CY1122332T1 - Ανιχνευση και ποσοτικος προσδιορισμος dna ελευθερου κυτταρων δοτη στο κυκλοφοριακο συστημα ληπτων μεταμοσχευσης οργανων - Google Patents

Ανιχνευση και ποσοτικος προσδιορισμος dna ελευθερου κυτταρων δοτη στο κυκλοφοριακο συστημα ληπτων μεταμοσχευσης οργανων

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Publication number
CY1122332T1
CY1122332T1 CY20191100106T CY191100106T CY1122332T1 CY 1122332 T1 CY1122332 T1 CY 1122332T1 CY 20191100106 T CY20191100106 T CY 20191100106T CY 191100106 T CY191100106 T CY 191100106T CY 1122332 T1 CY1122332 T1 CY 1122332T1
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Cyprus
Prior art keywords
detection
circulatory system
organ transplant
quantification
donor cell
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CY20191100106T
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English (en)
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Ekkehard Schutz
Julia Beck
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Chronix Biomedical
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Application filed by Chronix Biomedical filed Critical Chronix Biomedical
Publication of CY1122332T1 publication Critical patent/CY1122332T1/el

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/24Immunology or allergic disorders
    • G01N2800/245Transplantation related diseases, e.g. graft versus host disease

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Transplanting Machines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μεθόδους, συνθέσεις και κιτ που σχετίζονται με την ανίχνευση ελεύθερου κυττάρων DNA δότη στο κυκλοφορικό σύστημα ενός λήπτη μεταμόσχευσης οργάνου για τον έγκαιρο εντοπισμό της απόρριψης του μοσχεύματος.
CY20191100106T 2013-05-29 2019-01-24 Ανιχνευση και ποσοτικος προσδιορισμος dna ελευθερου κυτταρων δοτη στο κυκλοφοριακο συστημα ληπτων μεταμοσχευσης οργανων CY1122332T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361828553P 2013-05-29 2013-05-29
PCT/US2014/040055 WO2014194113A2 (en) 2013-05-29 2014-05-29 Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients

Publications (1)

Publication Number Publication Date
CY1122332T1 true CY1122332T1 (el) 2021-01-27

Family

ID=51989530

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100106T CY1122332T1 (el) 2013-05-29 2019-01-24 Ανιχνευση και ποσοτικος προσδιορισμος dna ελευθερου κυτταρων δοτη στο κυκλοφοριακο συστημα ληπτων μεταμοσχευσης οργανων

Country Status (12)

Country Link
US (3) US20160115541A1 (el)
EP (1) EP3004388B2 (el)
CY (1) CY1122332T1 (el)
DK (1) DK3004388T4 (el)
ES (1) ES2704682T5 (el)
HR (1) HRP20190209T4 (el)
HU (1) HUE041935T2 (el)
LT (1) LT3004388T (el)
PL (1) PL3004388T5 (el)
PT (1) PT3004388T (el)
SI (1) SI3004388T2 (el)
WO (1) WO2014194113A2 (el)

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Also Published As

Publication number Publication date
HUE041935T2 (hu) 2019-06-28
US20180346982A1 (en) 2018-12-06
WO2014194113A3 (en) 2015-01-22
DK3004388T4 (da) 2023-08-28
HRP20190209T1 (hr) 2019-04-05
DK3004388T3 (en) 2019-02-04
HRP20190209T4 (hr) 2023-09-15
PL3004388T3 (pl) 2019-04-30
SI3004388T1 (sl) 2019-03-29
US20160115541A1 (en) 2016-04-28
LT3004388T (lt) 2019-01-25
EP3004388A2 (en) 2016-04-13
PT3004388T (pt) 2019-01-29
EP3004388B2 (en) 2023-05-31
ES2704682T3 (es) 2019-03-19
ES2704682T5 (es) 2023-11-10
EP3004388A4 (en) 2017-01-11
US20220025459A1 (en) 2022-01-27
WO2014194113A2 (en) 2014-12-04
EP3004388B1 (en) 2018-10-31
SI3004388T2 (sl) 2023-11-30
PL3004388T5 (pl) 2023-10-09
US11155872B2 (en) 2021-10-26

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