DD273262A5 - Verfahren zur herstellung von 19,11 beta ueberbrueckte steroide - Google Patents
Verfahren zur herstellung von 19,11 beta ueberbrueckte steroide Download PDFInfo
- Publication number
- DD273262A5 DD273262A5 DD88313750A DD31375088A DD273262A5 DD 273262 A5 DD273262 A5 DD 273262A5 DD 88313750 A DD88313750 A DD 88313750A DD 31375088 A DD31375088 A DD 31375088A DD 273262 A5 DD273262 A5 DD 273262A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- radical
- group
- hydroxy
- hydrogen atom
- meaning
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0063—Nitrogen and oxygen at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873708942 DE3708942A1 (de) | 1987-03-18 | 1987-03-18 | 19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
Publications (1)
Publication Number | Publication Date |
---|---|
DD273262A5 true DD273262A5 (de) | 1989-11-08 |
Family
ID=6323462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD88313750A DD273262A5 (de) | 1987-03-18 | 1988-03-17 | Verfahren zur herstellung von 19,11 beta ueberbrueckte steroide |
Country Status (19)
Country | Link |
---|---|
US (1) | US5095129A (fi) |
EP (1) | EP0283428B1 (fi) |
JP (1) | JP2588267B2 (fi) |
CN (3) | CN1033033C (fi) |
AT (1) | ATE69055T1 (fi) |
AU (1) | AU628015B2 (fi) |
CA (1) | CA1326015C (fi) |
DD (1) | DD273262A5 (fi) |
DE (2) | DE3708942A1 (fi) |
ES (1) | ES2040373T3 (fi) |
FI (1) | FI101883B (fi) |
GR (1) | GR3003362T3 (fi) |
HU (2) | HU206368B (fi) |
IE (1) | IE62480B1 (fi) |
IL (1) | IL85773A (fi) |
NZ (1) | NZ223924A (fi) |
PT (1) | PT87007B (fi) |
WO (1) | WO1988007051A1 (fi) |
ZA (1) | ZA881962B (fi) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5446178A (en) * | 1987-03-18 | 1995-08-29 | Schering Aktiengesellschaft | Process for preparing 19,11β-bridged steroids |
DE3832303A1 (de) * | 1988-09-20 | 1990-04-12 | Schering Ag | 11ss-phenyl-14ssh-steroide |
DE3917274A1 (de) * | 1989-05-24 | 1990-11-29 | Schering Ag | 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3921059A1 (de) * | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
DD289541A5 (de) * | 1989-08-04 | 1991-05-02 | ��@�K@�������������@�K@��������������@��������k�� | Verfahren zur herstellung von 11beta-aryl-16 alpha, 17 alph-cyclohexanoestra-4,9-dienen |
DE4038128A1 (de) * | 1990-11-27 | 1992-06-04 | Schering Ag | 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
US5439913A (en) * | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
DE4235220A1 (de) * | 1992-10-13 | 1994-06-16 | Schering Ag | Gestagen wirksame 19,11ß-überbrückte 4-Estrene |
DE4413185A1 (de) * | 1994-04-12 | 1995-10-19 | Schering Ag | 11beta,19-überbrückte 13alpha-Alkylsteroide |
DE4413184A1 (de) * | 1994-04-12 | 1995-10-19 | Schering Ag | 10,11-C¶3¶-überbrückte Steroide |
DE4417880A1 (de) * | 1994-05-18 | 1995-11-23 | Schering Ag | 19,11beta-Überbrückte 18-Nor-Steroide, Verfahren zu ihrer Herstellung, diese Steroide enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln |
US5639598A (en) * | 1994-05-19 | 1997-06-17 | The Trustees Of The University Of Pennsylvania | Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions |
US5780220A (en) * | 1994-05-19 | 1998-07-14 | Trustees Of The University Of Pennsylvania | Methods and compositions for inhibiting HIV replication |
DE4424222C1 (de) * | 1994-07-09 | 1995-09-14 | Metallgesellschaft Ag | Gelöstes Methyllithium enthaltendes Synthesemittel sowie Verfahren zu deren Herstellung |
DE4434488A1 (de) * | 1994-09-14 | 1996-03-21 | Schering Ag | Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
US5521166A (en) * | 1994-12-19 | 1996-05-28 | Ortho Pharmaceitical Corporation | Antiprogestin cyclophasic hormonal regimen |
ZA9510926B (en) | 1994-12-23 | 1996-07-03 | Schering Ag | Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception |
IL118974A (en) * | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
DE19652408C2 (de) * | 1996-12-06 | 2002-04-18 | Schering Ag | Steroidester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln |
US6090798A (en) * | 1997-12-19 | 2000-07-18 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with glucocorticoid antagonists |
GB0000313D0 (en) * | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
SI2078032T1 (sl) | 2006-10-24 | 2017-12-29 | Repros Therapeutics Inc. | Sestave in postopki za zaviranje proliferacije endometrija |
