DD299311A5 - Rekombinante aprotinin-varianten-gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben - Google Patents

Rekombinante aprotinin-varianten-gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben Download PDF

Info

Publication number
DD299311A5
DD299311A5 DD90343955A DD34395590A DD299311A5 DD 299311 A5 DD299311 A5 DD 299311A5 DD 90343955 A DD90343955 A DD 90343955A DD 34395590 A DD34395590 A DD 34395590A DD 299311 A5 DD299311 A5 DD 299311A5
Authority
DD
German Democratic Republic
Prior art keywords
aprotinin
variants
ala
arg
yeast
Prior art date
Application number
DD90343955A
Other languages
German (de)
English (en)
Inventor
Juergen Ebbers
Dietrich Hoerlein
Michael Schedel
Rathindra Das
Original Assignee
������@������������k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������@������������k�� filed Critical ������@������������k��
Publication of DD299311A5 publication Critical patent/DD299311A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DD90343955A 1989-09-13 1990-09-11 Rekombinante aprotinin-varianten-gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben DD299311A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3930522A DE3930522A1 (de) 1989-09-13 1989-09-13 Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Publications (1)

Publication Number Publication Date
DD299311A5 true DD299311A5 (de) 1992-04-09

Family

ID=6389306

Family Applications (1)

Application Number Title Priority Date Filing Date
DD90343955A DD299311A5 (de) 1989-09-13 1990-09-11 Rekombinante aprotinin-varianten-gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Country Status (15)

Country Link
US (1) US5164482A (fr)
EP (1) EP0419878B1 (fr)
JP (1) JP2916228B2 (fr)
KR (1) KR0169976B1 (fr)
AT (1) ATE113074T1 (fr)
AU (1) AU632361B2 (fr)
CA (1) CA2025070C (fr)
DD (1) DD299311A5 (fr)
DE (2) DE3930522A1 (fr)
DK (1) DK0419878T3 (fr)
ES (1) ES2062235T3 (fr)
FI (1) FI104724B (fr)
HU (1) HU213582B (fr)
IL (1) IL95618A (fr)
ZA (1) ZA907266B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
US5056341A (en) * 1989-06-08 1991-10-15 Sanyo Electric Co., Ltd. Washing machine
US5231010A (en) * 1989-09-13 1993-07-27 Bayer Aktiengesellschaft Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
DE4417353A1 (de) * 1994-05-18 1996-01-25 Bayer Ag Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
DE19629982A1 (de) 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
CA2453264A1 (fr) * 2001-07-10 2003-04-24 Omnio Ab Nouvelles cibles medicamenteuses pour l'arthrite
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
AU2006290733B8 (en) 2005-09-16 2012-07-05 Bayer Intellectual Property Gmbh Transplastomic plants expressing lumen-targeted protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037806A (en) * 1985-02-22 1991-08-06 Monsanto Company Biologically active method using somatotropins
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid

Also Published As

Publication number Publication date
AU6245390A (en) 1991-03-21
AU632361B2 (en) 1992-12-24
IL95618A (en) 1996-09-12
IL95618A0 (en) 1991-06-30
HUT62031A (en) 1993-03-29
US5164482A (en) 1992-11-17
FI104724B (fi) 2000-03-31
JPH03197496A (ja) 1991-08-28
DK0419878T3 (da) 1994-11-21
ZA907266B (en) 1991-07-31
DE59007498D1 (de) 1994-11-24
EP0419878A1 (fr) 1991-04-03
DE3930522A1 (de) 1991-03-21
CA2025070A1 (fr) 1991-03-14
ATE113074T1 (de) 1994-11-15
KR910006483A (ko) 1991-04-29
HU905877D0 (en) 1991-03-28
JP2916228B2 (ja) 1999-07-05
KR0169976B1 (ko) 1999-02-01
CA2025070C (fr) 2001-01-02
HU213582B (en) 1997-08-28
FI904474A0 (fi) 1990-09-11
ES2062235T3 (es) 1994-12-16
EP0419878B1 (fr) 1994-10-19

Similar Documents

Publication Publication Date Title
EP0401508B1 (fr) Inhibiteurs de protéinase, leur procédé de préparation ainsi que compositions pharmaceutiques les contenant
EP0307592B1 (fr) Analogues de l'inhibiteur de la trypsine pancréatique bovine, leur production et utilisation
DE68923878T2 (de) Rekombinante techniken zur herstellung neuer natriuretischer und gefässerweiternder peptide.
DE69004966T2 (de) Antikoagulierendes protein.
EP0419878B1 (fr) Variants de l'aprotinine et procédé recombinant pour la préparation microbienne de ces variants de forme homogène
DE69024104T2 (de) Polypeptide und Polypeptidanaloge mit inhibitorischer Aktivität gegenüber menschlicher Elastase
JPS62502661A (ja) 形質転換された酵母及びヒルジンの製造方法
DE3587875T2 (de) Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu.
EP0278112A2 (fr) Inhibiteur de trypsine secrété par le pancréas et ses variants produits par génie génétique
EP0393431A1 (fr) Homologues de l'inhibiteur de la protéase d'Alzheimer préparés de manière génétique, des souches hôtes et vecteurs d'expression pour leur préparation et leur utilisation comme médicament
EP0419099B1 (fr) Protéines ayant des propriétés anticoagulantes
DE3600571A1 (de) Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
JPH05247090A (ja) 抗トロンビンポリペプチド
EP0297362A2 (fr) Aprotinine humaine dont le reste Lys en 15 est substitué par un autre reste protogène d'amino-acide
EP0821007B1 (fr) Variant de l'aprotinine ayant des propriétés améliorées
DE3724581A1 (de) Dna-sequenzen, die fuer proteine mit den biologischen eigenschaften des cystatin c codieren, herstellung dieser dna-sequenzen, expression des cystatin c sowie dieses enthaltende pharmazeutische zubereitungen
US6090585A (en) Human collagenase inhibitor sequence, recombinant vector system for using same and recombinant-DNA method for the manufacture of same
US5231010A (en) Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
EP0683229A2 (fr) Procédé de préparation de l'aprotinine recombinante et de variants recombinants de l'aprotinine avec une séquence N-terminale naturelle
EP0332576B1 (fr) Protéine modifiée
EP1002083A1 (fr) Variantes d'aprotinine a proprietes ameliorees et bikunines de variantes d'aprotinine
EP0712934A2 (fr) Protéines avec une activité fibrinolytique et anticoagulante
EP0373335A2 (fr) Protéines inhibitrices des protéases du type sérine, médicaments les contenant, séquence d'ADN codant pour ces protéines et les procédés de production de ces protéines, médicament et séquences
DE3710430A1 (de) Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE19860801A1 (de) Rekombinanter Wachstumsfaktor mit der biologischen Aktivität eines G-CSF (Granulocyte Colony Stimulating Factor)

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee