CY1122332T1 - Ανιχνευση και ποσοτικος προσδιορισμος dna ελευθερου κυτταρων δοτη στο κυκλοφοριακο συστημα ληπτων μεταμοσχευσης οργανων - Google Patents
Ανιχνευση και ποσοτικος προσδιορισμος dna ελευθερου κυτταρων δοτη στο κυκλοφοριακο συστημα ληπτων μεταμοσχευσης οργανωνInfo
- Publication number
- CY1122332T1 CY1122332T1 CY20191100106T CY191100106T CY1122332T1 CY 1122332 T1 CY1122332 T1 CY 1122332T1 CY 20191100106 T CY20191100106 T CY 20191100106T CY 191100106 T CY191100106 T CY 191100106T CY 1122332 T1 CY1122332 T1 CY 1122332T1
- Authority
- CY
- Cyprus
- Prior art keywords
- detection
- circulatory system
- organ transplant
- quantification
- donor cell
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Transplanting Machines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μεθόδους, συνθέσεις και κιτ που σχετίζονται με την ανίχνευση ελεύθερου κυττάρων DNA δότη στο κυκλοφορικό σύστημα ενός λήπτη μεταμόσχευσης οργάνου για τον έγκαιρο εντοπισμό της απόρριψης του μοσχεύματος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361828553P | 2013-05-29 | 2013-05-29 | |
PCT/US2014/040055 WO2014194113A2 (en) | 2013-05-29 | 2014-05-29 | Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122332T1 true CY1122332T1 (el) | 2021-01-27 |
Family
ID=51989530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100106T CY1122332T1 (el) | 2013-05-29 | 2019-01-24 | Ανιχνευση και ποσοτικος προσδιορισμος dna ελευθερου κυτταρων δοτη στο κυκλοφοριακο συστημα ληπτων μεταμοσχευσης οργανων |
Country Status (12)
Country | Link |
---|---|
US (3) | US20160115541A1 (el) |
EP (1) | EP3004388B2 (el) |
CY (1) | CY1122332T1 (el) |
DK (1) | DK3004388T4 (el) |
ES (1) | ES2704682T5 (el) |
HR (1) | HRP20190209T4 (el) |
HU (1) | HUE041935T2 (el) |
LT (1) | LT3004388T (el) |
PL (1) | PL3004388T5 (el) |
PT (1) | PT3004388T (el) |
SI (1) | SI3004388T2 (el) |
WO (1) | WO2014194113A2 (el) |
Families Citing this family (42)
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US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
EP2854057B1 (en) | 2010-05-18 | 2018-03-07 | Natera, Inc. | Methods for non-invasive pre-natal ploidy calling |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
WO2012108920A1 (en) | 2011-02-09 | 2012-08-16 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
EP3741871A3 (en) | 2012-04-19 | 2021-02-17 | The Medical College of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
ES2726650T3 (es) | 2014-03-14 | 2019-10-08 | Caredx Inc | Métodos de monitorización de terapias inmunosupresoras en un receptor de trasplante |
CN109971852A (zh) | 2014-04-21 | 2019-07-05 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
KR102441391B1 (ko) * | 2014-07-25 | 2022-09-07 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
WO2016123698A1 (en) * | 2015-02-06 | 2016-08-11 | Uti Limited Partnership | Diagnostic assay for post-transplant assessment of potential rejection of donor organs |
KR101850437B1 (ko) * | 2015-04-14 | 2018-04-20 | 이원다이애그노믹스(주) | 차세대 염기서열 분석기법을 이용한 장기 이식 거부 반응 예측 방법 |
EP3289102A1 (en) * | 2015-04-30 | 2018-03-07 | Medical College of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
CN106544407B (zh) * | 2015-09-18 | 2019-11-08 | 广州华大基因医学检验所有限公司 | 确定受体cfDNA样本中供体来源cfDNA比例的方法 |
WO2017190106A1 (en) * | 2016-04-29 | 2017-11-02 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-target number |
WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
EA201991105A1 (ru) * | 2016-11-02 | 2020-01-27 | Дзе Медикал Колледж Оф Висконсин, Инк. | Методы оценки риска с использованием общей и специфической неклеточной днк |
CA3042722A1 (en) * | 2016-11-02 | 2018-05-11 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using mismatch amplification and statistical methods |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
US20210139983A1 (en) * | 2017-06-20 | 2021-05-13 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
WO2018237075A1 (en) | 2017-06-20 | 2018-12-27 | The Medical College Of Wisconsin, Inc. | ASSESSING THE RISK OF GRAFT COMPLICATION WITH TOTAL ACELLULAR DNA |
