CY1117490T1 - Μεθοδος παραγωγης της μεδετομιδινης - Google Patents

Μεθοδος παραγωγης της μεδετομιδινης

Info

Publication number
CY1117490T1
CY1117490T1 CY20161100228T CY161100228T CY1117490T1 CY 1117490 T1 CY1117490 T1 CY 1117490T1 CY 20161100228 T CY20161100228 T CY 20161100228T CY 161100228 T CY161100228 T CY 161100228T CY 1117490 T1 CY1117490 T1 CY 1117490T1
Authority
CY
Cyprus
Prior art keywords
medetomidin
production
dimethylbenzene
bromo
acetone
Prior art date
Application number
CY20161100228T
Other languages
English (en)
Inventor
Doerwald Florencio Zaragoza
Anna Kulesza
Stephan Elzner
Robert Bujok
Zbigniew Wrobel
Krzysztof Wojciechowski
Original Assignee
Lonza Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47558543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117490(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Ltd filed Critical Lonza Ltd
Publication of CY1117490T1 publication Critical patent/CY1117490T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Η εφεύρεση αποκαλύπτει μια μέθοδο για την παρασκευή της μεδετομιδίνης εκκινώντας από 1-βρωμο-2,3-διμεθυλοβενζόλιο και ακετόνη.
CY20161100228T 2012-05-08 2016-03-17 Μεθοδος παραγωγης της μεδετομιδινης CY1117490T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261644284P 2012-05-08 2012-05-08
EP12167134 2012-05-08
EP12192612 2012-11-14
EP12784296.1A EP2847173B1 (en) 2012-05-08 2012-11-15 Method for preparation of medetomidine

Publications (1)

Publication Number Publication Date
CY1117490T1 true CY1117490T1 (el) 2017-04-26

Family

ID=47558543

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100228T CY1117490T1 (el) 2012-05-08 2016-03-17 Μεθοδος παραγωγης της μεδετομιδινης

Country Status (21)

Country Link
US (1) US9045433B2 (el)
EP (1) EP2847173B1 (el)
JP (1) JP5779297B2 (el)
KR (1) KR101530506B1 (el)
CN (1) CN104245679B (el)
AU (1) AU2012285675B2 (el)
CA (1) CA2866424A1 (el)
CL (1) CL2014002905A1 (el)
CY (1) CY1117490T1 (el)
DK (1) DK2847173T3 (el)
EA (1) EA025950B1 (el)
ES (1) ES2563816T3 (el)
HK (1) HK1201532A1 (el)
HR (1) HRP20160215T1 (el)
HU (1) HUE027384T2 (el)
IN (1) IN2014DN07983A (el)
MY (1) MY166058A (el)
PL (1) PL2847173T3 (el)
SG (1) SG11201405606RA (el)
TW (1) TWI529164B (el)
WO (1) WO2013011155A2 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2847173B1 (en) * 2012-05-08 2015-12-30 Lonza Ltd Method for preparation of medetomidine
SG11201405611SA (en) * 2012-05-08 2014-11-27 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
JP5777841B2 (ja) 2012-06-28 2015-09-09 ロンザ・リミテッド クロロアセトンを用いてメデトミジンを調製するための方法
CA2866441C (en) 2012-06-28 2017-01-17 Lonza Ltd. Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
CN106518812A (zh) * 2016-10-25 2017-03-22 湖南大学 一种美托咪定及其中间体的制备方法
CN111548308A (zh) * 2020-03-18 2020-08-18 遂成药业股份有限公司 一种盐酸右美托咪定的合成工艺
KR102341174B1 (ko) * 2021-09-13 2021-12-20 주식회사 세라수 양이온교환 섬유를 사용한 테레프탈릴리덴 디캠퍼 설폰산염의 산성화 방법
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790604A (fr) 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
JPS51100042A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100041A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
ATE78722T1 (de) 1984-02-24 1992-08-15 Sagami Chem Res Methode zum isomerisieren eines glycidats.
JPS62103037A (ja) * 1985-10-29 1987-05-13 Hamari Yakuhin Kogyo Kk ２−（４−イソブチルフエニル）−プロピオンアルデヒドの製造法
DE19714042A1 (de) 1997-04-05 1998-10-08 Henkel Kgaa Verfahren zur Herstellung aromatischer Aldehyde
SE513474C2 (sv) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Metod för att förhindra kräftdjurs, särskilt havstulpaners, etablering på fasta ytor med hjälp av en substans som stör nervsignaler, varvid substansen är medetomidin, dvs (+)-4-/1- (2,3-dimetylfenyl)-etyl/-IH-imidazol
EP1918282A1 (en) 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
GB2453982B (en) 2007-10-24 2009-09-16 Norbrook Lab Ltd Chemical process for the preparation of Medetomidine
US7902247B2 (en) * 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
WO2012172120A2 (en) 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
SG11201405611SA (en) 2012-05-08 2014-11-27 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
EP2847173B1 (en) * 2012-05-08 2015-12-30 Lonza Ltd Method for preparation of medetomidine
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
JP5777841B2 (ja) 2012-06-28 2015-09-09 ロンザ・リミテッド クロロアセトンを用いてメデトミジンを調製するための方法
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
CA2866441C (en) 2012-06-28 2017-01-17 Lonza Ltd. Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
WO2012172122A2 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal

Also Published As

Publication number Publication date
HRP20160215T1 (hr) 2016-03-25
CA2866424A1 (en) 2013-01-24
WO2013011155A3 (en) 2013-04-04
US20150057453A1 (en) 2015-02-26
JP5779297B2 (ja) 2015-09-16
CN104245679A (zh) 2014-12-24
TWI529164B (zh) 2016-04-11
HK1201532A1 (zh) 2015-09-04
CN104245679B (zh) 2016-03-02
PL2847173T3 (pl) 2016-06-30
TW201408648A (zh) 2014-03-01
AU2012285675B2 (en) 2016-03-03
CL2014002905A1 (es) 2014-12-12
JP2015517472A (ja) 2015-06-22
IN2014DN07983A (el) 2015-05-01
KR20140136523A (ko) 2014-11-28
HUE027384T2 (en) 2016-10-28
WO2013011155A2 (en) 2013-01-24
EA025950B1 (ru) 2017-02-28
US9045433B2 (en) 2015-06-02
KR101530506B1 (ko) 2015-06-19
EP2847173B1 (en) 2015-12-30
EP2847173A2 (en) 2015-03-18
NZ700640A (en) 2016-03-31
ES2563816T3 (es) 2016-03-16
DK2847173T3 (en) 2016-04-04
SG11201405606RA (en) 2014-11-27
AU2012285675A1 (en) 2014-10-16
EA201400940A1 (ru) 2015-01-30
MY166058A (en) 2018-05-22

Similar Documents

Publication Publication Date Title
CY1122398T1 (el) Συνδυαστικες θεραπειες με αντισωματα anti-cd38
CY1121862T1 (el) Αντισωματα anti-phf-tau και χρησεις αυτων
CY1117490T1 (el) Μεθοδος παραγωγης της μεδετομιδινης
PH12016501763A1 (en) Multispecific antibodies
TR201909606T4 (tr) Pi̇razollari hazirlamak i̇çi̇n i̇şlem
BR112016016020A2 (pt) anticorpos dirigidos contra interleucina-33 (il-33)
BR112016029333A2 (pt) síntese de compostos de carbamoilpiridona policíclico
IT201600117287A1 (it) Metodo di trasfezione transiente per produzione retrovirale.
CY1120759T1 (el) Παρασκευη διγλυκοζιτη (s,s)-σεκοϊσολαρικιρεσινολης και διγλυκοζιτη (r,r)-σεκοϊσολαρικιρεσινολης
CY1117492T1 (el) Μεθοδος για την παρασκευη μεδετομιδινης με χλωροακετονη
WO2014145897A3 (en) Immunotherapy system and method thereof
BR112017023854A2 (pt) estator.
CY1117404T1 (el) Μεθοδος παρασκευης 2-(2,3-διμεθυλφαινυλ)-1-προπαναλης
TR201902611T4 (tr) Sentetik pentapeptit üretme metodu.
TR201906000T4 (tr) Kompozit materyallerin üretimi için metot.
BR112017002139A2 (pt) ?método para preparar um composto?
MX2023009431A (es) Metodo para crear un compuesto a base de mercurio, compuesto a base de mercurio, metodos de uso del compuesto a base de mercurio y usos del compuesto a base de mercurio.
EA201692246A1 (ru) Способ получения 2,6-диметилбензохинона
MX2016005146A (es) Metodo para producir halocetonas.
EA201500764A1 (ru) Способ получения 2-алкил-3-бутин-2-олов
EA201491679A1 (ru) Способ получения полупродуктов производства фенибута
CY1123685T1 (el) Μεθοδος πεγκυλιωσης
ITUB20153925A1 (it) Metodo per produrre porzioni discrete autoadesive.
TN2014000384A1 (fr) نظام صوتي ذكي وآمن
UA103911U (ru) Средство с вазодилатирующей активностью