CY1117713T1 - Μορια για την καθοδηγηση ενωσεων σε διαφορα επιλεγμενα οργανα ή ιστους - Google Patents
Μορια για την καθοδηγηση ενωσεων σε διαφορα επιλεγμενα οργανα ή ιστουςInfo
- Publication number
- CY1117713T1 CY1117713T1 CY20161100611T CY161100611T CY1117713T1 CY 1117713 T1 CY1117713 T1 CY 1117713T1 CY 20161100611 T CY20161100611 T CY 20161100611T CY 161100611 T CY161100611 T CY 161100611T CY 1117713 T1 CY1117713 T1 CY 1117713T1
- Authority
- CY
- Cyprus
- Prior art keywords
- molecules
- guidance
- tissues
- compounds
- various selected
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000002064 heart cell Anatomy 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 210000000663 muscle cell Anatomy 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 108700026220 vif Genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
- A61K49/0047—Green fluorescent protein [GFP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Η εφεύρεση παρέχει συζευγμένα μόρια, τα οποία περιλαμβάνουν όργανο, ιστό ή καρκινικό κύτταρο συνδεδεμένο με κάποιο τμήμα. Τέτοιο τμήμα μπορεί να είναι για παράδειγμα ολιγονουκλεοτίδιο, μικρό παρεμβαλλόμενο RNA, γονίδιο, ιός, πρωτεΐνη, φαρμακευτικός ή ανιχνευτικός παράγοντας. Επιπλέον η εφεύρεση παρέχει μεθόδους για τη διάγνωση ή την αντιμετώπιση παθολογικών καταστάσεων των μυών ή της καρδιάς, με τη χορήγηση σε άτομο που πάσχει ή υπάρχει υποψία ότι πάσχει, μορίου ή συζευγμένου μορίου που κατευθύνεται, προσδένεται ή απορροφάται από τα μυϊκά ή τα καρδιακά κύτταρα.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07112323 | 2007-07-12 | ||
EP08779023.4A EP2167136B1 (en) | 2007-07-12 | 2008-07-14 | Molecules for targeting compounds to various selected organs or tissues |
PCT/NL2008/050475 WO2009008727A2 (en) | 2007-07-12 | 2008-07-14 | Molecules for targeting compounds to various selected organs or tissues |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117713T1 true CY1117713T1 (el) | 2017-05-17 |
Family
ID=39471746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100611T CY1117713T1 (el) | 2007-07-12 | 2016-07-01 | Μορια για την καθοδηγηση ενωσεων σε διαφορα επιλεγμενα οργανα ή ιστους |
Country Status (12)
Country | Link |
---|---|
US (2) | US8268962B2 (el) |
EP (2) | EP2167136B1 (el) |
JP (1) | JP5706157B2 (el) |
CN (2) | CN101815535B (el) |
AU (1) | AU2008273096B2 (el) |
CA (2) | CA2942716C (el) |
CY (1) | CY1117713T1 (el) |
DK (1) | DK2167136T3 (el) |
HK (1) | HK1145635A1 (el) |
IL (2) | IL203273A (el) |
NZ (1) | NZ582521A (el) |
WO (1) | WO2009008727A2 (el) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2524255C (en) | 2003-03-21 | 2014-02-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
ES2397441T5 (es) | 2006-02-13 | 2022-09-14 | Daiichi Sankyo Co Ltd | Secuencias polinucleotídicas y polipeptídicas implicadas en el proceso de remodelación ósea |
US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
NZ574807A (en) | 2006-08-11 | 2011-01-28 | Prosensa Technologies Bv | Methods and means for treating dna repeat instability associated genetic disorders |
CN105641700B (zh) | 2007-10-26 | 2021-01-01 | 莱顿教学医院 | 对抗肌肉病症的方式和方法 |
EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
JP2012524540A (ja) | 2009-04-24 | 2012-10-18 | プロセンサ テクノロジーズ ビー.ブイ. | Dmdを処置するためのイノシンを含むオリゴヌクレオチド |
CN102048694B (zh) * | 2009-11-06 | 2013-03-13 | 复旦大学 | 一种多肽修饰的肝肿瘤靶向纳米给药系统及其制备方法 |
