DE102005026194A1 - Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln - Google Patents

Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln Download PDF

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Publication number
DE102005026194A1
DE102005026194A1 DE102005026194A DE102005026194A DE102005026194A1 DE 102005026194 A1 DE102005026194 A1 DE 102005026194A1 DE 102005026194 A DE102005026194 A DE 102005026194A DE 102005026194 A DE102005026194 A DE 102005026194A DE 102005026194 A1 DE102005026194 A1 DE 102005026194A1
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Prior art keywords
benzo
isoxazol
phenyl
butyl
fluoro
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DE102005026194A
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German (de)
English (en)
Inventor
Beatrix Dr. Merla
Matthias Dr. Gerlach
Corinna Dr. Sundermann
Utz-Peter Jagusch
Hagen-Heinrich Dr. Hennies
Stefan Dr. Oberbörsch
Michael Dr. Haurand
Ruth Dr. Jostock
Melanie Dr. Reich
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Gruenenthal GmbH
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Gruenenthal GmbH
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Priority to DE102005026194A priority Critical patent/DE102005026194A1/de
Priority to JP2008515121A priority patent/JP2008542414A/ja
Priority to SI200631193T priority patent/SI1893589T1/sl
Priority to DK06761974.2T priority patent/DK1893589T3/da
Priority to CA002610373A priority patent/CA2610373A1/en
Priority to US11/916,613 priority patent/US20080312301A1/en
Priority to EP06761974A priority patent/EP1893589B1/de
Priority to PT06761974T priority patent/PT1893589E/pt
Priority to ES06761974T priority patent/ES2373684T3/es
Priority to PL06761974T priority patent/PL1893589T3/pl
Priority to AT06761974T priority patent/ATE524451T1/de
Priority to PCT/EP2006/005356 priority patent/WO2006131296A1/de
Publication of DE102005026194A1 publication Critical patent/DE102005026194A1/de
Priority to CY20111101238T priority patent/CY1112449T1/el
Withdrawn legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P25/36—Opioid-abuse
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Diabetes (AREA)
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DE102005026194A 2005-06-06 2005-06-06 Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln Withdrawn DE102005026194A1 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE102005026194A DE102005026194A1 (de) 2005-06-06 2005-06-06 Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
PT06761974T PT1893589E (pt) 2005-06-06 2006-06-06 Derivados substituídos de n-benzo[d]isoxazol-3-il-amina como inibidores de recetores mglur5, recetores de serotonina-(5-ht) e recetores de noradrenalina e sua utilização na produção de medicamentos
ES06761974T ES2373684T3 (es) 2005-06-06 2006-06-06 Derivados de n-benzo[d]isoxazol-3-il-amina sustituidos como inhibidores de los receptores mglur5, serotonina (5-ht) y noradrenalina y su utilización en la producción de medicamentos.
DK06761974.2T DK1893589T3 (da) 2005-06-06 2006-06-06 Substituerede N-benzo[d]isoxazol-3-yl-amin-derivater som inhibitorer af mGluR5-, serotonin-(5-HT) og noradrenalinreceptorer og deres anvendelse til fremstilling af lægemidler
CA002610373A CA2610373A1 (en) 2005-06-06 2006-06-06 Substituted n-benzo [d] isoxazol-3-ylamine derivatives as inhibitors of mglur5, serotonine (5-ht) and noradrenaline receptors, and the use thereof for producing medicaments
US11/916,613 US20080312301A1 (en) 2005-06-06 2006-06-06 Substituted N-Benzo[D]Isoxazol-3-Yl-Amine Compounds as Inhibitors of Mglur5, Serotonin (5-Ht) and Noradrenaline Receptors, and Uses Thereof
EP06761974A EP1893589B1 (de) 2005-06-06 2006-06-06 Substituierte n-benzo [d] isoxazol-3-yl-amin-derivative als inhibitoren von mglur5, serotonin-(5-ht) und noradrenalin rezeptoren und deren verwendung zur herstellung von arzneimitteln
JP2008515121A JP2008542414A (ja) 2005-06-06 2006-06-06 ＭＧｌＵＲ５、セロトニン（５−ＨＴ）及びノルアドレナリン受容体の阻害剤としての置換されたＮ−ベンゾ［Ｄ］イソオキサゾール−３−イル−アミン誘導体及び医薬の製造へのその使用
SI200631193T SI1893589T1 (sl) 2005-06-06 2006-06-06 Substituirani N-benzo(d)izoksazol-3-il-aminski derivati kot inhibitorji mGluR5, serotonin-(5-HT) in noradrenalinskih receptorjev in njihova uporaba za pripravo zdravil
PL06761974T PL1893589T3 (pl) 2005-06-06 2006-06-06 PODSTAWIONE POCHODNE N-BENZO[D]IZOKSAZOL-3-ILOAMINY JAKO INHIBITORY RECEPTORÓW mGluR5, SEROTONINY (5-HT) I NORADRENALINY I ICH ZASTOSOWANIE DO WYTWARZANIA ŚRODKÓW LECZNICZYCH
AT06761974T ATE524451T1 (de) 2005-06-06 2006-06-06 Substituierte n-benzo ädü isoxazol-3-yl-amin- derivative als inhibitoren von mglur5, serotonin- (5-ht) und noradrenalin rezeptoren und deren verwendung zur herstellung von arzneimitteln
PCT/EP2006/005356 WO2006131296A1 (de) 2005-06-06 2006-06-06 Substituierte n-benzo [d] isoxazol-3-yl-amin-derivative als inhibitoren von mglur5, serotonin- (5-ht) und noradrenalin rezeptoren und deren verwendung zur herstellung von arzneimitteln
CY20111101238T CY1112449T1 (el) 2005-06-06 2011-12-13 Υποκατεστημενα ν-βενζο [d] ισοξαζολ-3-υλ-αμινο παραγωγα ως αναστολεις υποδοχεων mglur5, σεροτονινης-(5-ητ) και νοραδρεναλινης και η χρηση αυτων για την παραγωγη φαρμακων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005026194A DE102005026194A1 (de) 2005-06-06 2005-06-06 Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln

Publications (1)

Publication Number Publication Date
DE102005026194A1 true DE102005026194A1 (de) 2006-12-07

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ID=36792815

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DE102005026194A Withdrawn DE102005026194A1 (de) 2005-06-06 2005-06-06 Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln

Country Status (13)

Country Link
US (1) US20080312301A1 (https=)
EP (1) EP1893589B1 (https=)
JP (1) JP2008542414A (https=)
AT (1) ATE524451T1 (https=)
CA (1) CA2610373A1 (https=)
CY (1) CY1112449T1 (https=)
DE (1) DE102005026194A1 (https=)
DK (1) DK1893589T3 (https=)
ES (1) ES2373684T3 (https=)
PL (1) PL1893589T3 (https=)
PT (1) PT1893589E (https=)
SI (1) SI1893589T1 (https=)
WO (1) WO2006131296A1 (https=)

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DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
ES2457418T3 (es) * 2007-07-16 2014-04-25 Abbvie Inc. Indazoles, bencisoxazoles y bencisotiazoles como inhibidores de proteína cinasas
KR102746352B1 (ko) 2014-08-13 2024-12-24 오클랜드 유니서비시즈 리미티드 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도
CA2996681C (en) * 2015-08-27 2024-04-09 Auckland Uniservices Limited Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy
WO2017160930A1 (en) * 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
CN110117278B (zh) * 2018-02-07 2022-07-19 石家庄以岭药业股份有限公司 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途
US20230250088A1 (en) * 2020-07-15 2023-08-10 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
EP4190770A4 (en) * 2020-07-29 2024-07-31 Vivozon, Inc. DOUBLE REGULATOR FOR MGLUR5 AND 5-HT2A RECEIVERS AND USE THEREOF
IL310724A (en) 2021-08-10 2024-04-01 Ifm Due Inc COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH STING ACTIVITY

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JPS5721377A (en) * 1980-07-11 1982-02-04 Shionogi & Co Ltd 3-substituted-1,2-benzisoxazole derivative
WO2003022280A2 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 3-glyoxlylamideindoles for treating cancer
WO2005089753A2 (en) * 2004-03-16 2005-09-29 Janssen Pharmaceutica N.V. Daao inhibiting bξnzisoxazoles and their use for the treatment of mental disorders

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FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
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ES2373684T3 (es) 2012-02-07
EP1893589B1 (de) 2011-09-14
JP2008542414A (ja) 2008-11-27
WO2006131296A1 (de) 2006-12-14
CY1112449T1 (el) 2015-12-09
ATE524451T1 (de) 2011-09-15
EP1893589A1 (de) 2008-03-05
CA2610373A1 (en) 2006-12-14
US20080312301A1 (en) 2008-12-18

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