DD281961A5 - Verfahren zur herstellung eines antitumorwirksamen arzneimittels - Google Patents
Verfahren zur herstellung eines antitumorwirksamen arzneimittels Download PDFInfo
- Publication number
- DD281961A5 DD281961A5 DD29699686A DD29699686A DD281961A5 DD 281961 A5 DD281961 A5 DD 281961A5 DD 29699686 A DD29699686 A DD 29699686A DD 29699686 A DD29699686 A DD 29699686A DD 281961 A5 DD281961 A5 DD 281961A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- hexadecylphosphocholine
- optionally
- weight
- mixture
- homogenized
- Prior art date
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- QSQGNBGEHSFMAA-UHFFFAOYSA-N octane-1,2,3-triol Chemical compound CCCCCC(O)C(O)CO QSQGNBGEHSFMAA-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- AALKGALVYCZETF-UHFFFAOYSA-N pentane-1,2,3-triol Chemical compound CCC(O)C(O)CO AALKGALVYCZETF-UHFFFAOYSA-N 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 231100000456 subacute toxicity Toxicity 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000011521 systemic chemotherapy Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- BETUMLXGYDBOLV-UHFFFAOYSA-N tetradecyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C BETUMLXGYDBOLV-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- LONLGEZTBVAKJF-UHFFFAOYSA-N undecane-1,2,3-triol Chemical compound CCCCCCCCC(O)C(O)CO LONLGEZTBVAKJF-UHFFFAOYSA-N 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3542893 | 1985-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD281961A5 true DD281961A5 (de) | 1990-08-29 |
Family
ID=6287628
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD29699686A DD281961A5 (de) | 1985-12-04 | 1986-12-03 | Verfahren zur herstellung eines antitumorwirksamen arzneimittels |
| DD29699786A DD259405A5 (de) | 1985-12-04 | 1986-12-03 | Verfahren zur herstellung von verbindungen mit cytotoxischer wirkung |
| DD31847188A DD285293A5 (de) | 1985-12-04 | 1988-07-29 | Verfahren zur herstellung eines (antitumorwirksamen) synergistisch wirkenden arzneimitteln |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD29699786A DD259405A5 (de) | 1985-12-04 | 1986-12-03 | Verfahren zur herstellung von verbindungen mit cytotoxischer wirkung |
| DD31847188A DD285293A5 (de) | 1985-12-04 | 1988-07-29 | Verfahren zur herstellung eines (antitumorwirksamen) synergistisch wirkenden arzneimitteln |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2697736B2 (enrdf_load_stackoverflow) |
| DD (3) | DD281961A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3685214D1 (enrdf_load_stackoverflow) |
| ZA (2) | ZA869119B (enrdf_load_stackoverflow) |
-
1986
- 1986-12-03 ZA ZA869119A patent/ZA869119B/xx unknown
- 1986-12-03 DD DD29699686A patent/DD281961A5/de unknown
- 1986-12-03 ZA ZA869121A patent/ZA869121B/xx unknown
- 1986-12-03 DD DD29699786A patent/DD259405A5/de unknown
- 1986-12-04 DE DE87900101T patent/DE3685214D1/de not_active Expired - Lifetime
- 1986-12-04 JP JP62500472A patent/JP2697736B2/ja not_active Expired - Fee Related
-
1988
- 1988-07-29 DD DD31847188A patent/DD285293A5/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA869119B (en) | 1987-08-26 |
| JPS63501874A (ja) | 1988-07-28 |
| ZA869121B (en) | 1987-08-26 |
| DD259405A5 (de) | 1988-08-24 |
| JP2697736B2 (ja) | 1998-01-14 |
| DD285293A5 (de) | 1990-12-12 |
| DE3685214D1 (enrdf_load_stackoverflow) | 1992-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF04 | In force in the year 2004 |
Expiry date: 20061204 |