TWI539953B (zh) | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
SG10201504913UA (en) | 2010-03-22 | 2015-07-30 | Repros Therapeutics Inc | Compositions and methods for non-toxic delivery of antiprogestins |
PL2576582T3 (pl) | 2010-05-26 | 2020-06-29 | Corcept Therapeutics, Inc. | Leczenie dystrofii mięśniowej |
CN103555806B (zh) * | 2013-11-16 | 2015-05-13 | 江南大学 | 一种高效利用亚麻刺盘孢霉合成7α-羟基-雄甾烯酮的方法 |
EP3265127B1 (en) | 2015-03-02 | 2024-02-21 | Corcept Therapeutics, Inc. | Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor |
MX2017011885A (es) | 2015-03-30 | 2018-02-19 | Corcept Therapeutics Inc | Uso de antagonistas de receptores de glucocorticoides en combinacion con glucocorticoides para tratar la insuficiencia adrenal. |
ES2865334T3 (es) | 2015-08-13 | 2021-10-15 | Corcept Therapeutics Inc | Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH |
KR102197526B1 (ko) | 2016-01-19 | 2020-12-31 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 이소성 쿠싱 증후군의 감별 진단 |
CA3065555A1 (en) | 2017-06-20 | 2018-12-27 | Corcept Therapeutics, Inc. | Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators |
US20240269280A1 (en) | 2020-12-18 | 2024-08-15 | Instil Bio (Uk) Limited | Processing of tumor infiltrating lymphocytes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
FR2576025B1 (fr) * | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
-
1987
- 1987-03-18 DE DE19873708942 patent/DE3708942A1/de not_active Withdrawn
-
1988
- 1988-03-11 DE DE88730061T patent/DE3865863D1/de not_active Expired - Lifetime
- 1988-03-11 WO PCT/DE1988/000150 patent/WO1988007051A1/de active IP Right Grant
- 1988-03-11 AT AT88730061T patent/ATE69055T1/de not_active IP Right Cessation
- 1988-03-11 AU AU14209/88A patent/AU628015B2/en not_active Ceased
- 1988-03-11 HU HU911518A patent/HU206368B/hu not_active IP Right Cessation
- 1988-03-11 EP EP88730061A patent/EP0283428B1/de not_active Expired - Lifetime
- 1988-03-11 JP JP63502319A patent/JP2588267B2/ja not_active Expired - Fee Related
- 1988-03-11 ES ES198888730061T patent/ES2040373T3/es not_active Expired - Lifetime
- 1988-03-17 IL IL8577388A patent/IL85773A/en not_active IP Right Cessation
- 1988-03-17 DD DD88313750A patent/DD273262A5/de not_active IP Right Cessation
- 1988-03-17 NZ NZ223924A patent/NZ223924A/en unknown
- 1988-03-17 CA CA000561771A patent/CA1326015C/en not_active Expired - Fee Related
- 1988-03-18 ZA ZA881962A patent/ZA881962B/xx unknown
- 1988-03-18 CN CN88102162A patent/CN1033033C/zh not_active Expired - Fee Related
- 1988-03-18 PT PT87007A patent/PT87007B/pt not_active IP Right Cessation
- 1988-03-18 IE IE79388A patent/IE62480B1/en not_active IP Right Cessation
- 1988-12-09 US US07/283,632 patent/US5095129A/en not_active Expired - Fee Related
-
1989
- 1989-09-15 FI FI894364A patent/FI101883B/fi not_active IP Right Cessation
-
1991
- 1991-12-17 GR GR91401682T patent/GR3003362T3/el unknown
-
1994
- 1994-07-11 HU HU94P/P00010P patent/HU210532A9/hu unknown
-
1996
- 1996-01-17 CN CN96100917A patent/CN1057770C/zh not_active Expired - Fee Related
- 1996-02-01 CN CN96102566A patent/CN1080267C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1057770C (zh) | 2000-10-25 |
ZA881962B (en) | 1988-09-08 |
NZ223924A (en) | 1991-12-23 |
EP0283428A1 (de) | 1988-09-21 |
EP0283428B1 (de) | 1991-10-30 |
DE3708942A1 (de) | 1988-09-29 |
FI894364A0 (fi) | 1989-09-15 |
CN1141926A (zh) | 1997-02-05 |
AU1420988A (en) | 1988-10-10 |
HU206368B (en) | 1992-10-28 |
ES2040373T3 (es) | 1993-10-16 |
CN1080267C (zh) | 2002-03-06 |
FI101883B1 (fi) | 1998-09-15 |
US5095129A (en) | 1992-03-10 |
JP2588267B2 (ja) | 1997-03-05 |
IL85773A0 (en) | 1988-09-30 |
GR3003362T3 (en) | 1993-02-17 |
JPH02503194A (ja) | 1990-10-04 |
FI101883B (fi) | 1998-09-15 |
DE3865863D1 (fi) | 1991-12-05 |
HU911518D0 (en) | 1991-11-28 |
ATE69055T1 (de) | 1991-11-15 |
CA1326015C (en) | 1994-01-11 |
IE880793L (en) | 1988-09-18 |
PT87007A (pt) | 1988-04-01 |
HU210532A9 (en) | 1995-04-28 |
CN88102162A (zh) | 1988-11-23 |
CN1033033C (zh) | 1996-10-16 |
IL85773A (en) | 1994-01-01 |
WO1988007051A1 (en) | 1988-09-22 |
IE62480B1 (en) | 1995-02-08 |
AU628015B2 (en) | 1992-09-10 |
PT87007B (pt) | 1992-06-30 |
CN1135488A (zh) | 1996-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ENJ | Ceased due to non-payment of renewal fee |