DE102017002454A1 - Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln - Google Patents

Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln Download PDF

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Publication number
DE102017002454A1
DE102017002454A1 DE102017002454.5A DE102017002454A DE102017002454A1 DE 102017002454 A1 DE102017002454 A1 DE 102017002454A1 DE 102017002454 A DE102017002454 A DE 102017002454A DE 102017002454 A1 DE102017002454 A1 DE 102017002454A1
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Germany
Prior art keywords
oxazoline
polymer particles
organic polymer
poly
acids
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Pending
Application number
DE102017002454.5A
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German (de)
English (en)
Inventor
Meike Nicole Leiske
Anja Träger
Ulrich Schubert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Friedrich Schiller Universtaet Jena FSU
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Friedrich Schiller Universtaet Jena FSU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Friedrich Schiller Universtaet Jena FSU filed Critical Friedrich Schiller Universtaet Jena FSU
Priority to DE102017002454.5A priority Critical patent/DE102017002454A1/de
Priority to CA3061034A priority patent/CA3061034A1/en
Priority to CN201880026806.4A priority patent/CN110545904A/zh
Priority to US16/493,368 priority patent/US11806355B2/en
Priority to PCT/EP2018/000094 priority patent/WO2018166651A1/de
Priority to EP18711475.6A priority patent/EP3595804A1/de
Priority to JP2019550744A priority patent/JP7193470B2/ja
Publication of DE102017002454A1 publication Critical patent/DE102017002454A1/de
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/02Polyamines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02Polyamines
    • C08G73/0233Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04Homopolymers or copolymers of esters
    • C09D133/06Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09D133/062Copolymers with monomers not covered by C09D133/06
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D167/00Coating compositions based on polyesters obtained by reactions forming a carboxylic ester link in the main chain; Coating compositions based on derivatives of such polymers
    • C09D167/04Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40Additives
    • C09D7/45Anti-settling agents
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D7/00Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
    • C09D7/40Additives
    • C09D7/65Additives macromolecular
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/16Amines or polyamines

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
DE102017002454.5A 2017-03-14 2017-03-14 Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln Pending DE102017002454A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE102017002454.5A DE102017002454A1 (de) 2017-03-14 2017-03-14 Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln
CA3061034A CA3061034A1 (en) 2017-03-14 2018-03-12 Organic polymer particles containing poly(oxazoline) stabilizers and use of poly(oxazoline)s for the stabilization of organic polymer particles
CN201880026806.4A CN110545904A (zh) 2017-03-14 2018-03-12 包含聚(噁唑啉)稳定剂的有机聚合物颗粒以及聚(噁唑啉)用于稳定有机聚合物颗粒的用途
US16/493,368 US11806355B2 (en) 2017-03-14 2018-03-12 Organic polymer particles containing poly(oxazoline) stabilizers and use of poly(oxazolines) for stabilizing organic polymer particles
PCT/EP2018/000094 WO2018166651A1 (de) 2017-03-14 2018-03-12 Organische polymerpartikel enthaltend poly(oxazolin)-stabilisatoren und verwendung von poly(oxazolinen) zur stabilisierung von organischen polymerpartikeln
EP18711475.6A EP3595804A1 (de) 2017-03-14 2018-03-12 Organische polymerpartikel enthaltend poly(oxazolin)-stabilisatoren und verwendung von poly(oxazolinen) zur stabilisierung von organischen polymerpartikeln
JP2019550744A JP7193470B2 (ja) 2017-03-14 2018-03-12 ポリ(オキサゾリン)安定化剤を含有する有機ポリマー粒子および有機ポリマー粒子の安定化のためのポリ(オキサゾリン)の使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102017002454.5A DE102017002454A1 (de) 2017-03-14 2017-03-14 Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln

Publications (1)

Publication Number Publication Date
DE102017002454A1 true DE102017002454A1 (de) 2018-09-20

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DE102017002454.5A Pending DE102017002454A1 (de) 2017-03-14 2017-03-14 Organische Polymerpartikel enthaltend Poly(oxazolin)-Stabilisatoren und Verwendung von Poly(oxazolinen) zur Stabilisierung von organischen Polymerpartikeln

Country Status (7)

