DE102006021872B4 - 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel - Google Patents

4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel Download PDF

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Publication number
DE102006021872B4
DE102006021872B4 DE102006021872A DE102006021872A DE102006021872B4 DE 102006021872 B4 DE102006021872 B4 DE 102006021872B4 DE 102006021872 A DE102006021872 A DE 102006021872A DE 102006021872 A DE102006021872 A DE 102006021872A DE 102006021872 B4 DE102006021872 B4 DE 102006021872B4
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DE
Germany
Prior art keywords
alkyl
inhibitors
agonists
mono
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn - After Issue
Application number
DE102006021872A
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German (de)
English (en)
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DE102006021872A1 (de
Inventor
Elisabeth Dr. Defossa
Jochen Dr. Goerlitzer
Thomas Dr. Klabunde
Viktoria Dr. Drosou
Siegfried Dr. Stengelin
Guido Dr. Haschke
Andreas Dr. Herling
Stefan Dr. Bartoschek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102006021872A priority Critical patent/DE102006021872B4/de
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to CNA2007800133694A priority patent/CN101421249A/zh
Priority to MYPI20084471A priority patent/MY148483A/en
Priority to MX2008014208A priority patent/MX2008014208A/es
Priority to CA002651466A priority patent/CA2651466A1/en
Priority to BRPI0711399-4A priority patent/BRPI0711399A2/pt
Priority to PCT/EP2007/003803 priority patent/WO2007131619A1/de
Priority to EP07724730.2A priority patent/EP2024339B1/de
Priority to KR1020087027547A priority patent/KR20090007413A/ko
Priority to AU2007250210A priority patent/AU2007250210B2/en
Priority to JP2009508190A priority patent/JP2009536626A/ja
Priority to TW096116360A priority patent/TW200815367A/zh
Priority to ARP070102011A priority patent/AR060993A1/es
Priority to UY30340A priority patent/UY30340A1/es
Publication of DE102006021872A1 publication Critical patent/DE102006021872A1/de
Application granted granted Critical
Publication of DE102006021872B4 publication Critical patent/DE102006021872B4/de
Priority to IL195178A priority patent/IL195178A0/en
Priority to US12/267,925 priority patent/US7709494B2/en
Priority to NO20085064A priority patent/NO20085064L/no
Anticipated expiration legal-status Critical
Withdrawn - After Issue legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE102006021872A 2006-05-11 2006-05-11 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel Withdrawn - After Issue DE102006021872B4 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE102006021872A DE102006021872B4 (de) 2006-05-11 2006-05-11 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2007250210A AU2007250210B2 (en) 2006-05-11 2007-04-30 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
MX2008014208A MX2008014208A (es) 2006-05-11 2007-04-30 Acidos carboxilicos sustituidos con 4,5-difenil-pirimidinil-oxi o -mercapto, metodo para la produccion y su uso como medicamentos.
CA002651466A CA2651466A1 (en) 2006-05-11 2007-04-30 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
BRPI0711399-4A BRPI0711399A2 (pt) 2006-05-11 2007-04-30 ácidos carboxìlicos 4,5-difenil-primidinil-óxil ou -mercapto substituìdos, método para a produção e seu como medicamentos
PCT/EP2007/003803 WO2007131619A1 (de) 2006-05-11 2007-04-30 4,5-diphenyl-pyrimidinyl-oxy oder -mercapto substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP07724730.2A EP2024339B1 (de) 2006-05-11 2007-04-30 4,5-diphenyl-pyrimidinyl-oxy oder -mercapto substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
KR1020087027547A KR20090007413A (ko) 2006-05-11 2007-04-30 4,5-디페닐-피리미디닐-옥시 또는 -머캅토 치환된 카복실산, 이의 제조방법 및 약물로서의 이의 용도
CNA2007800133694A CN101421249A (zh) 2006-05-11 2007-04-30 4,5-二苯基-嘧啶基-氧基或-巯基取代的羧酸、其生产方法及作为药物的用途
JP2009508190A JP2009536626A (ja) 2006-05-11 2007-04-30 4,5−ジフェニル−ピリミジニル−オキシ又は−メルカプト置換カルボン酸類、それらの製造方法及び医薬品としての使用
MYPI20084471A MY148483A (en) 2006-05-11 2007-04-30 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
TW096116360A TW200815367A (en) 2006-05-11 2007-05-09 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, process for their preparation and their use as pharmaceuticals
ARP070102011A AR060993A1 (es) 2006-05-11 2007-05-09 Acidos carboxilicos sustituidos con 4,5-difenilpirimidiniloxi o mercapto, procedimiento para su preparacion y su uso como productos farmaceuticos
UY30340A UY30340A1 (es) 2006-05-11 2007-05-10 Acidos carboxilicos sustituidos con 4,5-difenilpirimidiniloxi o mercapto, procedimiento para su preparacion y su uso como productos farmacéuticos
IL195178A IL195178A0 (en) 2006-05-11 2008-11-09 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
US12/267,925 US7709494B2 (en) 2006-05-11 2008-11-10 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
NO20085064A NO20085064L (no) 2006-05-11 2008-12-04 4,5-difenyl-pyrimidinyl-oksy eller -merkaptosubstituerte karboksylsyrer, fremgangsmate for deres fremstilling og anvendelse derav som medikamenter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006021872A DE102006021872B4 (de) 2006-05-11 2006-05-11 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
DE102006021872A1 DE102006021872A1 (de) 2007-12-27
DE102006021872B4 true DE102006021872B4 (de) 2008-04-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE102006021872A Withdrawn - After Issue DE102006021872B4 (de) 2006-05-11 2006-05-11 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Country Status (16)

