CY1121090T1 - Εισπνευσιμα σωματιδια που περιλαμβανουν τιοτροπιο - Google Patents
Εισπνευσιμα σωματιδια που περιλαμβανουν τιοτροπιοInfo
- Publication number
- CY1121090T1 CY1121090T1 CY181100703T CY181100703T CY1121090T1 CY 1121090 T1 CY1121090 T1 CY 1121090T1 CY 181100703 T CY181100703 T CY 181100703T CY 181100703 T CY181100703 T CY 181100703T CY 1121090 T1 CY1121090 T1 CY 1121090T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tiotropy
- inhalatory
- inhalable particles
- particles including
- tiotropium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Abstract
Η παρούσα εφεύρεση αναφέρεται σε εισπνεύσιμα σωματίδια που περιλαμβάνουν μια σταθεροποιημένη άμορφη μορφή τιοτροπίου με έναν παράγοντα σταθεροποίησης. Επίσης αναφέρεται σε εισπνεύσιμα σωματίδια που περιλαμβάνουν μια σταθεροποιημένη άμορφη μορφή τιοτροπίου με έναν παράγοντα σταθεροποίησης αναμεμιγμένο με ένα ή περισσότερα χονδρό-κοκκα έκδοχα που έχουν μέσο μέγεθος σωματιδίων από 15 έως 250 μm. Επίσης αναφέρεται σε μια φαρμακευτική σύνθεση που περιλαμβάνει τα εισπνεύσιμα σωματίδια της εφεύρεσης, σε μια διαδικασία για την παρασκευή τους και στη χρήση τους για την παρασκευή ενός φαρμάκου για τη θεραπεία του άσθματος ή της χρόνιας αποφρακτικής πνευμονοπάθειας (ΧΑΠ).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08382040A EP2172190A1 (en) | 2008-10-02 | 2008-10-02 | Inhalable particles comprising tiotropium |
| US10411308P | 2008-10-09 | 2008-10-09 | |
| EP09783687.8A EP2349204B1 (en) | 2008-10-02 | 2009-10-02 | Inhalable particles comprising tiotropium |
| PCT/EP2009/062821 WO2010037845A1 (en) | 2008-10-02 | 2009-10-02 | Inhalable particles comprising tiotropium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121090T1 true CY1121090T1 (el) | 2019-12-11 |
Family
ID=40348057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY181100703T CY1121090T1 (el) | 2008-10-02 | 2018-07-04 | Εισπνευσιμα σωματιδια που περιλαμβανουν τιοτροπιο |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US20110311618A1 (el) |
| EP (2) | EP2172190A1 (el) |
| JP (1) | JP5622730B2 (el) |
| KR (1) | KR101639089B1 (el) |
| CN (1) | CN102170861B (el) |
| AR (1) | AR073528A1 (el) |
| AU (1) | AU2009299801B2 (el) |
| BR (1) | BRPI0920706B8 (el) |
| CA (1) | CA2737399C (el) |
| CL (1) | CL2011000696A1 (el) |
| CO (1) | CO6361899A2 (el) |
| CR (1) | CR20110227A (el) |
| CY (1) | CY1121090T1 (el) |
| DK (1) | DK2349204T3 (el) |
| DO (1) | DOP2011000091A (el) |
| EC (1) | ECSP11010925A (el) |
| ES (1) | ES2675857T3 (el) |
| HN (1) | HN2011000864A (el) |
| HR (1) | HRP20181009T1 (el) |
| HU (1) | HUE038208T2 (el) |
| LT (1) | LT2349204T (el) |
| MA (1) | MA34560B1 (el) |
| MX (1) | MX2011003491A (el) |
| MY (1) | MY159172A (el) |
| NI (1) | NI201100066A (el) |
| NZ (1) | NZ591923A (el) |
| PE (2) | PE20110850A1 (el) |
| PL (1) | PL2349204T3 (el) |
| PT (1) | PT2349204T (el) |
| RU (2) | RU2685236C2 (el) |
| SI (1) | SI2349204T1 (el) |
| SV (1) | SV2011003852A (el) |
| TR (1) | TR201808269T4 (el) |
| TW (1) | TWI433675B (el) |
| UA (1) | UA100777C2 (el) |
| UY (1) | UY32160A (el) |
| WO (1) | WO2010037845A1 (el) |
| ZA (1) | ZA201101735B (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2012138909A (ru) * | 2010-03-31 | 2014-05-10 | Гленмарк Фармасьютикалс Лимитед | Фармацевтическая порошковая композиция для ингаляций |
| WO2011152804A2 (en) * | 2010-06-03 | 2011-12-08 | Mahmut Bilgic | Process for dry powder formulations |
| WO2011154014A1 (en) * | 2010-06-11 | 2011-12-15 | Gea Process Engineering A/S | Controlled humidity drying |
| NZ607358A (en) | 2010-08-23 | 2015-04-24 | Takeda Gmbh | Humidified particles comprising a therapeutically active substance |
| WO2013109213A2 (en) * | 2012-01-16 | 2013-07-25 | Mahmut Bilgic | Pharmaceutical formulations comprising tiotropium |
| US9387616B2 (en) | 2012-08-03 | 2016-07-12 | Otto Männer Innovation GmbH | Hot runner injection molding apparatus with additional controller |
| EP2705838A1 (en) * | 2012-09-06 | 2014-03-12 | Xspray Microparticles Ab | Tiotropium preparations |
| CA2907566C (en) | 2013-04-01 | 2023-08-22 | Pulmatrix, Inc. | Tiotropium dry powders |
| KR101748796B1 (ko) * | 2015-09-30 | 2017-06-19 | 한미약품 주식회사 | 활성성분의 전달량이 향상된 흡입용 캡슐제 |
| EP4108230A1 (en) * | 2021-06-24 | 2022-12-28 | Laboratoires SMB | New dry powder composition of tiotropium for inhalation |
| GR1010358B (el) * | 2021-09-14 | 2022-12-16 | Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια, | Σταθερο φαρμακευτικο σκευασμα που περιεχει βρωμιουχο τιοτροπιο, για χορηγηση απο το αναπνευστικο |
| CN114191418B (zh) * | 2021-12-21 | 2023-06-09 | 丽珠医药集团股份有限公司 | 噻托溴铵双层微球及其制备方法和噻托溴铵缓释吸入剂 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| EP1131059B1 (de) * | 1998-11-13 | 2003-03-05 | Jago Research Ag | Trockenpulver zur inhalation |
| US20020081266A1 (en) * | 1999-08-20 | 2002-06-27 | Norton Healthcare Ltd. | Spray dried powders for pulmonary or nasal administration |
| EP1430887A1 (de) | 2000-10-12 | 2004-06-23 | Boehringer Ingelheim Pharma GmbH & Co.KG | Tiotropium-haltige Inhalationspulver |
| SK288222B6 (sk) * | 2000-12-14 | 2014-09-04 | Ortho-Mcneil Pharmaceutical, Inc. | Steroidné hormonálne prípravky a spôsoby ich prípravy |
| US6485279B2 (en) * | 2000-12-26 | 2002-11-26 | Carrier Corporation | Thrust load reliever |
| DE10126924A1 (de) * | 2001-06-01 | 2002-12-05 | Boehringer Ingelheim Pharma | Inhalationskapseln |
| US7754242B2 (en) * | 2002-03-20 | 2010-07-13 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
| AU2003230689B2 (en) * | 2002-03-20 | 2006-06-29 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
| DE10339197A1 (de) * | 2003-08-22 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität |
| CN102731494A (zh) * | 2005-12-19 | 2012-10-17 | 西科尔公司 | 噻托溴铵的新形式及其制备方法 |
| WO2007086039A1 (en) * | 2006-01-27 | 2007-08-02 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | A method of producing porous microparticles |
| GB0716026D0 (en) * | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| GB0801876D0 (en) * | 2008-02-01 | 2008-03-12 | Vectura Group Plc | Suspension formulations |
-
2008
- 2008-10-02 EP EP08382040A patent/EP2172190A1/en not_active Withdrawn
-
2009
- 2009-09-30 AR ARP090103794A patent/AR073528A1/es not_active Application Discontinuation
- 2009-10-01 TW TW098133428A patent/TWI433675B/zh active
- 2009-10-02 AU AU2009299801A patent/AU2009299801B2/en active Active
- 2009-10-02 SI SI200931854T patent/SI2349204T1/en unknown
- 2009-10-02 CA CA2737399A patent/CA2737399C/en active Active
- 2009-10-02 JP JP2011529566A patent/JP5622730B2/ja active Active
- 2009-10-02 PE PE2011000799A patent/PE20110850A1/es not_active Application Discontinuation
- 2009-10-02 KR KR1020117010097A patent/KR101639089B1/ko active IP Right Grant
- 2009-10-02 PT PT97836878T patent/PT2349204T/pt unknown
- 2009-10-02 HU HUE09783687A patent/HUE038208T2/hu unknown
- 2009-10-02 MY MYPI2011001426A patent/MY159172A/en unknown
- 2009-10-02 WO PCT/EP2009/062821 patent/WO2010037845A1/en active Application Filing
- 2009-10-02 EP EP09783687.8A patent/EP2349204B1/en active Active
- 2009-10-02 PL PL09783687T patent/PL2349204T3/pl unknown
- 2009-10-02 BR BRPI0920706A patent/BRPI0920706B8/pt active IP Right Grant
- 2009-10-02 UA UAA201105365A patent/UA100777C2/ru unknown
- 2009-10-02 DK DK09783687.8T patent/DK2349204T3/en active
- 2009-10-02 RU RU2014150986A patent/RU2685236C2/ru active
- 2009-10-02 LT LTEP09783687.8T patent/LT2349204T/lt unknown
- 2009-10-02 PE PE2014002239A patent/PE20142435A1/es active IP Right Grant
- 2009-10-02 NZ NZ591923A patent/NZ591923A/en unknown
- 2009-10-02 CN CN200980138843.5A patent/CN102170861B/zh active Active
- 2009-10-02 RU RU2011117256/15A patent/RU2011117256A/ru unknown
- 2009-10-02 US US13/122,134 patent/US20110311618A1/en not_active Abandoned
- 2009-10-02 MX MX2011003491A patent/MX2011003491A/es active IP Right Grant
- 2009-10-02 TR TR2018/08269T patent/TR201808269T4/tr unknown
- 2009-10-02 UY UY0001032160A patent/UY32160A/es active IP Right Grant
- 2009-10-02 ES ES09783687.8T patent/ES2675857T3/es active Active
- 2009-10-02 MA MA33805A patent/MA34560B1/fr unknown
-
2011
- 2011-03-07 SV SV2011003852A patent/SV2011003852A/es unknown
- 2011-03-07 ZA ZA2011/01735A patent/ZA201101735B/en unknown
- 2011-03-29 EC EC2011010925A patent/ECSP11010925A/es unknown
- 2011-03-30 CL CL2011000696A patent/CL2011000696A1/es unknown
- 2011-03-31 HN HN2011000864A patent/HN2011000864A/es unknown
- 2011-04-01 DO DO2011000091A patent/DOP2011000091A/es unknown
- 2011-04-01 NI NI201100066A patent/NI201100066A/es unknown
- 2011-04-29 CR CR20110227A patent/CR20110227A/es unknown
- 2011-04-29 CO CO11052660A patent/CO6361899A2/es not_active Application Discontinuation
-
2018
- 2018-06-28 HR HRP20181009TT patent/HRP20181009T1/hr unknown
- 2018-07-04 CY CY181100703T patent/CY1121090T1/el unknown
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