DE10161940A1 - N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren - Google Patents
N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitorenInfo
- Publication number
- DE10161940A1 DE10161940A1 DE10161940A DE10161940A DE10161940A1 DE 10161940 A1 DE10161940 A1 DE 10161940A1 DE 10161940 A DE10161940 A DE 10161940A DE 10161940 A DE10161940 A DE 10161940A DE 10161940 A1 DE10161940 A1 DE 10161940A1
- Authority
- DE
- Germany
- Prior art keywords
- group
- indole
- lower alkyl
- different
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003909 protein kinase inhibitor Substances 0.000 title claims description 18
- VVVPGLRKXQSQSZ-UHFFFAOYSA-N indolo[3,2-c]carbazole Chemical class C1=CC=CC2=NC3=C4C5=CC=CC=C5N=C4C=CC3=C21 VVVPGLRKXQSQSZ-UHFFFAOYSA-N 0.000 title description 14
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title description 6
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- 239000003814 drug Substances 0.000 claims abstract description 6
- 208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 6
- 230000004770 neurodegeneration Effects 0.000 claims abstract description 5
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- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 4
- 230000003211 malignant effect Effects 0.000 claims abstract description 4
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 4
- 125000003118 aryl group Chemical group 0.000 claims description 109
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- 125000000217 alkyl group Chemical group 0.000 claims description 80
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 75
- 239000000203 mixture Substances 0.000 claims description 72
- 229910052736 halogen Inorganic materials 0.000 claims description 62
- 150000002367 halogens Chemical class 0.000 claims description 62
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 54
- 125000001072 heteroaryl group Chemical group 0.000 claims description 43
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- 125000003342 alkenyl group Chemical group 0.000 claims description 14
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- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims description 10
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- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000004434 sulfur atom Chemical group 0.000 claims description 6
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- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
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- 238000000034 method Methods 0.000 description 10
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- 125000001309 chloro group Chemical group Cl* 0.000 description 8
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- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 description 1
- 125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10161940A DE10161940A1 (de) | 2001-12-17 | 2001-12-17 | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
| PCT/EP2002/013753 WO2003051887A1 (en) | 2001-12-17 | 2002-12-04 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors |
| EP02804874A EP1456211A1 (en) | 2001-12-17 | 2002-12-04 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors |
| CA002467780A CA2467780A1 (en) | 2001-12-17 | 2002-12-04 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors |
| JP2003552769A JP2005518379A (ja) | 2001-12-17 | 2002-12-04 | プロテインキナーゼ阻害剤としてのｎ−炭素環式単置換インドロカルバゾール |
| US10/496,505 US7262215B2 (en) | 2001-12-17 | 2002-12-04 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors |
| AU2002356625A AU2002356625A1 (en) | 2001-12-17 | 2002-12-04 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10161940A DE10161940A1 (de) | 2001-12-17 | 2001-12-17 | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10161940A1 true DE10161940A1 (de) | 2003-07-03 |
Family
ID=7709523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10161940A Withdrawn DE10161940A1 (de) | 2001-12-17 | 2001-12-17 | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7262215B2 (https=) |
| EP (1) | EP1456211A1 (https=) |
| JP (1) | JP2005518379A (https=) |
| AU (1) | AU2002356625A1 (https=) |
| CA (1) | CA2467780A1 (https=) |
| DE (1) | DE10161940A1 (https=) |
| WO (1) | WO2003051887A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122526B2 (en) * | 2000-10-31 | 2006-10-17 | Nanosphere, Inc. | Indolocarbazole anticancer agents and methods of using same |
| CL2007003693A1 (es) | 2006-12-22 | 2008-06-27 | Actelion Pharmaceuticals Ltd | Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas. |
| US20100273769A1 (en) * | 2009-01-26 | 2010-10-28 | Hanno Roder | Composition and method for the treatment of parkinson's disease |
| CN102557967A (zh) * | 2011-12-28 | 2012-07-11 | 合肥科尚医药科技有限公司 | 一种盐酸氨溴索的制备方法 |
| CN103113379A (zh) * | 2013-03-12 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 阿塞那平马来酸盐的合成工艺 |
| CN117886799B (zh) * | 2024-01-11 | 2025-07-29 | 浙江工业大学 | 一类靶向降解GSK-3β的蛋白降解靶向嵌合体化合物及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018766A1 (en) * | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Further indole derivatives with antiviral activity |
| WO1996004906A1 (en) * | 1994-08-13 | 1996-02-22 | The Wellcome Foundation Limited | Compounds for the treatment of restenosis |
| WO2000001699A1 (en) * | 1998-07-02 | 2000-01-13 | Bayer Aktiengesellschaft | Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5438050A (en) * | 1988-02-06 | 1995-08-01 | Godecke Aktiengesellschaft | Indolocarbazole derivatives, processes for their preparation and compositions containing them |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| DK1044203T3 (da) * | 1997-12-31 | 2003-07-14 | Cephalon Inc | 3'-epimere K-252a-derivater |
| US7122526B2 (en) * | 2000-10-31 | 2006-10-17 | Nanosphere, Inc. | Indolocarbazole anticancer agents and methods of using same |
| EP1432721A4 (en) * | 2001-09-13 | 2008-02-20 | Bristol Myers Squibb Co | PROCESS FOR THE PREPARATION OF REBECCAMYCIN AND ANALOGUE THEREOF |
-
2001
- 2001-12-17 DE DE10161940A patent/DE10161940A1/de not_active Withdrawn
-
2002
- 2002-12-04 AU AU2002356625A patent/AU2002356625A1/en not_active Abandoned
- 2002-12-04 EP EP02804874A patent/EP1456211A1/en not_active Withdrawn
- 2002-12-04 CA CA002467780A patent/CA2467780A1/en not_active Abandoned
- 2002-12-04 US US10/496,505 patent/US7262215B2/en not_active Expired - Fee Related
- 2002-12-04 WO PCT/EP2002/013753 patent/WO2003051887A1/en not_active Ceased
- 2002-12-04 JP JP2003552769A patent/JP2005518379A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018766A1 (en) * | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Further indole derivatives with antiviral activity |
| WO1996004906A1 (en) * | 1994-08-13 | 1996-02-22 | The Wellcome Foundation Limited | Compounds for the treatment of restenosis |
| WO2000001699A1 (en) * | 1998-07-02 | 2000-01-13 | Bayer Aktiengesellschaft | Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005518379A (ja) | 2005-06-23 |
| US20050075386A1 (en) | 2005-04-07 |
| WO2003051887A1 (en) | 2003-06-26 |
| US7262215B2 (en) | 2007-08-28 |
| EP1456211A1 (en) | 2004-09-15 |
| CA2467780A1 (en) | 2003-06-26 |
| AU2002356625A1 (en) | 2003-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8130 | Withdrawal |