AU2012234325B2 - Benzoic acid salt of Otamixaban - Google Patents
Benzoic acid salt of Otamixaban Download PDFInfo
- Publication number
- AU2012234325B2 AU2012234325B2 AU2012234325A AU2012234325A AU2012234325B2 AU 2012234325 B2 AU2012234325 B2 AU 2012234325B2 AU 2012234325 A AU2012234325 A AU 2012234325A AU 2012234325 A AU2012234325 A AU 2012234325A AU 2012234325 B2 AU2012234325 B2 AU 2012234325B2
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- amino
- benzoic acid
- acid salt
- oxidopyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305348 | 2011-03-29 | ||
| EP11305348.2 | 2011-03-29 | ||
| US201161500342P | 2011-06-23 | 2011-06-23 | |
| US61/500,342 | 2011-06-23 | ||
| PCT/EP2012/055364 WO2012130821A1 (en) | 2011-03-29 | 2012-03-27 | Benzoic acid salt of otamixaban |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012234325A1 AU2012234325A1 (en) | 2013-10-17 |
| AU2012234325B2 true AU2012234325B2 (en) | 2016-08-11 |
Family
ID=44065390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012234325A Ceased AU2012234325B2 (en) | 2011-03-29 | 2012-03-27 | Benzoic acid salt of Otamixaban |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8993602B2 (enExample) |
| EP (1) | EP2691371B1 (enExample) |
| JP (1) | JP5959617B2 (enExample) |
| KR (1) | KR101852226B1 (enExample) |
| CN (1) | CN103562183B (enExample) |
| AU (1) | AU2012234325B2 (enExample) |
| BR (1) | BR112013025105A2 (enExample) |
| CA (1) | CA2830965C (enExample) |
| CY (1) | CY1116659T1 (enExample) |
| DK (1) | DK2691371T3 (enExample) |
| ES (1) | ES2539236T3 (enExample) |
| HR (1) | HRP20150613T1 (enExample) |
| IL (1) | IL228574A (enExample) |
| MX (1) | MX2013011266A (enExample) |
| MY (1) | MY161396A (enExample) |
| PL (1) | PL2691371T3 (enExample) |
| PT (1) | PT2691371E (enExample) |
| RU (1) | RU2597423C2 (enExample) |
| SG (1) | SG193612A1 (enExample) |
| SI (1) | SI2691371T1 (enExample) |
| WO (1) | WO2012130821A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012234323A1 (en) | 2011-03-29 | 2013-10-17 | Sanofi | Otamixaban formulations with improved stability |
| CN106565698B (zh) * | 2016-08-15 | 2019-03-08 | 南京帕隆材料科技有限公司 | 取代噻唑类衍生物及其制备方法和用途 |
| CN106518859B (zh) * | 2016-08-15 | 2019-01-18 | 南京帕隆材料科技有限公司 | 噻唑类衍生物及其制备方法和用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024118A1 (en) * | 1996-01-02 | 1997-07-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| US7034160B2 (en) * | 2000-10-05 | 2006-04-25 | Aventis Pharmaceuticals Inc. | Crystalline forms of a factor Xa inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424334A (en) | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
| US6080767A (en) * | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| EA020045B1 (ru) * | 2007-05-02 | 2014-08-29 | Портола Фармасьютиклз, Инк. | Комбинированная терапия соединением, проявляющим активность ингибитора рецептора адф на тромбоцитах |
| AU2010277725B2 (en) * | 2009-07-29 | 2016-08-18 | Sanofi | Otamixaban for treatment of elderly and renal impaired non-ST elevation myocardial infarction patients |
-
2012
- 2012-03-27 PT PT127118586T patent/PT2691371E/pt unknown
- 2012-03-27 SG SG2013071766A patent/SG193612A1/en unknown
- 2012-03-27 WO PCT/EP2012/055364 patent/WO2012130821A1/en not_active Ceased
- 2012-03-27 RU RU2013148005/04A patent/RU2597423C2/ru not_active IP Right Cessation
- 2012-03-27 MX MX2013011266A patent/MX2013011266A/es active IP Right Grant
- 2012-03-27 ES ES12711858.6T patent/ES2539236T3/es active Active
- 2012-03-27 EP EP12711858.6A patent/EP2691371B1/en active Active
- 2012-03-27 MY MYPI2013003459A patent/MY161396A/en unknown
