CY1123060T1 - Μεθοδοι για τον καθορισμο των διαφορων στη δραστικοτητα της αλφα-4 ιντεγκρινης δια συσχετισμου των διαφορων στα επιπεδα svcam και/ή smadcam - Google Patents
Μεθοδοι για τον καθορισμο των διαφορων στη δραστικοτητα της αλφα-4 ιντεγκρινης δια συσχετισμου των διαφορων στα επιπεδα svcam και/ή smadcamInfo
- Publication number
- CY1123060T1 CY1123060T1 CY20201100555T CY201100555T CY1123060T1 CY 1123060 T1 CY1123060 T1 CY 1123060T1 CY 20201100555 T CY20201100555 T CY 20201100555T CY 201100555 T CY201100555 T CY 201100555T CY 1123060 T1 CY1123060 T1 CY 1123060T1
- Authority
- CY
- Cyprus
- Prior art keywords
- differences
- alpha
- svcam
- correlating
- methods
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/7056—Selectin superfamily, e.g. LAM-1, GlyCAM, ELAM-1, PADGEM
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
Παρέχεται εδώ μία μέθοδος παρακολούθησης της αλλαγής των δραστικοτήτων αλφα-4 ιντεγκρίνης σε ένα άτομο δια συσχέτισης με τα επίπεδα διαλυτού μορίου προσκόλλησης αγγειακών κυττάρων (sVCAM) και/ή διαλυτού μορίου βλεννογονικής αντρεσσίνης σε μόριο προσκόλλησης κυττάρων βλεννογονικής αντρεσσίνης (sMAdCAM). Συγκεκριμένα, η παρούσα μέθοδος μπορεί να χρησιμοποιηθεί, παραδείγματος χάριν, για την αξιολόγηση της φαρμακοκινητικής και της φαρμακοδυναμικής (PK/PD) ενός αναστολέα άλφα-4 ιντεγκρίνης που χρησιμοποιείται για τη θεραπεία μιας νόσος που σχετίζεται με παθολογική ή χρόνια φλεγμονή.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40635810P | 2010-10-25 | 2010-10-25 | |
US40636510P | 2010-10-25 | 2010-10-25 | |
EP11838481.7A EP2632492B1 (en) | 2010-10-25 | 2011-10-24 | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMAdCAM LEVELS |
PCT/US2011/057519 WO2012061074A1 (en) | 2010-10-25 | 2011-10-24 | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMAdCAM LEVELS |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1123060T1 true CY1123060T1 (el) | 2021-10-29 |
Family
ID=46024768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100555T CY1123060T1 (el) | 2010-10-25 | 2020-06-17 | Μεθοδοι για τον καθορισμο των διαφορων στη δραστικοτητα της αλφα-4 ιντεγκρινης δια συσχετισμου των διαφορων στα επιπεδα svcam και/ή smadcam |
Country Status (17)
Country | Link |
---|---|
US (3) | US20130337470A1 (el) |
EP (3) | EP2632492B1 (el) |
JP (2) | JP5847188B2 (el) |
AU (4) | AU2011323820A1 (el) |
CA (1) | CA2816016A1 (el) |
CY (1) | CY1123060T1 (el) |
DK (1) | DK3326645T3 (el) |
ES (2) | ES2800066T3 (el) |
HK (1) | HK1256157A1 (el) |
HR (1) | HRP20200920T1 (el) |
HU (1) | HUE050713T2 (el) |
LT (1) | LT3326645T (el) |
PL (1) | PL3326645T3 (el) |
PT (1) | PT3326645T (el) |
RS (1) | RS60565B1 (el) |
SI (1) | SI3326645T1 (el) |
WO (1) | WO2012061074A1 (el) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2632492B1 (en) | 2010-10-25 | 2017-10-04 | Biogen MA Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMAdCAM LEVELS |
WO2016088068A1 (en) * | 2014-12-02 | 2016-06-09 | Nestec S.A. | Methods for establishing a vedolizumab dosing regimen to treat patients with irritable bowel disease |
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EP2632492B1 (en) | 2010-10-25 | 2017-10-04 | Biogen MA Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMAdCAM LEVELS |
