CY1118814T1 - Διαδικασια για την παρασκευη πιπεραζινυλο και διαζεπανυλο βενζαμιδο παραγωγων - Google Patents
Διαδικασια για την παρασκευη πιπεραζινυλο και διαζεπανυλο βενζαμιδο παραγωγωνInfo
- Publication number
- CY1118814T1 CY1118814T1 CY20171100420T CY171100420T CY1118814T1 CY 1118814 T1 CY1118814 T1 CY 1118814T1 CY 20171100420 T CY20171100420 T CY 20171100420T CY 171100420 T CY171100420 T CY 171100420T CY 1118814 T1 CY1118814 T1 CY 1118814T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- peperazinyl
- producers
- diabetic
- pumping
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Η παρούσα εφεύρεση απευθύνεται σε μία νέα διαδικασία για την παρασκευή πιπεραζινυλο και διαζεπανυλο βενζαμιδο παραγώγων, τα οποία είναι χρήσιμα για τη θεραπεία διαταραχών και καταστάσεων που διαμεσολαβούνται από έναν υποδοχέα της ισταμίνης, κατά προτίμηση τον Η3 υποδοχέα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87000306P | 2006-12-14 | 2006-12-14 | |
PCT/US2007/086936 WO2008076685A2 (en) | 2006-12-14 | 2007-12-10 | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118814T1 true CY1118814T1 (el) | 2018-01-10 |
Family
ID=39387172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100420T CY1118814T1 (el) | 2006-12-14 | 2017-04-07 | Διαδικασια για την παρασκευη πιπεραζινυλο και διαζεπανυλο βενζαμιδο παραγωγων |
Country Status (33)
Country | Link |
---|---|
US (2) | US7893257B2 (el) |
EP (1) | EP2121636B1 (el) |
JP (2) | JP5385150B2 (el) |
KR (1) | KR101462891B1 (el) |
CN (1) | CN101605767A (el) |
AR (1) | AR064358A1 (el) |
BR (1) | BRPI0721088B8 (el) |
CA (2) | CA2672661C (el) |
CL (1) | CL2007003637A1 (el) |
CO (1) | CO6210827A2 (el) |
CR (1) | CR10928A (el) |
CY (1) | CY1118814T1 (el) |
DK (1) | DK2121636T3 (el) |
EA (1) | EA200970583A1 (el) |
EC (1) | ECSP099405A (el) |
ES (1) | ES2620818T3 (el) |
HR (1) | HRP20170621T1 (el) |
HU (1) | HUE032761T2 (el) |
IL (2) | IL199309A0 (el) |
LT (1) | LT2121636T (el) |
MX (1) | MX2009006472A (el) |
MY (1) | MY147320A (el) |
NO (1) | NO344305B1 (el) |
NZ (1) | NZ577603A (el) |
PH (1) | PH12012502236A1 (el) |
PL (1) | PL2121636T3 (el) |
PT (1) | PT2121636T (el) |
RS (1) | RS55866B1 (el) |
SG (1) | SG177207A1 (el) |
SI (1) | SI2121636T1 (el) |
TW (1) | TW200846004A (el) |
WO (1) | WO2008076685A2 (el) |
ZA (1) | ZA200904894B (el) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
SI1976828T1 (sl) | 2005-12-29 | 2017-07-31 | Celtaxsys, Inc. | Diaminski derivati kot inhibitorji levkotrien A4 hidrolaze |
EA200970583A1 (ru) * | 2006-12-14 | 2009-12-30 | Янссен Фармацевтика Н.В. | Способ получения пиперазиниловых и диазепаниловых производных бензамида |
CL2008002622A1 (es) | 2007-09-06 | 2009-11-27 | Glaxo Group Ltd | 1-(1-metiletil)-4-{[4-(tetrahidro-2h-piran-4-iloxi)fenil]carbonil}piperazina y su sal hidrocloruro; formas cristalinas de la sal; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento o profilaxis de deterioro cognitivo, fatiga o trastorno del sueno. |
CN101939054B (zh) | 2007-12-10 | 2014-10-29 | 诺华股份有限公司 | 有机化合物 |
US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
ES2864862T3 (es) | 2013-03-12 | 2021-10-14 | Celltaxis Llc | Métodos de inhibición de la leucotrieno A4 hidrolasa |
AU2014239567B2 (en) | 2013-03-14 | 2017-12-14 | Celtaxsys, Inc. | Inhibitors of leukotriene A4 hydrolase |
WO2014152536A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
RU2696559C2 (ru) | 2013-03-14 | 2019-08-05 | Селтакссис, Инк. | Ингибиторы лейкотриен а4-гидролазы |
CN108341792B (zh) * | 2018-04-28 | 2021-09-17 | 苏州莱克施德药业有限公司 | 一种Volasertib中间体1-环丙基甲基哌嗪的制备方法 |
US10898484B2 (en) | 2018-05-31 | 2021-01-26 | Celltaxis, Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
CN113372245B (zh) * | 2021-06-17 | 2023-01-13 | 仪征市海帆化工有限公司 | 一种n-苯甲酰基-o,o-对甲苯磺酰基-二乙醇胺的合成方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2525223A (en) | 1948-05-25 | 1950-10-10 | American Cyanamid Co | Preparation of n-substituted piperazines |
DE818805C (de) * | 1948-08-02 | 1951-10-29 | Rhone Poulenc Sa | Verfahren zur Herstellung von am Stickstoff durch eine Alkylgruppe monosubstituierten Piperazinen |
US3342816A (en) * | 1965-06-01 | 1967-09-19 | Lilly Co Eli | Cyclopropylpiperazinoalkyl-phenothiazines |
DE3542002A1 (de) * | 1985-11-28 | 1987-06-04 | Bayer Ag | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3605005A1 (de) * | 1986-02-18 | 1987-08-20 | Basf Ag | Verfahren zur herstellung von n-methylpiperazin |
US6011029A (en) | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
CA2235642C (en) * | 1998-05-15 | 2007-11-13 | Torcan Chemical Ltd. | Processes for preparing sildenafil |
AU2001288432A1 (en) | 2000-09-01 | 2002-03-22 | Icos Corporation | Materials and methods to potentiate cancer treatment |
US6642226B2 (en) | 2001-02-06 | 2003-11-04 | Hoffman-La Roche Inc. | Substituted phenyl-piperidine methanone compounds |
DE10201240A1 (de) * | 2002-01-15 | 2003-07-24 | Bayer Ag | Substituierte Alkyluracile und ihre Verwendung |
CN100558718C (zh) | 2002-10-23 | 2009-11-11 | 詹森药业有限公司 | 哌嗪基和二氮杂环庚基苯甲酰胺和硫代苯甲酰胺 |
WO2005035534A1 (ja) * | 2003-10-08 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 複素ビシクロ環および複素トリシクロ環化合物およびその医薬 |
GB0324159D0 (en) * | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
WO2006042103A2 (en) | 2004-10-05 | 2006-04-20 | Axys Pharmaceuticals, Inc. | Reversible inhibitors of cathepsin b |
AU2005317928B2 (en) | 2004-12-24 | 2010-06-10 | Astrazeneca Ab | Heterocyclic compounds as CCR2b antagonists |
FR2885616B1 (fr) * | 2005-05-12 | 2007-06-22 | Servier Lab | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2007035425A2 (en) | 2005-09-16 | 2007-03-29 | Janssen Pharmaceutica N.V. | Cyclopropyl amines as modulators of the histamine h3 receptor |
US7795426B2 (en) * | 2005-10-31 | 2010-09-14 | Janssen Pharmaceutica Nv | Processes for the preparation of cyclopropyl-amide derivatives |
BRPI0617947A2 (pt) * | 2005-10-31 | 2011-08-09 | Janssen Pharmaceutica Nv | processos para a preparação de derivados de piperazinil e diazapanil benzamida |
EA200970583A1 (ru) * | 2006-12-14 | 2009-12-30 | Янссен Фармацевтика Н.В. | Способ получения пиперазиниловых и диазепаниловых производных бензамида |
-
2007
- 2007-12-10 EA EA200970583A patent/EA200970583A1/ru unknown
- 2007-12-10 WO PCT/US2007/086936 patent/WO2008076685A2/en active Application Filing
- 2007-12-10 JP JP2009541499A patent/JP5385150B2/ja not_active Expired - Fee Related
- 2007-12-10 CN CNA2007800512756A patent/CN101605767A/zh active Pending
- 2007-12-10 RS RS20170402A patent/RS55866B1/sr unknown
- 2007-12-10 US US11/953,262 patent/US7893257B2/en not_active Expired - Fee Related
- 2007-12-10 SG SG2011092046A patent/SG177207A1/en unknown
- 2007-12-10 MY MYPI20092444A patent/MY147320A/en unknown
- 2007-12-10 PL PL07855037T patent/PL2121636T3/pl unknown
- 2007-12-10 CA CA2672661A patent/CA2672661C/en active Active
- 2007-12-10 BR BRPI0721088A patent/BRPI0721088B8/pt not_active IP Right Cessation
- 2007-12-10 NZ NZ577603A patent/NZ577603A/en not_active IP Right Cessation
- 2007-12-10 CA CA2880932A patent/CA2880932A1/en not_active Abandoned
- 2007-12-10 SI SI200731919A patent/SI2121636T1/sl unknown
- 2007-12-10 PT PT78550373T patent/PT2121636T/pt unknown
- 2007-12-10 DK DK07855037.3T patent/DK2121636T3/en active
- 2007-12-10 ES ES07855037.3T patent/ES2620818T3/es active Active
- 2007-12-10 HU HUE07855037A patent/HUE032761T2/en unknown
- 2007-12-10 MX MX2009006472A patent/MX2009006472A/es active IP Right Grant
- 2007-12-10 KR KR1020097014605A patent/KR101462891B1/ko active IP Right Grant
- 2007-12-10 EP EP07855037.3A patent/EP2121636B1/en active Active
- 2007-12-10 LT LTEP07855037.3T patent/LT2121636T/lt unknown
- 2007-12-13 TW TW096147556A patent/TW200846004A/zh unknown
- 2007-12-14 CL CL200703637A patent/CL2007003637A1/es unknown
- 2007-12-14 AR ARP070105628A patent/AR064358A1/es active IP Right Grant
-
2009
- 2009-06-11 IL IL199309A patent/IL199309A0/en active IP Right Grant
- 2009-06-11 EC EC2009009405A patent/ECSP099405A/es unknown
- 2009-06-12 CO CO09061632A patent/CO6210827A2/es not_active Application Discontinuation
- 2009-07-10 NO NO20092634A patent/NO344305B1/no not_active IP Right Cessation
- 2009-07-13 ZA ZA200904894A patent/ZA200904894B/xx unknown
- 2009-07-14 CR CR10928A patent/CR10928A/es unknown
-
2011
- 2011-01-10 US US12/987,370 patent/US8680273B2/en active Active
-
2012
- 2012-11-13 PH PH12012502236A patent/PH12012502236A1/en unknown
-
2013
- 2013-08-05 JP JP2013162225A patent/JP2013241453A/ja active Pending
-
2014
- 2014-09-30 IL IL234893A patent/IL234893A/en active IP Right Grant
-
2017
- 2017-04-07 CY CY20171100420T patent/CY1118814T1/el unknown
- 2017-04-19 HR HRP20170621TT patent/HRP20170621T1/hr unknown
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