AU2018301716B2 (en) | 2017-07-14 | 2024-06-13 | The Regents Of The University Of California | Novel methods of predicting transplant rejection risk |
CA3085933A1 (en) * | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
US11479819B2 (en) | 2017-12-15 | 2022-10-25 | Acrannolife Genomics Pvt. Ltd. | Non-invasive method for monitoring transplanted organ status in organ-transplant recipients |
EP3517629A1 (en) | 2018-01-30 | 2019-07-31 | Myway Genetics S.r.L. | Use of cfdna fragments as biomarkers in patients after organ transplantation |
JP2021520816A (ja) | 2018-04-14 | 2021-08-26 | ナテラ, インコーポレイテッド | 循環腫瘍dnaの個別化された検出を用いる癌検出およびモニタリングの方法 |
US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
US20200109449A1 (en) * | 2018-10-09 | 2020-04-09 | Tai Diagnostics, Inc. | Cell lysis assay for cell-free dna analysis |
US20220073989A1 (en) * | 2018-12-20 | 2022-03-10 | The Regents Of The University Of California | Optimizing Detection of Transplant Injury by Donor-Derived Cell-Free DNA |
US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
CN114645077A (zh) * | 2020-12-17 | 2022-06-21 | 厦门大学 | 一种检测受体样品中供体的存在或比例的方法和试剂盒 |
CN113061666A (zh) * | 2020-12-30 | 2021-07-02 | 中南大学湘雅二医院 | 肝移植后巨细胞病毒的检测方法、应用及系统 |
WO2023116717A1 (en) * | 2021-12-22 | 2023-06-29 | The First Affiliated Hospital Of Guangzhou Medical University | Method for monitoring donar dna fraction |
CN114381511A (zh) * | 2021-12-31 | 2022-04-22 | 上海药明奥测医疗科技有限公司 | 一种评估肝移植术后移植物损伤及排斥风险的检测方法 |
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WO1989001050A1 (en) | 1987-07-31 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
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DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
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WO2012115851A1 (en) * | 2011-02-22 | 2012-08-30 | City Of Hope | Ultra-high sensitive monitoring of early transplantation failure |
EP3741871A3 (en) † | 2012-04-19 | 2021-02-17 | The Medical College of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
ES2726650T3 (es) * | 2014-03-14 | 2019-10-08 | Caredx Inc | Métodos de monitorización de terapias inmunosupresoras en un receptor de trasplante |
-
2014
- 2014-05-29 PT PT14804474T patent/PT3004388T/pt unknown
- 2014-05-29 HR HRP20190209TT patent/HRP20190209T4/hr unknown
- 2014-05-29 HU HUE14804474A patent/HUE041935T2/hu unknown
- 2014-05-29 EP EP14804474.6A patent/EP3004388B2/en active Active
- 2014-05-29 ES ES14804474T patent/ES2704682T5/es active Active
- 2014-05-29 SI SI201431041T patent/SI3004388T2/sl unknown
- 2014-05-29 LT LTEP14804474.6T patent/LT3004388T/lt unknown
- 2014-05-29 DK DK14804474.6T patent/DK3004388T4/da active
- 2014-05-29 PL PL14804474.6T patent/PL3004388T5/pl unknown
- 2014-05-29 WO PCT/US2014/040055 patent/WO2014194113A2/en active Application Filing
- 2014-05-29 US US14/893,807 patent/US20160115541A1/en not_active Abandoned
-
2018
- 2018-03-13 US US15/920,356 patent/US11155872B2/en active Active
-
2019
- 2019-01-24 CY CY20191100106T patent/CY1122332T1/el unknown
-
2021
- 2021-10-15 US US17/503,056 patent/US20220025459A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
HUE041935T2 (hu) | 2019-06-28 |
US20180346982A1 (en) | 2018-12-06 |
WO2014194113A3 (en) | 2015-01-22 |
DK3004388T4 (da) | 2023-08-28 |
HRP20190209T1 (hr) | 2019-04-05 |
DK3004388T3 (en) | 2019-02-04 |
HRP20190209T4 (hr) | 2023-09-15 |
PL3004388T3 (pl) | 2019-04-30 |
SI3004388T1 (sl) | 2019-03-29 |
US20160115541A1 (en) | 2016-04-28 |
LT3004388T (lt) | 2019-01-25 |
EP3004388A2 (en) | 2016-04-13 |
PT3004388T (pt) | 2019-01-29 |
EP3004388B2 (en) | 2023-05-31 |
ES2704682T3 (es) | 2019-03-19 |
ES2704682T5 (es) | 2023-11-10 |
EP3004388A4 (en) | 2017-01-11 |
US20220025459A1 (en) | 2022-01-27 |
WO2014194113A2 (en) | 2014-12-04 |
EP3004388B1 (en) | 2018-10-31 |
SI3004388T2 (sl) | 2023-11-30 |
PL3004388T5 (pl) | 2023-10-09 |
US11155872B2 (en) | 2021-10-26 |
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