CY1120493T1 - Πρωτεϊνη συντηξης που περιλαμβανει ιντερλευκινη 4 και ιντερλευκινη 10 - Google Patents
Πρωτεϊνη συντηξης που περιλαμβανει ιντερλευκινη 4 και ιντερλευκινη 10Info
- Publication number
- CY1120493T1 CY1120493T1 CY20181100796T CY181100796T CY1120493T1 CY 1120493 T1 CY1120493 T1 CY 1120493T1 CY 20181100796 T CY20181100796 T CY 20181100796T CY 181100796 T CY181100796 T CY 181100796T CY 1120493 T1 CY1120493 T1 CY 1120493T1
- Authority
- CY
- Cyprus
- Prior art keywords
- fusion protein
- interleukin
- nucleic acid
- acid molecule
- protein including
- Prior art date
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
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- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Abstract
Η εφεύρεση αφορά μια πρωτεΐνη σύντηξης που περιλαμβάνει ιντερλευκίνη 10 και ιντερλευκίνη 4, μόριο νουκλεϊνικού οξέος που κωδικοποιεί την εν λόγω πρωτεΐνη σύντηξης, φορέα που περιλαμβάνει το εν λόγω μόριο νουκλεϊνικού οξέος και κύτταρο ξενιστή που περιλαμβάνει το εν λόγω μόριο νουκλεϊνικού οξέος ή τον εν λόγω φορέα. Η εφεύρεση επιπλέον σχετίζεται με μια μέθοδο για την παραγωγή της εν λόγω πρωτεΐνης σύντηξης. Η πρωτεΐνη σύντηξης ή ένας φορέας γονιδιακής θεραπείας που κωδικοποιεί την πρωτεΐνη σύντηξης μπορεί να χρησιμοποιηθεί στην πρόληψη ή τη θεραπευτική αγωγή της οστεοαρθρίτιδας, του χρόνιου πόνου, μιας πάθησης που χαρακτηρίζεται από τοπική ή συστηματική φλεγμονή, ανοσοποιητική ενεργοποίηση, λεμφοϋπερπλαστικές διαταραχές και/ή χρόνιο πόνο.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161556843P | 2011-11-08 | 2011-11-08 | |
US201261691816P | 2012-08-22 | 2012-08-22 | |
PCT/NL2012/050790 WO2013070076A1 (en) | 2011-11-08 | 2012-11-08 | Fusion protein comprising an interleukin 4 and interleukin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1120493T1 true CY1120493T1 (el) | 2019-07-10 |
Family
ID=47226379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100796T CY1120493T1 (el) | 2011-11-08 | 2018-08-01 | Πρωτεϊνη συντηξης που περιλαμβανει ιντερλευκινη 4 και ιντερλευκινη 10 |
Country Status (14)
Country | Link |
---|---|
US (4) | US20140314712A1 (el) |
EP (1) | EP2776460B1 (el) |
JP (2) | JP6284482B2 (el) |
CN (2) | CN108129574A (el) |
CY (1) | CY1120493T1 (el) |
DK (1) | DK2776460T3 (el) |
ES (1) | ES2683844T3 (el) |
HR (1) | HRP20181210T1 (el) |
HU (1) | HUE038668T2 (el) |
LT (1) | LT2776460T (el) |
PL (1) | PL2776460T3 (el) |
RS (1) | RS57480B1 (el) |
TR (1) | TR201811024T4 (el) |
WO (1) | WO2013070076A1 (el) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2776460T3 (en) * | 2011-11-08 | 2018-08-06 | Umc Utrecht Holding Bv | Fusion protein comprising interleukin 4 and interleukin 10 |
CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
CN106139125A (zh) * | 2015-04-24 | 2016-11-23 | 复旦大学 | 白细胞介素4在制备促进急性脑损伤后神经功能恢复药物中的用途 |
KR20170034701A (ko) * | 2015-09-21 | 2017-03-29 | 코오롱생명과학 주식회사 | 통증 치료용 조성물 |
WO2018190713A1 (en) | 2017-04-12 | 2018-10-18 | Umc Utrecht Holding B.V. | Inhibitors of lysine methyltransferase for treatment of pain |
CN112142859A (zh) * | 2017-05-22 | 2020-12-29 | 杭州博虎生物科技有限公司 | 一种人白细胞介素10-Fc融合蛋白及其编码基因与应用 |
EP3927728A2 (en) | 2019-02-21 | 2021-12-29 | Xencor, Inc. | Untargeted and targeted il-10 fc-fusion proteins |
NL2022982B1 (en) | 2019-04-19 | 2020-10-27 | Synerkine Pharma B V | A fusion protein comprising IL13 |
AU2020258026A1 (en) | 2019-04-19 | 2021-11-11 | Synerkine Pharma B.V. | A fusion protein comprising IL13 |
