CY1124885T1 - Διαδικασια κρυσταλλοποιησης για ληψη κρυσταλλων ημιυδρικης καναγλιφλοζινης - Google Patents
Διαδικασια κρυσταλλοποιησης για ληψη κρυσταλλων ημιυδρικης καναγλιφλοζινηςInfo
- Publication number
- CY1124885T1 CY1124885T1 CY20201100631T CY201100631T CY1124885T1 CY 1124885 T1 CY1124885 T1 CY 1124885T1 CY 20201100631 T CY20201100631 T CY 20201100631T CY 201100631 T CY201100631 T CY 201100631T CY 1124885 T1 CY1124885 T1 CY 1124885T1
- Authority
- CY
- Cyprus
- Prior art keywords
- kanagliflozine
- hemihydrate
- crystallization procedure
- vessel
- obtaining crystals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με βελτιωμένη διαδικασία κρυσταλλοποίησης για τη λήψη κρυστάλλων ημιυδρικής καναγλιφλοζίνης με περιορισμένη κατανομή μεγέθους σωματιδίων μέσω αφαίρεσης ενός μικρού μέρους του κρυσταλλικού εναιωρήματος στο σκεύος κρυσταλλοποίησης από το εν λόγω σκεύος και υποβολής του εν λόγω μέρους σε μείωση μεγέθους σωματιδίων των σχηματισμένων κρυστάλλων ακολουθούμενη από θέρμανση και επανεισαγωγή του εν λόγω μέρους του κρυσταλλικού εναιωρήματος στο σκεύος κρυσταλλοποίησης το οποίο διατηρείται εντός συγκεκριμένου εύρους θερμοκρασίας.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15201459 | 2015-12-21 | ||
| EP16172070 | 2016-05-31 | ||
| PCT/EP2016/081861 WO2017108752A1 (en) | 2015-12-21 | 2016-12-20 | Crystallization procedure for obtaining canagliflozin hemihydrate crystals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124885T1 true CY1124885T1 (el) | 2022-07-22 |
Family
ID=57681580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100631T CY1124885T1 (el) | 2015-12-21 | 2020-07-09 | Διαδικασια κρυσταλλοποιησης για ληψη κρυσταλλων ημιυδρικης καναγλιφλοζινης |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10323025B2 (el) |
| EP (1) | EP3394051B1 (el) |
| JP (1) | JP6851379B2 (el) |
| KR (1) | KR20180095839A (el) |
| CN (1) | CN108368096B (el) |
| AU (1) | AU2016376653B2 (el) |
| CA (1) | CA3006237C (el) |
| CY (1) | CY1124885T1 (el) |
| DK (1) | DK3394051T3 (el) |
| EA (1) | EA036793B1 (el) |
| ES (1) | ES2794909T3 (el) |
| HR (1) | HRP20200755T1 (el) |
| HU (1) | HUE049895T2 (el) |
| LT (1) | LT3394051T (el) |
| PL (1) | PL3394051T3 (el) |
| PT (1) | PT3394051T (el) |
| SI (1) | SI3394051T1 (el) |
| WO (1) | WO2017108752A1 (el) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021012044A1 (en) | 2019-07-22 | 2021-01-28 | Canopy Growth Corporation | Continuous crystallization of cannabinoids in a stirred-tank reactor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2780403B3 (fr) * | 1998-06-24 | 2000-07-21 | Sanofi Sa | Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant |
| GB0301259D0 (en) * | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
| TWI385177B (zh) | 2003-08-01 | 2013-02-11 | Mitsubishi Tanabe Pharma Corp | 吡喃葡萄糖基衍生物及其製造方法 |
