CY1117260T1 - Δοκιμασια συλληψης -επανω σε- αποκομμα διαμορφωσης χρωμοσωματων (chromosome conformation capture-on-chip) (4c) - Google Patents

Δοκιμασια συλληψης -επανω σε- αποκομμα διαμορφωσης χρωμοσωματων (chromosome conformation capture-on-chip) (4c)

Info

Publication number
CY1117260T1
CY1117260T1 CY20151101142T CY151101142T CY1117260T1 CY 1117260 T1 CY1117260 T1 CY 1117260T1 CY 20151101142 T CY20151101142 T CY 20151101142T CY 151101142 T CY151101142 T CY 151101142T CY 1117260 T1 CY1117260 T1 CY 1117260T1
Authority
CY
Cyprus
Prior art keywords
nucleotide sequences
test
sequences
nucleotide
interest
Prior art date
Application number
CY20151101142T
Other languages
English (en)
Inventor
Frank Grosveld
Laat Wouter De
Original Assignee
Erasmus University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0513676.7A external-priority patent/GB0513676D0/en
Priority claimed from GBGB0605449.8A external-priority patent/GB0605449D0/en
Application filed by Erasmus University Medical Center filed Critical Erasmus University Medical Center
Publication of CY1117260T1 publication Critical patent/CY1117260T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/101—Crosslinking agents, e.g. psoralen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/501—Detection characterised by immobilisation to a surface being an array of oligonucleotides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε μια άποψη μια μέθοδο για ανάλυση της συχνότητας αλληλεπίδρασης μιας αλληλουχίας νουκλεοτιδίων στόχου με μια ή περισσότερες αλληλουχίες νουκλεοτιδίων που ενδιαφέρουν (π.χ. έναν ή περισσότερους γονιδιωματικούς τόπους) η οποία περιλαμβάνει τα στάδια: (α) παροχής ενός δείγματος διασταυρούμενα συνδεδεμένου DNA, (β) πέψης του διασταυρούμενα συνδεδεμένου DNA με ένα πρωτογενές ένζυμο περιορισμού, (γ) σύνδεσης των διασταυρούμενα συνδεδεμένων αλληλουχιών νουκλεοτιδίων, (δ) αντιστροφής της διασταυρούμενης σύνδεσης, (ε) πέψης των αλληλουχιών νουκλεοτιδίων με ένα δευτερογενές ένζυμο περιορισμού, (στ) σύνδεσης μιας ή περισσότερων αλληλουχιών DNA γνωστής νουκλεοτιδικής σύνθεσης στη διαθέσιμη τοποθεσία(-ες) δευτερογενούς ενζύμου περιορισμού που είναι παρακείμενες στη μια ή περισσότερες αλληλουχίες νουκλεοτιδίων που ενδιαφέρουν, (ζ) ενίσχυσης της μιας ή περισσότερων αλληλουχιών νουκλεοτιδίων που ενδιαφέρουν χρησιμοποιώντας τουλάχιστον δυο ολιγονουκλεοτιδικούς˙ εκκινητές, όπου κάθε εκκινητής υβριδίζεται προς τις αλληλουχίες DNA οι οποίες είναι παρακείμενες στις αλληλουχίες νουκλεοτιδίων που ενδιαφέρουν, (η) υβριδισμού της ενισχυμένης αλληλουχίας(ών) προς μια συστοιχία, και (θ) προσδιορισμού της συχνότητας αλληλεπίδρασης μεταξύ των αλληλουχιών DNA.
CY20151101142T 2005-07-04 2015-12-15 Δοκιμασια συλληψης -επανω σε- αποκομμα διαμορφωσης χρωμοσωματων (chromosome conformation capture-on-chip) (4c) CY1117260T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0513676.7A GB0513676D0 (en) 2005-07-04 2005-07-04 4c
GBGB0605449.8A GB0605449D0 (en) 2006-03-17 2006-03-17 4c
EP06795293.7A EP1899488B1 (en) 2005-07-04 2006-07-03 Chromosome conformation capture-on-chip (4c) assay

Publications (1)

Publication Number Publication Date
CY1117260T1 true CY1117260T1 (el) 2017-04-26

Family

ID=37604842

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151101142T CY1117260T1 (el) 2005-07-04 2015-12-15 Δοκιμασια συλληψης -επανω σε- αποκομμα διαμορφωσης χρωμοσωματων (chromosome conformation capture-on-chip) (4c)

Country Status (18)

Country Link
US (2) US20070231817A1 (el)
EP (1) EP1899488B1 (el)
JP (1) JP5416405B2 (el)
KR (1) KR101383593B1 (el)
AU (1) AU2006264564B2 (el)
BR (1) BRPI0611702B1 (el)
CA (1) CA2614118C (el)
CY (1) CY1117260T1 (el)
DK (1) DK1899488T3 (el)
ES (1) ES2556113T3 (el)
HU (1) HUE026922T2 (el)
IL (1) IL187919A (el)
NO (1) NO20076430L (el)
NZ (1) NZ564262A (el)
PL (1) PL1899488T3 (el)
RU (1) RU2478716C2 (el)
SI (1) SI1899488T1 (el)
WO (1) WO2007004057A2 (el)

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Publication number Priority date Publication date Assignee Title
GB0603251D0 (en) 2006-02-17 2006-03-29 Isis Innovation DNA conformation
US8071296B2 (en) 2006-03-13 2011-12-06 Agency For Science, Technology And Research Nucleic acid interaction analysis
BRPI0806565A2 (pt) 2007-01-11 2014-05-06 Erasmus University Medical Center Captura de conformação de cromossomo circular
US8263367B2 (en) 2008-01-25 2012-09-11 Agency For Science, Technology And Research Nucleic acid interaction analysis
WO2010036323A1 (en) 2008-09-25 2010-04-01 University Of Massachusetts Medical School Method of identifing interactions between genomic loci
KR101862756B1 (ko) * 2010-07-09 2018-05-30 세르겐티스 비.브이. 관심있는 3-d 게놈 영역 서열화 전략
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
WO2014121091A1 (en) 2013-02-01 2014-08-07 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
GB2517936B (en) * 2013-09-05 2016-10-19 Babraham Inst Chromosome conformation capture method including selection and enrichment steps
GB201320351D0 (en) * 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
GB2520763A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Nucleic acid probe and method of detecting genomic fragments
GB2520765A (en) * 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
US11091758B2 (en) 2013-12-11 2021-08-17 The Regents Of The University Of California Methods for labeling DNAa fragments to reconstruct physical linkage and phase
CA2956925C (en) 2014-08-01 2024-02-13 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
EP3031929A1 (en) * 2014-12-11 2016-06-15 Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch Genome architecture mapping
WO2016134034A1 (en) 2015-02-17 2016-08-25 Dovetail Genomics Llc Nucleic acid sequence assembly
US11807896B2 (en) 2015-03-26 2023-11-07 Dovetail Genomics, Llc Physical linkage preservation in DNA storage
JP2018518203A (ja) 2015-06-24 2018-07-12 オックスフォード バイオダイナミックス リミテッド エピジェネティックな染色体相互作用
AU2016341198B2 (en) 2015-10-19 2023-03-09 Dovetail Genomics, Llc Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection
WO2017066907A1 (zh) * 2015-10-19 2017-04-27 安诺优达基因科技(北京)有限公司 一种构建高可利用数据率的Hi-C文库的方法
US10975417B2 (en) 2016-02-23 2021-04-13 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
GB201608000D0 (en) * 2016-05-06 2016-06-22 Oxford Biodynamics Ltd Chromosome detection
JP7497976B2 (ja) 2016-05-13 2024-06-11 ダブテイル ゲノミクス エルエルシー 保存されたサンプルからの長距離連鎖情報の回復
KR102481242B1 (ko) * 2016-12-01 2022-12-23 옥스포드 바이오다이나믹스 피엘씨 암 진단에서 후생적 염색체 상호 작용의 적용
CA3047888A1 (en) * 2016-12-23 2018-06-28 Oxford Biodynamics Limited Method for typing epigenetic chromosome interactions
EP3692168A1 (en) * 2017-10-02 2020-08-12 Oxford Biodynamics Limited Biomarker
USD877547S1 (en) 2018-07-09 2020-03-10 Apple Inc. Retail fixture
GB202111195D0 (en) 2021-08-03 2021-09-15 Cergentis B V Method for targeted sequencing
GB202111194D0 (en) 2021-08-03 2021-09-15 Cergentis B V Method

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* Cited by examiner, † Cited by third party
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CA2481312A1 (en) * 2002-03-08 2003-09-18 The Babraham Institute Tagging and recovery of elements associated with target molecules
BRPI0806565A2 (pt) * 2007-01-11 2014-05-06 Erasmus University Medical Center Captura de conformação de cromossomo circular

Also Published As

Publication number Publication date
NZ564262A (en) 2010-02-26
CA2614118A1 (en) 2007-01-11
EP1899488B1 (en) 2015-09-16
KR20080016953A (ko) 2008-02-22
PL1899488T3 (pl) 2016-03-31
DK1899488T3 (en) 2015-12-21
JP2009500031A (ja) 2009-01-08
SI1899488T1 (sl) 2016-05-31
NO20076430L (no) 2008-04-03
BRPI0611702B1 (pt) 2015-05-19
US20070231817A1 (en) 2007-10-04
CA2614118C (en) 2013-11-26
US20100075861A1 (en) 2010-03-25
IL187919A (en) 2012-10-31
BRPI0611702A2 (pt) 2010-09-28
AU2006264564B2 (en) 2012-04-19
RU2478716C2 (ru) 2013-04-10
ES2556113T3 (es) 2016-01-13
KR101383593B1 (ko) 2014-04-09
RU2008104024A (ru) 2009-08-10
WO2007004057A3 (en) 2007-05-18
WO2007004057A2 (en) 2007-01-11
JP5416405B2 (ja) 2014-02-12
IL187919A0 (en) 2008-03-20
AU2006264564A1 (en) 2007-01-11
EP1899488A2 (en) 2008-03-19
US8153373B2 (en) 2012-04-10
HUE026922T2 (en) 2016-07-28

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