CY1122496T1 - Παραγωγα αιμινης με αντιβακτηριακη και αντιιικη δραστικοτητα - Google Patents

Παραγωγα αιμινης με αντιβακτηριακη και αντιιικη δραστικοτητα

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Publication number
CY1122496T1
CY1122496T1 CY20191101177T CY191101177T CY1122496T1 CY 1122496 T1 CY1122496 T1 CY 1122496T1 CY 20191101177 T CY20191101177 T CY 20191101177T CY 191101177 T CY191101177 T CY 191101177T CY 1122496 T1 CY1122496 T1 CY 1122496T1
Authority
CY
Cyprus
Prior art keywords
antibacterial
antivilic
activity
amine derivatives
antiviral agents
Prior art date
Application number
CY20191101177T
Other languages
English (en)
Inventor
Vladimir Evgenievich Nebolsin
Galina Alexandrovna Zheltukhina
Sergei Alexandrovich OKOROCHENKOV
Original Assignee
Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises" filed Critical Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
Publication of CY1122496T1 publication Critical patent/CY1122496T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η εφεύρεση αφορά νέα παράγωγα αιμίνης του γενικού τύπου (I) και την παραγωγή και χρήση αυτών ως αντιβακτηριακών και/ή αντιιικών παραγόντων, συμπεριλαμβανομένης της παρασκευής φαρμακευτικών συνθέσεων. Τα πλεονεκτήματα των νέων αντιβακτηριακών και αντιιικών παραγόντων με βάση τα παράγωγα της αιμίνης συμπεριλαμβάνουν τη βιοσυμβατότητα και βιοαποικοδομησιμότητα αυτών και τον υψηλό βαθμό αποτελεσματικότητας αυτών έναντι ανθεκτικών βακτηρίων και ευρέως διαδεδομένων ιών που είναι επικίνδυνοι για τους ανθρώπους, και έλλειψη τοξικότητας.
CY20191101177T 2011-11-17 2019-11-11 Παραγωγα αιμινης με αντιβακτηριακη και αντιιικη δραστικοτητα CY1122496T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011146831/04A RU2475498C1 (ru) 2011-11-17 2011-11-17 Новые производные гемина с антибактериальной и противовирусной активностью
PCT/RU2012/000939 WO2013073998A2 (ru) 2011-11-17 2012-11-15 Новые производные гемина с антибактериальной и противовирусной активностью

Publications (1)

Publication Number Publication Date
CY1122496T1 true CY1122496T1 (el) 2021-01-27

Family

ID=48430327

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101177T CY1122496T1 (el) 2011-11-17 2019-11-11 Παραγωγα αιμινης με αντιβακτηριακη και αντιιικη δραστικοτητα

Country Status (14)

Country Link
US (1) US9605013B2 (el)
EP (1) EP2781525B1 (el)
CN (1) CN104039824B (el)
CY (1) CY1122496T1 (el)
DK (1) DK2781525T3 (el)
EA (1) EA023667B1 (el)
ES (1) ES2755937T3 (el)
HU (1) HUE046503T2 (el)
PL (1) PL2781525T3 (el)
PT (1) PT2781525T (el)
RU (1) RU2475498C1 (el)
SI (1) SI2781525T1 (el)
UA (1) UA116877C2 (el)
WO (1) WO2013073998A2 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2664411T3 (es) 2013-03-15 2018-04-19 Suncor Energy Inc. Composiciones herbicidas
RU2656595C1 (ru) * 2018-03-16 2018-06-06 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Циклическое производное гемина с антимикробными свойствами и способ его синтеза
CN111848656B (zh) * 2020-06-24 2023-03-14 天津大学 离子修饰的原卟啉镓化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645131B2 (en) 1990-07-31 1994-01-06 Rockefeller University, The Use of metalloporphyrins to potentiate aids therapy
RU2238950C2 (ru) * 2002-04-25 2004-10-27 Небольсин Владимир Евгеньевич Производные гемина и их фармацевтически приемлемые соли, способ получения, применение и фармацевтическая композиция
RU2250906C2 (ru) * 2003-07-10 2005-04-27 Небольсин Владимир Евгеньевич Способы получения геминпептидов и их применение в качестве нуклеолитических агентов
RU2280649C1 (ru) * 2004-11-26 2006-07-27 ООО "Фарминтерпрайсез" Геминпептиды, их фармацевтически приемлемые соли, фармкомпозиция и применение в качестве противоопухолевых агентов
RU2296131C2 (ru) * 2004-11-26 2007-03-27 ООО "Фарминтерпрайсез" Геминпептид, его фармацевтически приемлемые соли и применение в качестве противовирусного и вирулецидного агента
RU2404191C2 (ru) * 2007-07-09 2010-11-20 ООО "Фарминтерпрайсез" Производные гемина или их фармацевтически приемлемые соли, способ получения, композиция и применение
RU2415868C1 (ru) 2009-09-10 2011-04-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Производные гемина, обладающие антимикробной активностью, или их фармацевтически приемлемые соли, способ получения, фармкомпозиция и применение

Also Published As

Publication number Publication date
WO2013073998A2 (ru) 2013-05-23
WO2013073998A3 (ru) 2013-08-08
US9605013B2 (en) 2017-03-28
EP2781525B1 (en) 2019-10-16
US20150031854A1 (en) 2015-01-29
EP2781525A4 (en) 2015-05-27
CN104039824B (zh) 2017-06-06
HUE046503T2 (hu) 2020-03-30
SI2781525T1 (sl) 2020-02-28
EA023667B1 (ru) 2016-06-30
CN104039824A (zh) 2014-09-10
DK2781525T3 (da) 2019-11-18
EP2781525A2 (en) 2014-09-24
PL2781525T3 (pl) 2020-05-18
EA201490963A1 (ru) 2014-12-30
RU2475498C1 (ru) 2013-02-20
PT2781525T (pt) 2019-12-05
ES2755937T3 (es) 2020-04-24
UA116877C2 (uk) 2018-05-25

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