- 2012-03-27 JP JP2014501569A patent/JP5959617B2/ja active Active
- 2012-03-27 BR BR112013025105A patent/BR112013025105A2/pt not_active Application Discontinuation
- 2012-03-27 KR KR1020137028416A patent/KR101852226B1/ko not_active Expired - Fee Related
- 2012-03-27 AU AU2012234325A patent/AU2012234325B2/en not_active Ceased
- 2012-03-27 US US14/008,332 patent/US8993602B2/en active Active
- 2012-03-27 HR HRP20150613TT patent/HRP20150613T1/hr unknown
- 2012-03-27 PL PL12711858T patent/PL2691371T3/pl unknown
- 2012-03-27 CN CN201280026534.0A patent/CN103562183B/zh active Active
- 2012-03-27 SI SI201230219T patent/SI2691371T1/sl unknown
- 2012-03-27 CA CA2830965A patent/CA2830965C/en not_active Expired - Fee Related
- 2012-03-27 DK DK12711858.6T patent/DK2691371T3/da active
-
2013
- 2013-09-29 IL IL228574A patent/IL228574A/en active IP Right Grant
-
2015
- 2015-06-17 CY CY20151100521T patent/CY1116659T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024118A1 (en) * | 1996-01-02 | 1997-07-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| US7034160B2 (en) * | 2000-10-05 | 2006-04-25 | Aventis Pharmaceuticals Inc. | Crystalline forms of a factor Xa inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013025105A2 (pt) | 2017-06-06 |
| CA2830965A1 (en) | 2012-10-04 |
| HK1189584A1 (en) | 2014-06-13 |
| CN103562183A (zh) | 2014-02-05 |
| SG193612A1 (en) | 2013-11-29 |
| SI2691371T1 (sl) | 2015-07-31 |
| WO2012130821A1 (en) | 2012-10-04 |
| CY1116659T1 (el) | 2017-03-15 |
| MX2013011266A (es) | 2014-03-27 |
| DK2691371T3 (da) | 2015-06-22 |
| CA2830965C (en) | 2019-04-09 |
| ES2539236T3 (es) | 2015-06-29 |
| EP2691371B1 (en) | 2015-03-18 |
| CN103562183B (zh) | 2015-12-23 |
| PT2691371E (pt) | 2015-07-20 |
| KR20140022851A (ko) | 2014-02-25 |
| EP2691371A1 (en) | 2014-02-05 |
| US8993602B2 (en) | 2015-03-31 |
| US20140024684A1 (en) | 2014-01-23 |
| MY161396A (en) | 2017-04-14 |
| RU2013148005A (ru) | 2015-05-10 |
| IL228574A0 (en) | 2013-12-31 |
| JP2014509622A (ja) | 2014-04-21 |
| RU2597423C2 (ru) | 2016-09-10 |
| HRP20150613T1 (hr) | 2015-07-17 |
| JP5959617B2 (ja) | 2016-08-02 |
| KR101852226B1 (ko) | 2018-04-25 |
| IL228574A (en) | 2015-07-30 |
| AU2012234325A1 (en) | 2013-10-17 |
| PL2691371T3 (pl) | 2015-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2010201538B2 (en) | Process for preparing atazanavir bisulfate and novel forms | |
| JP2019135258A (ja) | 第Ｘａ因子阻害剤の結晶形態 | |
| AU2012234325B2 (en) | Benzoic acid salt of Otamixaban | |
| JPWO2014034626A1 (ja) | Ｎ−［２−（｛２−［（２Ｓ）−２−シアノピロリジン−１−イル］−２−オキソエチル｝アミノ）−２−メチルプロピル］−２−メチルピラゾロ［１，５−ａ］ピリミジン−６−カルボキサミドの結晶 | |
| HK1189584B (en) | Benzoic acid salt of otamixaban | |
| CA3180417A1 (en) | Synthesis of (2s,5r)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid | |
| US9145385B2 (en) | Crystalline salts of R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexy1-1H-imidazol-4-yl)-propionic acid | |
| EP2782576B1 (en) | Sodium salt of (r)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1h-imidazol-4-yl)-propionic acid | |
| KR20130033242A (ko) | 클로피도그렐의 공결정 | |
| EP1674468A1 (en) | Polymorphs of clopidogrel hydrobromide | |
| TWI722466B (zh) | 氧代吡啶醯胺類衍生物的晶型及製備方法 | |
| WO2006036927A1 (en) | Crytalline forms of a pyrazolo `3, 4-c ! pyridine factor xa inhibitor | |
| JP2025533955A (ja) | （２ｓ，５ｒ）－５－（２－クロロフェニル）－１－（２’－メトキシ－［１，１’－ビフェニル］－４－カルボニル）ピロリジン－２－カルボン酸の多形およびその調製プロセス | |
| JP2021529201A (ja) | オキシピリジンアミド誘導体の結晶形およびその調製方法 | |
| KR20160042107A (ko) | 시스테인 프로테아제 억제제로서 유용한 n-[1-6-(에티닐-3-옥소-헥사하이드로-푸로[3,2-b]피롤-4-카르보닐)-3-메틸-부틸]-4-[5-플루오로-2-(4-메틸-피페라지닐)티아졸-4-일]-벤즈아미드의 염의 2형 결정질 다형체 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |