CZ255197A3 - Použití 1-{4-[4-aryl (nebo heteroaryl)-1-piperazinyl]butyl}-1H-azolových derivátů pro přípravu léků pro použití při léčení obsedantních neuróz, syndromu spánkové apnoe, sexuálních disfunkcí, zvracení a kinetózy savců, včetně člověka - Google Patents
Použití 1-{4-[4-aryl (nebo heteroaryl)-1-piperazinyl]butyl}-1H-azolových derivátů pro přípravu léků pro použití při léčení obsedantních neuróz, syndromu spánkové apnoe, sexuálních disfunkcí, zvracení a kinetózy savců, včetně člověka Download PDFInfo
- Publication number
- CZ255197A3 CZ255197A3 CZ972551A CZ255197A CZ255197A3 CZ 255197 A3 CZ255197 A3 CZ 255197A3 CZ 972551 A CZ972551 A CZ 972551A CZ 255197 A CZ255197 A CZ 255197A CZ 255197 A3 CZ255197 A3 CZ 255197A3
- Authority
- CZ
- Czechia
- Prior art keywords
- butyl
- piperazinyl
- pyrimidinyl
- pyrazole
- imidazole
- Prior art date
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001107 psychogenic effect Effects 0.000 description 1
- 230000001003 psychopharmacologic effect Effects 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 230000002295 serotoninergic effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9514690A FR2742052B1 (fr) | 1995-12-12 | 1995-12-12 | Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ255197A3 true CZ255197A3 (cs) | 1998-01-14 |
Family
ID=9485400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ972551A CZ255197A3 (cs) | 1995-12-12 | 1996-12-11 | Použití 1-{4-[4-aryl (nebo heteroaryl)-1-piperazinyl]butyl}-1H-azolových derivátů pro přípravu léků pro použití při léčení obsedantních neuróz, syndromu spánkové apnoe, sexuálních disfunkcí, zvracení a kinetózy savců, včetně člověka |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0808166A1 (de) |
| JP (1) | JPH11501051A (de) |
| CN (1) | CN1177297A (de) |
| AR (1) | AR004378A1 (de) |
| AU (1) | AU716665B2 (de) |
| CA (1) | CA2211161A1 (de) |
| CZ (1) | CZ255197A3 (de) |
| ES (1) | ES2134709B1 (de) |
| FR (1) | FR2742052B1 (de) |
| HU (1) | HUP9800198A2 (de) |
| IL (1) | IL121461A0 (de) |
| NO (1) | NO973589L (de) |
| PL (1) | PL321779A1 (de) |
| TR (1) | TR199700794T1 (de) |
| WO (1) | WO1997021439A1 (de) |
| ZA (1) | ZA9610457B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763950B1 (fr) | 1997-06-02 | 2002-09-20 | Esteve Labor Dr | 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique |
| TW526202B (en) * | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
| US6046331A (en) * | 1998-12-17 | 2000-04-04 | Synaptic Pharmaceutical Corporation | Imidazolones and their use in treating benign prostatic hyperplasia and other disorders |
| CA2419552C (en) | 2000-08-14 | 2010-10-12 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
| DK1309592T3 (da) | 2000-08-14 | 2006-08-21 | Ortho Mcneil Pharm Inc | Substituerede pyrazoler |
| US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| MXPA03001421A (es) | 2000-08-14 | 2004-01-26 | Johnson & Johnson | Pirazoles sustituidos. |
| CN1642973A (zh) | 2000-09-06 | 2005-07-20 | 奥索-麦克尼尔药品公司 | 治疗变态反应的方法 |
| US7795266B2 (en) | 2003-09-25 | 2010-09-14 | Helton David R | Tetrahydroindolone derivatives for treament of neurological conditions |
| WO2005094827A1 (en) * | 2004-03-30 | 2005-10-13 | Kestrel Pharmaceuticals Inc. | Methods for treating sexual dysfunction |
| PT1877390E (pt) * | 2005-04-26 | 2010-05-31 | Hypnion Inc | Compostos benzisoxazole-piridina e métodos para a sua utilização |
| WO2006116615A1 (en) | 2005-04-26 | 2006-11-02 | Hypnion, Inc. | Benzisoxazole piperazine compounds and methods of use thereof |
| GB2435827A (en) * | 2006-03-09 | 2007-09-12 | Del Dr Esteve S A Spain Lab | Use of substituted piperazine compounds for the treatment of food related disorders |
| CN115304590B (zh) * | 2022-09-19 | 2024-05-28 | 皮摩尔新药(辽宁)有限公司 | 2h-苯并三氮唑衍生物及其制备方法及含有它们的药物组合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
| FR2723091B1 (fr) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles |
-
1995
- 1995-12-12 FR FR9514690A patent/FR2742052B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-11 WO PCT/EP1996/005736 patent/WO1997021439A1/fr not_active Application Discontinuation
- 1996-12-11 PL PL96321779A patent/PL321779A1/xx unknown
- 1996-12-11 HU HU9800198A patent/HUP9800198A2/hu unknown
- 1996-12-11 AU AU13764/97A patent/AU716665B2/en not_active Ceased
- 1996-12-11 JP JP9521756A patent/JPH11501051A/ja active Pending
- 1996-12-11 EP EP96944029A patent/EP0808166A1/de not_active Withdrawn
- 1996-12-11 CN CN96192286A patent/CN1177297A/zh active Pending
- 1996-12-11 CA CA002211161A patent/CA2211161A1/fr not_active Abandoned
- 1996-12-11 CZ CZ972551A patent/CZ255197A3/cs unknown
- 1996-12-11 TR TR97/00794T patent/TR199700794T1/xx unknown
- 1996-12-11 IL IL12146196A patent/IL121461A0/xx unknown
- 1996-12-12 AR ARP960105644A patent/AR004378A1/es unknown
- 1996-12-12 ZA ZA9610457A patent/ZA9610457B/xx unknown
- 1996-12-12 ES ES009602700A patent/ES2134709B1/es not_active Expired - Lifetime
-
1997
- 1997-08-04 NO NO973589A patent/NO973589L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2742052B1 (fr) | 1998-04-10 |
| TR199700794T1 (xx) | 1997-11-21 |
| IL121461A0 (en) | 1998-02-08 |
| PL321779A1 (en) | 1997-12-22 |
| AR004378A1 (es) | 1998-11-04 |
| AU1376497A (en) | 1997-07-03 |
| CA2211161A1 (fr) | 1997-06-19 |
| ES2134709B1 (es) | 2000-05-16 |
| NO973589L (no) | 1997-10-08 |
| JPH11501051A (ja) | 1999-01-26 |
| CN1177297A (zh) | 1998-03-25 |
| WO1997021439A1 (fr) | 1997-06-19 |
| EP0808166A1 (de) | 1997-11-26 |
| AU716665B2 (en) | 2000-03-02 |
| NO973589D0 (no) | 1997-08-04 |
| MX9706133A (es) | 1997-11-29 |
| ZA9610457B (en) | 1997-06-24 |
| HUP9800198A2 (hu) | 1999-09-28 |
| ES2134709A1 (es) | 1999-10-01 |
| FR2742052A1 (fr) | 1997-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic |