CY2273B1 - Intermediates for the synthesis of eliprodil enantiomers and process for their preparation - Google Patents

Intermediates for the synthesis of eliprodil enantiomers and process for their preparation

Info

Publication number
CY2273B1
CY2273B1 CY0200026A CY0200026A CY2273B1 CY 2273 B1 CY2273 B1 CY 2273B1 CY 0200026 A CY0200026 A CY 0200026A CY 0200026 A CY0200026 A CY 0200026A CY 2273 B1 CY2273 B1 CY 2273B1
Authority
CY
Cyprus
Prior art keywords
lipase
chlorophenyl
enantiomers
iia
eliprodil
Prior art date
Application number
CY0200026A
Other languages
English (en)
Inventor
Lydia Zard
Arlette Tixidre
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CY2273B1 publication Critical patent/CY2273B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/36—Halogenated alcohols the halogen not being fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida
CY0200026A 1994-12-23 2002-05-15 Intermediates for the synthesis of eliprodil enantiomers and process for their preparation CY2273B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415548A FR2728568B1 (fr) 1994-12-23 1994-12-23 Intermediaires de synthese des enantiomeres de l'eliprodil et leur procede de preparation

Publications (1)

Publication Number Publication Date
CY2273B1 true CY2273B1 (en) 2003-07-04

Family

ID=9470165

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0200026A CY2273B1 (en) 1994-12-23 2002-05-15 Intermediates for the synthesis of eliprodil enantiomers and process for their preparation

Country Status (12)

Country Link
US (1) US5677168A (de)
EP (1) EP0718407B1 (de)
JP (1) JPH08252097A (de)
AT (1) ATE213273T1 (de)
CA (1) CA2166013A1 (de)
CY (1) CY2273B1 (de)
DE (1) DE69525433T2 (de)
DK (1) DK0718407T3 (de)
ES (1) ES2171516T3 (de)
FR (1) FR2728568B1 (de)
IL (1) IL116472A (de)
PT (1) PT718407E (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0893422A1 (de) * 1997-07-18 1999-01-27 Mitsubishi Gas Chemical Company, Inc. Optisch reiner Alkohol und Verfahren zu seiner Herstellung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US5266485A (en) * 1990-07-24 1993-11-30 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Method of manufacturing optically active (-)-2-halo-1-(substituted phenyl) ethanol by ketone reduction
WO1992014830A1 (en) * 1991-02-13 1992-09-03 Schneider Manfred P Enzymatic reverse hydrolysis of hydrophilic substrates - preparation of amphiphilic compounds
FR2696741B1 (fr) * 1992-10-12 1994-11-25 Synthelabo Dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl]piperidin-1-yl] éthanol, leur préparation et leur application en thérapeutique.
US5312950A (en) * 1993-08-31 1994-05-17 Eastman Kodak Company Method for purification of alcohols

Also Published As

Publication number Publication date
FR2728568A1 (fr) 1996-06-28
CA2166013A1 (en) 1996-06-24
DE69525433D1 (de) 2002-03-21
ATE213273T1 (de) 2002-02-15
FR2728568B1 (fr) 1997-04-11
IL116472A0 (en) 1996-03-31
JPH08252097A (ja) 1996-10-01
US5677168A (en) 1997-10-14
DK0718407T3 (da) 2002-05-27
ES2171516T3 (es) 2002-09-16
PT718407E (pt) 2002-07-31
EP0718407A1 (de) 1996-06-26
IL116472A (en) 2002-07-25
EP0718407B1 (de) 2002-02-13
DE69525433T2 (de) 2002-10-24

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