DE102009016553A1 - Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung - Google Patents

Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung Download PDF

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Publication number
DE102009016553A1
DE102009016553A1 DE102009016553A DE102009016553A DE102009016553A1 DE 102009016553 A1 DE102009016553 A1 DE 102009016553A1 DE 102009016553 A DE102009016553 A DE 102009016553A DE 102009016553 A DE102009016553 A DE 102009016553A DE 102009016553 A1 DE102009016553 A1 DE 102009016553A1
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formula
phenyl
cyano
hydrogen
substituted
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DE102009016553A
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German (de)
English (en)
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Bayer Pharma AG
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Bayer Schering Pharma AG
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Priority to DE102009016553A priority Critical patent/DE102009016553A1/de
Priority to US13/262,159 priority patent/US8691817B2/en
Priority to PCT/EP2010/002000 priority patent/WO2010115548A1/de
Priority to ES10713311.8T priority patent/ES2499417T3/es
Priority to CA2757654A priority patent/CA2757654C/en
Priority to CN201080024887.8A priority patent/CN102482231B/zh
Priority to EP10713311.8A priority patent/EP2417112B1/de
Priority to JP2012503892A priority patent/JP5608217B2/ja
Priority to HK12112264.0A priority patent/HK1171451B/xx
Publication of DE102009016553A1 publication Critical patent/DE102009016553A1/de
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE102009016553A 2009-04-06 2009-04-06 Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung Withdrawn DE102009016553A1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE102009016553A DE102009016553A1 (de) 2009-04-06 2009-04-06 Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung
US13/262,159 US8691817B2 (en) 2009-04-06 2010-03-30 Sulfonic amide and sulfoximine-substituted diaryl-dihydropyrimidinones and usage thereof
PCT/EP2010/002000 WO2010115548A1 (de) 2009-04-06 2010-03-30 Sulfonamid- und sulfoximin-substituierte diaryldihydropyrimidinone und ihre verwendung
ES10713311.8T ES2499417T3 (es) 2009-04-06 2010-03-30 Diarildihidropirimidinonas sustituidas con sulfonamida y sulfoximina y su uso
CA2757654A CA2757654C (en) 2009-04-06 2010-03-30 Sulfonic amide and sulfoximine-substituted diaryl-dihydropyrimidinones and usage thereof
CN201080024887.8A CN102482231B (zh) 2009-04-06 2010-03-30 磺酰胺和磺基肟-取代的二芳基-二氢嘧啶酮和其应用
EP10713311.8A EP2417112B1 (de) 2009-04-06 2010-03-30 Sulfonamid- und sulfoximin-substituierte diaryldihydropyrimidinone und ihre verwendung
JP2012503892A JP5608217B2 (ja) 2009-04-06 2010-03-30 スルホン酸アミドおよびスルホキシイミン置換ジアリール−シヒドロピリミジノンおよびその使用
HK12112264.0A HK1171451B (en) 2009-04-06 2010-03-30 Sulfonic amide and sulfoximine-substituted diaryl-dihydropyrimidinones and usage thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102009016553A DE102009016553A1 (de) 2009-04-06 2009-04-06 Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung

Publications (1)

Publication Number Publication Date
DE102009016553A1 true DE102009016553A1 (de) 2010-10-07

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Family Applications (1)

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DE102009016553A Withdrawn DE102009016553A1 (de) 2009-04-06 2009-04-06 Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung

Country Status (8)

Country Link
US (1) US8691817B2 (https=)
EP (1) EP2417112B1 (https=)
JP (1) JP5608217B2 (https=)
CN (1) CN102482231B (https=)
CA (1) CA2757654C (https=)
DE (1) DE102009016553A1 (https=)
ES (1) ES2499417T3 (https=)
WO (1) WO2010115548A1 (https=)

Families Citing this family (18)

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US8288402B2 (en) * 2007-12-20 2012-10-16 Bayer Intellectual Property Gmbh 4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use
US20140221335A1 (en) 2013-02-06 2014-08-07 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9115093B2 (en) 2013-03-04 2015-08-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
USRE47493E1 (en) 2014-02-20 2019-07-09 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
EP3126339A1 (de) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung
US20170114049A1 (en) 2014-04-03 2017-04-27 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratory tract diseases
US20170119776A1 (en) 2014-04-03 2017-05-04 Bayer Pharma Aktiengesellschaft Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
US9440930B2 (en) 2014-07-31 2016-09-13 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9458113B2 (en) 2014-07-31 2016-10-04 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9657015B2 (en) 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9290457B2 (en) * 2014-07-31 2016-03-22 Boehringer Ingelheim International Gmbh Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9475779B2 (en) 2014-07-31 2016-10-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
CN110981815A (zh) 2015-03-18 2020-04-10 Ph制药有限公司 用于生产化合物的方法
WO2017081044A1 (en) 2015-11-13 2017-05-18 Bayer Pharma Aktiengesellschaft 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds
US12569481B2 (en) 2020-06-12 2026-03-10 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
WO2024161371A1 (en) * 2023-02-02 2024-08-08 Gt Gain Therapeutics Sa Substituted azoles their use in the treatment of diseases associated with alpha-1 -antitrypsin (a1at) deficiency
WO2026032210A1 (zh) * 2024-08-05 2026-02-12 上海壹迪生物技术有限公司 一种含嘧啶酮的化合物、其药物组合物及其用途
CN118845775B (zh) * 2024-09-24 2024-12-20 四川大学华西第二医院 Iacs-010759在制备预防和/或治疗原发性纤毛不动综合征的药物中的用途

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Also Published As

Publication number Publication date
CN102482231B (zh) 2014-12-17
JP2012522814A (ja) 2012-09-27
EP2417112B1 (de) 2014-07-09
US8691817B2 (en) 2014-04-08
ES2499417T3 (es) 2014-09-29
CA2757654C (en) 2017-03-14
JP5608217B2 (ja) 2014-10-15
CN102482231A (zh) 2012-05-30
US20120094968A1 (en) 2012-04-19
EP2417112A1 (de) 2012-02-15
WO2010115548A1 (de) 2010-10-14
CA2757654A1 (en) 2010-10-14
HK1171451A1 (en) 2013-03-28

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