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2011
- 2011-10-24 EP EP11838481.7A patent/EP2632492B1/en active Active
- 2011-10-24 EP EP20162844.3A patent/EP3722808A1/en active Pending
- 2011-10-24 ES ES17192860T patent/ES2800066T3/es active Active
- 2011-10-24 WO PCT/US2011/057519 patent/WO2012061074A1/en active Application Filing
- 2011-10-24 AU AU2011323820A patent/AU2011323820A1/en not_active Abandoned
- 2011-10-24 LT LTEP17192860.9T patent/LT3326645T/lt unknown
- 2011-10-24 HU HUE17192860A patent/HUE050713T2/hu unknown
- 2011-10-24 EP EP17192860.9A patent/EP3326645B1/en active Active
- 2011-10-24 DK DK17192860.9T patent/DK3326645T3/da active
- 2011-10-24 CA CA2816016A patent/CA2816016A1/en active Pending
- 2011-10-24 PL PL17192860T patent/PL3326645T3/pl unknown
- 2011-10-24 SI SI201131889T patent/SI3326645T1/sl unknown
- 2011-10-24 PT PT171928609T patent/PT3326645T/pt unknown
- 2011-10-24 US US13/881,520 patent/US20130337470A1/en not_active Abandoned
- 2011-10-24 RS RS20200712A patent/RS60565B1/sr unknown
- 2011-10-24 JP JP2013536701A patent/JP5847188B2/ja active Active
- 2011-10-24 ES ES11838481.7T patent/ES2654820T3/es active Active
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2014
- 2014-02-19 HK HK18115240.6A patent/HK1256157A1/zh unknown
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2015
- 2015-08-27 JP JP2015167690A patent/JP2015215363A/ja not_active Withdrawn
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2016
- 2016-04-18 US US15/131,804 patent/US11079393B2/en active Active
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2017
- 2017-03-10 AU AU2017201658A patent/AU2017201658B2/en active Active
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2019
- 2019-06-12 AU AU2019204089A patent/AU2019204089A1/en not_active Abandoned
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2020
- 2020-06-08 HR HRP20200920TT patent/HRP20200920T1/hr unknown
- 2020-06-17 CY CY20201100555T patent/CY1123060T1/el unknown
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2021
- 2021-08-03 US US17/393,267 patent/US20220206012A1/en active Pending
- 2021-08-05 AU AU2021212059A patent/AU2021212059A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
HRP20200920T1 (hr) | 2020-10-30 |
EP2632492A4 (en) | 2014-04-02 |
WO2012061074A1 (en) | 2012-05-10 |
EP2632492A1 (en) | 2013-09-04 |
JP2014500950A (ja) | 2014-01-16 |
EP3722808A1 (en) | 2020-10-14 |
ES2800066T3 (es) | 2020-12-23 |
HK1256157A1 (zh) | 2019-09-13 |
LT3326645T (lt) | 2020-08-10 |
CA2816016A1 (en) | 2012-05-10 |
JP5847188B2 (ja) | 2016-01-20 |
RS60565B1 (sr) | 2020-08-31 |
AU2017201658B2 (en) | 2019-03-21 |
EP2632492B1 (en) | 2017-10-04 |
JP2015215363A (ja) | 2015-12-03 |
AU2011323820A1 (en) | 2013-05-23 |
AU2021212059A1 (en) | 2021-08-26 |
SI3326645T1 (sl) | 2020-09-30 |
EP3326645A1 (en) | 2018-05-30 |
EP3326645B1 (en) | 2020-03-18 |
AU2019204089A1 (en) | 2019-07-04 |
HUE050713T2 (hu) | 2020-12-28 |
US20160291035A1 (en) | 2016-10-06 |
PT3326645T (pt) | 2020-06-23 |
PL3326645T3 (pl) | 2020-09-21 |
DK3326645T3 (da) | 2020-06-15 |
AU2017201658A1 (en) | 2017-03-30 |
US11079393B2 (en) | 2021-08-03 |
US20130337470A1 (en) | 2013-12-19 |
ES2654820T3 (es) | 2018-02-15 |
US20220206012A1 (en) | 2022-06-30 |
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