CY1126071T1 - Φαρμακευτικα σκευασματα αναλογων κυκλοσπορινης - Google Patents

Φαρμακευτικα σκευασματα αναλογων κυκλοσπορινης

Info

Publication number
CY1126071T1
CY1126071T1 CY20231100293T CY231100293T CY1126071T1 CY 1126071 T1 CY1126071 T1 CY 1126071T1 CY 20231100293 T CY20231100293 T CY 20231100293T CY 231100293 T CY231100293 T CY 231100293T CY 1126071 T1 CY1126071 T1 CY 1126071T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical preparation
cyclosporin analogues
cyclosporin
analogues
stability
Prior art date
Application number
CY20231100293T
Other languages
English (en)
Inventor
Daniel Joseph TREPANIER
Daren Raymond URE
Robert Thomas FOSTER
Original Assignee
Hepion Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hepion Pharmaceuticals, Inc. filed Critical Hepion Pharmaceuticals, Inc.
Publication of CY1126071T1 publication Critical patent/CY1126071T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Η παρούσα αποκάλυψη αφορά φαρμακευτικές συνθέσεις που περιέχουν CR.V431 ή φαρμακευτικά αποδεκτό άλας αυτού. Οι συνθέσεις παρουσιάζουν υψηλή διαλυτότητα και σταθερότητα.
CY20231100293T 2018-11-26 2023-06-22 Φαρμακευτικα σκευασματα αναλογων κυκλοσπορινης CY1126071T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862771453P 2018-11-26 2018-11-26
PCT/US2019/062849 WO2020112562A1 (en) 2018-11-26 2019-11-22 Pharmaceutical formulations of cyclosporine analogs

Publications (1)

Publication Number Publication Date
CY1126071T1 true CY1126071T1 (el) 2023-11-15

Family

ID=68916602

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20231100293T CY1126071T1 (el) 2018-11-26 2023-06-22 Φαρμακευτικα σκευασματα αναλογων κυκλοσπορινης

Country Status (27)

Country Link
US (3) US20200163876A1 (el)
EP (1) EP3886813B1 (el)
JP (1) JP2022513635A (el)
KR (1) KR20210099038A (el)
CN (1) CN113194927B (el)
AR (1) AR117150A1 (el)
AU (1) AU2019386859A1 (el)
BR (1) BR112021009967A2 (el)
CA (1) CA3120015A1 (el)
CY (1) CY1126071T1 (el)
DK (1) DK3886813T3 (el)
ES (1) ES2942473T3 (el)
FI (1) FI3886813T3 (el)
HR (1) HRP20230548T1 (el)
HU (1) HUE061877T2 (el)
IL (1) IL283286A (el)
LT (1) LT3886813T (el)
MX (1) MX2021006010A (el)
PH (1) PH12021551086A1 (el)
PL (1) PL3886813T3 (el)
PT (1) PT3886813T (el)
RS (1) RS64239B1 (el)
SG (1) SG11202105336TA (el)
SI (1) SI3886813T1 (el)
TW (1) TW202038911A (el)
WO (1) WO2020112562A1 (el)
ZA (1) ZA202103090B (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210260153A1 (en) 2020-02-19 2021-08-26 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating fibrosis
WO2021173723A1 (en) 2020-02-25 2021-09-02 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating cancer
WO2022115651A1 (en) * 2020-11-29 2022-06-02 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues as antithrombotic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6262022B1 (en) * 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
CA2313024C (en) * 1997-12-10 2008-06-03 Severson, Mary L. Pharmaceutical compositions containing an omega-3 fatty acid oil
US20030216303A1 (en) * 1998-03-06 2003-11-20 Michael Ambuhl Emulsion preconcentrates containing cyclosporin or a macrolide
ID25908A (id) * 1998-03-06 2000-11-09 Novartis Ag Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida
AU7638200A (en) * 1999-10-20 2001-04-30 Vesifact Ag Microemulsion preconcentrates which contain cyclosporines and corresponding microemulsions
IL158765A0 (en) * 2001-06-21 2004-05-12 Pfizer Prod Inc Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors
PL206018B1 (pl) * 2001-10-19 2010-06-30 Isotechnika Inc Preparat farmaceutyczny, sposób jego wytwarzania, mikroemulsja i zastosowanie tego preparatu farmaceutycznego
US20180296588A1 (en) * 2017-04-14 2018-10-18 Contravir Pharmaceuticals, Inc. Combination therapy for treating viral infections

Also Published As

Publication number Publication date
CN113194927B (zh) 2023-10-27
ZA202103090B (en) 2023-09-27
EP3886813B1 (en) 2023-03-22
BR112021009967A2 (pt) 2021-08-17
CA3120015A1 (en) 2020-06-04
PL3886813T3 (pl) 2023-06-19
JP2022513635A (ja) 2022-02-09
AU2019386859A1 (en) 2021-05-27
DK3886813T3 (da) 2023-05-01
SI3886813T1 (sl) 2023-05-31
US20230390198A1 (en) 2023-12-07
PH12021551086A1 (en) 2022-01-03
MX2021006010A (es) 2021-09-21
TW202038911A (zh) 2020-11-01
SG11202105336TA (en) 2021-06-29
WO2020112562A1 (en) 2020-06-04
RS64239B1 (sr) 2023-06-30
IL283286A (en) 2021-07-29
HUE061877T2 (hu) 2023-08-28
US20200163876A1 (en) 2020-05-28
LT3886813T (lt) 2023-04-11
KR20210099038A (ko) 2021-08-11
HRP20230548T1 (hr) 2023-08-04
FI3886813T3 (fi) 2023-05-04
PT3886813T (pt) 2023-04-26
EP3886813A1 (en) 2021-10-06
US20230390199A1 (en) 2023-12-07
AR117150A1 (es) 2021-07-14
ES2942473T3 (es) 2023-06-01
CN113194927A (zh) 2021-07-30

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