CY1121624T1 - Παραγωγα 2-αρυλο-4-υδροξυ-1,3-θειαζολιου χρησιμα ως αναστολεις trpm8 για τη θεραπεια της νευραλγιας, του πονου, της χαπ και του ασθματος - Google Patents

Παραγωγα 2-αρυλο-4-υδροξυ-1,3-θειαζολιου χρησιμα ως αναστολεις trpm8 για τη θεραπεια της νευραλγιας, του πονου, της χαπ και του ασθματος

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Publication number
CY1121624T1
CY1121624T1 CY20191100508T CY191100508T CY1121624T1 CY 1121624 T1 CY1121624 T1 CY 1121624T1 CY 20191100508 T CY20191100508 T CY 20191100508T CY 191100508 T CY191100508 T CY 191100508T CY 1121624 T1 CY1121624 T1 CY 1121624T1
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CY
Cyprus
Prior art keywords
pain
treatment
trpm8
neuralgia
copd
Prior art date
Application number
CY20191100508T
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English (en)
Inventor
Andrea Aramini
Gianluca Bianchini
Laura Brandolini
Andrea Beccari
Samuele Lillini
Giuseppe Nano
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Dompé Farmaceutici S.P.A.
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Publication date
Application filed by Dompé Farmaceutici S.P.A. filed Critical Dompé Farmaceutici S.P.A.
Publication of CY1121624T1 publication Critical patent/CY1121624T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
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  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Η εφεύρεση αναφέρεται σε ενώσεις που δρουν ως επιλεκτικοί ανταγωνιστές του μέλους 8 υποοικογένειας Μ διαύλων κατιόντων Transient Receptor Potential (εφεξής TRPM8) και έχουν τον τύπου (I). Οι εν λόγω ενώσεις είναι χρήσιμες στη θεραπεία νόσων συνδεόμενων με τη δράση του TRPM8 όπως πόνου, φλεγμονής, ισχαιμίας, νευροεκφυλισμού, εγκεφαλικού επεισοδίου, ψυχιατρικών διαταραχών, φαγούρας, ευερέθιστου εντέρου, ψυχρό επαγόμενων και/ή παροξυνόμενων αναπνευστικών ασθενειών και ουρολογικών διαταραχών.
CY20191100508T 2014-06-23 2019-05-10 Παραγωγα 2-αρυλο-4-υδροξυ-1,3-θειαζολιου χρησιμα ως αναστολεις trpm8 για τη θεραπεια της νευραλγιας, του πονου, της χαπ και του ασθματος CY1121624T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14173502 2014-06-23
PCT/EP2015/064146 WO2015197640A1 (en) 2014-06-23 2015-06-23 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as trpm8-inhibitors in treatment of neuralgia, pain, copd and asthma

Publications (1)

Publication Number Publication Date
CY1121624T1 true CY1121624T1 (el) 2020-07-31

Family

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CY20191100508T CY1121624T1 (el) 2014-06-23 2019-05-10 Παραγωγα 2-αρυλο-4-υδροξυ-1,3-θειαζολιου χρησιμα ως αναστολεις trpm8 για τη θεραπεια της νευραλγιας, του πονου, της χαπ και του ασθματος

Country Status (21)

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US (2) US10196368B2 (el)
EP (1) EP3157918B1 (el)
JP (1) JP6557332B2 (el)
KR (1) KR102493005B1 (el)
CN (1) CN106660975B (el)
AU (1) AU2015279272B2 (el)
CY (1) CY1121624T1 (el)
DK (1) DK3157918T3 (el)
EA (1) EA034525B1 (el)
ES (1) ES2724111T3 (el)
HR (1) HRP20190819T1 (el)
HU (1) HUE043586T2 (el)
LT (1) LT3157918T (el)
MA (1) MA39912B1 (el)
ME (1) ME03399B (el)
PL (1) PL3157918T3 (el)
PT (1) PT3157918T (el)
RS (1) RS58590B1 (el)
SI (1) SI3157918T1 (el)
TR (1) TR201905319T4 (el)
WO (1) WO2015197640A1 (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3184524A1 (en) * 2015-12-21 2017-06-28 Dompé farmaceutici S.p.A. 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as trpm8 antagonists
EP3409277A1 (en) * 2017-05-30 2018-12-05 Dompé farmaceutici s.p.a. Il-8 inhibitors for use in the treatment and/or prevention of bacterial secondary infections
EP3782702A1 (en) * 2019-08-21 2021-02-24 AC BioScience SA Compounds and use thereof for the treatment of infectious diseases and cancer
EP3907214A1 (en) * 2020-05-04 2021-11-10 Dompe' Farmaceutici S.P.A. Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122008000051I1 (de) * 1990-11-30 2009-02-05 Teijin Ltd 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
US20080214654A1 (en) 2004-10-13 2008-09-04 Bayer Healthcare Ag Substituted Benzyloxy-Phenylmethylamide Derivatives
WO2007017094A1 (en) 2005-08-04 2007-02-15 Bayer Healthcare Ag Substituted benzyloxy-phenylmethylcarbamate derivatives
WO2007017093A1 (en) 2005-08-04 2007-02-15 Bayer Healthcare Ag Substituted 2-benzyloxy-benzoic acid amide derivatives
WO2007017092A1 (en) 2005-08-04 2007-02-15 Bayer Healthcare Ag Substituted 4-benzyloxy-benzoic acid amide derivatives
WO2007080109A1 (en) 2006-01-16 2007-07-19 Bayer Healthcare Ag Substituded benzyloxy-phenylmethylurea derivatives
JP5404388B2 (ja) 2006-05-10 2014-01-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 冷メントール受容体−１拮抗薬
MY153971A (en) 2007-07-18 2015-04-30 Janssen Pharmaceutica Nv Sulfonamides as trpm8 modulators
WO2010103381A1 (en) 2009-03-13 2010-09-16 Glenmark Pharmaceuticals S.A. Spirocyclic piperidine derivatives as trpm 8 modulators
WO2010125831A1 (en) 2009-05-01 2010-11-04 Raqualia Pharma Inc. Sulfamoyl benzoic acid derivatives as trpm8 antagonists
EP2606888A1 (en) * 2011-12-19 2013-06-26 Dompe' S.P.A. Trpm8 antagonists
CN104220069B (zh) 2011-12-19 2018-10-02 多姆皮制药公司 Trpm8拮抗剂

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Publication number Publication date
CN106660975B (zh) 2019-12-31
PT3157918T (pt) 2019-05-09
TR201905319T4 (tr) 2019-05-21
US11046662B2 (en) 2021-06-29
EP3157918B1 (en) 2019-03-27
HUE043586T2 (hu) 2019-08-28
LT3157918T (lt) 2019-05-27
WO2015197640A1 (en) 2015-12-30
AU2015279272A2 (en) 2017-01-19
EA034525B1 (ru) 2020-02-17
EA201790072A1 (ru) 2017-11-30
SI3157918T1 (sl) 2019-05-31
JP2017520623A (ja) 2017-07-27
CN106660975A (zh) 2017-05-10
MA39912A (fr) 2017-04-26
PL3157918T3 (pl) 2019-08-30
AU2015279272B2 (en) 2018-01-18
US20190106395A1 (en) 2019-04-11
EP3157918A1 (en) 2017-04-26
HRP20190819T1 (hr) 2019-06-28
DK3157918T3 (da) 2019-05-13
KR102493005B1 (ko) 2023-01-30
US20170190678A1 (en) 2017-07-06
RS58590B1 (sr) 2019-05-31
KR20170031664A (ko) 2017-03-21
ME03399B (me) 2020-01-20
JP6557332B2 (ja) 2019-08-07
US10196368B2 (en) 2019-02-05
MA39912B1 (fr) 2019-05-31
AU2015279272A1 (en) 2017-01-12
ES2724111T3 (es) 2019-09-06

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