ES2171516T3 - Procedimiento para la preparacion de los enantiomeros del 1-(4-clorofenil)-2-cloroetanol. - Google Patents

Procedimiento para la preparacion de los enantiomeros del 1-(4-clorofenil)-2-cloroetanol.

Info

Publication number
ES2171516T3
ES2171516T3 ES95402839T ES95402839T ES2171516T3 ES 2171516 T3 ES2171516 T3 ES 2171516T3 ES 95402839 T ES95402839 T ES 95402839T ES 95402839 T ES95402839 T ES 95402839T ES 2171516 T3 ES2171516 T3 ES 2171516T3
Authority
ES
Spain
Prior art keywords
preparation
chlorophenyl
chlorethethanol
enantiomers
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95402839T
Other languages
English (en)
Inventor
Lydia Zard
Arlette Tixidre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2171516T3 publication Critical patent/ES2171516T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/36—Halogenated alcohols the halogen not being fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ENANTIOMEROS DE 1-(4-CLOROFENIL)-2-CLOROETANOL, SU PROCEDIMENTO DE PREPARACION POR HIDROLISIS ENZIMATICA ENANTIOSELECTIVA DEL ACETATO DE (+/-) -{AL}-(4-CLOROFENIL)CLOROETILO Y SU APLICACION EN LA PREPARACION DE LOS ENANTIOMEROS DE ELIPRODILO Y DE SUS SALES.
ES95402839T 1994-12-23 1995-12-18 Procedimiento para la preparacion de los enantiomeros del 1-(4-clorofenil)-2-cloroetanol. Expired - Lifetime ES2171516T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415548A FR2728568B1 (fr) 1994-12-23 1994-12-23 Intermediaires de synthese des enantiomeres de l'eliprodil et leur procede de preparation

Publications (1)

Publication Number Publication Date
ES2171516T3 true ES2171516T3 (es) 2002-09-16

Family

ID=9470165

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95402839T Expired - Lifetime ES2171516T3 (es) 1994-12-23 1995-12-18 Procedimiento para la preparacion de los enantiomeros del 1-(4-clorofenil)-2-cloroetanol.

Country Status (12)

Country Link
US (1) US5677168A (es)
EP (1) EP0718407B1 (es)
JP (1) JPH08252097A (es)
AT (1) ATE213273T1 (es)
CA (1) CA2166013A1 (es)
CY (1) CY2273B1 (es)
DE (1) DE69525433T2 (es)
DK (1) DK0718407T3 (es)
ES (1) ES2171516T3 (es)
FR (1) FR2728568B1 (es)
IL (1) IL116472A (es)
PT (1) PT718407E (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0893422A1 (en) * 1997-07-18 1999-01-27 Mitsubishi Gas Chemical Company, Inc. Optically active alcohol and process for the production thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
WO1992001804A1 (en) * 1990-07-24 1992-02-06 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for producing optically active (-)-2-halo-1-(substituted phenyl)ethanol and (-)-substituted styrene oxide
JPH06505148A (ja) * 1991-02-13 1994-06-16 シュナイダー，マンフレット　ペー． 親水性基質の酵素的逆加水分解−両親媒性化合物の製法
FR2696741B1 (fr) * 1992-10-12 1994-11-25 Synthelabo Dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl]piperidin-1-yl] éthanol, leur préparation et leur application en thérapeutique.
US5312950A (en) * 1993-08-31 1994-05-17 Eastman Kodak Company Method for purification of alcohols

Also Published As

Publication number Publication date
JPH08252097A (ja) 1996-10-01
US5677168A (en) 1997-10-14
DK0718407T3 (da) 2002-05-27
EP0718407A1 (fr) 1996-06-26
FR2728568B1 (fr) 1997-04-11
CY2273B1 (en) 2003-07-04
IL116472A (en) 2002-07-25
DE69525433T2 (de) 2002-10-24
IL116472A0 (en) 1996-03-31
ATE213273T1 (de) 2002-02-15
FR2728568A1 (fr) 1996-06-28
DE69525433D1 (de) 2002-03-21
EP0718407B1 (fr) 2002-02-13
CA2166013A1 (en) 1996-06-24
PT718407E (pt) 2002-07-31

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