CY1118574T1 - Ενωσεις υποκατεστημενου πυριδινο-2-καρβοξαμιδιου ως αναστολεις κινασης ρυθμισης σηματος αποπτωσης - Google Patents
Ενωσεις υποκατεστημενου πυριδινο-2-καρβοξαμιδιου ως αναστολεις κινασης ρυθμισης σηματος αποπτωσηςInfo
- Publication number
- CY1118574T1 CY1118574T1 CY20171100143T CY171100143T CY1118574T1 CY 1118574 T1 CY1118574 T1 CY 1118574T1 CY 20171100143 T CY20171100143 T CY 20171100143T CY 171100143 T CY171100143 T CY 171100143T CY 1118574 T1 CY1118574 T1 CY 1118574T1
- Authority
- CY
- Cyprus
- Prior art keywords
- diseases
- diabetes mellitus
- significant signal
- compounds
- carboxamide compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Η παρούσα εφεύρεση αφορά σε ενώσεις του Τύπου (I), όπου οι μεταβλητές είναι όπως ορίζεται ανωτέρω. Οι ενώσεις έχουν ανασταλτική δραστικότητα κινάσης ρύθμισης σήματος απόπτωσης ("ASK1") και είναι τοιουτοτρόπως χρήσιμες εις την αγωγή ASK1-μεσολαβούμενων καταστάσεων, στις οποίες συμπεριλαμβάνονται αυτοάνοσα νοσήματα, φλεγμονώδη νοσήματα, καρδιαγγειακά νοσήματα, διαβήτης, διαβητική νεφροπάθεια, καρδιονεφρικά νοσήματα στα οποία συμπεριλαμβάνεται η νεφρική νόσος, ινωτικά νοσήματα, αναπνευστικά νοσήματα, ΧΑΠ, ιδιοπαθής πνευμονική ίνωση, οξεία πνευμονική βλάβη, οξέα και χρόνια ηπατικά νοσήματα και νευροεκφυλιστικά νοσήματα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261740777P | 2012-12-21 | 2012-12-21 | |
| PCT/US2013/076811 WO2014100541A1 (en) | 2012-12-21 | 2013-12-20 | Substituted pyridine-2-carboxamide compounds as apoptosis signal-regulating kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118574T1 true CY1118574T1 (el) | 2017-07-12 |
Family
ID=49943575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100143T CY1118574T1 (el) | 2012-12-21 | 2017-01-31 | Ενωσεις υποκατεστημενου πυριδινο-2-καρβοξαμιδιου ως αναστολεις κινασης ρυθμισης σηματος αποπτωσης |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US9051313B2 (el) |
| EP (2) | EP2935258B1 (el) |
| JP (2) | JP6086633B2 (el) |
| KR (1) | KR101712758B1 (el) |
| CN (1) | CN104918936B (el) |
| AR (1) | AR094214A1 (el) |
| AU (2) | AU2013361140B2 (el) |
| BR (1) | BR112015014567A2 (el) |
| CA (1) | CA2896060C (el) |
| CY (1) | CY1118574T1 (el) |
| DK (1) | DK2935258T3 (el) |
| EA (1) | EA027645B1 (el) |
| ES (1) | ES2612979T3 (el) |
| HK (1) | HK1214247A1 (el) |
| HR (1) | HRP20170112T8 (el) |
| HU (1) | HUE032988T2 (el) |
| IL (2) | IL239322A (el) |
| LT (1) | LT2935258T (el) |
| MX (1) | MX2015008090A (el) |
| NZ (1) | NZ709248A (el) |
| PL (1) | PL2935258T3 (el) |
| PT (1) | PT2935258T (el) |
| RS (1) | RS55676B1 (el) |
| SG (1) | SG11201504865YA (el) |
| SI (1) | SI2935258T1 (el) |
| SM (1) | SMT201700051B (el) |
| TW (1) | TWI622589B (el) |
| UY (1) | UY35212A (el) |
| WO (1) | WO2014100541A1 (el) |
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| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2588475B1 (en) * | 2010-07-02 | 2015-05-20 | Gilead Sciences, Inc. | Apoptosis signal-regulating kinase inhibitors |
| EP2651417B1 (en) | 2010-12-16 | 2016-11-30 | Calchan Limited | Ask1 inhibiting pyrrolopyrimidine derivatives |
| UY35212A (es) | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
| AP2016009248A0 (en) | 2013-12-20 | 2016-05-31 | Gilead Sciences Inc | Apoptosis signal-regulating kinase inhibitors |
| WO2015187499A1 (en) * | 2014-06-03 | 2015-12-10 | Gilead Sciences, Inc. | Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor |
| TW201618781A (zh) | 2014-08-13 | 2016-06-01 | 吉李德科學股份有限公司 | 治療肺高血壓之方法 |
| NZ729678A (en) | 2014-09-24 | 2018-07-27 | Gilead Sciences Inc | Methods of treating non-alcoholic steatohepatitis using ask1 inhibitor in combination with a fxr agonist |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| CA3202893A1 (en) | 2014-12-23 | 2016-06-30 | Gilead Science, Inc. | Processes for preparing ask1 inhibitors |
| CN110036005B (zh) * | 2016-11-16 | 2022-09-27 | 广东东阳光药业有限公司 | 酰胺衍生物及其在药物中的应用 |
| WO2018094964A1 (zh) * | 2016-11-25 | 2018-05-31 | 武汉大学 | 一种以凋亡信号调节激酶1n端二聚化为靶点筛选用于治疗脂肪性肝炎药物的方法 |
| JP6827113B2 (ja) | 2017-01-21 | 2021-02-10 | 広州白雲山漢方現代薬業有限公司Ｇｕａｎｇｚｈｏｕ Ｈａｎｆａｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ． | シェーグレン症候群の治療におけるペオニフロリン−６’−ｏ−ベンゼンスルホン酸の使用 |
| US10787435B2 (en) | 2017-01-22 | 2020-09-29 | Fuijan Cosunter Pharmaceutical Co. Ltd. | ASK1 inhibitor and preparation method and use thereof |
| CN111094250B (zh) | 2017-03-03 | 2022-11-04 | 江苏豪森药业集团有限公司 | 凋亡信号调节激酶抑制剂及其制备方法和应用 |
| WO2018209354A1 (en) | 2017-05-12 | 2018-11-15 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10450301B2 (en) | 2017-05-25 | 2019-10-22 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10253018B2 (en) | 2017-05-25 | 2019-04-09 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2018218044A2 (en) | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals Inc | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2019046186A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF |
| WO2019047094A1 (en) * | 2017-09-07 | 2019-03-14 | Eli Lilly And Company | CYCLOBUTYL-IMIDAZOLIDINONE COMPOUNDS |
| US10370352B2 (en) | 2017-09-07 | 2019-08-06 | Eli Lilly And Company | Cyclobutyl-imidazolidinone compounds |
| WO2019099703A1 (en) * | 2017-11-16 | 2019-05-23 | Sidecar Therapeutics, Inc. | Apoptosis signal-regulating kinase 1 (ask 1) inhibitor compounds |
| WO2019099203A1 (en) * | 2017-11-17 | 2019-05-23 | Hepagene Therapeutics, Inc. | Oxazole and thiazole derivatives as inhibitors of ask1 |
| CN110407806B (zh) * | 2018-04-28 | 2021-08-17 | 深圳微芯生物科技股份有限公司 | 甲酰胺类化合物、其制备方法及其应用 |
| AU2019262016A1 (en) * | 2018-05-02 | 2020-11-19 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10683289B2 (en) | 2018-05-02 | 2020-06-16 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020006031A1 (en) * | 2018-06-27 | 2020-01-02 | Biogen Ma Inc. | Ask1 inhibiting agents |
| WO2020030107A1 (zh) * | 2018-08-10 | 2020-02-13 | 江苏豪森药业集团有限公司 | 一种含有酰胺类衍生物的药物组合物及其制备方法和应用 |
| WO2020041417A1 (en) | 2018-08-22 | 2020-02-27 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11345699B2 (en) | 2018-11-19 | 2022-05-31 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11466033B2 (en) | 2019-03-25 | 2022-10-11 | Enanta Pharmaceuticals, Inc. | Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors |
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| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
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| PT1654261E (pt) * | 2003-05-21 | 2008-01-18 | Boehringer Ingelheim Int | Compostos inibidores da hepatite c |
| WO2005009470A1 (ja) | 2003-07-28 | 2005-02-03 | Osaka Industrial Promotion Organization | Ａｓｋ１阻害剤を有効成分とする心不全治療薬およびそのスクリーニング方法 |
| US20070276050A1 (en) | 2006-02-27 | 2007-11-29 | Gilead Sciences, Inc. | Methods for identifying ASK1 inhibitors useful for preventing and/or treating cardiovascular diseases |
| WO2008061796A2 (en) | 2006-11-24 | 2008-05-29 | Ac Immune Sa | Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
