CY1122673T1 - Συνθεση για την αντιμετωπιση της ασθενειας της φλεγμονωδους αρθριτιδας - Google Patents
Συνθεση για την αντιμετωπιση της ασθενειας της φλεγμονωδους αρθριτιδαςInfo
- Publication number
- CY1122673T1 CY1122673T1 CY20191101267T CY191101267T CY1122673T1 CY 1122673 T1 CY1122673 T1 CY 1122673T1 CY 20191101267 T CY20191101267 T CY 20191101267T CY 191101267 T CY191101267 T CY 191101267T CY 1122673 T1 CY1122673 T1 CY 1122673T1
- Authority
- CY
- Cyprus
- Prior art keywords
- composition
- treatment
- bursitis
- bacterial
- inflammatory arthritis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
Abstract
Αυτή η εφεύρεση παρέχει συνθέσεις και μεθόδους για την πρόληψη φλεγμονωδών ασθενειών των αρθρώσεων, συμπεριλαμβανομένης της ρευματοειδούς αρθρίτιδας και της οστεοαρθρίτιδας, της τενοντίτιδας, της θυλακίτιδας, της φλεγμονής των συνδέσμων, της αρθροθυλακίτιδας, της ουρικής αρθρίτιδας και του συστημικού ερυθηματώδους λύκου, όπου οι μέθοδοι περιλαμβάνουν την έγχυση στην φλεγμαίνουσα άρθρωση μιας θεραπευτικής αντιφλεγμονώδους σύνθεσης που περιλαμβάνει μια βακτηριακή ή ιική κατασκευή έκφρασης IL-10, όπου η κατασκευή έκφρασης IL-10 περιλαμβάνει ένα βακτηριακό ή ιικό σκελετό και μια αλληλουχία νουκλεϊκού οξέος που κωδικοποιεί ιντερλευκίνη-10.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361847851P | 2013-07-18 | 2013-07-18 | |
EP14826787.5A EP3021873B8 (en) | 2013-07-18 | 2014-07-17 | Composition for the treatment of inflammatory joint disease |
PCT/US2014/047071 WO2015009955A1 (en) | 2013-07-18 | 2014-07-17 | Methods for the treatment of inflammatory joint disease |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122673T1 true CY1122673T1 (el) | 2021-03-12 |
Family
ID=52346725
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181101297T CY1120946T1 (el) | 2013-07-18 | 2018-11-28 | Μεθοδοι για τη θεραπευτικη αγωγη φλεγμονωδους αρθροπαθειας |
CY20191101267T CY1122673T1 (el) | 2013-07-18 | 2019-12-03 | Συνθεση για την αντιμετωπιση της ασθενειας της φλεγμονωδους αρθριτιδας |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181101297T CY1120946T1 (el) | 2013-07-18 | 2018-11-28 | Μεθοδοι για τη θεραπευτικη αγωγη φλεγμονωδους αρθροπαθειας |
Country Status (14)
Country | Link |
---|---|
US (4) | US10512672B2 (el) |
EP (2) | EP3369435B1 (el) |
JP (3) | JP2016525522A (el) |
CY (2) | CY1120946T1 (el) |
DK (2) | DK3369435T3 (el) |
ES (2) | ES2760902T3 (el) |
HR (2) | HRP20181913T1 (el) |
HU (2) | HUE042463T2 (el) |
LT (2) | LT3369435T (el) |
PL (2) | PL3021873T3 (el) |
PT (2) | PT3369435T (el) |
RS (2) | RS59735B1 (el) |
SI (2) | SI3021873T1 (el) |
WO (1) | WO2015009955A1 (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE042463T2 (hu) | 2013-07-18 | 2019-07-29 | Univ Colorado Regents | Készítmény gyulladásos ízületi betegség kezelésére |
JP7163189B2 (ja) * | 2016-04-22 | 2022-10-31 | ザルード セラピューティクス インコーポレイテッド | インターロイキン10の抗炎症効果を亢進するための方法および組成物 |
IL299149A (en) * | 2020-06-26 | 2023-02-01 | Amgen Inc | IL-10 mutants and their related proteins |
WO2023114958A1 (en) * | 2021-12-16 | 2023-06-22 | Xalud Therapeutics, Inc. | Dosing regimen for il-10 encoding expression construct |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
US6217857B1 (en) | 1989-06-28 | 2001-04-17 | Schering Corporation | Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof |
US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
US6018036A (en) | 1990-06-29 | 2000-01-25 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (Interleukin-10) |
HU220103B (hu) | 1992-08-20 | 2001-10-28 | Schering-Plough Corp. | IL-10 új alkalmazása |
US5922018A (en) | 1992-12-21 | 1999-07-13 | Artann Corporation | Method for using a transrectal probe to mechanically image the prostate gland |
US5373317B1 (en) | 1993-05-28 | 2000-11-21 | Welch Allyn Inc | Control and display section for borescope or endoscope |
JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル. グラハム,フランク | 遺伝子治療のためのアデノウイルスベクター |
US6652850B1 (en) | 1993-09-13 | 2003-11-25 | Aventis Pharmaceuticals Inc. | Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity |
ATE437232T1 (de) | 1993-10-25 | 2009-08-15 | Canji Inc | Rekombinanter adenoviren-vektor und verfahren zur verwendung |
US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
AP690A (en) | 1994-07-05 | 1998-10-16 | Steeno Res Group A/S | Immunomodulators based on a polypeptide other than human interleukin 10. |
CA2205572A1 (en) | 1994-12-12 | 1996-06-20 | Beth Israel Hospital Association | Chimeric cytokines and uses thereof |
US5716804A (en) | 1995-04-19 | 1998-02-10 | Schering Corporation | Mammalian interleukin-10 (IL-10) super-activating receptors; and variants |
US6083919A (en) | 1996-12-05 | 2000-07-04 | University Of Florida | Materials and methods for treating autoimmune disease |
US6201880B1 (en) | 1996-12-31 | 2001-03-13 | Electro-Optical Sciences | Method and apparatus for electronically imaging a tooth through transillumination by light |
US5783567A (en) | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
US6013253A (en) | 1997-08-15 | 2000-01-11 | Amgen, Inc. | Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist |
US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
AU3063899A (en) | 1998-03-17 | 1999-10-11 | Schering Corporation | Use of il-10 to treat major depressive disorder |
US6528312B1 (en) | 1998-05-06 | 2003-03-04 | Transgene S.A. | Use of G-actin for improving transfection of a polynucleotide into a cell |
US6428985B1 (en) | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
US6982089B2 (en) | 1999-02-24 | 2006-01-03 | Tact Ip, Llc | Cytokine antagonists for neurological and neuropsychiatric disorders |
US6165754A (en) | 1999-06-08 | 2000-12-26 | Cornell Research Foundation, Inc. | Method of expressing an exogenous nucleic acid |
US20050129669A1 (en) | 1999-06-21 | 2005-06-16 | Transkaryotic Therapies, Inc., A Massachusetts Corporation | DNA construct for effecting homologous recombination and uses thereof |
WO2001080897A2 (en) | 2000-04-21 | 2001-11-01 | Vical Incorporated | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics |
AU2002217929A1 (en) | 2000-11-28 | 2002-06-11 | Sangamo Biosciences, Inc. | Modulation of gene expression using insulator binding proteins |
ATE309788T1 (de) * | 2000-12-13 | 2005-12-15 | Merckle Gmbh | Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung |
WO2002083080A2 (en) * | 2001-04-17 | 2002-10-24 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
US20030166593A1 (en) | 2001-04-30 | 2003-09-04 | Kenneth Chien | Non-viral vesicle vector for cardiac specific gene delivery |
JP4578735B2 (ja) | 2001-08-28 | 2010-11-10 | オリンパス株式会社 | 内視鏡画像ファイリングシステム |
CA2361462A1 (en) | 2001-11-07 | 2003-05-08 | Katherine A. High | Induction of tolerance to a therapeutic polypeptide |
JP2003146909A (ja) | 2001-11-07 | 2003-05-21 | Children's Hospital Of Philadelphia | 治療用ポリペプチドに対する免疫寛容の誘導 |
US6967018B2 (en) | 2002-01-11 | 2005-11-22 | Applied Genetic Technologies Corporation | Adiponectin gene therapy |
AU2003221745A1 (en) | 2002-04-19 | 2003-11-03 | University Of Florida | rAAV VECTOR-BASED COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MAMMALIAN DISEASES |
WO2004042001A2 (en) * | 2002-05-17 | 2004-05-21 | Emory University | Virus-like particles, methods of preparation, and immonogenic compositions |
GB0212648D0 (en) | 2002-05-31 | 2002-07-10 | Immunoclin Lab Ltd | Treatment with cytokines |
US20040186357A1 (en) | 2002-08-20 | 2004-09-23 | Welch Allyn, Inc. | Diagnostic instrument workstation |
IL166612A0 (en) | 2002-08-29 | 2006-01-15 | Univ Leland Stanford Junior | Circular nucleic acid vectors and methods for making and using the same |
US20040142893A1 (en) | 2002-10-21 | 2004-07-22 | Uichi Ikeda | Methods for treating and preventing vascular disease |
US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
US7530946B2 (en) | 2003-08-15 | 2009-05-12 | Scimed Life Systems, Inc. | Compact endoscope |
US7276486B2 (en) | 2004-03-15 | 2007-10-02 | Kimberly-Clark Worldwide, Inc. | Compositions for vaginal treatment |
JP2008505104A (ja) * | 2004-07-01 | 2008-02-21 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 免疫抑制性エキソソーム |
US20060073119A1 (en) | 2004-09-01 | 2006-04-06 | Avigen, Inc. | Methods for treating neurodegenerative disorders |
EP1901769A2 (en) | 2005-05-02 | 2008-03-26 | Avigen, Inc. | Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease |
EP2816118B1 (en) | 2005-05-31 | 2018-10-17 | The Regents of the University of Colorado, a body corporate | Methods for delivering genes |
CA2609543C (en) | 2005-05-31 | 2015-03-24 | Avigen, Inc. | Mutant il-10 |
WO2007016501A2 (en) | 2005-08-01 | 2007-02-08 | The University Of Chicago | Compositions and method for brain specific targeted delivery of therapeutic agents |
US20100196492A1 (en) | 2007-03-08 | 2010-08-05 | Green Jordan J | Electrostatic coating of particles for drug delivery |
US7846428B2 (en) | 2007-10-05 | 2010-12-07 | Merial Limited | Articular cartilage gene therapy with recombinant vector encoding BMP-7 |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
JP5932830B2 (ja) | 2010-12-15 | 2016-06-08 | オラテック セラピューティクス リミティド ライアビリティ カンパニー | 炎症及び疼痛を処置するための3‐メタンスルホニルプロピオニトリル |
EP2800554A4 (en) | 2012-01-06 | 2015-06-03 | Univ Colorado Regents | METHOD FOR TREATING MULTIPLE SCLEROSIS AND OTHER DEMYELINISING DISEASES |
HUE042463T2 (hu) | 2013-07-18 | 2019-07-29 | Univ Colorado Regents | Készítmény gyulladásos ízületi betegség kezelésére |
JP7163189B2 (ja) | 2016-04-22 | 2022-10-31 | ザルード セラピューティクス インコーポレイテッド | インターロイキン10の抗炎症効果を亢進するための方法および組成物 |
-
2014
- 2014-07-17 HU HUE14826787A patent/HUE042463T2/hu unknown
- 2014-07-17 LT LTEP18167083.7T patent/LT3369435T/lt unknown
- 2014-07-17 DK DK18167083T patent/DK3369435T3/da active
- 2014-07-17 ES ES18167083T patent/ES2760902T3/es active Active
- 2014-07-17 HU HUE18167083A patent/HUE046944T2/hu unknown
- 2014-07-17 SI SI201430972T patent/SI3021873T1/sl unknown
- 2014-07-17 RS RS20191473A patent/RS59735B1/sr unknown
- 2014-07-17 WO PCT/US2014/047071 patent/WO2015009955A1/en active Application Filing
- 2014-07-17 JP JP2016527107A patent/JP2016525522A/ja not_active Withdrawn
- 2014-07-17 SI SI201431402T patent/SI3369435T1/sl unknown
- 2014-07-17 PT PT181670837T patent/PT3369435T/pt unknown
- 2014-07-17 DK DK14826787.5T patent/DK3021873T3/en active
