CY1116659T1 - Αλας βενζοϊκου οξεος της οταμιξαβανης - Google Patents
Αλας βενζοϊκου οξεος της οταμιξαβανηςInfo
- Publication number
- CY1116659T1 CY1116659T1 CY20151100521T CY151100521T CY1116659T1 CY 1116659 T1 CY1116659 T1 CY 1116659T1 CY 20151100521 T CY20151100521 T CY 20151100521T CY 151100521 T CY151100521 T CY 151100521T CY 1116659 T1 CY1116659 T1 CY 1116659T1
- Authority
- CY
- Cyprus
- Prior art keywords
- benzoic acid
- amino
- methyl
- salamo
- ottamixavan
- Prior art date
Links
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 2
- 239000005711 Benzoic acid Substances 0.000 title 1
- 235000010233 benzoic acid Nutrition 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- -1 methyl (2R, 3R) -2- {3- [amino (imino) methyl] benzyl} -3 - {[4- (1-oxidopyridin-4-yl) benzoyl] amino} butanoic acid benzoic acid salt Chemical compound 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305348 | 2011-03-29 | ||
| US201161500342P | 2011-06-23 | 2011-06-23 | |
| EP12711858.6A EP2691371B1 (en) | 2011-03-29 | 2012-03-27 | Benzoic acid salt of otamixaban |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116659T1 true CY1116659T1 (el) | 2017-03-15 |
Family
ID=44065390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100521T CY1116659T1 (el) | 2011-03-29 | 2015-06-17 | Αλας βενζοϊκου οξεος της οταμιξαβανης |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8993602B2 (enExample) |
| EP (1) | EP2691371B1 (enExample) |
| JP (1) | JP5959617B2 (enExample) |
| KR (1) | KR101852226B1 (enExample) |
| CN (1) | CN103562183B (enExample) |
| AU (1) | AU2012234325B2 (enExample) |
| BR (1) | BR112013025105A2 (enExample) |
| CA (1) | CA2830965C (enExample) |
| CY (1) | CY1116659T1 (enExample) |
| DK (1) | DK2691371T3 (enExample) |
| ES (1) | ES2539236T3 (enExample) |
| HR (1) | HRP20150613T1 (enExample) |
| IL (1) | IL228574A (enExample) |
| MX (1) | MX2013011266A (enExample) |
| MY (1) | MY161396A (enExample) |
| PL (1) | PL2691371T3 (enExample) |
| PT (1) | PT2691371E (enExample) |
| RU (1) | RU2597423C2 (enExample) |
| SG (1) | SG193612A1 (enExample) |
| SI (1) | SI2691371T1 (enExample) |
| WO (1) | WO2012130821A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG193932A1 (en) | 2011-03-29 | 2013-11-29 | Sanofi Sa | Otamixaban formulations with improved stability |
| CN106565698B (zh) * | 2016-08-15 | 2019-03-08 | 南京帕隆材料科技有限公司 | 取代噻唑类衍生物及其制备方法和用途 |
| CN106518859B (zh) * | 2016-08-15 | 2019-01-18 | 南京帕隆材料科技有限公司 | 噻唑类衍生物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424334A (en) | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
| US6080767A (en) * | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| IL125163A0 (en) * | 1996-01-02 | 1999-01-26 | Rhone Poulenc Rorer Pharma | Substituted n-[(aminoiminomethyl or aminomethyl) phenyl] propyl amides |