WO2012144906A1 (en) * | 2011-04-22 | 2012-10-26 | Prosensa Technologies B.V. | New compounds for treating, delaying and/or preventing a human genetic disorder such as myotonic dystrophy type 1 (dm1) |
US20150010475A1 (en) * | 2011-12-30 | 2015-01-08 | Stc.Unm | Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all) |
CN112251436A (zh) | 2012-01-27 | 2021-01-22 | 比奥马林技术公司 | 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸 |
NZ700561A (en) | 2012-04-23 | 2016-07-29 | Biomarin Technologies B V | Rna modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders |
EP2875051B1 (en) | 2012-07-19 | 2019-02-20 | Daiichi Sankyo Company, Limited | Anti-siglec-15 antibodies |
CN103705465B (zh) * | 2012-10-09 | 2016-01-13 | 复旦大学 | 一种微酸环境靶向多肽修饰的肿瘤靶向纳米给药系统及其制备方法 |
BR112016016153A2 (pt) | 2014-01-13 | 2017-12-12 | Berg Llc | composições de enolase 1 (eno1) e usos das mesmas |
US10500290B2 (en) * | 2014-08-22 | 2019-12-10 | The Regents Of The University Of Michigan | Peptide reagents and methods for detection and targeting of dysplasia, early cancer and cancer |
CN104800858B (zh) * | 2015-04-27 | 2017-11-21 | 中国医学科学院基础医学研究所 | Hsp90抑制肽偶联物及其在肿瘤治疗中的应用 |
US11369569B2 (en) | 2015-06-15 | 2022-06-28 | University Of Virginia Patent Foundation | Target-specific delivery of therapeutic agents |
WO2017011836A1 (en) * | 2015-07-16 | 2017-01-19 | Berg Llc | Enolase 1 (eno1) compositions and uses thereof |
WO2017120504A1 (en) | 2016-01-08 | 2017-07-13 | Durfee Paul N | Osteotropic nanoparticles for prevention or treatment of bone metastases |
WO2017136435A1 (en) | 2016-02-01 | 2017-08-10 | The Usa, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer National Institute Of Health | Compounds for modulating fc-epsilon-ri-beta expression and uses thereof |
CA3043864A1 (en) * | 2016-11-16 | 2018-05-24 | Biomarin Technologies B.V. | Substances for targeting various selected organs or tissues |
US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
GB2563875B (en) * | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US5541308A (en) | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
US5766847A (en) | 1988-10-11 | 1998-06-16 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Process for analyzing length polymorphisms in DNA regions |
DE3834636A1 (de) | 1988-10-11 | 1990-04-19 | Max Planck Gesellschaft | Verfahren zur analyse von laengenpolymorphismen in dna-bereichen |
US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
AU659482B2 (en) | 1991-06-28 | 1995-05-18 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
CA2082411A1 (en) | 1991-06-28 | 1992-12-29 | Robert D. Rosenberg | Localized oligonucleotide therapy |
US6200747B1 (en) | 1992-01-28 | 2001-03-13 | North Shore University Hospital Research Corp. | Method and kits for detection of fragile X specific, GC-rich DNA sequences |
US5869252A (en) | 1992-03-31 | 1999-02-09 | Abbott Laboratories | Method of multiplex ligase chain reaction |
US5418139A (en) | 1993-02-10 | 1995-05-23 | University Of Iowa Research Foundation | Method for screening for cardiomyopathy |
CA2116280A1 (en) | 1993-03-05 | 1994-09-06 | Marcy E. Macdonald | Huntingtin dna, protein and uses thereof |
US5741645A (en) | 1993-06-29 | 1998-04-21 | Regents Of The University Of Minnesota | Gene sequence for spinocerebellar ataxia type 1 and method for diagnosis |