| CA2691448A1 (en) | 2007-08-31 | 2009-03-05 | Dominique Swinnen | Triazolopyridine compounds and their use as ask inhibitors |
| TWI598347B (zh) * | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2588475B1 (en) * | 2010-07-02 | 2015-05-20 | Gilead Sciences, Inc. | Apoptosis signal-regulating kinase inhibitors |
| US9255072B2 (en) * | 2011-03-04 | 2016-02-09 | National Health Rsearch Institutes | Pyrazole compounds and thiazole compounds as protein kinases inhibitors |
| UY35212A (es) * | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
| AP2016009248A0 (en) * | 2013-12-20 | 2016-05-31 | Gilead Sciences Inc | Apoptosis signal-regulating kinase inhibitors |
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2013
- 2013-12-19 UY UY0001035212A patent/UY35212A/es not_active Application Discontinuation
- 2013-12-20 PT PT138189402T patent/PT2935258T/pt unknown
- 2013-12-20 ES ES13818940.2T patent/ES2612979T3/es active Active
- 2013-12-20 SI SI201330489A patent/SI2935258T1/sl unknown
- 2013-12-20 TW TW102147530A patent/TWI622589B/zh active
- 2013-12-20 CA CA2896060A patent/CA2896060C/en active Active
- 2013-12-20 AU AU2013361140A patent/AU2013361140B2/en active Active
- 2013-12-20 HU HUE13818940A patent/HUE032988T2/hu unknown
- 2013-12-20 CN CN201380066600.1A patent/CN104918936B/zh active Active
- 2013-12-20 RS RS20170126A patent/RS55676B1/sr unknown
- 2013-12-20 KR KR1020157019179A patent/KR101712758B1/ko active IP Right Grant
- 2013-12-20 EP EP13818940.2A patent/EP2935258B1/en active Active
- 2013-12-20 JP JP2015549760A patent/JP6086633B2/ja active Active
- 2013-12-20 LT LTEP13818940.2T patent/LT2935258T/lt unknown
- 2013-12-20 US US14/135,812 patent/US9051313B2/en active Active
- 2013-12-20 BR BR112015014567A patent/BR112015014567A2/pt not_active IP Right Cessation
- 2013-12-20 SG SG11201504865YA patent/SG11201504865YA/en unknown
- 2013-12-20 EP EP16195735.2A patent/EP3150597A1/en not_active Withdrawn
- 2013-12-20 NZ NZ709248A patent/NZ709248A/en not_active IP Right Cessation
- 2013-12-20 DK DK13818940.2T patent/DK2935258T3/en active
- 2013-12-20 AR ARP130104949A patent/AR094214A1/es unknown
- 2013-12-20 MX MX2015008090A patent/MX2015008090A/es unknown
- 2013-12-20 WO PCT/US2013/076811 patent/WO2014100541A1/en active Application Filing
- 2013-12-20 EA EA201591018A patent/EA027645B1/ru not_active IP Right Cessation
- 2013-12-20 PL PL13818940T patent/PL2935258T3/pl unknown
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2015
- 2015-05-13 US US14/711,331 patent/US20150246910A1/en not_active Abandoned
- 2015-06-10 IL IL239322A patent/IL239322A/en not_active IP Right Cessation
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2016
- 2016-02-23 HK HK16102017.7A patent/HK1214247A1/zh unknown
- 2016-09-29 JP JP2016191437A patent/JP2016222721A/ja not_active Withdrawn
- 2016-10-21 AU AU2016247182A patent/AU2016247182B2/en active Active
- 2016-11-21 US US15/357,878 patent/US9943521B2/en active Active
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2017
- 2017-01-24 SM SM201700051T patent/SMT201700051B/it unknown
- 2017-01-24 HR HRP20170112TT patent/HRP20170112T8/hr unknown
- 2017-01-31 CY CY20171100143T patent/CY1118574T1/el unknown
- 2017-11-21 IL IL255799A patent/IL255799B/en not_active IP Right Cessation
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2018
- 2018-03-21 US US15/927,948 patent/US10307427B2/en active Active
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