- 2014-07-17 US US14/905,915 patent/US10512672B2/en active Active
- 2014-07-17 LT LTEP14826787.5T patent/LT3021873T/lt unknown
- 2014-07-17 PT PT14826787T patent/PT3021873T/pt unknown
- 2014-07-17 RS RS20181419A patent/RS57974B1/sr unknown
- 2014-07-17 EP EP18167083.7A patent/EP3369435B1/en active Active
- 2014-07-17 PL PL14826787T patent/PL3021873T3/pl unknown
- 2014-07-17 ES ES14826787T patent/ES2700826T3/es active Active
- 2014-07-17 EP EP14826787.5A patent/EP3021873B8/en active Active
- 2014-07-17 PL PL18167083T patent/PL3369435T3/pl unknown
-
2018
- 2018-11-16 HR HRP20181913TT patent/HRP20181913T1/hr unknown
- 2018-11-28 CY CY181101297T patent/CY1120946T1/el unknown
-
2019
- 2019-10-31 US US16/670,987 patent/US20200093892A1/en not_active Abandoned
- 2019-11-01 JP JP2019199475A patent/JP7066669B2/ja active Active
- 2019-11-12 HR HRP20192043TT patent/HRP20192043T1/hr unknown
- 2019-12-03 CY CY20191101267T patent/CY1122673T1/el unknown
-
2021
- 2021-11-05 JP JP2021180762A patent/JP2022031682A/ja active Pending
-
2022
- 2022-06-21 US US17/845,101 patent/US20220313785A1/en not_active Abandoned
-
2023
- 2023-01-25 US US18/159,161 patent/US20230158114A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1122673T1 (el) | Συνθεση για την αντιμετωπιση της ασθενειας της φλεγμονωδους αρθριτιδας | |
CY1123815T1 (el) | Υποκατεστημενες ινδαζολες, διαδικασια για την παρασκευη τους, φαρμακευτικα παρασκευασματα, τα οποια τις περιεχουν, καθως και η χρηση τους για την παρασκευη φαρμακευτικων μεσων | |
CY1124407T1 (el) | Ενωσεις αναστολεα αυτοταξινης | |
CY1123381T1 (el) | Συνθεσεις που περιεχουν βακτηριακα στελεχη | |
CY1124004T1 (el) | Υποδορια σκευασματα αντισωματων αντι-cd38 και οι χρησεις τους | |
CY1122738T1 (el) | Αντιπληροφοριακα ολιγομερη και συζευγματα που στοχευουν την pcsk9 | |
CY1117204T1 (el) | ΕΝΩΣΕΙΣ ΤΡΙΑΖΟΛΟΝΗΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ mPGES-1 | |
CY1121876T1 (el) | Συνθεσεις παρακαμψης εξωνιου για τη θεραπεια της μυϊκης δυστροφiας | |
CY1124013T1 (el) | Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη | |
CY1122707T1 (el) | Ετεροκυκλικοι αναστολεις γλουταμινασης | |
CY1123407T1 (el) | Σταθερες υδατικες φαρμακοτεχνικες μορφες της αδαλιμουμαμπης | |
CY1122581T1 (el) | Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη | |
CY1122148T1 (el) | Συνθεσεις που περιεχουν βακτηριακα στελεχη | |
CY1121473T1 (el) | Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη | |
CY1124222T1 (el) | Ενωσεις πυριδινονης-πυριδινυλιου υποκατεστημενες με μεθυλο/φθορο-πυριδινυλο-μεθοξυ και ενωσεις πυριδινονης-πυριδινυλιου υποκατεστημενες με φθορο-πυριδινυλο-μεθοξυ | |
CY1124698T1 (el) | Πρωτεϊνη δεσμευσης il-18 (il-18bp) σε φλεγμονωδεις νοσους | |
CY1122850T1 (el) | Υπερδιακλαδισμενος πολυ (βητα-αμινοεστερας) για γονιδιακη θεραπεια | |
CY1119892T1 (el) | Φορεις και αλληλουχιες για την αγωγη ασθενειων | |
CY1121395T1 (el) | Τετραϋδροπυριδοπυραζινες-διαμορφωτες toy gpr6 | |
CY1123093T1 (el) | Φαρμακοφορο για την επαγωγη του trail | |
CY1123349T1 (el) | Ενωσεις 6-ετεροκυκλυλ-4-μορφολιν-4-υλπυρiδιν-2-οnhς χρησιμες για τη θεραπεια καρκινου και διαβητη | |
CY1124749T1 (el) | Παραγωγα διπυραζολιου χρησιμα για την θεραπεια αυτοανοσων νοσηματων | |
CY1120493T1 (el) | Πρωτεϊνη συντηξης που περιλαμβανει ιντερλευκινη 4 και ιντερλευκινη 10 | |
CY1124425T1 (el) | Συνθεσεις οι οποιες περιλαμβανουν συζευγματα φαρμακου αντισωματος-δουοκαρμυκινης | |
CY1121550T1 (el) | Ενωσεις πυριδινης πλαδιενολιδης και μεθοδοι χρησης |