CY1124360T1 - Αντισωματα aντι-il-33 και χρησεις αυτων - Google Patents
Αντισωματα aντι-il-33 και χρησεις αυτωνInfo
- Publication number
- CY1124360T1 CY1124360T1 CY20211100672T CY211100672T CY1124360T1 CY 1124360 T1 CY1124360 T1 CY 1124360T1 CY 20211100672 T CY20211100672 T CY 20211100672T CY 211100672 T CY211100672 T CY 211100672T CY 1124360 T1 CY1124360 T1 CY 1124360T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- treatment
- bind
- agents
- useful
- Prior art date
Links
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 101000998137 Homo sapiens Interleukin-33 Proteins 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 102000045906 human IL33 Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Παρέχονται αντισώματα που δεσμεύουν και εξουδετερώνουν την ανθρώπινη IL-33. και μέθοδοι χρήσης αυτών, όπου τα εν λόγω αντισώματα είναι χρήσιμα ως μέσα για τη θεραπευτική αντιμετώπιση παθήσεων που σχετίζονται με αλλεργική νόσο συμπεριλαμβανομένης της θεραπευτικής αντιμετώπισης της ατοπικής δερματίτιδας.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662414258P | 2016-10-28 | 2016-10-28 | |
| PCT/US2017/058020 WO2018081075A1 (en) | 2016-10-28 | 2017-10-24 | Anti-il-33 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124360T1 true CY1124360T1 (el) | 2022-07-22 |
Family
ID=60263117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100672T CY1124360T1 (el) | 2016-10-28 | 2021-07-26 | Αντισωματα aντι-il-33 και χρησεις αυτων |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US10501536B2 (el) |
| EP (1) | EP3532499B1 (el) |
| JP (1) | JP6830533B2 (el) |
| KR (1) | KR102266144B1 (el) |
| CN (1) | CN109863173B (el) |
| AR (1) | AR109948A1 (el) |
| AU (1) | AU2017351183B2 (el) |
| BR (1) | BR112019005139A2 (el) |
| CA (1) | CA3039232C (el) |
| CL (1) | CL2019001043A1 (el) |
| CO (1) | CO2019003047A2 (el) |
| CR (1) | CR20190179A (el) |
| CY (1) | CY1124360T1 (el) |
| DK (1) | DK3532499T3 (el) |
| EA (1) | EA201990778A1 (el) |
| EC (1) | ECSP19029758A (el) |
| ES (1) | ES2878037T3 (el) |
| HR (1) | HRP20211221T1 (el) |
| HU (1) | HUE055621T2 (el) |
| IL (1) | IL265689B2 (el) |
| JO (1) | JOP20190093A1 (el) |
| LT (1) | LT3532499T (el) |
| MA (1) | MA46619B1 (el) |
| MD (1) | MD3532499T2 (el) |
| MX (1) | MX2019004863A (el) |
| PE (1) | PE20191045A1 (el) |
| PH (1) | PH12019500929A1 (el) |
| PL (1) | PL3532499T3 (el) |
| PT (1) | PT3532499T (el) |
| RS (1) | RS62120B1 (el) |
| SI (1) | SI3532499T1 (el) |
| TN (1) | TN2019000086A1 (el) |
| TW (2) | TWI676680B (el) |
| UA (1) | UA121293C2 (el) |
| WO (1) | WO2018081075A1 (el) |
| ZA (1) | ZA201901935B (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190093A1 (ar) * | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
| EP4045641A1 (en) | 2019-10-15 | 2022-08-24 | Eli Lilly and Company | Recombinantly engineered, lipase/esterase-deficient mammalian cell lines |
| KR20220092927A (ko) | 2019-11-04 | 2022-07-04 | 메디뮨 리미티드 | 신장 장애를 치료하기 위한 항 il-33 치료제 |
| CN114901361A (zh) | 2019-11-04 | 2022-08-12 | 免疫医疗有限公司 | 使用il-33拮抗剂的方法 |
| WO2021180858A1 (en) | 2020-03-13 | 2021-09-16 | Medimmune Limited | Therapeutic methods for the treatment of subjects with risk alelles in il33 |
| KR20220152262A (ko) | 2020-03-13 | 2022-11-15 | 제넨테크, 인크. | 항-인터루킨-33 항체 및 이의 용도 |
| US20230174637A1 (en) | 2020-04-06 | 2023-06-08 | Medimmune Limited | Treating acute respiratory distress syndrome with il-33 axis binding antagonists |
| WO2021228760A1 (en) | 2020-05-11 | 2021-11-18 | Medimmune Limited | Formulations of anti-il-33 antibodies |
| CN111620948B (zh) * | 2020-06-10 | 2022-04-08 | 南京赛新生物科技有限公司 | 针对il-33的抗体 |
| CN113603775B (zh) * | 2021-09-03 | 2022-05-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素-33单克隆抗体及其应用 |
| TW202402790A (zh) | 2022-03-25 | 2024-01-16 | 英商梅迪繆思有限公司 | 減少呼吸系統感染之方法 |
| WO2024038185A1 (en) | 2022-08-19 | 2024-02-22 | Medimmune Limited | Method of selecting patients for treatment with an il-33 axis antagonist |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| WO2008132709A1 (en) | 2007-04-26 | 2008-11-06 | Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | Products for altering il-33 activity and methods therefor |