US5627263A (en) | 1993-11-24 | 1997-05-06 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
DE4342605A1 (de) | 1993-12-14 | 1995-06-22 | Buna Gmbh | Funktionalisierte Olefinhomo- und -copolymere |
US5962332A (en) | 1994-03-17 | 1999-10-05 | University Of Massachusetts | Detection of trinucleotide repeats by in situ hybridization |
DE69503126T2 (de) | 1994-05-05 | 1998-11-12 | Beckman Instruments Inc | Repetitive oligonukleotide matrix |
US5968909A (en) | 1995-08-04 | 1999-10-19 | Hybridon, Inc. | Method of modulating gene expression with reduced immunostimulatory response |
US5854223A (en) | 1995-10-06 | 1998-12-29 | The Trustees Of Columbia University In The City Of New York | S-DC28 as an antirestenosis agent after balloon injury |
US6300060B1 (en) | 1995-11-09 | 2001-10-09 | Dana-Farber Cancer Institute, Inc. | Method for predicting the risk of prostate cancer morbidity and mortality |
SK109198A3 (en) | 1996-02-14 | 1999-06-11 | Isis Pharmaceuticals Inc | Sugar-modified gapped oligonucleotides |
US6251589B1 (en) | 1996-07-18 | 2001-06-26 | Srl, Inc. | Method for diagnosing spinocerebellar ataxia type 2 and primers therefor |
JP3976346B2 (ja) | 1996-10-30 | 2007-09-19 | 株式会社エスアールエル | 脊髄小脳変性症2型の原因遺伝子のcDNA断片 |
US5853995A (en) | 1997-01-07 | 1998-12-29 | Research Development Foundation | Large scale genotyping of diseases and a diagnostic test for spinocerebellar ataxia type 6 |
US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
WO1998049345A1 (en) | 1997-04-29 | 1998-11-05 | Trustees Of Boston University | Methods and compositions for targeted dna differential display |
US6329501B1 (en) * | 1997-05-29 | 2001-12-11 | Auburn University | Methods and compositions for targeting compounds to muscle |
US6514755B1 (en) | 1998-08-18 | 2003-02-04 | Regents Of The University Of Minnesota | SCA7 gene and methods of use |
US6280938B1 (en) | 1997-08-19 | 2001-08-28 | Regents Of The University Of Minnesota | SCA7 gene and method of use |
US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
US6130207A (en) | 1997-11-05 | 2000-10-10 | South Alabama Medical Science Foundation | Cell-specific molecule and method for importing DNA into a nucleus |
JP3012923B2 (ja) | 1998-01-26 | 2000-02-28 | 新潟大学長 | Cagリピート病の治療薬 |
KR100280219B1 (ko) | 1998-02-26 | 2001-04-02 | 이수빈 | 삼핵산 반복 서열을 이용한 신경정신 질환의 진단 방법 및 진단 시약 |
US6322978B1 (en) | 1998-04-20 | 2001-11-27 | Joslin Diabetes Center, Inc. | Repeat polymorphism in the frataxin gene and uses therefore |
US20030096955A1 (en) | 1998-09-01 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
CA2343934A1 (en) | 1998-09-25 | 2000-04-06 | The Children's Medical Center Corporation | Short peptides which selectively modulate the activity of protein kinases |
US6172216B1 (en) | 1998-10-07 | 2001-01-09 | Isis Pharmaceuticals Inc. | Antisense modulation of BCL-X expression |
US6399575B1 (en) * | 1998-11-10 | 2002-06-04 | Auburn University | Methods and compositions for targeting compounds to the central nervous system |
US6133031A (en) | 1999-08-19 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense inhibition of focal adhesion kinase expression |
US20040226056A1 (en) | 1998-12-22 | 2004-11-11 | Myriad Genetics, Incorporated | Compositions and methods for treating neurological disorders and diseases |