Country Link
US (1) US7709494B2 (https=)
EP (1) EP2024339B1 (https=)
JP (1) JP2009536626A (https=)
KR (1) KR20090007413A (https=)
CN (1) CN101421249A (https=)
AR (1) AR060993A1 (https=)
AU (1) AU2007250210B2 (https=)
BR (1) BRPI0711399A2 (https=)
CA (1) CA2651466A1 (https=)
DE (1) DE102006021872B4 (https=)
IL (1) IL195178A0 (https=)
MX (1) MX2008014208A (https=)
MY (1) MY148483A (https=)
NO (1) NO20085064L (https=)
TW (1) TW200815367A (https=)
WO (1) WO2007131619A1 (https=)

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AU2007292816B2 (en) 2006-09-07 2011-11-17 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
CA2662305C (en) 2006-09-07 2012-04-17 Amgen Inc. Heterocyclic gpr40 modulators
EP2139843B1 (en) 2007-04-16 2013-12-25 Amgen, Inc Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN102083783A (zh) 2007-10-10 2011-06-01 安姆根有限公司 取代的联苯gpr40调节剂
WO2009111056A1 (en) 2008-03-06 2009-09-11 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
AU2009303475B2 (en) 2008-10-15 2012-09-13 Amgen Inc. Spirocyclic GPR40 modulators
WO2010134074A1 (en) 2009-05-19 2010-11-25 Neuroderm Ltd Compositions for continuous administration of dopa decarboxylase inhibitors
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (en) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
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RU2013114390A (ru) 2010-08-31 2014-10-10 СНУ Ар энд ДиБи ФАУНДЕЙШН Применение фетального репрограммирования посредством ppar-дельта-агониста
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Also Published As

Publication number Publication date
MX2008014208A (es) 2008-11-14
MY148483A (en) 2013-04-30
CA2651466A1 (en) 2007-11-22
NO20085064L (no) 2009-02-06
US20090149486A1 (en) 2009-06-11
DE102006021872A1 (de) 2007-12-27
JP2009536626A (ja) 2009-10-15
TW200815367A (en) 2008-04-01
EP2024339B1 (de) 2013-04-10
IL195178A0 (en) 2009-08-03
AU2007250210A1 (en) 2007-11-22
EP2024339A1 (de) 2009-02-18
BRPI0711399A2 (pt) 2011-11-01
AR060993A1 (es) 2008-07-30
CN101421249A (zh) 2009-04-29
AU2007250210B2 (en) 2011-11-10
KR20090007413A (ko) 2009-01-16
US7709494B2 (en) 2010-05-04
WO2007131619A1 (de) 2007-11-22

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