DE102013211426A1 - Verfahren und optische Vorrichtung zum mikroskopischen Untersuchen einer Vielzahl von Proben - Google Patents
Verfahren und optische Vorrichtung zum mikroskopischen Untersuchen einer Vielzahl von Proben Download PDFInfo
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- DE102013211426A1 DE102013211426A1 DE102013211426.5A DE102013211426A DE102013211426A1 DE 102013211426 A1 DE102013211426 A1 DE 102013211426A1 DE 102013211426 A DE102013211426 A DE 102013211426A DE 102013211426 A1 DE102013211426 A1 DE 102013211426A1
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- 238000000034 method Methods 0.000 title claims abstract description 41
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- 238000001514 detection method Methods 0.000 claims abstract description 41
- 238000006073 displacement reaction Methods 0.000 claims description 11
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/26—Stages; Adjusting means therefor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
- G01N2021/135—Sample holder displaceable
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Microscoopes, Condenser (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102013211426.5A DE102013211426A1 (de) | 2013-06-18 | 2013-06-18 | Verfahren und optische Vorrichtung zum mikroskopischen Untersuchen einer Vielzahl von Proben |
| PCT/EP2014/062907 WO2014202704A1 (de) | 2013-06-18 | 2014-06-18 | Verfahren und optische vorrichtung zum mikroskopischen untersuchen einer vielzahl von proben |
| JP2016520481A JP6632523B2 (ja) | 2013-06-18 | 2014-06-18 | 顕微鏡で複数のサンプルを検査するための光学装置および方法 |
| EP14733586.3A EP3011379B1 (de) | 2013-06-18 | 2014-06-18 | Verfahren und optische vorrichtung zum mikroskopischen untersuchen einer vielzahl von proben |
| US14/899,157 US10458899B2 (en) | 2013-06-18 | 2014-06-18 | Method and optical device for microscopically examining a multiplicity of specimens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102013211426.5A DE102013211426A1 (de) | 2013-06-18 | 2013-06-18 | Verfahren und optische Vorrichtung zum mikroskopischen Untersuchen einer Vielzahl von Proben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102013211426A1 true DE102013211426A1 (de) | 2014-12-18 |
Family
ID=51022841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102013211426.5A Pending DE102013211426A1 (de) | 2013-06-18 | 2013-06-18 | Verfahren und optische Vorrichtung zum mikroskopischen Untersuchen einer Vielzahl von Proben |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10458899B2 (https=) |
| EP (1) | EP3011379B1 (https=) |
| JP (1) | JP6632523B2 (https=) |
| DE (1) | DE102013211426A1 (https=) |
| WO (1) | WO2014202704A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102018222271A1 (de) * | 2018-12-19 | 2020-06-25 | Carl Zeiss Microscopy Gmbh | Verfahren zum Betrieb einer Probenkammer für eine mikroskopische Bildgebung sowie Vorrichtung und Probenkammer |
| DE102018200923B4 (de) | 2017-01-20 | 2024-11-07 | Leica Microsystems Cms Gmbh | Verfahren zum sequentiellen Untersuchen einer Mehrzahl von Proben, Probenträgereinheit und Aufnahmeeinheit für Lichtblattebenenmikroskopie |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013213781A1 (de) * | 2013-03-20 | 2014-09-25 | Leica Microsystems Cms Gmbh | Verfahren und optische Anordnung zum Manipulieren und Abbilden einer mikroskopischen Probe |