NL2022984B1 (en) * | 2019-04-19 | 2020-10-27 | Synerkine Pharma B V | Therapeutic crosslinking of cytokine receptors |
GB202003428D0 (en) * | 2020-03-10 | 2020-04-22 | Univ Dundee | IL-10 mutiens |
CN115078728A (zh) * | 2021-03-11 | 2022-09-20 | 盛禾(中国)生物制药有限公司 | 一种融合蛋白的快速分析方法 |
WO2024094755A1 (en) * | 2022-11-02 | 2024-05-10 | Synerkine Pharma B.V. | Engineered immunocytokines, fusion polypeptides, and il10 polypeptides |
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WO2007128563A1 (en) * | 2006-05-08 | 2007-11-15 | Philogen Spa | Antibody-targeted cytokines for therapy |
KR20190064664A (ko) * | 2008-10-02 | 2019-06-10 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Cd86 길항제 다중-표적 결합 단백질 |
EP2542679A1 (en) * | 2010-03-05 | 2013-01-09 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | B-cell stimulating fusion proteins of an antigen with baff or april |
CA2795325A1 (en) | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
EP2457579A1 (en) | 2010-11-26 | 2012-05-30 | Technische Universität Dresden | Covalently linked interleukin -10 |
DK2776460T3 (en) | 2011-11-08 | 2018-08-06 | Umc Utrecht Holding Bv | Fusion protein comprising interleukin 4 and interleukin 10 |
-
2012
- 2012-11-08 DK DK12791293.9T patent/DK2776460T3/en active
- 2012-11-08 HU HUE12791293A patent/HUE038668T2/hu unknown
- 2012-11-08 CN CN201810088371.8A patent/CN108129574A/zh active Pending
- 2012-11-08 WO PCT/NL2012/050790 patent/WO2013070076A1/en active Application Filing
- 2012-11-08 US US14/356,855 patent/US20140314712A1/en not_active Abandoned
- 2012-11-08 EP EP12791293.9A patent/EP2776460B1/en active Active
- 2012-11-08 CN CN201280066029.9A patent/CN104136457A/zh active Pending
- 2012-11-08 PL PL12791293T patent/PL2776460T3/pl unknown
- 2012-11-08 TR TR2018/11024T patent/TR201811024T4/tr unknown
- 2012-11-08 JP JP2014540991A patent/JP6284482B2/ja active Active
- 2012-11-08 ES ES12791293.9T patent/ES2683844T3/es active Active
- 2012-11-08 LT LTEP12791293.9T patent/LT2776460T/lt unknown
- 2012-11-08 RS RS20180904A patent/RS57480B1/sr unknown
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2017
- 2017-10-05 JP JP2017195002A patent/JP6527925B2/ja active Active
- 2017-12-14 US US15/842,353 patent/US10851143B2/en active Active
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2018
- 2018-07-25 HR HRP20181210TT patent/HRP20181210T1/hr unknown
- 2018-08-01 CY CY20181100796T patent/CY1120493T1/el unknown
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2019
- 2019-12-09 US US16/707,435 patent/US10981964B2/en active Active
-
2021
- 2021-03-04 US US17/192,183 patent/US20210261639A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN108129574A (zh) | 2018-06-08 |
JP2018007693A (ja) | 2018-01-18 |
EP2776460B1 (en) | 2018-05-02 |
HRP20181210T1 (hr) | 2018-09-21 |
TR201811024T4 (tr) | 2018-08-27 |
ES2683844T3 (es) | 2018-09-28 |
US10981964B2 (en) | 2021-04-20 |
US10851143B2 (en) | 2020-12-01 |
PL2776460T3 (pl) | 2018-10-31 |
CN104136457A (zh) | 2014-11-05 |
US20200147178A1 (en) | 2020-05-14 |
RS57480B1 (sr) | 2018-10-31 |
JP6527925B2 (ja) | 2019-06-12 |
US20140314712A1 (en) | 2014-10-23 |
JP6284482B2 (ja) | 2018-02-28 |
WO2013070076A1 (en) | 2013-05-16 |
HUE038668T2 (hu) | 2018-11-28 |
JP2014533110A (ja) | 2014-12-11 |
EP2776460A1 (en) | 2014-09-17 |
LT2776460T (lt) | 2018-09-10 |
US20210261639A1 (en) | 2021-08-26 |
US20180094037A1 (en) | 2018-04-05 |
DK2776460T3 (en) | 2018-08-06 |
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