DE102017126248B4 - ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs) - Google Patents

ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs) Download PDF

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DE102017126248B4
DE102017126248B4 DE102017126248.2A DE102017126248A DE102017126248B4 DE 102017126248 B4 DE102017126248 B4 DE 102017126248B4 DE 102017126248 A DE102017126248 A DE 102017126248A DE 102017126248 B4 DE102017126248 B4 DE 102017126248B4
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cells
seq
cpg
methylation
mmdscs
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DE102017126248A1 (de
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Sven Olek
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Precision for Medicine GmbH
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Epiontis GmbH
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Priority to DE102017126248.2A priority Critical patent/DE102017126248B4/de
Application filed by Epiontis GmbH filed Critical Epiontis GmbH
Priority to PCT/EP2018/080235 priority patent/WO2019091942A1/en
Priority to US16/762,534 priority patent/US11976327B2/en
Priority to CN201880071954.8A priority patent/CN111315896A/zh
Priority to CA3082261A priority patent/CA3082261C/en
Priority to EP18799716.8A priority patent/EP3669005B1/en
Priority to JP2020524841A priority patent/JP2021502809A/ja
Priority to AU2018364335A priority patent/AU2018364335A1/en
Publication of DE102017126248A1 publication Critical patent/DE102017126248A1/de
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE102017126248.2A 2017-11-09 2017-11-09 ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs) Active DE102017126248B4 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE102017126248.2A DE102017126248B4 (de) 2017-11-09 2017-11-09 ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs)
US16/762,534 US11976327B2 (en) 2017-11-09 2018-11-06 ERGIC1 as epigenetic marker for the identification of immune cells, in particular monocytic myeloid-derived suppressor cells (mMDSCs)
CN201880071954.8A CN111315896A (zh) 2017-11-09 2018-11-06 作为用于鉴定免疫细胞，特别是单核细胞骨髓源性抑制细胞(mMDSC)的表观遗传标志物的ERGIC1
CA3082261A CA3082261C (en) 2017-11-09 2018-11-06 Ergic1 as epigenetic marker for the identification of immune cells, in particular monocytic myeloid-derived suppressor cells (mmdscs)
PCT/EP2018/080235 WO2019091942A1 (en) 2017-11-09 2018-11-06 ERGIC1 AS EPIGENETIC MARKER FOR THE IDENTIFICATION OF IMMUNE CELLS, IN PARTICULAR MONOCYTIC MYELOID-DERIVED SUPPRESSOR CELLS (mMDSCs)
EP18799716.8A EP3669005B1 (en) 2017-11-09 2018-11-06 Ergic1 as epigenetic marker for the identification of immune cells, in particular monocytic myeloid-derived suppressor cells (mmdscs)
JP2020524841A JP2021502809A (ja) 2017-11-09 2018-11-06 免疫細胞、特に単球性骨髄由来抑制細胞（ｍＭＤＳＣ）の同定のためのエピジェネティックマーカーとしてのＥＲＧＩＣ１
AU2018364335A AU2018364335A1 (en) 2017-11-09 2018-11-06 ERGIC1 as epigenetic marker for the identification of immune cells, in particular monocytic myeloid-derived suppressor cells (mMDSCs)

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DE102017126248.2A DE102017126248B4 (de) 2017-11-09 2017-11-09 ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs)

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DE102017126248A1 DE102017126248A1 (de) 2019-05-09
DE102017126248B4 true DE102017126248B4 (de) 2019-10-17

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US (1) US11976327B2 (https=)
EP (1) EP3669005B1 (https=)
JP (1) JP2021502809A (https=)
CN (1) CN111315896A (https=)
AU (1) AU2018364335A1 (https=)
DE (1) DE102017126248B4 (https=)
WO (1) WO2019091942A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012162660A2 (en) 2011-05-25 2012-11-29 Brown University Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
US20160237493A1 (en) 2013-06-20 2016-08-18 Immunexpress Pty Ltd Biomarker identification

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6590790B2 (ja) * 2013-04-19 2019-10-16 エピオンティス ゲーエムベーハー 生体サンプルにおける定量的細胞組成を特定する方法
EP3132055A2 (en) 2014-04-14 2017-02-22 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012162660A2 (en) 2011-05-25 2012-11-29 Brown University Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
US20160237493A1 (en) 2013-06-20 2016-08-18 Immunexpress Pty Ltd Biomarker identification

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Esteller, Oncogene 21:5427-5440, 2002
Jones und Laird, Nature Genetics 21:163-167, 1999
KIRBY, M.K. [u.a.]: Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns. BMC Cancer (elektronisch veröffentlicht 17.04.2017) 17 (1):273, Seiten 1-10 *
Kristensen und Hansen PCR-Based Methods for Detecting Single-Locus DNA Methylation Biomarkers in Cancer Diagnostics, Prognostics, and Response to Treatment Clinical Chemistry 55:8 1471-1483 (2009)
Laird, Nature Reviews/Cancer 3:253-266, 2003
Michael J. Booth et al. Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution Science 18 May 2012, Vol. 336 no. 6083 pp. 934-937
ntequera und Bird, Proc Natl Acad Sei USA 90: 11995-9, 1993
ZHANG, C. [u.a.]: Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer. Oncotarget (2016) 7 (35):57452-57463 *

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Publication number Publication date
JP2021502809A (ja) 2021-02-04
US20200347453A1 (en) 2020-11-05
CA3082261A1 (en) 2019-05-16
DE102017126248A1 (de) 2019-05-09
AU2018364335A1 (en) 2020-05-28
CN111315896A (zh) 2020-06-19
WO2019091942A1 (en) 2019-05-16
EP3669005B1 (en) 2026-03-04
US11976327B2 (en) 2024-05-07
EP3669005A1 (en) 2020-06-24

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