US20020049173A1 (en) | 1999-03-26 | 2002-04-25 | Bennett C. Frank | Alteration of cellular behavior by antisense modulation of mRNA processing |
US6379698B1 (en) | 1999-04-06 | 2002-04-30 | Isis Pharmaceuticals, Inc. | Fusogenic lipids and vesicles |
JP2000325085A (ja) | 1999-05-21 | 2000-11-28 | Masafumi Matsuo | デュシェンヌ型筋ジストロフィー治療剤 |
US20030236214A1 (en) | 1999-06-09 | 2003-12-25 | Wolff Jon A. | Charge reversal of polyion complexes and treatment of peripheral occlusive disease |
US6355481B1 (en) | 1999-06-18 | 2002-03-12 | Emory University | Hybridoma cell line and monoclonal antibody for huntingtin protein |
EP1133993A1 (en) | 2000-03-10 | 2001-09-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Substances for the treatment of spinal muscular atrophy |
US20020187931A1 (en) | 2000-04-13 | 2002-12-12 | Michael Hayden | Modulating cell survival by modulating huntingtin function |
US6653467B1 (en) | 2000-04-26 | 2003-11-25 | Jcr Pharmaceutical Co., Ltd. | Medicament for treatment of Duchenne muscular dystrophy |
CA2407309C (en) | 2000-04-28 | 2011-08-02 | Xiao Xiao | Dna sequences encoding dystrophin minigenes and methods of use thereof |
US20020013287A1 (en) | 2000-05-09 | 2002-01-31 | Reliable Biopharmaceuticals, Inc. St Louis Missouri | Polymeric compounds useful as prodrugs |
ATE464378T1 (de) | 2000-05-31 | 2010-04-15 | Serono Genetics Inst Sa | Verwendung des globulären kopfes von acrp30 zur verstärkung der zunahme von muskelmasse und - differenzierung |
US20030124523A1 (en) | 2000-06-22 | 2003-07-03 | Asselbergs Fredericus Alphonsus Maria | Organic compounds |
US6794192B2 (en) | 2000-06-29 | 2004-09-21 | Pfizer Inc. | Target |
RU2165149C1 (ru) | 2000-07-03 | 2001-04-20 | Шапошников Валерий Геннадьевич | Система формования и упаковки изделий из сахарной ваты |
US6727355B2 (en) | 2000-08-25 | 2004-04-27 | Jcr Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treatment of Duchenne muscular dystrophy |
EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
US6623927B1 (en) | 2000-11-08 | 2003-09-23 | Council Of Scientific And Industrial Research | Method of detection of allelic variants of SCA2 gene |
US6743893B2 (en) | 2000-11-30 | 2004-06-01 | The Uab Research Foundation | Receptor-mediated uptake of peptides that bind the human transferrin receptor |
TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
CA2414782C (en) | 2001-05-11 | 2012-10-09 | Regents Of The University Of Minnesota | Intron associated with myotonic dystrophy type 2 and methods of use |
CA2526831C (en) | 2001-05-18 | 2012-07-31 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) |
US20050277133A1 (en) | 2001-05-18 | 2005-12-15 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
EP1423537A4 (en) | 2001-08-07 | 2006-11-29 | Univ Delaware | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING HUNTINGTON'S DISEASE |
US20060074034A1 (en) | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
KR20030035047A (ko) | 2001-10-29 | 2003-05-09 | (주)바이오코돈 | Bmp-4 유전자 발현을 이용한 편평태선 질환의 치료 및진단방법 |
AU2002363253A1 (en) * | 2001-11-01 | 2003-05-12 | Gpc Biotech Inc. | Endothelial-cell binding peptides for diagnosis and therapy |
US20030134790A1 (en) | 2002-01-11 | 2003-07-17 | University Of Medicine And Dentistry Of New Jersey | Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer |
WO2003069330A1 (en) | 2002-02-11 | 2003-08-21 | The Trustees Of Columbia University In The City Of New York | System and method for identifying proteins involved in force-initiated signal transduction |
US20050096284A1 (en) | 2002-02-20 | 2005-05-05 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
CN1649625A (zh) | 2002-03-01 | 2005-08-03 | 图兰恩教育基金管理人 | 治疗剂或细胞毒性剂与生物活性肽的偶联物 |
US20040101852A1 (en) | 2002-11-21 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of CGG triplet repeat binding protein 1 expression |
ITRM20020253A1 (it) | 2002-05-08 | 2003-11-10 | Univ Roma | Molecole chimeriche di snrna con sequenze antisenso per le giunzioni di splicing del gene della distrofina e applicazioni terapeutiche. |
EP1380644A1 (en) | 2002-07-08 | 2004-01-14 | Kylix B.V. | The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role |
EP1585560A4 (en) | 2002-07-26 | 2011-03-16 | Mirus Bio Corp | ADMINISTRATION OF MOLECULES AND COMPLEXES TO IN VIVO MAMMAL CELLS |
US20050255086A1 (en) | 2002-08-05 | 2005-11-17 | Davidson Beverly L | Nucleic acid silencing of Huntington's Disease gene |
WO2004015106A1 (en) | 2002-08-12 | 2004-02-19 | UNIVERSITé DE SHERBROOKE | Methods to reprogram splice site selection in pre-messenger rnas |
GB0219143D0 (en) | 2002-08-16 | 2002-09-25 | Univ Leicester | Modified tailed oligonucleotides |
WO2004037854A1 (en) * | 2002-10-23 | 2004-05-06 | Centre For Research And Technology Hellas/Institute Of Agrobiotechnology In.A | Prion protein-binding peptide sequences |
US7892793B2 (en) | 2002-11-04 | 2011-02-22 | University Of Massachusetts | Allele-specific RNA interference |
DK2284266T3 (da) | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
CA2942791C (en) | 2002-11-25 | 2019-08-20 | Masafumi Matsuo | Ena nucleic acid pharmaceuticals capable of modifying splicing of mrna precursors |
GB0228079D0 (en) | 2002-12-02 | 2003-01-08 | Laxdale Ltd | Huntington's Disease |
CA2524255C (en) | 2003-03-21 | 2014-02-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
US7589189B2 (en) | 2003-05-14 | 2009-09-15 | Japan Science And Technology Agency | Inhibition of the expression of huntingtin gene |
KR20060026860A (ko) | 2003-06-02 | 2006-03-24 | 와이어쓰 | 신경근 장애의 치료를 위한, 코르티코스테로이드와 조합된미오스타틴 (gdf8) 저해제의 용도 |
ATE387217T1 (de) | 2003-07-11 | 2008-03-15 | Lbr Medbiotech B V | Mannose-6-phosphat rezeptor vermittelter gentransfer zu muskelzellen |
US20050054752A1 (en) * | 2003-09-08 | 2005-03-10 | O'brien John P. | Peptide-based diblock and triblock dispersants and diblock polymers |
US7355018B2 (en) | 2003-09-30 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Modified IGF1 polypeptides with increased stability and potency |
JP2007508030A (ja) | 2003-10-14 | 2007-04-05 | カーネル・バイオファーマ・インコーポレイテッド | 血液脳関門を介してpnaを送達するための2相pna結合体 |
US20050191636A1 (en) | 2004-03-01 | 2005-09-01 | Biocept, Inc. | Detection of STRP, such as fragile X syndrome |
EP1735443A2 (en) | 2004-04-14 | 2006-12-27 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF POLYGLUTAMINE (POLYQ) REPEAT EXPANSION DISEASES USING SHORT INTERFERING NUCLEIC ACID (siNA) |
JPWO2005116204A1 (ja) | 2004-05-11 | 2008-06-19 | 株式会社アルファジェン | Rna干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法 |
ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
EP1618881A1 (en) | 2004-07-20 | 2006-01-25 | Santhera Pharmaceuticals (Schweiz) GmbH | Use of non-glucocorticoid steroids for the treatment of muscular dystrophy |
