CY1122541T1 - Συνδυαστικη θεραπεια καρκινου - Google Patents
Συνδυαστικη θεραπεια καρκινουInfo
- Publication number
- CY1122541T1 CY1122541T1 CY20201100070T CY201100070T CY1122541T1 CY 1122541 T1 CY1122541 T1 CY 1122541T1 CY 20201100070 T CY20201100070 T CY 20201100070T CY 201100070 T CY201100070 T CY 201100070T CY 1122541 T1 CY1122541 T1 CY 1122541T1
- Authority
- CY
- Cyprus
- Prior art keywords
- combinative
- cancer therapy
- modifier
- cancer
- vrac
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση αφορά την αγωγή καρκίνου, συγκεκριμένα μεθόδους ευαισθητοποίησης καρκινικών κυττάρων σε αντικαρκινική θεραπεία, δια της χορήγησης μιας αποτελεσματικής ποσότητας ενός τροποποιητή διαύλων ανιόντων ρύθμισης όγκου, δηλαδή ενός τροποποιητή VRAC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201670325 | 2016-05-17 | ||
PCT/EP2017/061823 WO2017198700A1 (en) | 2016-05-17 | 2017-05-17 | Combination treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122541T1 true CY1122541T1 (el) | 2021-01-27 |
Family
ID=58800797
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100070T CY1122541T1 (el) | 2016-05-17 | 2020-01-27 | Συνδυαστικη θεραπεια καρκινου |
CY20211100332T CY1124242T1 (el) | 2016-05-17 | 2021-04-15 | Συνδυαστικη θεραπεια καρκινου |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100332T CY1124242T1 (el) | 2016-05-17 | 2021-04-15 | Συνδυαστικη θεραπεια καρκινου |
Country Status (18)
Country | Link |
---|---|
US (2) | US11103481B2 (el) |
EP (3) | EP3622953B1 (el) |
JP (1) | JP7033554B2 (el) |
CN (1) | CN109475535A (el) |
AU (1) | AU2017266724B2 (el) |
BR (1) | BR112018073518A2 (el) |
CA (1) | CA3023202A1 (el) |
CY (2) | CY1122541T1 (el) |
DK (2) | DK3458052T3 (el) |
ES (2) | ES2770374T3 (el) |
HR (2) | HRP20200076T1 (el) |
HU (2) | HUE047542T2 (el) |
LT (2) | LT3622953T (el) |
PL (2) | PL3458052T3 (el) |
PT (2) | PT3458052T (el) |
RS (2) | RS61786B1 (el) |
SI (2) | SI3622953T1 (el) |
WO (1) | WO2017198700A1 (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS61786B1 (sr) * | 2016-05-17 | 2021-06-30 | Scandion Oncology As | Kombinovani tretman za kancer |
US11530181B2 (en) | 2018-02-22 | 2022-12-20 | University Of Florida Research Foundation, Incorporated | IL-6 inhibitors and methods of treatment |
WO2020049139A1 (en) * | 2018-09-06 | 2020-03-12 | Scandion Oncology A/S | Urea derivatives for use in the treatment of subjects with elevated expression and/or activity of srpk1 |
WO2020079051A1 (en) | 2018-10-16 | 2020-04-23 | Scandion Oncology A/S | Compounds for treatment of microbial infection |
EP4104834A1 (en) | 2021-06-14 | 2022-12-21 | Scandion Oncology A/S | Combination treatments for cancer patients and methods for identifying same |
EP4355322A1 (en) | 2021-06-14 | 2024-04-24 | Scandion Oncology A/S | Methods of increasing the plasma drug exposure of anticancer agents |
AU2022295049A1 (en) | 2021-06-14 | 2023-12-14 | Scandion Oncology A/S | Combination treatments for cancer patients and methods for identifying same |
TW202321205A (zh) | 2021-07-16 | 2023-06-01 | 丹麥商斯坎丁腫瘤公司 | Sco-101的熱力穩定形式 |
EP4197525A1 (en) | 2021-12-20 | 2023-06-21 | Scandion Oncology A/S | Combination of drugs for the treatment of cancer |
CN117229258A (zh) * | 2022-06-07 | 2023-12-15 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
WO2023242235A1 (en) | 2022-06-14 | 2023-12-21 | Scandion Oncology A/S | Abcg2 inhibitor and nae inhibitor for the treatment of cancer |
WO2024013058A1 (en) | 2022-07-11 | 2024-01-18 | Scandion Oncology A/S | Salts of sco-101 and methods involving salts |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
DK0977741T3 (da) | 1997-04-22 | 2003-12-01 | Neurosearch As | Substituerede phenylderivater, deres fremstilling og anvendelse |
OA11665A (en) | 1998-10-22 | 2004-12-08 | Neurosearch As | Substituted phenyl derivatives, their preparation and use. |
KR20050026091A (ko) | 2002-08-01 | 2005-03-14 | 뉴로서치 에이/에스 | 항혈관형성 요법에 반응하는 질환의 치료에 유용한 화합물 |
EP1638948B1 (en) | 2003-06-17 | 2008-10-15 | Neurosearch A/S | Diphenylurea derivatives and their use as chloride channel blockers |
US7674899B2 (en) | 2004-02-04 | 2010-03-09 | Neurosearch A/S | Dimeric azacyclic compounds and their use |
CA2591616A1 (en) | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Diphenylurea derivatives useful as potassium channel activators |
EP1996190A1 (en) | 2006-03-14 | 2008-12-03 | Neurosearch A/S | Diphenylurea derivatives and their use as chloride channel blockers or bkca channel modulators |
JO2885B1 (en) * | 2008-12-22 | 2015-03-15 | ايلي ليلي اند كومباني | Protein kinase inhibitors |
TWI508954B (zh) * | 2012-04-27 | 2015-11-21 | Nat Defense Medical Ct | 雜環融合蒽醌衍生物、其製備方法與醫藥組合物 |
EP2919009B1 (en) | 2014-03-10 | 2018-09-19 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | LRRC8 proteins and protein complexes and methods for identification of channel modulators |
ES2662822T3 (es) | 2015-03-04 | 2018-04-09 | Scandion Oncology A/S | Derivados de 4-amino-3-fenilamino-6-fenilpirazol[3,4-d]pirimidina para uso como inhibidores de la BCRP en tratamientos terapéuticos |
RS61786B1 (sr) * | 2016-05-17 | 2021-06-30 | Scandion Oncology As | Kombinovani tretman za kancer |
-
2017
- 2017-05-17 RS RS20210510A patent/RS61786B1/sr unknown
- 2017-05-17 WO PCT/EP2017/061823 patent/WO2017198700A1/en unknown
- 2017-05-17 PL PL17726573T patent/PL3458052T3/pl unknown
- 2017-05-17 SI SI201730713T patent/SI3622953T1/sl unknown
- 2017-05-17 LT LTEP19205104.3T patent/LT3622953T/lt unknown
- 2017-05-17 RS RS20200088A patent/RS59844B1/sr unknown
- 2017-05-17 EP EP19205104.3A patent/EP3622953B1/en active Active
- 2017-05-17 ES ES17726573T patent/ES2770374T3/es active Active
- 2017-05-17 EP EP21162597.5A patent/EP3854393A1/en active Pending
- 2017-05-17 HU HUE17726573A patent/HUE047542T2/hu unknown
- 2017-05-17 AU AU2017266724A patent/AU2017266724B2/en active Active
- 2017-05-17 PT PT177265733T patent/PT3458052T/pt unknown
- 2017-05-17 BR BR112018073518-3A patent/BR112018073518A2/pt active Search and Examination
- 2017-05-17 JP JP2018560218A patent/JP7033554B2/ja active Active
- 2017-05-17 PT PT192051043T patent/PT3622953T/pt unknown
- 2017-05-17 SI SI201730169T patent/SI3458052T1/sl unknown
- 2017-05-17 DK DK17726573.3T patent/DK3458052T3/da active
- 2017-05-17 LT LTEP17726573.3T patent/LT3458052T/lt unknown
- 2017-05-17 US US16/302,195 patent/US11103481B2/en active Active
- 2017-05-17 DK DK19205104.3T patent/DK3622953T3/da active
- 2017-05-17 PL PL19205104T patent/PL3622953T3/pl unknown
- 2017-05-17 CA CA3023202A patent/CA3023202A1/en active Pending
- 2017-05-17 HU HUE19205104A patent/HUE053744T2/hu unknown
- 2017-05-17 CN CN201780043536.3A patent/CN109475535A/zh active Pending
- 2017-05-17 EP EP17726573.3A patent/EP3458052B1/en active Active
- 2017-05-17 ES ES19205104T patent/ES2870805T3/es active Active
-
2020
- 2020-01-17 HR HRP20200076TT patent/HRP20200076T1/hr unknown
- 2020-01-27 CY CY20201100070T patent/CY1122541T1/el unknown
-
2021
- 2021-04-09 HR HRP20210572TT patent/HRP20210572T1/hr unknown
- 2021-04-15 CY CY20211100332T patent/CY1124242T1/el unknown
- 2021-07-29 US US17/388,208 patent/US11903927B2/en active Active
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