| WO2008144610A1 (en) | 2007-05-18 | 2008-11-27 | Medimmune, Llc | Il-33 in inflammatory disease |
| EP2475388B1 (en) | 2009-09-10 | 2017-11-08 | Merck Sharp & Dohme Corp. | Use of il-33 antagonists to treat fibrotic disease |
| TW201238976A (en) * | 2011-02-23 | 2012-10-01 | Hoffmann La Roche | Antibodies against human IL33R and uses thereof |
| FR2972006B1 (fr) | 2011-02-24 | 2016-03-25 | Centre Nat Rech Scient | Nouveaux fragments d'il-33 superactifs et leurs utilisations |
| US9212227B2 (en) | 2012-04-30 | 2015-12-15 | Janssen Biotech, Inc. | ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| EP3088517B1 (en) | 2013-12-26 | 2023-11-01 | Mitsubishi Tanabe Pharma Corporation | Human anti-il-33 neutralizing monoclonal antibody |
| KR102446386B1 (ko) * | 2014-01-10 | 2022-09-22 | 아납티스바이오, 아이엔씨. | 인터루킨-33 (il-33)에 대한 항체 |
| US10040859B2 (en) * | 2014-04-21 | 2018-08-07 | The Children's Hospital Of Philadelphia | Methods of treating hemophagocytic lymphohistiocytosis with an IL-33 receptor antibody |
| TWI705976B (zh) * | 2014-11-10 | 2020-10-01 | 美商建南德克公司 | 抗介白素-33抗體及其用途 |
| AU2016239331C1 (en) | 2015-03-31 | 2020-01-30 | Medimmune Limited | A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same |
| EA201891628A1 (ru) | 2016-01-14 | 2018-12-28 | Анаптисбайо, Инк. | Ингибирование аллергической реакции с использованием ингибитора il-33 |
| JOP20190093A1 (ar) * | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
-
2017
- 2017-06-16 JO JOP/2019/0093A patent/JOP20190093A1/ar unknown
- 2017-10-13 AR ARP170102863A patent/AR109948A1/es unknown
- 2017-10-13 TW TW107143762A patent/TWI676680B/zh active
- 2017-10-13 TW TW106135006A patent/TWI647238B/zh active
- 2017-10-24 CR CR20190179A patent/CR20190179A/es unknown
- 2017-10-24 UA UAA201903400A patent/UA121293C2/uk unknown
- 2017-10-24 AU AU2017351183A patent/AU2017351183B2/en active Active
- 2017-10-24 LT LTEP17794593.8T patent/LT3532499T/lt unknown
- 2017-10-24 JP JP2019522272A patent/JP6830533B2/ja active Active
- 2017-10-24 RS RS20210875A patent/RS62120B1/sr unknown
- 2017-10-24 PT PT177945938T patent/PT3532499T/pt unknown
- 2017-10-24 EA EA201990778A patent/EA201990778A1/ru unknown
- 2017-10-24 MD MDE20190980T patent/MD3532499T2/ro unknown
- 2017-10-24 WO PCT/US2017/058020 patent/WO2018081075A1/en active Application Filing
- 2017-10-24 CN CN201780065572.XA patent/CN109863173B/zh active Active
- 2017-10-24 TN TNP/2019/000086A patent/TN2019000086A1/en unknown
- 2017-10-24 BR BR112019005139A patent/BR112019005139A2/pt unknown
- 2017-10-24 SI SI201730830T patent/SI3532499T1/sl unknown
- 2017-10-24 MA MA46619A patent/MA46619B1/fr unknown
- 2017-10-24 ES ES17794593T patent/ES2878037T3/es active Active
- 2017-10-24 US US15/791,641 patent/US10501536B2/en active Active
- 2017-10-24 PE PE2019000838A patent/PE20191045A1/es unknown
- 2017-10-24 MX MX2019004863A patent/MX2019004863A/es unknown
- 2017-10-24 DK DK17794593.8T patent/DK3532499T3/da active
- 2017-10-24 HU HUE17794593A patent/HUE055621T2/hu unknown
- 2017-10-24 KR KR1020197012190A patent/KR102266144B1/ko active IP Right Grant
- 2017-10-24 CA CA3039232A patent/CA3039232C/en active Active
- 2017-10-24 IL IL265689A patent/IL265689B2/en unknown
- 2017-10-24 EP EP17794593.8A patent/EP3532499B1/en active Active
- 2017-10-24 PL PL17794593T patent/PL3532499T3/pl unknown
-
2019
- 2019-03-28 ZA ZA201901935A patent/ZA201901935B/en unknown
- 2019-03-28 CO CONC2019/0003047A patent/CO2019003047A2/es unknown
- 2019-04-16 CL CL2019001043A patent/CL2019001043A1/es unknown
- 2019-04-25 PH PH12019500929A patent/PH12019500929A1/en unknown
- 2019-04-26 EC ECSENADI201929758A patent/ECSP19029758A/es unknown
- 2019-10-25 US US16/663,561 patent/US10913793B2/en active Active
-
2021
- 2021-07-26 CY CY20211100672T patent/CY1124360T1/el unknown
- 2021-07-28 HR HRP20211221TT patent/HRP20211221T1/hr unknown
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