| DE102013226277A1 (de) * | 2013-12-17 | 2015-06-18 | Leica Microsystems Cms Gmbh | Verfahren und Vorrichtung zum Untersuchen einer Probe mittels optischer Projektionstomografie |
| LU92505B1 (de) * | 2014-07-22 | 2016-01-25 | Leica Microsystems | Verfahren und vorrichtung zum mikroskopischen untersuchen einer probe |
| US11085901B2 (en) * | 2014-08-19 | 2021-08-10 | Dan Slater | Acoustical microscope |
| DE102015114756B4 (de) * | 2014-09-25 | 2021-07-22 | Leica Microsystems Cms Gmbh | Spiegelvorrichtung |
| LU93022B1 (de) * | 2016-04-08 | 2017-11-08 | Leica Microsystems | Verfahren und Mikroskop zum Untersuchen einer Probe |
| US10310248B2 (en) * | 2016-08-18 | 2019-06-04 | Olympus Corporation | Microscope including a medium container containing an immersion medium in which a specimen container containing an immersion medium and a sample is immersed |
| US10690898B2 (en) * | 2016-09-15 | 2020-06-23 | Molecular Devices (Austria) GmbH | Light-field microscope with selective-plane illumination |
| JP2018096703A (ja) * | 2016-12-08 | 2018-06-21 | オリンパス株式会社 | マイクロプレートおよび顕微鏡システム |
| EP3495865A1 (en) * | 2017-12-07 | 2019-06-12 | European Molecular Biology Laboratory | A sample holder for imaging a plurality of samples |
| JP7207860B2 (ja) | 2018-04-09 | 2023-01-18 | 浜松ホトニクス株式会社 | 試料観察装置 |
| JP7329113B2 (ja) * | 2018-04-09 | 2023-08-17 | 浜松ホトニクス株式会社 | 試料観察装置 |
| DE102018128264B4 (de) * | 2018-11-12 | 2020-08-20 | Leica Microsystems Cms Gmbh | Lichtblattmikroskop |
| JP7108564B2 (ja) * | 2019-03-06 | 2022-07-28 | アンリツ株式会社 | Ｘ線検査装置 |
| EP4341664A1 (en) * | 2021-05-19 | 2024-03-27 | Leica Microsystems CMS GmbH | Method and apparatus for imaging a biological sample |
| CN114264576B (zh) * | 2021-12-24 | 2024-12-17 | 欧波同科技产业有限公司 | 一种基于电镜的提高颗粒分析速度的颗粒识别方法 |
| CN114252371A (zh) * | 2021-12-24 | 2022-03-29 | 欧波同科技产业有限公司 | 一种夹杂物分析系统中同时获得不同灰度阶颗粒的方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19950225A1 (de) | 1998-10-24 | 2000-05-18 | Leica Microsystems | Anordnung zur optischen Abtastung eines Objekts |
| DE10257423A1 (de) | 2002-12-09 | 2004-06-24 | Europäisches Laboratorium für Molekularbiologie (EMBL) | Mikroskop |
| WO2005036451A1 (en) * | 2003-10-08 | 2005-04-21 | Lifespan Biosciences, Inc. | Automated microspcope slide tissue sample mapping and image acquisition |
| DE102004034957A1 (de) | 2004-07-16 | 2006-02-02 | Carl Zeiss Jena Gmbh | Anordnung zur mikroskopischen Beobachtung und/oder Detektion und Verwendung |
| WO2007065711A1 (en) * | 2005-12-09 | 2007-06-14 | Europäisches Laboratorium für Molekularbiologie (EMBL) | Miscroscope specimen holder |
| DE102011054914A1 (de) * | 2011-10-28 | 2013-05-02 | Leica Microsystems Cms Gmbh | Verfahren und Anordnung zur Beleuchtung einer Probe |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002377A (en) | 1988-07-07 | 1991-03-26 | City Of Hope | Multi-specimen slides for immunohistologic procedures |
| US20030002148A1 (en) | 1998-10-24 | 2003-01-02 | Johann Engelhardt | Arrangement for optically scanning an object |
| EP2637787A1 (en) * | 2010-11-08 | 2013-09-18 | Reactrix Systems, Inc. | Sample assembly for a measurement device |
| DE102011000835C5 (de) * | 2011-02-21 | 2019-08-22 | Leica Microsystems Cms Gmbh | Abtastmikroskop und Verfahren zur lichtmikroskopischen Abbildung eines Objektes |
