CY2521B1 - Preparation of aminoepoxides from aminoaldehydes and an in situ formed halomethyl organometallic reagent - Google Patents

Preparation of aminoepoxides from aminoaldehydes and an in situ formed halomethyl organometallic reagent

Info

Publication number
CY2521B1
CY2521B1 CY0500018A CY0500018A CY2521B1 CY 2521 B1 CY2521 B1 CY 2521B1 CY 0500018 A CY0500018 A CY 0500018A CY 0500018 A CY0500018 A CY 0500018A CY 2521 B1 CY2521 B1 CY 2521B1
Authority
CY
Cyprus
Prior art keywords
organometallic reagent
halomethyl
aminoepoxides
aminoaldehydes
preparation
Prior art date
Application number
CY0500018A
Other languages
English (en)
Inventor
Chin Liu
John S Ng
James R Behling
Arthur L Campbell
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of CY2521B1 publication Critical patent/CY2521B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Epoxy Resins (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CY0500018A 1996-12-31 2005-03-16 Preparation of aminoepoxides from aminoaldehydes and an in situ formed halomethyl organometallic reagent CY2521B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3380196P 1996-12-31 1996-12-31

Publications (1)

Publication Number Publication Date
CY2521B1 true CY2521B1 (en) 2006-02-08

Family

ID=21872516

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0500018A CY2521B1 (en) 1996-12-31 2005-03-16 Preparation of aminoepoxides from aminoaldehydes and an in situ formed halomethyl organometallic reagent

Country Status (21)

Country Link
US (1) US6127556A (xx)
EP (1) EP0970066B1 (xx)
JP (1) JP3710488B2 (xx)
KR (1) KR100523190B1 (xx)
CN (1) CN1247535A (xx)
AT (1) ATE250047T1 (xx)
AU (1) AU733905B2 (xx)
BR (1) BR9714129A (xx)
CA (1) CA2276488C (xx)
CY (1) CY2521B1 (xx)
CZ (1) CZ297432B6 (xx)
DE (1) DE69725014T2 (xx)
ES (1) ES2207760T3 (xx)
IL (1) IL130609A (xx)
NO (1) NO320276B1 (xx)
NZ (1) NZ336451A (xx)
PL (1) PL334387A1 (xx)
PT (1) PT970066E (xx)
RO (1) RO120135B1 (xx)
RU (1) RU2194045C2 (xx)
WO (1) WO1998029401A1 (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6123662A (en) 1998-07-13 2000-09-26 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6085754A (en) * 1998-07-13 2000-07-11 Acorn Cardiovascular, Inc. Cardiac disease treatment method
US6169922B1 (en) 1998-11-18 2001-01-02 Acorn Cardiovascular, Inc. Defibrillating cardiac jacket with interwoven electrode grids
US6230714B1 (en) * 1998-11-18 2001-05-15 Acorn Cardiovascular, Inc. Cardiac constraint with prior venus occlusion methods
US6155972A (en) 1999-02-02 2000-12-05 Acorn Cardiovascular, Inc. Cardiac constraint jacket construction
US6193648B1 (en) 1999-09-21 2001-02-27 Acorn Cardiovascular, Inc. Cardiac constraint with draw string tensioning
US6179791B1 (en) 1999-09-21 2001-01-30 Acorn Cardiovascular, Inc. Device for heart measurement
US6174279B1 (en) 1999-09-21 2001-01-16 Acorn Cardiovascular, Inc. Cardiac constraint with tension indicator
US6293906B1 (en) 2000-01-14 2001-09-25 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US6755779B2 (en) 2000-12-01 2004-06-29 Acorn Cardiovascular, Inc. Apparatus and method for delivery of cardiac constraint jacket
US6575921B2 (en) 2001-02-09 2003-06-10 Acorn Cardiovascular, Inc. Device for heart measurement
US6696594B2 (en) 2002-05-13 2004-02-24 Saudi Basic Industries Corporation Process for the conversion of aldehydes to esters
RU2485114C2 (ru) 2006-12-29 2013-06-20 Эбботт Гмбх Унд Ко.Кг Карбоксамидные соединения и их применение в качестве ингибиторов кальпаинов
WO2009136365A1 (en) * 2008-05-08 2009-11-12 Ranbaxy Laboratories Limited Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
ES2523343T3 (es) * 2008-09-24 2014-11-25 Zach System Procedimiento de preparación de nebivolol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268688A (en) * 1973-02-16 1981-05-19 Monsanto Company Asymmetric hydroformylation process
DE3711911A1 (de) * 1987-04-08 1988-10-20 Bayer Ag Optisch aktive (alpha)-aminoaldehyde, verfahren zu ihrer herstellung und ihre verwendung zur stereoselektiven herstellung optisch aktiver ss-aminoalkohole
WO1993023388A1 (en) * 1992-05-20 1993-11-25 G.D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
EP0730570B1 (en) * 1993-11-23 2000-04-19 G.D. SEARLE & CO. Method for making intermediates useful in synthesis of retroviral protease inhibitors
CA2137406C (en) * 1994-12-06 2005-09-13 Pierre Louis Beaulieu Process for key intermediates for hiv protease inhibitors

Also Published As

Publication number Publication date
RU2194045C2 (ru) 2002-12-10
JP3710488B2 (ja) 2005-10-26
PL334387A1 (en) 2000-02-28
KR100523190B1 (ko) 2005-10-21
NO993223D0 (no) 1999-06-29
KR20000069808A (ko) 2000-11-25
EP0970066A1 (en) 2000-01-12
US6127556A (en) 2000-10-03
ES2207760T3 (es) 2004-06-01
NO993223L (no) 1999-08-24
PT970066E (pt) 2004-02-27
CZ230599A3 (cs) 1999-11-17
RO120135B1 (ro) 2005-09-30
IL130609A0 (en) 2000-06-01
CA2276488C (en) 2006-07-18
IL130609A (en) 2003-04-10
AU733905B2 (en) 2001-05-31
ATE250047T1 (de) 2003-10-15
NO320276B1 (no) 2005-11-21
JP2001507693A (ja) 2001-06-12
WO1998029401A1 (en) 1998-07-09
DE69725014D1 (de) 2003-10-23
BR9714129A (pt) 2000-02-29
CA2276488A1 (en) 1998-07-09
NZ336451A (en) 2000-09-29
AU5700898A (en) 1998-07-31
EP0970066B1 (en) 2003-09-17
CZ297432B6 (cs) 2006-12-13
CN1247535A (zh) 2000-03-15
DE69725014T2 (de) 2004-06-09

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