Country Link
US (1) US11806355B2 (https=)
EP (1) EP3595804A1 (https=)
JP (1) JP7193470B2 (https=)
CN (1) CN110545904A (https=)
CA (1) CA3061034A1 (https=)
DE (1) DE102017002454A1 (https=)
WO (1) WO2018166651A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11697746B2 (en) * 2013-03-15 2023-07-11 Conservation Technologies, Llc Protective water reversible clear coating for substrates
CN114940756B (zh) * 2022-06-02 2023-11-07 北京清科胜因生物科技有限公司 一种聚(2-噁唑啉)脂质与脂质纳米颗粒及应用

Citations (6)

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CN102552146B (zh) 2012-02-13 2013-08-14 江西本草天工科技有限责任公司 表阿霉素脂质体及其制备和储存方法
US20140158931A1 (en) 2011-05-11 2014-06-12 Commissariat A L'energie Atomique Et Aux Energies Alternatives Self-Dispersing Nanoparticles
WO2014172355A1 (en) * 2013-04-16 2014-10-23 Case Western Reserve University Neutrally-charged synthetic platelets to mitigate complement response
WO2015028685A1 (en) 2013-09-02 2015-03-05 Vito Nv (Vlaamse Instelling Voor Technologisch Onderzoek Nv) Apparatus and method for product recovery and electrical energy generation
WO2016061201A1 (en) * 2014-10-14 2016-04-21 The Brigham And Women's Hospital, Inc. Nanoparticles and methods of use
WO2016087598A1 (en) 2014-12-04 2016-06-09 Basf Se Microcapsules

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JP2613384B2 (ja) * 1987-03-06 1997-05-28 コニカ株式会社 新規な界面活性剤を含有するハロゲン化銀写真感光材料
DE3932041A1 (de) * 1989-09-26 1991-04-04 Huels Chemische Werke Ag Polymere costabilisatoren fuer formmassen auf basis von polymerisaten des vinylchlorids
US5837768A (en) * 1994-12-08 1998-11-17 Hercules Incorporated Creping adhesives containing oxazoline polymers and methods of use thereof
JP4368183B2 (ja) 2003-11-06 2009-11-18 財団法人川村理化学研究所 ポリイオン会合体およびポリイオン会合体からなる生体物質キャリアー
US9028829B2 (en) 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
KR20080002842A (ko) 2005-04-20 2008-01-04 니폰 쇼쿠바이 컴파니 리미티드 반응성 에멀젼 및 이의 제조 방법
JP2010511097A (ja) 2006-11-27 2010-04-08 マイクロアクティブ・コーポレイション 気体を徐放するための溶融加工可能な相溶性ポリマーブレンド
US20100041592A1 (en) * 2008-06-26 2010-02-18 Kabanov Alexander V Use of Amphiphilic Biocompatible Polymers for Solubilization of Hydrophobic Drugs
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US20140158931A1 (en) 2011-05-11 2014-06-12 Commissariat A L'energie Atomique Et Aux Energies Alternatives Self-Dispersing Nanoparticles
CN102552146B (zh) 2012-02-13 2013-08-14 江西本草天工科技有限责任公司 表阿霉素脂质体及其制备和储存方法
WO2014172355A1 (en) * 2013-04-16 2014-10-23 Case Western Reserve University Neutrally-charged synthetic platelets to mitigate complement response
WO2015028685A1 (en) 2013-09-02 2015-03-05 Vito Nv (Vlaamse Instelling Voor Technologisch Onderzoek Nv) Apparatus and method for product recovery and electrical energy generation
WO2016061201A1 (en) * 2014-10-14 2016-04-21 The Brigham And Women's Hospital, Inc. Nanoparticles and methods of use
WO2016087598A1 (en) 2014-12-04 2016-06-09 Basf Se Microcapsules

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Also Published As

Publication number Publication date
JP2020512448A (ja) 2020-04-23
US20200122106A1 (en) 2020-04-23
CA3061034A1 (en) 2019-10-22
EP3595804A1 (de) 2020-01-22
US11806355B2 (en) 2023-11-07
WO2018166651A1 (de) 2018-09-20
CN110545904A (zh) 2019-12-06
JP7193470B2 (ja) 2022-12-20

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