CY1123120T1 - Υδατικες φαρμακευτικες συνθεσεις που περιεχουν συμπλοκα βορικου-πολυολης - Google Patents
Υδατικες φαρμακευτικες συνθεσεις που περιεχουν συμπλοκα βορικου-πολυοληςInfo
- Publication number
- CY1123120T1 CY1123120T1 CY20201100637T CY201100637T CY1123120T1 CY 1123120 T1 CY1123120 T1 CY 1123120T1 CY 20201100637 T CY20201100637 T CY 20201100637T CY 201100637 T CY201100637 T CY 201100637T CY 1123120 T1 CY1123120 T1 CY 1123120T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- aqueous pharmaceutical
- containing borate
- polyol complexes
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση απευθύνεται στην παροχή οφθαλμικών φαρμακευτικών συνθέσεων πολλαπλών δόσεων. Οι φαρμακευτικές συνθέσεις διαθέτουν επαρκή αντιμικροβιακή δραστικότητα για την ικανοποίηση των απαιτήσεων αποτελεσματικότητας διατήρησης της USP, καθώς επίσης παρόμοια πρότυπα διατήρησης (π.χ., ΕΡ και JP). Οι φαρμακευτικές συνθέσεις περιλαμβάνουν δυο διαφορετικές πολυόλες σε συνδυασμό με βορικό και μια χαμηλή συγκέντρωση χλωριούχου βενζαλκονίου.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21847209P | 2009-06-19 | 2009-06-19 | |
EP14150805.1A EP2722035B1 (en) | 2009-06-19 | 2010-06-17 | Aqueous pharmaceutical compositions containing borate-polyol complexes |
PCT/US2010/038979 WO2010148190A1 (en) | 2009-06-19 | 2010-06-17 | Aqueous pharmaceutical compositions containing borate-polyol complexes |
EP10727317.9A EP2442790B1 (en) | 2009-06-19 | 2010-06-17 | Aqueous pharmaceutical compositions containing borate-polyol complexes |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1123120T1 true CY1123120T1 (el) | 2021-10-29 |
Family
ID=42364357
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100735T CY1117835T1 (el) | 2009-06-19 | 2016-07-26 | Υδατικες φαρμακευτικες συνθεσεις που περιεχουν συμπλοκα βορικου - πολυολης |
CY20201100637T CY1123120T1 (el) | 2009-06-19 | 2020-07-10 | Υδατικες φαρμακευτικες συνθεσεις που περιεχουν συμπλοκα βορικου-πολυολης |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100735T CY1117835T1 (el) | 2009-06-19 | 2016-07-26 | Υδατικες φαρμακευτικες συνθεσεις που περιεχουν συμπλοκα βορικου - πολυολης |
Country Status (27)
Country | Link |
---|---|
US (3) | US9044484B2 (el) |
EP (4) | EP2442790B1 (el) |
JP (3) | JP6017956B2 (el) |
KR (1) | KR101738502B1 (el) |
CN (2) | CN104707145A (el) |
AR (2) | AR077126A1 (el) |
AU (1) | AU2010262898B2 (el) |
BR (1) | BRPI1015996B8 (el) |
CA (1) | CA2763778C (el) |
CL (1) | CL2010000634A1 (el) |
CY (2) | CY1117835T1 (el) |
DK (3) | DK2722035T3 (el) |
ES (3) | ES2584858T3 (el) |
HK (2) | HK1194007A1 (el) |
HR (2) | HRP20160953T1 (el) |
HU (2) | HUE049477T2 (el) |
LT (1) | LT3045164T (el) |
MX (1) | MX2011013107A (el) |
PL (3) | PL3045164T3 (el) |
PT (3) | PT2722035T (el) |
RU (1) | RU2563125C2 (el) |
SI (3) | SI2442790T1 (el) |
SM (1) | SMT201600249B (el) |
TW (1) | TWI489997B (el) |
UY (1) | UY32709A (el) |
WO (1) | WO2010148190A1 (el) |
ZA (1) | ZA201108384B (el) |
Families Citing this family (20)
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CN101959500A (zh) * | 2008-03-17 | 2011-01-26 | 爱尔康研究有限公司 | 包含硼酸类化合物-多元醇络合物的水性药物组合物 |
TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
BR112013018025A2 (pt) * | 2011-01-18 | 2020-10-27 | Senju Pharmaceutical Co., Ltd | composição de bromfenac líquida aquosa método para reforçar a eficácia conservante de uma solução aquosa |
RU2601115C2 (ru) | 2011-04-22 | 2016-10-27 | Алькон Рисерч, Лтд. | Офтальмологическая композиция с повышающей вязкость системой, содержащей два различных средства повышения вязкости |
WO2012145460A2 (en) | 2011-04-22 | 2012-10-26 | Alcon Research, Ltd. | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
US20120312840A1 (en) * | 2011-05-13 | 2012-12-13 | Ayako Hasegawa | Container closure system with integral antimicrobial additives |
TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠(olopatadine)眼用組成物 |
CA2899342C (en) | 2013-02-01 | 2021-09-21 | Ocularis Pharma, Llc | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
US9795560B2 (en) | 2013-02-01 | 2017-10-24 | Ocularis Pharma, Llc | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
US9693563B2 (en) | 2013-08-20 | 2017-07-04 | 3M Innovative Properties Company | Boron-silane polyether complex |
WO2017217450A1 (ja) * | 2016-06-15 | 2017-12-21 | 千寿製薬株式会社 | 眼科用医薬製品 |
JP6247430B1 (ja) * | 2016-06-15 | 2017-12-13 | 千寿製薬株式会社 | 眼科用医薬製品 |
CN106237337B (zh) * | 2016-08-05 | 2019-11-08 | 河南中帅医药科技股份有限公司 | 一种液体药物制剂用防腐组合物 |
GR1009419B (el) * | 2017-11-07 | 2018-12-14 | Φαρματεν Αβεε | Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου |
JP7413040B2 (ja) | 2018-02-21 | 2024-01-15 | 三菱重工サーマルシステムズ株式会社 | スクロール流体機械及びその設計方法 |
SG11202104094YA (en) | 2018-10-26 | 2021-05-28 | Ocuphire Pharma Inc | Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders |
US20220241296A1 (en) | 2019-07-23 | 2022-08-04 | Nicox Ophthalmics, Inc. | Process for the preparation of sterile ophthalmic aqueous fluticasone propionate form a nanocrystals suspensions |
US20230218611A1 (en) | 2020-04-29 | 2023-07-13 | Sentiss Pharma Private Limited | Ophthalmic compositions comprising a combination of brinzolamide and brimonidine |
US11850249B2 (en) | 2020-10-05 | 2023-12-26 | Somerset Therapeutics, Llc | Methods of efficiently reducing intraocular pressure |
CN115368310A (zh) | 2021-05-18 | 2022-11-22 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
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