DE102004029909A1 - Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern - Google Patents

Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern Download PDF

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Publication number
DE102004029909A1
DE102004029909A1 DE102004029909A DE102004029909A DE102004029909A1 DE 102004029909 A1 DE102004029909 A1 DE 102004029909A1 DE 102004029909 A DE102004029909 A DE 102004029909A DE 102004029909 A DE102004029909 A DE 102004029909A DE 102004029909 A1 DE102004029909 A1 DE 102004029909A1
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Germany
Prior art keywords
treatment
reagent carrier
reagent
carrier body
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004029909A
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German (de)
English (en)
Inventor
Hans Dr. Hornauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Priority to DE102004029909A priority Critical patent/DE102004029909A1/de
Priority to AU2005202528A priority patent/AU2005202528B2/en
Priority to SG200503727A priority patent/SG118365A1/en
Priority to KR1020050049645A priority patent/KR101080024B1/ko
Priority to MXPA05006324A priority patent/MXPA05006324A/es
Priority to CA002510125A priority patent/CA2510125C/en
Priority to JP2005179580A priority patent/JP2006010690A/ja
Priority to BRPI0502150-2A priority patent/BRPI0502150A/pt
Priority to US11/156,855 priority patent/US7608466B2/en
Priority to EP05013260A priority patent/EP1610129B1/de
Priority to CNA2005100795762A priority patent/CN1712969A/zh
Publication of DE102004029909A1 publication Critical patent/DE102004029909A1/de
Priority to US12/554,060 priority patent/US20090325279A1/en
Withdrawn legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
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    • B01J2219/0061The surface being organic
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    • B01J2219/00583Features relative to the processes being carried out
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    • B01J2219/00623Immobilisation or binding
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    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/0063Other, e.g. van der Waals forces, hydrogen bonding
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00637Introduction of reactive groups to the surface by coating it with another layer
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00718Type of compounds synthesised
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
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    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/110833Utilizing a moving indicator strip or tape
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/112499Automated chemical analysis with sample on test slide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Peptides Or Proteins (AREA)
DE102004029909A 2004-06-21 2004-06-21 Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern Withdrawn DE102004029909A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE102004029909A DE102004029909A1 (de) 2004-06-21 2004-06-21 Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern
AU2005202528A AU2005202528B2 (en) 2004-06-21 2005-06-09 Process and device for producing reagent carriers having a binding capability
SG200503727A SG118365A1 (en) 2004-06-21 2005-06-10 Process and device for producing reagent carriers having a binding capability
KR1020050049645A KR101080024B1 (ko) 2004-06-21 2005-06-10 결합성을 갖는 시약 캐리어를 제조하기 위한 공정 및 장치
MXPA05006324A MXPA05006324A (es) 2004-06-21 2005-06-13 Proceso y dispositivo para producir portadores reactivos que tienen una capacidad de union.
CA002510125A CA2510125C (en) 2004-06-21 2005-06-17 Process and device for producing reagent carriers having a binding capability
JP2005179580A JP2006010690A (ja) 2004-06-21 2005-06-20 結合能力をもった試薬担体を製造する方法および装置
BRPI0502150-2A BRPI0502150A (pt) 2004-06-21 2005-06-20 processo e dispositivo para produzir veìculos de reagente que têm uma capacidade de ligação
US11/156,855 US7608466B2 (en) 2004-06-21 2005-06-20 Process and device for producing reagent carriers
EP05013260A EP1610129B1 (de) 2004-06-21 2005-06-20 Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern
CNA2005100795762A CN1712969A (zh) 2004-06-21 2005-06-21 用于制造具有绑定能力的试剂载体的方法和设备
US12/554,060 US20090325279A1 (en) 2004-06-21 2009-09-04 Process and device for producing reagent carriers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004029909A DE102004029909A1 (de) 2004-06-21 2004-06-21 Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern

Publications (1)

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DE102004029909A1 true DE102004029909A1 (de) 2006-01-19

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DE102004029909A Withdrawn DE102004029909A1 (de) 2004-06-21 2004-06-21 Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern

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Country Link
US (2) US7608466B2 (https=)
EP (1) EP1610129B1 (https=)
JP (1) JP2006010690A (https=)
KR (1) KR101080024B1 (https=)
CN (1) CN1712969A (https=)
AU (1) AU2005202528B2 (https=)
BR (1) BRPI0502150A (https=)
CA (1) CA2510125C (https=)
DE (1) DE102004029909A1 (https=)
MX (1) MXPA05006324A (https=)
SG (1) SG118365A1 (https=)

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AU2011281706A1 (en) 2010-07-19 2013-01-10 F. Hoffmann-La Roche Ag Blood plasma biomarkers for bevacizumab combination therapies for treatment of breast cancer
JP5963005B2 (ja) 2010-07-19 2016-08-03 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 膵臓癌の治療のためのベバシズマブ組合せ療法のための血漿バイオマーカー
EP2848939A1 (en) 2010-07-19 2015-03-18 F. Hoffmann-La Roche AG Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
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EP1610129B1 (de) 2012-10-24
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US20090325279A1 (en) 2009-12-31
CA2510125A1 (en) 2005-12-21
CN1712969A (zh) 2005-12-28
SG118365A1 (en) 2006-01-27
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US20050282235A1 (en) 2005-12-22
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