ITRM20040568A1 (it) | 2004-11-18 | 2005-02-18 | Uni Degli Studi Di Roma Tor Vergata | Uso della tecnica "phage display" per l'identificazione di peptidi con capacita' di legame a cellule staminali/progenitore, peptidi cosi' ottenuti e loro usi. |
US20060148740A1 (en) | 2005-01-05 | 2006-07-06 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
CA2596588C (en) | 2005-01-31 | 2017-06-27 | University Of Iowa Research Foundation | Nucleic acid silencing of huntington's disease gene |
US20060257912A1 (en) | 2005-05-06 | 2006-11-16 | Medtronic, Inc. | Methods and sequences to suppress primate huntington gene expression |
CN100393320C (zh) * | 2005-06-24 | 2008-06-11 | 奥林格斯技术有限公司 | 治疗肌肉萎缩的寡核苷酸药物 |
WO2007002904A2 (en) | 2005-06-28 | 2007-01-04 | Medtronic, Inc. | Methods and sequences to preferentially suppress expression of mutated huntingtin |
US7906617B2 (en) * | 2005-12-15 | 2011-03-15 | E. I. Du Pont De Nemours And Company | Polyethylene binding peptides and methods of use |
US20100248239A1 (en) | 2009-03-24 | 2010-09-30 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting fragile x mutations |
US20110166081A1 (en) | 2009-12-03 | 2011-07-07 | University Of Iowa Research Foundation | Alpha-dystroglycan as a Protein Therapeutic |
-
2008
- 2008-07-14 WO PCT/NL2008/050475 patent/WO2009008727A2/en active Application Filing
- 2008-07-14 AU AU2008273096A patent/AU2008273096B2/en not_active Ceased
- 2008-07-14 EP EP08779023.4A patent/EP2167136B1/en active Active
- 2008-07-14 JP JP2010515992A patent/JP5706157B2/ja not_active Expired - Fee Related
- 2008-07-14 CA CA2942716A patent/CA2942716C/en not_active Expired - Fee Related
- 2008-07-14 CA CA2693048A patent/CA2693048C/en not_active Expired - Fee Related
- 2008-07-14 DK DK08779023.4T patent/DK2167136T3/en active
- 2008-07-14 CN CN2008801016669A patent/CN101815535B/zh not_active Expired - Fee Related
- 2008-07-14 EP EP12174179.7A patent/EP2505211B1/en active Active
- 2008-07-14 CN CN2013100912811A patent/CN103212085A/zh active Pending
- 2008-07-14 NZ NZ582521A patent/NZ582521A/en not_active IP Right Cessation
-
2010
- 2010-01-11 US US12/685,369 patent/US8268962B2/en active Active
- 2010-01-12 IL IL203273A patent/IL203273A/en active IP Right Grant
- 2010-12-23 HK HK10112090.2A patent/HK1145635A1/xx not_active IP Right Cessation
-
2012
- 2012-07-16 IL IL220979A patent/IL220979A0/en unknown
- 2012-08-07 US US13/568,866 patent/US8519097B2/en active Active
-
2016
- 2016-07-01 CY CY20161100611T patent/CY1117713T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US8519097B2 (en) | 2013-08-27 |
HK1145635A1 (en) | 2011-04-29 |
AU2008273096A1 (en) | 2009-01-15 |
CA2693048A1 (en) | 2009-01-15 |
AU2008273096B2 (en) | 2013-05-02 |
CN101815535A (zh) | 2010-08-25 |
US8268962B2 (en) | 2012-09-18 |
JP2010533171A (ja) | 2010-10-21 |
EP2505211B1 (en) | 2020-04-08 |
WO2009008727A3 (en) | 2009-08-13 |
CN101815535B (zh) | 2013-04-24 |
IL220979A0 (en) | 2012-08-30 |
CN103212085A (zh) | 2013-07-24 |
US20100184948A1 (en) | 2010-07-22 |
EP2167136B1 (en) | 2016-04-20 |
CA2693048C (en) | 2016-10-18 |
CA2942716C (en) | 2019-07-09 |
EP2167136A2 (en) | 2010-03-31 |
EP2505211A1 (en) | 2012-10-03 |
JP5706157B2 (ja) | 2015-04-22 |
WO2009008727A2 (en) | 2009-01-15 |
DK2167136T3 (en) | 2016-07-25 |
US20120322724A1 (en) | 2012-12-20 |
