CZ375692A3 - Bradykinin antagonists for treating acute pancreatitis and pharmaceutical preparations based thereon - Google Patents
Bradykinin antagonists for treating acute pancreatitis and pharmaceutical preparations based thereon Download PDFInfo
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- CZ375692A3 CZ375692A3 CS923756A CS375692A CZ375692A3 CZ 375692 A3 CZ375692 A3 CZ 375692A3 CS 923756 A CS923756 A CS 923756A CS 375692 A CS375692 A CS 375692A CZ 375692 A3 CZ375692 A3 CZ 375692A3
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- Prior art keywords
- arg
- pro
- gly
- hyp
- benzoyl
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- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 108010081551 glycylphenylalanine Proteins 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 235000019626 lipase activity Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229960002511 phenobarbital sodium Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical group [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical class C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/043—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91122055 | 1991-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ375692A3 true CZ375692A3 (en) | 1993-12-15 |
Family
ID=8207466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS923756A CZ375692A3 (en) | 1991-12-21 | 1992-12-18 | Bradykinin antagonists for treating acute pancreatitis and pharmaceutical preparations based thereon |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5670619A (no) |
| EP (1) | EP0548825B1 (no) |
| JP (1) | JP3588472B2 (no) |
| KR (1) | KR930012034A (no) |
| CN (1) | CN1073603A (no) |
| AT (1) | ATE152733T1 (no) |
| AU (1) | AU662188B2 (no) |
| BG (1) | BG97168A (no) |
| BR (1) | BR9205062A (no) |
| CA (1) | CA2085781C (no) |
| CY (1) | CY2116B1 (no) |
| CZ (1) | CZ375692A3 (no) |
| DE (1) | DE69219574T2 (no) |
| DK (1) | DK0548825T3 (no) |
| ES (1) | ES2101017T3 (no) |
| FI (1) | FI925782A (no) |
| GR (1) | GR3024179T3 (no) |
| HU (1) | HU214056B (no) |
| IL (1) | IL104163A0 (no) |
| MA (1) | MA22743A1 (no) |
| MX (1) | MX9207440A (no) |
| NO (1) | NO924925L (no) |
| PL (1) | PL297044A1 (no) |
| SI (1) | SI9200406A (no) |
| TW (1) | TW199863B (no) |
| YU (1) | YU108192A (no) |
| ZA (1) | ZA929829B (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105172B1 (en) | 1999-11-18 | 2006-09-12 | Bolla John D | Treatment of rosacea |
| US20040248809A1 (en) * | 2003-02-07 | 2004-12-09 | Aventis Pharma Deutschland Gmbh | Use of antagonists of the bradykinin B2 receptor for the treatment of osteoarthrosis |
| RU2425669C1 (ru) * | 2010-04-13 | 2011-08-10 | Общество С Ограниченной Ответственностью "Гамаветфарм" | Средство для профилактики и лечения острого и хронического панкреатита |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2964956D1 (en) * | 1978-07-18 | 1983-04-07 | Kabi Ab | Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them |
| US4801613A (en) * | 1985-06-13 | 1989-01-31 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| US4693993A (en) * | 1985-06-13 | 1987-09-15 | Stewart John M | Bradykinin antagonist peptides |
| US4923963A (en) * | 1987-09-02 | 1990-05-08 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| US5162497A (en) * | 1987-09-24 | 1992-11-10 | The Administrators Of The Tulane Educational Fund | Bradykinin analogs with non-peptide bond |
| DE4013270A1 (de) * | 1990-04-26 | 1991-10-31 | Hoechst Ag | Peptide mit bradykinin-antagonistischer wirkung |
| IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
| DE3926822A1 (de) * | 1989-08-14 | 1991-02-21 | Hoechst Ag | Peptide mit bradykinin-antagonistischer wirkung |
| WO1991009055A1 (en) * | 1989-12-08 | 1991-06-27 | Boston University | Acylated bradykinin antagonists and uses therefor |
| EP0451791A2 (de) * | 1990-04-12 | 1991-10-16 | Hoechst Aktiengesellschaft | Langwirksame Liposomenpräparate von Peptidarzneistoffen und Verfahren zu ihrer Herstellung |
-
1992
- 1992-03-26 TW TW081102310A patent/TW199863B/zh active
- 1992-12-14 BG BG097168A patent/BG97168A/bg unknown
- 1992-12-16 MA MA23033A patent/MA22743A1/fr unknown
- 1992-12-17 AU AU30212/92A patent/AU662188B2/en not_active Ceased
- 1992-12-17 PL PL29704492A patent/PL297044A1/xx unknown
- 1992-12-18 ES ES92121558T patent/ES2101017T3/es not_active Expired - Lifetime
- 1992-12-18 NO NO92924925A patent/NO924925L/no unknown
- 1992-12-18 DE DE69219574T patent/DE69219574T2/de not_active Expired - Lifetime
- 1992-12-18 YU YU108192A patent/YU108192A/sh unknown
- 1992-12-18 CZ CS923756A patent/CZ375692A3/cs unknown
- 1992-12-18 BR BR9205062A patent/BR9205062A/pt not_active Application Discontinuation
- 1992-12-18 DK DK92121558.8T patent/DK0548825T3/da active
- 1992-12-18 MX MX9207440A patent/MX9207440A/es unknown
- 1992-12-18 CA CA002085781A patent/CA2085781C/en not_active Expired - Lifetime
- 1992-12-18 AT AT92121558T patent/ATE152733T1/de active
- 1992-12-18 IL IL104163A patent/IL104163A0/xx unknown
- 1992-12-18 EP EP92121558A patent/EP0548825B1/en not_active Expired - Lifetime
- 1992-12-18 JP JP33773592A patent/JP3588472B2/ja not_active Expired - Lifetime
- 1992-12-18 ZA ZA929829A patent/ZA929829B/xx unknown
- 1992-12-18 FI FI925782A patent/FI925782A/fi unknown
- 1992-12-19 KR KR1019920024742A patent/KR930012034A/ko not_active Application Discontinuation
- 1992-12-21 SI SI19929200406A patent/SI9200406A/sl unknown
- 1992-12-21 CN CN92114564A patent/CN1073603A/zh active Pending
- 1992-12-21 HU HU9204074A patent/HU214056B/hu not_active IP Right Cessation
-
1994
- 1994-04-22 US US08/232,338 patent/US5670619A/en not_active Expired - Lifetime
-
1997
- 1997-07-22 GR GR970401824T patent/GR3024179T3/el unknown
-
1998
- 1998-09-29 CY CY9800034A patent/CY2116B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI925782A (fi) | 1993-06-22 |
| HU9204074D0 (en) | 1993-04-28 |
| ZA929829B (en) | 1994-02-16 |
| CY2116B1 (en) | 2002-04-26 |
| DE69219574D1 (de) | 1997-06-12 |
| CA2085781A1 (en) | 1993-06-22 |
| YU108192A (sh) | 1995-12-04 |
| AU662188B2 (en) | 1995-08-24 |
| MX9207440A (es) | 1993-07-01 |
| EP0548825A1 (en) | 1993-06-30 |
| JPH05255107A (ja) | 1993-10-05 |
| SI9200406A (en) | 1993-06-30 |
| JP3588472B2 (ja) | 2004-11-10 |
| CN1073603A (zh) | 1993-06-30 |
| HU214056B (en) | 1997-12-29 |
| FI925782A0 (fi) | 1992-12-18 |
| ES2101017T3 (es) | 1997-07-01 |
| NO924925L (no) | 1993-06-22 |
| NO924925D0 (no) | 1992-12-18 |
| ATE152733T1 (de) | 1997-05-15 |
| CA2085781C (en) | 2003-09-23 |
| KR930012034A (ko) | 1993-07-20 |
| PL297044A1 (en) | 1993-09-06 |
| BR9205062A (pt) | 1993-09-28 |
| US5670619A (en) | 1997-09-23 |
| GR3024179T3 (en) | 1997-10-31 |
| TW199863B (no) | 1993-02-11 |
| DE69219574T2 (de) | 1997-11-13 |
| MA22743A1 (fr) | 1993-07-01 |
| HUT63336A (en) | 1993-08-30 |
| AU3021292A (en) | 1993-06-24 |
| IL104163A0 (en) | 1993-05-13 |
| BG97168A (bg) | 1993-12-24 |
| DK0548825T3 (da) | 1997-11-03 |
| EP0548825B1 (en) | 1997-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic |