CY1120688T1 - Ενωσεις για χρηση στην ενισχυση της πηξης - Google Patents
Ενωσεις για χρηση στην ενισχυση της πηξηςInfo
- Publication number
- CY1120688T1 CY1120688T1 CY181100967T CY181100967T CY1120688T1 CY 1120688 T1 CY1120688 T1 CY 1120688T1 CY 181100967 T CY181100967 T CY 181100967T CY 181100967 T CY181100967 T CY 181100967T CY 1120688 T1 CY1120688 T1 CY 1120688T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bleeding
- antithrombin iii
- inhibitors
- coagulation
- enhancement
- Prior art date
Links
- 230000015271 coagulation Effects 0.000 title 1
- 238000005345 coagulation Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 102000004411 Antithrombin III Human genes 0.000 abstract 3
- 108090000935 Antithrombin III Proteins 0.000 abstract 3
- 208000032843 Hemorrhage Diseases 0.000 abstract 3
- 229960005348 antithrombin iii Drugs 0.000 abstract 3
- 208000034158 bleeding Diseases 0.000 abstract 3
- 230000000740 bleeding effect Effects 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- 108091023037 Aptamer Proteins 0.000 abstract 1
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161527140P | 2011-08-25 | 2011-08-25 | |
| PCT/NL2012/050581 WO2013028070A2 (en) | 2011-08-25 | 2012-08-24 | Compounds for use in boosting coagulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120688T1 true CY1120688T1 (el) | 2019-12-11 |
Family
ID=46845975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY181100967T CY1120688T1 (el) | 2011-08-25 | 2018-09-19 | Ενωσεις για χρηση στην ενισχυση της πηξης |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140356377A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2747776B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6198277B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103930129A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012299524B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014004297B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2846494C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1120688T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2747776T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2689776T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE039590T2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2747776T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2747776T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013028070A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015021399A2 (pt) | 2013-03-14 | 2017-07-18 | Bayer Healthcare Llc | anticórpos monoclonais contra antitrombina beta complexada com heparina |
| WO2016069694A2 (en) | 2014-10-30 | 2016-05-06 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof |
| US11091759B2 (en) | 2015-12-07 | 2021-08-17 | Genzyme Corporation | Methods and compositions for treating a Serpinc1-associated disorder |
| US20190100602A1 (en) * | 2016-03-18 | 2019-04-04 | INSERM (Institut National de la Santé et de la Recherche Médicale | Anti-antithrombin single-domain antibodies and polypeptides comprising thereof |
| GB201709970D0 (en) * | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| US20220064327A1 (en) | 2018-12-21 | 2022-03-03 | Kymab Limited | Fixaxfx bispecific antibody with common light chain |
| JP6883899B1 (ja) * | 2020-12-07 | 2021-06-09 | 株式会社血栓トランスレーショナルリサーチラボ | 血液凝固検査試薬、および血液凝固検査方法 |
| PL440675A1 (pl) * | 2022-03-17 | 2023-09-18 | Politechnika Wrocławska | Związki do równoległego wykrywania i hamowania proteaz szlaku krzepnięcia - APC, trombiny, czynnika Xa i czynnika XIa w ludzkim osoczu |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US748913A (en) * | 1904-01-05 | Fo model | ||
| ATE539764T1 (de) * | 2007-07-20 | 2012-01-15 | Univ Paris Sud Xi | Verwendung mutierter antithrombine zur behandlung oder verhinderung von gerinnungserkrankungen |
| DE102011081871A1 (de) * | 2011-08-31 | 2013-02-28 | Henkel Ag & Co. Kgaa | Oxazolidine zur Fehlgeruchsbekämpfung |
-
2012
- 2012-02-24 US US14/240,903 patent/US20140356377A1/en not_active Abandoned
- 2012-08-24 AU AU2012299524A patent/AU2012299524B2/en not_active Ceased
- 2012-08-24 ES ES12758914.1T patent/ES2689776T3/es active Active
- 2012-08-24 WO PCT/NL2012/050581 patent/WO2013028070A2/en not_active Ceased
- 2012-08-24 HU HUE12758914A patent/HUE039590T2/hu unknown
- 2012-08-24 EP EP12758914.1A patent/EP2747776B1/en active Active
- 2012-08-24 JP JP2014527112A patent/JP6198277B2/ja not_active Expired - Fee Related
- 2012-08-24 PT PT12758914T patent/PT2747776T/pt unknown
- 2012-08-24 PL PL12758914T patent/PL2747776T3/pl unknown
- 2012-08-24 CN CN201280052327.2A patent/CN103930129A/zh active Pending
- 2012-08-24 CA CA2846494A patent/CA2846494C/en active Active
- 2012-08-24 DK DK12758914.1T patent/DK2747776T3/en active
- 2012-08-24 BR BR112014004297-7A patent/BR112014004297B1/pt not_active IP Right Cessation
-
2017
- 2017-04-20 JP JP2017083956A patent/JP2017186340A/ja active Pending
-
2018
- 2018-09-19 CY CY181100967T patent/CY1120688T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013028070A3 (en) | 2013-04-18 |
| BR112014004297B1 (pt) | 2021-12-14 |
| CA2846494C (en) | 2020-10-20 |
| CN103930129A (zh) | 2014-07-16 |
| PL2747776T3 (pl) | 2019-03-29 |
| DK2747776T3 (en) | 2018-09-17 |
| AU2012299524A1 (en) | 2014-03-13 |
| EP2747776A2 (en) | 2014-07-02 |
| ES2689776T3 (es) | 2018-11-15 |
| AU2012299524B2 (en) | 2017-03-23 |
| BR112014004297A2 (pt) | 2017-03-28 |
| HUE039590T2 (hu) | 2019-01-28 |
| CA2846494A1 (en) | 2013-02-28 |
| EP2747776B1 (en) | 2018-07-11 |
| WO2013028070A2 (en) | 2013-02-28 |
| JP2017186340A (ja) | 2017-10-12 |
| US20140356377A1 (en) | 2014-12-04 |
| JP2014529606A (ja) | 2014-11-13 |
| PT2747776T (pt) | 2018-10-31 |
| JP6198277B2 (ja) | 2017-09-20 |
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