| GB0108903D0 (en) * | 2000-10-05 | 2001-05-30 | Aventis Pharm Prod Inc | Novel crystalline forms of a factor Xa inhibitor |
| KR101509829B1 (ko) * | 2007-05-02 | 2015-04-06 | 포톨라 파마슈티컬스, 인코포레이티드 | 혈소판 ａｄｐ 수용체 억제제로 작용하는 화합물을 이용한 병용요법 |
| BR112012001900A2 (pt) * | 2009-07-29 | 2016-03-15 | Sanofi Sa | otamixabano para tratamento de pacientes idosos com insuficiência renal e infarto do miocárdio sem elevação do st |
-
2012
- 2012-03-27 RU RU2013148005/04A patent/RU2597423C2/ru not_active IP Right Cessation
- 2012-03-27 JP JP2014501569A patent/JP5959617B2/ja active Active
- 2012-03-27 CN CN201280026534.0A patent/CN103562183B/zh active Active
- 2012-03-27 US US14/008,332 patent/US8993602B2/en active Active
- 2012-03-27 MY MYPI2013003459A patent/MY161396A/en unknown
- 2012-03-27 PT PT127118586T patent/PT2691371E/pt unknown
- 2012-03-27 CA CA2830965A patent/CA2830965C/en not_active Expired - Fee Related
- 2012-03-27 SI SI201230219T patent/SI2691371T1/sl unknown
- 2012-03-27 MX MX2013011266A patent/MX2013011266A/es active IP Right Grant
- 2012-03-27 SG SG2013071766A patent/SG193612A1/en unknown
- 2012-03-27 PL PL12711858T patent/PL2691371T3/pl unknown
- 2012-03-27 WO PCT/EP2012/055364 patent/WO2012130821A1/en not_active Ceased
- 2012-03-27 BR BR112013025105A patent/BR112013025105A2/pt not_active Application Discontinuation
- 2012-03-27 AU AU2012234325A patent/AU2012234325B2/en not_active Ceased
- 2012-03-27 KR KR1020137028416A patent/KR101852226B1/ko not_active Expired - Fee Related
- 2012-03-27 DK DK12711858.6T patent/DK2691371T3/da active
- 2012-03-27 ES ES12711858.6T patent/ES2539236T3/es active Active
- 2012-03-27 HR HRP20150613TT patent/HRP20150613T1/hr unknown
- 2012-03-27 EP EP12711858.6A patent/EP2691371B1/en active Active
-
2013
- 2013-09-29 IL IL228574A patent/IL228574A/en active IP Right Grant
-
2015
- 2015-06-17 CY CY20151100521T patent/CY1116659T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG193612A1 (en) | 2013-11-29 |
| PT2691371E (pt) | 2015-07-20 |
| US20140024684A1 (en) | 2014-01-23 |
| KR101852226B1 (ko) | 2018-04-25 |
| ES2539236T3 (es) | 2015-06-29 |
| MX2013011266A (es) | 2014-03-27 |
| MY161396A (en) | 2017-04-14 |
| EP2691371B1 (en) | 2015-03-18 |
| CN103562183A (zh) | 2014-02-05 |
| RU2013148005A (ru) | 2015-05-10 |
| HRP20150613T1 (hr) | 2015-07-17 |
| IL228574A (en) | 2015-07-30 |
| BR112013025105A2 (pt) | 2017-06-06 |
| JP5959617B2 (ja) | 2016-08-02 |
| KR20140022851A (ko) | 2014-02-25 |
| CA2830965A1 (en) | 2012-10-04 |
| DK2691371T3 (da) | 2015-06-22 |
| SI2691371T1 (sl) | 2015-07-31 |
| HK1189584A1 (en) | 2014-06-13 |
| AU2012234325A1 (en) | 2013-10-17 |
| AU2012234325B2 (en) | 2016-08-11 |
| CN103562183B (zh) | 2015-12-23 |
| WO2012130821A1 (en) | 2012-10-04 |
| CA2830965C (en) | 2019-04-09 |
| PL2691371T3 (pl) | 2015-08-31 |
| IL228574A0 (en) | 2013-12-31 |
| EP2691371A1 (en) | 2014-02-05 |
| US8993602B2 (en) | 2015-03-31 |
| JP2014509622A (ja) | 2014-04-21 |
| RU2597423C2 (ru) | 2016-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1121815T1 (el) | Αναστολεις αργινασης και μεθοδοι χρησης | |
| CY1124000T1 (el) | Υποκατεστημενες 5-φθορο-1η-πυραζολοπυριδινες σε κρυσταλλικη μορφη | |
| CY1121150T1 (el) | Νευροδραστικα 19-αλκοξυ-17-υποκατεστημενα στεροειδη, χρησιμα σε μεθοδους θεραπειας | |
| CY1123852T1 (el) | Αλατα ή συγκρυσταλλοι της 3-(3-διμεθυλαμινο-1-αιθυλο-2-μεθυλο-προπυλο)-φαινολης | |
| CY1118156T1 (el) | Ενωσεις αντιστροφης αμιδης ως αναστολεις δεακετυλασης πρωτεϊνων και μεθοδοι χρησης αυτων | |
| CY1122498T1 (el) | Δευτεριωμενα παραγωγα ιβακαφτορης | |
| CY1121379T1 (el) | Πολυθεραπεια για την ισχαιμια | |
| CY1124874T1 (el) | Διεργασια για την παρασκευη [(5-(3-χλωροφαινυλ)-3-υδροξυπυριδινο-2-καρβονυλ)-αμινο]οξικου οξεος απο 5-((3-χλωροφαινυλ)-3-χλωρο-πυριδιν-2-υλ)-νιτριλιο, και διεργασια για την παρασκευη παραγωγων 5-((αλογονοφαινυλ)-3-αλογονο-πυριδιν-2-υλ)-νιτριλιου | |
| CY1121695T1 (el) | Ενωσεις και συνθεσεις ως αναστολεις κινασης c-kit | |
| CY1118416T1 (el) | Υποκατεστημενες 4-φαινυλο-πυριδινες για τη θεραπεια ασθενειων που σχετιζονται με τον νκ-1 υποδοχεα | |
| CY1123426T1 (el) | Μεθοδος για τη ληψη κρυσταλλων αλατος μεγλουμινης του 1-(5,6-διχλωρο-1η-βενζο[d]ιμιδαζολ-2-υλο)-1η-πυραζολο-4-καρβοξυλικου οξεος | |
| CY1117424T1 (el) | Βενζοδιαζεπινικος αναστολεας bromodomain | |
| CY1119533T1 (el) | Νεοι θεραπευτικοι παραγοντες | |
| CY1118726T1 (el) | Αναστολεις αντιγραφης ιων γριπης | |
| CY1118947T1 (el) | Ασυμμετρες ουριες και ιατρικες χρησεις αυτων | |
| CY1117078T1 (el) | Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων | |
| CY1118128T1 (el) | Αρυλ διϋδροπυριδινονες και πιπεριδiνονες ως αναστολεις του mgat2 | |
| EA201590330A1 (ru) | Соли и твердые формы (s)-3-(4-((4-(морфолинометил)бензил)окси)-1-оксоизоиндолин-2-ил)пиперидин-2,6-диона и включающие их композиции и способы их применения | |
| CY1118246T1 (el) | Αναστολεις αντιγραφης ιων γριπης | |
| ECSP11011157A (es) | Inhibidores de proteína cinasa | |
| CL2012002716A1 (es) | Uso de un compuesto inhibidores de dgat1 porque es útil en la prevención, demora del progreso o el tratamiento de una enfermedad o condición seleccionada a partir de quilomicronemia, síndrome de quilomicronemia familiar e hiperlipoproteinemia tipo v; un compuesto derivado de heteroarilo sustituido; composición farmacéutica. | |
| BR112014013872A2 (pt) | amidas dos ácidos n-(1,2,5-oxadiazol-3-il) -, n-(1,3,4-oxadiazol-2-il)-, n-(tetrazol - 5 - il) - e n - (triazol -5-il) - aril-carboxílico e sua utilização enquanto herbicidas | |
| CY1117962T1 (el) | Υδροχλωρικο αλας 4-[2-[[5-μεθυλο-1-(2- ναφθαλενυλο)-1η- πυραζολ-3-υλ]οξυ]αιθυλο] μορφολινης | |
| CY1116168T1 (el) | Συγκρυσταλλοι και αλατα αναστολεων toy ccr3 | |
| EP2725016A4 (en) | HETEROCYCLIC CARBOXYLIC ESTER DERIVATIVE |