| WO2008106194A1 (en) | 2007-02-28 | 2008-09-04 | The Regents Of The University Of Michigan | Carboxylic acid-modified edot for bioconjugation |
| WO2014152423A1 (en) | 2013-03-15 | 2014-09-25 | Bard Access Systems, Inc. | Antithrombic coatings and uses thereof |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4027393A (en) * | 1975-09-19 | 1977-06-07 | Sybron Corporation | Method of in vivo sterilization of surgical implantables |
| US4027392A (en) * | 1976-05-10 | 1977-06-07 | Interface Biomedical Laboratories Corporation | Endosteal bionic tooth and implantation method |
| SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
| JPS6238174A (ja) * | 1985-08-14 | 1987-02-19 | 三菱レイヨン株式会社 | 抗凝血性有機重合体の製法 |
| JPS6238171A (ja) * | 1985-08-14 | 1987-02-19 | 三菱レイヨン株式会社 | 抗凝血性高分子材料 |
| JPS6239636A (ja) * | 1985-08-14 | 1987-02-20 | Mitsubishi Rayon Co Ltd | 親水性有機重合体基質の製法 |
| US5755788A (en) * | 1987-02-19 | 1998-05-26 | Rutgers, The State University | Prosthesis and implants having liposomes bound thereto and methods of preparation |
| US4781591A (en) * | 1987-04-06 | 1988-11-01 | Allen James P | Endosteal implant and method for performing implantation thereof |
| GB8813395D0 (en) | 1988-06-07 | 1988-07-13 | Elliott T S J | Medical devices |
| US5213898A (en) | 1989-10-12 | 1993-05-25 | Norsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| KR940003863B1 (ko) * | 1991-01-07 | 1994-05-04 | 한국과학기술연구원 | 혈액적합성이 개선된 불소화 폴리우레탄 |
| CA2074318A1 (en) * | 1992-07-22 | 1994-01-23 | Morteza Shirkhanzadeh | Prosthetic implant with self-generated current for early fixation in skeletal bone |
| US5308641A (en) * | 1993-01-19 | 1994-05-03 | Medtronic, Inc. | Biocompatibility of solid surfaces |
| WO1995019796A1 (en) * | 1994-01-21 | 1995-07-27 | Brown University Research Foundation | Biocompatible implants |
| US5725377A (en) * | 1996-03-29 | 1998-03-10 | Lemler; Jeffrey Richard | Dental implant apparatus |
| JP4119507B2 (ja) * | 1997-12-26 | 2008-07-16 | 株式会社ダイショウー | 機能性被覆体の製造法 |
| EP0930344A2 (de) * | 1998-01-14 | 1999-07-21 | Hüls Aktiengesellschaft | Hämokompatible und bakterienabweisende hydrophile Copolymere |
| US7207800B1 (en) * | 2001-09-28 | 2007-04-24 | Norman Ho-Kwong Kwan | Dental implant system and additional methods of attachment |
| US9089407B2 (en) | 2001-04-23 | 2015-07-28 | Massachusetts Institute Of Technology | Antibacterial coatings that inhibit biofilm formation on implants |
| US20120276501A1 (en) * | 2004-01-29 | 2012-11-01 | Cellectric Medical Ltd. | Disposable osteogenesis and osseointegration promotion and maintenance device for endosseous implants |
| FR2878248B1 (fr) | 2004-11-22 | 2007-01-12 | Surfactis Technologies Soc Par | Composes bisphosphoniques pour empecher ou limiter la fixation de macromolecules, de microorganismes et d'un biofilm sur des surfaces solides, notamment metallique ou minerales |
| US9084546B2 (en) | 2005-08-31 | 2015-07-21 | The Regents Of The University Of Michigan | Co-electrodeposited hydrogel-conducting polymer electrodes for biomedical applications |
| US8137735B2 (en) * | 2005-11-10 | 2012-03-20 | Allegiance Corporation | Elastomeric article with antimicrobial coating |
| ES2726355T3 (es) * | 2005-11-14 | 2019-10-03 | Biomet 3I Llc | Deposición de nanopartículas discretas en una superficie de implante |
| KR100736826B1 (ko) * | 2005-12-26 | 2007-07-09 | (주) 코웰메디 | 재조합 골형성 촉진 단백질을 도포한 치과용 임플란트 및그 도포 방법 |
| US8834912B2 (en) * | 2005-12-30 | 2014-09-16 | Boston Scientific Scimed, Inc. | Medical devices having multiple charged layers |
| US8944804B2 (en) | 2006-01-04 | 2015-02-03 | Liquidia Technologies, Inc. | Nanostructured surfaces for biomedical/biomaterial applications and processes thereof |
| US20070264509A1 (en) * | 2006-05-11 | 2007-11-15 | Yu-Chin Lai | Copolymer and Medical Device with the Copolymer |
| US20090010980A1 (en) | 2006-10-12 | 2009-01-08 | Alok Singh | Materials coatings and methods for self-cleaning and self-decontamination of metal surface |
| US10426578B2 (en) * | 2006-10-16 | 2019-10-01 | Natural Dental Implants, Ag | Customized dental prosthesis for periodontal or osseointegration and related systems |
| US20080221681A1 (en) * | 2007-03-09 | 2008-09-11 | Warsaw Orthopedic, Inc. | Methods for Improving Fatigue Performance of Implants With Osteointegrating Coatings |
| US8374697B2 (en) * | 2007-04-11 | 2013-02-12 | J. Lee Berger | Electrical dental screw implant |
| US8168297B2 (en) | 2007-04-23 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Fluoropolymer coated film, process for forming the same, and fluoropolymer liquid composition |
| US7985881B2 (en) | 2007-09-12 | 2011-07-26 | Guard Products Llc | Aromatic imine compounds for use as sulfide scavengers |
| NZ588865A (en) | 2008-04-30 | 2012-05-25 | Xyleco Inc | Processing biomass |
| GB0818074D0 (en) | 2008-10-02 | 2008-11-05 | Lytix Biopharma As | Treatment of biofilms |
| US9333163B2 (en) | 2008-10-06 | 2016-05-10 | Massachusetts Institute Of Technology | Particles with multiple functionalized surface domains |
| US20120058355A1 (en) * | 2009-06-02 | 2012-03-08 | Hyomin Lee | Coatings |
| EP2289971A1 (en) | 2009-08-27 | 2011-03-02 | Total Petrochemicals Research Feluy | Ring opening polymerisation of cyclic carbonates with organic catalyst systems |
| US20110076387A1 (en) * | 2009-09-29 | 2011-03-31 | Lonza, Inc. | Method for imparting antibiotic activity to the surface of a solid substrate |
| US20110171279A1 (en) * | 2009-11-02 | 2011-07-14 | Ndsu Research Foundation | Polyethylenimine biocides |
| EP2611474A1 (en) | 2010-06-03 | 2013-07-10 | Capsulution Pharma AG | Coating of a drug-eluting medical device |
| GB2481644A (en) | 2010-07-02 | 2012-01-04 | Cambridge Display Tech Ltd | A method of forming an organic thin film transistor |
| WO2012009239A2 (en) | 2010-07-13 | 2012-01-19 | The University Of Houston System | Sensors and separation based on molecular recognition via electropolymerization and colloidal layer templates |
| JP5910505B2 (ja) * | 2010-12-06 | 2016-04-27 | 味の素株式会社 | 医療用材料及びその製造方法 |
| JP6109144B2 (ja) | 2011-03-28 | 2017-04-05 | スリーエム イノベイティブ プロパティズ カンパニー | 硬化性組成物、物品、硬化方法及びタックフリー反応生成物 |
| CN103889562B (zh) | 2011-05-27 | 2017-09-08 | 康奈尔大学 | 纳米粒子官能化的膜及其制备方法和用途 |
| CA2837726C (en) * | 2011-06-20 | 2016-09-20 | Sri International | Electrochemical disinfection of implanted catheters |
| RU2602250C2 (ru) * | 2011-08-31 | 2016-11-10 | Селф-Саспендинг Проппант Ллс | Самосуспендирующиеся проппанты для гидравлического разрыва пласта |
| US9839213B2 (en) * | 2011-10-14 | 2017-12-12 | The University Of Georgia Research Foundation, Inc. | Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers |
| CA2860934A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Modification of surfaces for fluid and solid repellency |
| BR112014020021B1 (pt) * | 2012-02-20 | 2020-12-15 | Basf Se | Composição, método para melhorar a atividade antimicrobiana de um biocida, e, usos de uma poliamina e de uma composição |
| JP6090317B2 (ja) * | 2012-06-19 | 2017-03-08 | 住友化学株式会社 | 高分子化合物およびそれを用いた発光素子 |
| US9018172B2 (en) | 2012-09-26 | 2015-04-28 | Massachusetts Institute Of Technology | Modification of peptides via SNAr reactions of thiols with fluorinated aromatics |
| US9508806B2 (en) | 2012-09-28 | 2016-11-29 | Sony Corporation | Electronic device, image display device and sensor, and method for manufacturing electronic device |
| US9109140B2 (en) | 2013-01-22 | 2015-08-18 | Xerox Corporation | Mixed organosiloxane networks for tunable surface properties for blanket substrates for indirect printing methods |
| SG11201505823PA (en) | 2013-01-30 | 2015-08-28 | Agency Science Tech & Res | Method for improved stability of layer-by-layer assemblies for marine antifouling performance with a novel polymer |
| DE102013201885A1 (de) * | 2013-02-05 | 2014-08-07 | Urs Brodbeck | Keramikkörper, insbesondere zur Verwendung in einem Knochenimplantat, insbesondere als Dentalimplantat |
| CN105102386A (zh) | 2013-03-15 | 2015-11-25 | 肖特玻璃科技(苏州)有限公司 | 化学钢化的柔性超薄玻璃 |
| US9701931B2 (en) | 2013-09-30 | 2017-07-11 | Chemlink Laboratories, Llc | Environmentally preferred antimicrobial compositions |
| US9399044B2 (en) * | 2014-05-28 | 2016-07-26 | International Business Machines Corporation | Antimicrobial cationic polyamines |
| US20160095876A1 (en) * | 2014-10-01 | 2016-04-07 | Rochal Industries, Llp | Composition and kits for inhibition of pathogenic microbial infection and methods of using the same |
| EP3221404B8 (en) * | 2014-11-19 | 2019-05-15 | Biotectix LLC | Conductive polymer coatings for three dimensional substrates |
| US9862802B2 (en) | 2015-11-30 | 2018-01-09 | International Business Machines Corporation | Poly(thioaminal) probe based lithography |
| US11241660B2 (en) * | 2016-08-08 | 2022-02-08 | Versitech Limited | Preparation of hand-carry gravity-driven water filter with high throughput and water disinfection performance |
| US10563069B2 (en) * | 2017-03-30 | 2020-02-18 | International Business Machines Corporation | Prevention of biofilm formation |
| US10507267B2 (en) | 2017-04-25 | 2019-12-17 | International Business Machines Corporation | Highly hydrophobic antifouling coatings for implantable medical devices |
| US10745586B2 (en) | 2017-08-08 | 2020-08-18 | International Business Machines Corporation | Fluorinated networks for anti-fouling surfaces |
| US10696849B2 (en) | 2017-08-08 | 2020-06-30 | International Business Machines Corporation | Tailorable surface topology for antifouling coatings |
-
2017
- 2017-03-30 US US15/474,330 patent/US10563069B2/en active Active
-
2018
- 2018-03-27 WO PCT/IB2018/052075 patent/WO2018178859A1/en not_active Ceased
- 2018-03-27 JP JP2020503378A patent/JP7212436B2/ja active Active
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-
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- 2019-11-08 US US16/678,315 patent/US11572477B2/en active Active
- 2019-11-08 US US16/678,076 patent/US11560484B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030194504A1 (en) | 1999-10-19 | 2003-10-16 | Alexander Bilyk | Preparation of functional polymeric surface |
| WO2008106194A1 (en) | 2007-02-28 | 2008-09-04 | The Regents Of The University Of Michigan | Carboxylic acid-modified edot for bioconjugation |
| WO2014152423A1 (en) | 2013-03-15 | 2014-09-25 | Bard Access Systems, Inc. | Antithrombic coatings and uses thereof |
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| GB2575000B (en) | 2021-11-24 |
| CN110678506A (zh) | 2020-01-10 |
| US11560484B2 (en) | 2023-01-24 |
| GB201915070D0 (en) | 2019-12-04 |
| JP7212436B2 (ja) | 2023-01-25 |
| US20200071542A1 (en) | 2020-03-05 |
| US10563069B2 (en) | 2020-02-18 |
| JP2020515374A (ja) | 2020-05-28 |
| US20200071543A1 (en) | 2020-03-05 |
| US11572477B2 (en) | 2023-02-07 |
| US20180282556A1 (en) | 2018-10-04 |
| WO2018178859A1 (en) | 2018-10-04 |
| DE112018000451T5 (de) | 2019-10-10 |
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