| US9446411B2 (en) * | 2011-02-24 | 2016-09-20 | Reametrix, Inc. | Sample assembly for a measurement device |
| US9316824B2 (en) * | 2011-03-04 | 2016-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Optomechanical module for converting a microscope to provide selective plane illumination microscopy |
-
2013
- 2013-06-18 DE DE102013211426.5A patent/DE102013211426A1/de active Pending
-
2014
- 2014-06-18 JP JP2016520481A patent/JP6632523B2/ja active Active
- 2014-06-18 EP EP14733586.3A patent/EP3011379B1/de active Active
- 2014-06-18 US US14/899,157 patent/US10458899B2/en active Active
- 2014-06-18 WO PCT/EP2014/062907 patent/WO2014202704A1/de not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19950225A1 (de) | 1998-10-24 | 2000-05-18 | Leica Microsystems | Anordnung zur optischen Abtastung eines Objekts |
| DE10257423A1 (de) | 2002-12-09 | 2004-06-24 | Europäisches Laboratorium für Molekularbiologie (EMBL) | Mikroskop |
| WO2005036451A1 (en) * | 2003-10-08 | 2005-04-21 | Lifespan Biosciences, Inc. | Automated microspcope slide tissue sample mapping and image acquisition |
| DE102004034957A1 (de) | 2004-07-16 | 2006-02-02 | Carl Zeiss Jena Gmbh | Anordnung zur mikroskopischen Beobachtung und/oder Detektion und Verwendung |
| WO2007065711A1 (en) * | 2005-12-09 | 2007-06-14 | Europäisches Laboratorium für Molekularbiologie (EMBL) | Miscroscope specimen holder |
| DE102011054914A1 (de) * | 2011-10-28 | 2013-05-02 | Leica Microsystems Cms Gmbh | Verfahren und Anordnung zur Beleuchtung einer Probe |
Non-Patent Citations (2)
| Title |
|---|
| Burns et al., "Preparation strategy and illumination of three-dimensional cell cultures in light sheet-based fluorescence microscopy", Journal of Biomedical Optics, Vol. 17(19), 101518 (Oct. 2012) |
| Yanik et al., "Technologies for Micromanipulating, Imaging, and Phenotyping Small Invertebrates and Vertebrates", Annu. Rev. Biomed. Eng. 2011; 13: 185-217 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102018200923B4 (de) | 2017-01-20 | 2024-11-07 | Leica Microsystems Cms Gmbh | Verfahren zum sequentiellen Untersuchen einer Mehrzahl von Proben, Probenträgereinheit und Aufnahmeeinheit für Lichtblattebenenmikroskopie |
| DE102018222271A1 (de) * | 2018-12-19 | 2020-06-25 | Carl Zeiss Microscopy Gmbh | Verfahren zum Betrieb einer Probenkammer für eine mikroskopische Bildgebung sowie Vorrichtung und Probenkammer |
| WO2020126419A1 (de) * | 2018-12-19 | 2020-06-25 | Carl Zeiss Microscopy Gmbh | Verfahren zum betrieb einer probenkammer für eine mikroskopische bildgebung sowie vorrichtung und probenkammer |
| US12259538B2 (en) | 2018-12-19 | 2025-03-25 | Carl Zeiss Microscopy Gmbh | Method for operating a sample chamber for microscopic imaging, apparatus, and sample chamber |
Also Published As
| Publication number | Publication date |
|---|---|
| US20160153892A1 (en) | 2016-06-02 |
| JP2016535861A (ja) | 2016-11-17 |
| WO2014202704A1 (de) | 2014-12-24 |
| EP3011379A1 (de) | 2016-04-27 |
| EP3011379B1 (de) | 2021-08-18 |
| JP6632523B2 (ja) | 2020-01-22 |
| US10458899B2 (en) | 2019-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R012 | Request for examination validly filed | ||
| R082 | Change of representative |
Representative=s name: ARROBA GBR, DE |
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| R016 | Response to examination communication |