NZ582521A (en) | 2011-09-30 |
IL203273A (en) | 2014-04-30 |
CA2942716A1 (en) | 2009-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1117713T1 (el) | Μορια για την καθοδηγηση ενωσεων σε διαφορα επιλεγμενα οργανα ή ιστους | |
CY1122557T1 (el) | Μορια αντι-gcc αντισωματος και χρηση αυτων στη δοκιμη για επιδεκτικοτητα σε θεραπεια στοχευμενη σε gcc | |
WO2009008725A3 (en) | Molecules for targeting compounds to various selected organs, tissues or tumor cells | |
CY1118549T1 (el) | Χρηση anti-vegf αντισωματος σε συνδυασμο με χημειοθεραπεια για τη θεραπευτικη αγωγη του καρκινου του μαστου | |
CY1122855T1 (el) | Θεραπευτικα συστατικα δεσμευσης κυτταρικης επιφανειας με αματοξινη για τη θεραπεια ογκου | |
CY1117312T1 (el) | Θεραπευτικη αγωγη συνουκλεϊνοπαθειων | |
CY1119951T1 (el) | Συνθεσεις για αυξηση δραστηριοτητας τελομερασης και αγωγη λοιμωξης hiv | |
CY1116344T1 (el) | Κυτταρα προερχομενα απο ιστο ομφαλιου λωρου για την θεραπεια νευροπαθητικου πονου και σπαστικοτητας | |
CY1118369T1 (el) | Αντισωματα εναντι cd38 για την θεραπεια πολλαπλου μυελωματος | |
Mallikaratchy et al. | Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy | |
SG161267A1 (en) | Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases | |
BRPI0816014A8 (pt) | anticorpo humano monoclonal isolado, composição, conjugado anticorpo-molécula parceiro, mólecula isolada de ácido nucléico, vetor de expressão, célula hospedeira, método para preparar um anticorpo anti-mesotelina, método de inibição do crescimento de uma célula tumoral expressando a mesotelina, método de tratamento do câncer em um indivíduo, anticorpo anti-mesotelina isolado, e método de inibir o crescimento de uma célula expressando a mesotelina | |
Jansen et al. | Postoperative chemoradiotherapy in gastric cancer––a phase I–II study of radiotherapy with dose escalation of weekly cisplatin and daily capecitabine chemotherapy | |
CY1118073T1 (el) | Συνθεσεις και μεθοδοι για την αυξηση της δρασης της τελομερασης | |
MX2019005671A (es) | Sustancias para direccionar diversos organos o tejidos seleccionados. | |
Tepeköylü et al. | Shockwaves prevent from heart failure after acute myocardial ischaemia via RNA/protein complexes | |
ECSP15028696A (es) | Anticuerpos anti-lamp1 y conjugados anticuerpo fármaco, y usos de éstos | |
Wu et al. | Trisulfide Bond‐Mediated Molecular Phototheranostic Platform for “Activatable” NIR‐II Imaging‐Guided Enhanced Gas/Chemo‐Hypothermal Photothermal Therapy | |
Pei et al. | Detecting the formation kinetics of doxorubicin-DNA interstrand cross-link at the single-molecule level and clinically relevant concentrations of doxorubicin | |
Saczko et al. | The effects of the electro-photodynamic in vitro treatment on human lung adenocarcinoma cells | |
CY1117234T1 (el) | Μεθοδος προσδιορισμου της ευαισθησιας ασθενους στη θεραπεια αναστολης της τελομερασης | |
Feng et al. | NIR Light‐Mediated Mitochondrial RNA Modification for Cancer RNA Interference Therapeutics | |
CY1109836T1 (el) | Διαμινοπαραγωγα βιοτινης και τα συζυγιακα τους με μακροκυκλικους χηλικους παραγοντεσς | |
Matsuoka et al. | Structure–activity relationships of succinimidyl-Cys-C (O)-Glu derivatives with different near-infrared fluorophores as optical imaging probes for prostate-specific membrane antigen | |
WO2005089123A3 (en) | Therapeutic anti-cancer dna |