DE102011053775A1 - Verfahren und Vorrichtungen zum Nachweis von Tau-Proteinablagerungen im Auge - Google Patents

Verfahren und Vorrichtungen zum Nachweis von Tau-Proteinablagerungen im Auge Download PDF

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Publication number
DE102011053775A1
DE102011053775A1 DE201110053775 DE102011053775A DE102011053775A1 DE 102011053775 A1 DE102011053775 A1 DE 102011053775A1 DE 201110053775 DE201110053775 DE 201110053775 DE 102011053775 A DE102011053775 A DE 102011053775A DE 102011053775 A1 DE102011053775 A1 DE 102011053775A1
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Germany
Prior art keywords
light emission
eye
probes
retina
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE201110053775
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German (de)
English (en)
Inventor
Michael Kempe
Tobias Schmitt-Manderbach
Jochen Herms
Christian Schön
Boris Schmidt
Daniel Kieser
Alexander Boländer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Maximilians Universitaet Muenchen LMU
Carl Zeiss AG
Technische Universitaet Darmstadt
Original Assignee
Ludwig Maximilians Universitaet Muenchen LMU
Carl Zeiss AG
Technische Universitaet Darmstadt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Maximilians Universitaet Muenchen LMU, Carl Zeiss AG, Technische Universitaet Darmstadt filed Critical Ludwig Maximilians Universitaet Muenchen LMU
Priority to DE201110053775 priority Critical patent/DE102011053775A1/de
Priority to PCT/EP2012/068343 priority patent/WO2013041522A1/fr
Publication of DE102011053775A1 publication Critical patent/DE102011053775A1/de
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1025Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for confocal scanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/1225Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0066Optical coherence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4842Monitoring progression or stage of a disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/0012Surgical microscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/102Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0068Confocal scanning

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Optics & Photonics (AREA)
  • Hospice & Palliative Care (AREA)
  • Developmental Disabilities (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
DE201110053775 2011-09-20 2011-09-20 Verfahren und Vorrichtungen zum Nachweis von Tau-Proteinablagerungen im Auge Ceased DE102011053775A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE201110053775 DE102011053775A1 (de) 2011-09-20 2011-09-20 Verfahren und Vorrichtungen zum Nachweis von Tau-Proteinablagerungen im Auge
PCT/EP2012/068343 WO2013041522A1 (fr) 2011-09-20 2012-09-18 Procédés et dispositifs pour déceler des dépôts de protéines tau dans l'oeil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE201110053775 DE102011053775A1 (de) 2011-09-20 2011-09-20 Verfahren und Vorrichtungen zum Nachweis von Tau-Proteinablagerungen im Auge

Publications (1)

Publication Number Publication Date
DE102011053775A1 true DE102011053775A1 (de) 2013-03-21

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DE201110053775 Ceased DE102011053775A1 (de) 2011-09-20 2011-09-20 Verfahren und Vorrichtungen zum Nachweis von Tau-Proteinablagerungen im Auge

Country Status (2)

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DE (1) DE102011053775A1 (fr)
WO (1) WO2013041522A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108227173A (zh) * 2016-12-22 2018-06-29 阿诺德和里克特电影技术公司 电子显微镜
DE102022131803A1 (de) 2022-11-30 2024-06-06 Rheinische Friedrich-Wilhelms-Universität Bonn, Körperschaft des öffentlichen Rechts Verfahren und Bildgebungseinrichtung zur in-vivo Erfassung von Autofluoreszenz eines Augenhintergrundes

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018026683A1 (fr) * 2016-08-01 2018-02-08 Cognoptix, Inc. Système et procédé de détection de la protéine tau dans un tissu oculaire

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19920158A1 (de) 1999-04-29 2000-11-02 Univ Schiller Jena Verfahren und Anordnung zur Bestimmung von Fluorophoren an Objekten, insbesondere am lebenden Augenhintergrund
DE10145823A1 (de) 2001-09-13 2003-04-10 Univ Schiller Jena Verfahren zur Auswertung intensitätsschwacher, zeitaufgelöster Fluoreszenzbilder
DE10330716A1 (de) 2003-07-03 2005-02-17 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Eliminierung von Falschlicht
DE10347389A1 (de) 2003-07-03 2005-05-19 Carl Zeiss Jena Gmbh Anordnung zur Eliminierung von Falschlicht
DE102004053730A1 (de) 2004-11-06 2006-05-24 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Unterdrückung von Falschlicht
DE102006031177A1 (de) 2006-07-06 2008-01-10 Carl Zeiss Microimaging Gmbh Verfahren und Vorrichtung zur Erzeugung eines Bildes einer dünnen Schicht eines Objekts
WO2011038892A1 (fr) 2009-09-30 2011-04-07 Carl Zeiss Meditec Ag Procédé et dispositif de détection de dépôts dans l'oeil

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485413B1 (en) * 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
US7884945B2 (en) * 2005-01-21 2011-02-08 Massachusetts Institute Of Technology Methods and apparatus for optical coherence tomography scanning
US8419186B2 (en) * 2009-09-30 2013-04-16 Nidek Co., Ltd. Fundus observation apparatus

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19920158A1 (de) 1999-04-29 2000-11-02 Univ Schiller Jena Verfahren und Anordnung zur Bestimmung von Fluorophoren an Objekten, insbesondere am lebenden Augenhintergrund
DE10145823A1 (de) 2001-09-13 2003-04-10 Univ Schiller Jena Verfahren zur Auswertung intensitätsschwacher, zeitaufgelöster Fluoreszenzbilder
DE10330716A1 (de) 2003-07-03 2005-02-17 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Eliminierung von Falschlicht
DE10347389A1 (de) 2003-07-03 2005-05-19 Carl Zeiss Jena Gmbh Anordnung zur Eliminierung von Falschlicht
DE102004053730A1 (de) 2004-11-06 2006-05-24 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Unterdrückung von Falschlicht
DE102006031177A1 (de) 2006-07-06 2008-01-10 Carl Zeiss Microimaging Gmbh Verfahren und Vorrichtung zur Erzeugung eines Bildes einer dünnen Schicht eines Objekts
WO2011038892A1 (fr) 2009-09-30 2011-04-07 Carl Zeiss Meditec Ag Procédé et dispositif de détection de dépôts dans l'oeil

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ertl, P. et al., Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties, J. Med. Chem., 2000, 43, 3714-3717
Lockhart, et al., The Journal of Biological Chemistry, 280, 7677-7684 vom 4. März 2005 unter Material und Methoden

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108227173A (zh) * 2016-12-22 2018-06-29 阿诺德和里克特电影技术公司 电子显微镜
CN108227173B (zh) * 2016-12-22 2021-09-28 阿瑞医疗有限公司 电子显微镜
DE102022131803A1 (de) 2022-11-30 2024-06-06 Rheinische Friedrich-Wilhelms-Universität Bonn, Körperschaft des öffentlichen Rechts Verfahren und Bildgebungseinrichtung zur in-vivo Erfassung von Autofluoreszenz eines Augenhintergrundes

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