| KR101040160B1 (ko) * | 2006-08-15 | 2011-06-09 | 브로드콤 코포레이션 | 패킷 손실 후의 제한되고 제어된 디코딩 |
| UY30730A1 (es) * | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
| PT2451797E (pt) * | 2009-07-10 | 2013-06-25 | Janssen Pharmaceutica Nv | Processo de cristalização para o 1-(β-d-glucopiranosilo)-4-metilo-3-[5-(4-fluorofenilo)-2-tienilometilo]benzeno |
| MX355831B (es) | 2013-05-08 | 2018-05-02 | Lek Pharmaceuticals | NOVEDOSOS HIDRATOS CRISTALINOS DE 1-(ß-D-GLUCOPIRANOSIL)-4-METIL-3 -[5-(4-FLUORO-FENIL)-2-TIENIL-METIL]-BENCENO. |
| CZ305172B6 (cs) * | 2014-03-28 | 2015-05-27 | Bochemie A.S. | Diskontinuální krystalizační jednotka pro výrobu kulovitých krystalů |
| CN103896930B (zh) * | 2014-04-02 | 2016-08-17 | 安徽联创生物医药股份有限公司 | 卡格列净半水合物药用晶型的制备方法 |
-
2016
- 2016-12-20 CN CN201680074830.6A patent/CN108368096B/zh active Active
- 2016-12-20 CA CA3006237A patent/CA3006237C/en active Active
- 2016-12-20 EP EP16819899.2A patent/EP3394051B1/en active Active
- 2016-12-20 JP JP2018532225A patent/JP6851379B2/ja active Active
- 2016-12-20 PT PT168198992T patent/PT3394051T/pt unknown
- 2016-12-20 DK DK16819899.2T patent/DK3394051T3/da active
- 2016-12-20 AU AU2016376653A patent/AU2016376653B2/en active Active
- 2016-12-20 LT LTEP16819899.2T patent/LT3394051T/lt unknown
- 2016-12-20 US US16/064,084 patent/US10323025B2/en active Active
- 2016-12-20 WO PCT/EP2016/081861 patent/WO2017108752A1/en active Application Filing
- 2016-12-20 PL PL16819899T patent/PL3394051T3/pl unknown
- 2016-12-20 SI SI201630770T patent/SI3394051T1/sl unknown
- 2016-12-20 HU HUE16819899A patent/HUE049895T2/hu unknown
- 2016-12-20 ES ES16819899T patent/ES2794909T3/es active Active
- 2016-12-20 EA EA201891470A patent/EA036793B1/ru unknown
- 2016-12-20 KR KR1020187018513A patent/KR20180095839A/ko not_active Application Discontinuation
-
2020
- 2020-05-11 HR HRP20200755TT patent/HRP20200755T1/hr unknown
- 2020-07-09 CY CY20201100631T patent/CY1124885T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT3394051T (pt) | 2020-06-08 |
| SI3394051T1 (sl) | 2020-07-31 |
| US20190002449A1 (en) | 2019-01-03 |
| EP3394051A1 (en) | 2018-10-31 |
| ES2794909T3 (es) | 2020-11-19 |
| LT3394051T (lt) | 2020-08-10 |
| AU2016376653B2 (en) | 2020-07-30 |
| CA3006237A1 (en) | 2017-06-29 |
| US10323025B2 (en) | 2019-06-18 |
| DK3394051T3 (da) | 2020-07-20 |
| JP6851379B2 (ja) | 2021-03-31 |
| AU2016376653A1 (en) | 2018-06-07 |
| CN108368096A (zh) | 2018-08-03 |
| HUE049895T2 (hu) | 2020-11-30 |
| EA036793B1 (ru) | 2020-12-22 |
| CA3006237C (en) | 2023-10-03 |
| EP3394051B1 (en) | 2020-04-22 |
| HRP20200755T1 (hr) | 2020-07-24 |
| CN108368096B (zh) | 2021-12-10 |
| WO2017108752A1 (en) | 2017-06-29 |
| EA201891470A1 (ru) | 2018-12-28 |
| KR20180095839A (ko) | 2018-08-28 |
| PL3394051T3 (pl) | 2020-10-19 |
| JP2019504022A (ja) | 2019-02-14 |
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