CY1115917T1 - Νεες κρυσταλλικες πολυμορφες κλοπιδογρελης - Google Patents
Νεες κρυσταλλικες πολυμορφες κλοπιδογρεληςInfo
- Publication number
- CY1115917T1 CY1115917T1 CY20151100024T CY151100024T CY1115917T1 CY 1115917 T1 CY1115917 T1 CY 1115917T1 CY 20151100024 T CY20151100024 T CY 20151100024T CY 151100024 T CY151100024 T CY 151100024T CY 1115917 T1 CY1115917 T1 CY 1115917T1
- Authority
- CY
- Cyprus
- Prior art keywords
- forms
- present
- clopidogrel
- relates
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Liquid Crystal Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η παρούσα εφεύρεση αφορά νέες κρυσταλλικές μορφές του αναστολέα συγκόλλησης αιμοπεταλίων (+)-(S)-μεθυλο-2-(2-χλωροφαινυλο)-(6,7-διϋδρο-4Η-θειενο[3,2-c]πυριδ-5-υλ)οξικό, κλοπιδογρέλη (1), σε μορφή αλάτων υδροβρωμίου, που προσδιορίζονται ως πολυμορφικές μορφές 1, 2 και 3. Η παρούσα εφεύρεση αφορά επιπλέον διαδικασίες παρασκευής τέτοιων μορφών, φαρμακευτικών συνθέσεων που περιλαμβάνουν τέτοιες μορφές, και χρήσης τέτοιων μορφών και συνθέσεων. Οι φαρμακευτικές συνθέσεις μπορούν να χρησιμοποιηθούν, συγκεκριμένα, για την αναστολή συγκόλλησης αιμοπεταλίων ή για τη θεραπεία, πρόληψη ή διαχείριση της θρόμβωσης, αθηροθρόμβωσης, αθηροθρομβωτικού επεισοδίου, ισχαιμικού εγκεφαλικού, εμφράγματος του μυοκαρδίου, εμφράγματος του μυοκαρδίου χωρίς κύμα Q, αθηροσκλήρωσης, περιφερικής αρτηριοπάθειας, ή ασταθούς στηθάγχης. Η παρούσα εφεύρεση αφορά επίσης μεθόδους θεραπευτικής αντιμετώπισης των προαναφερόμενων διαταραχών. Formula (1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0321256.0A GB0321256D0 (en) | 2003-09-11 | 2003-09-11 | Novel crystalline compounds |
EP06124851.4A EP1772456B1 (en) | 2003-09-11 | 2004-09-09 | Novel crystalline polymorphs of clopidogrel |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115917T1 true CY1115917T1 (el) | 2017-01-25 |
Family
ID=29226875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100024T CY1115917T1 (el) | 2003-09-11 | 2015-01-12 | Νεες κρυσταλλικες πολυμορφες κλοπιδογρελης |
Country Status (15)
Country | Link |
---|---|
US (1) | US7897613B2 (el) |
EP (4) | EP1618113B1 (el) |
AT (1) | ATE487725T1 (el) |
AU (1) | AU2004272337B2 (el) |
CA (3) | CA2536052C (el) |
CY (1) | CY1115917T1 (el) |
DE (1) | DE602004029999D1 (el) |
DK (2) | DK1618113T3 (el) |
ES (2) | ES2528198T3 (el) |
GB (1) | GB0321256D0 (el) |
HU (1) | HUE029256T2 (el) |
PL (2) | PL1837337T3 (el) |
PT (1) | PT1772456E (el) |
SI (1) | SI1772456T1 (el) |
WO (1) | WO2005026174A1 (el) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005068471A1 (en) * | 2004-01-13 | 2005-07-28 | Zentiva, A.S. | New crystalline forms of clopidogrel hydrobromide and methods of their preparation |
EP1756116A1 (en) * | 2004-04-20 | 2007-02-28 | Sanofi-Aventis | Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide |
EA010829B1 (ru) | 2004-04-20 | 2008-12-30 | Санофи-Авентис | Клопидогрель и его полиморфные формы |
WO2006018853A2 (en) | 2004-08-19 | 2006-02-23 | Hetero Drugs Limited | Novel polymorphs of efavirenz |
EP1704152A2 (en) | 2004-09-21 | 2006-09-27 | Teva Pharmaceutical Industries Ltd | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
EP1674468A1 (en) * | 2004-12-21 | 2006-06-28 | Ratiopharm GmbH | Polymorphs of clopidogrel hydrobromide |
EP1942110A4 (en) * | 2005-09-08 | 2010-08-04 | Zhejiang Huahai Pharm Co Ltd | PREPARATION OF CLOPIDOGREL AND ITS ANALOG METHYLTETRAHYDROTHIENOPYRIDINE ACETATE COMPOUNDS |
CN100417653C (zh) * | 2005-09-08 | 2008-09-10 | 浙江华海药业股份有限公司 | 噻吩并四氢吡啶乙酸及其盐的制备方法 |
MX2008012935A (es) | 2006-04-05 | 2008-10-15 | Schering Corp | Sales de clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etox i}-metil]-8-fenil-1,7-diaza-spiro[4,5]decan-2-ona y su procedmiento de preparacion. |
ITMI20062449A1 (it) * | 2006-12-19 | 2008-06-20 | Dipharma Spa | Forma cristallina di rabeprazolo sodico |
WO2008081473A2 (en) * | 2006-12-29 | 2008-07-10 | Cadila Healthcare Limited | Process for preparing clopidogrel |
EP1970054A3 (en) | 2007-03-14 | 2009-06-03 | Ranbaxy Laboratories Limited | Clopidogrel tablets |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
KR101834577B1 (ko) * | 2009-08-14 | 2018-03-05 | 옵코 헬스, 인크. | 뉴로키닌-1 길항제의 정맥내 제형 |
WO2012123958A1 (en) | 2011-02-14 | 2012-09-20 | Cadila Healthcare Limited | Highly pure salts of clopidogrel free of genotoxic impurities |
US9233103B2 (en) | 2011-03-25 | 2016-01-12 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for treating heartburn, gastric bleeding or hemorrhage in patients receiving clopidogrel therapy |
TWI461215B (zh) * | 2011-06-24 | 2014-11-21 | Acenda Pharma Inc | 用以改善酯類前驅藥吸收率的方法與改良之藥學組合物 |
US20140121178A1 (en) * | 2011-06-24 | 2014-05-01 | Acenda Pharma Inc. | Method and improved pharmaceutical composition for improving the absorption of an ester prodrug |
ES2791417T3 (es) * | 2013-02-06 | 2020-11-04 | Jingjun Huang | Composición farmacéutica estable de base libre de clopidogrel para administración oral y parenteral |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2530247B1 (fr) | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
FR2623810B2 (fr) | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2652575B1 (fr) | 1989-09-29 | 1992-01-24 | Sanofi Sa | Procede de preparation d'acides alpha-bromo phenylacetiques. |
FR2664596B1 (fr) | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
HU225504B1 (en) | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them |
HU222283B1 (hu) | 1997-05-13 | 2003-05-28 | Sanofi-Synthelabo | Eljárás tieno[3,2-c]piridin-származékok előállítására |
HU225503B1 (en) | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them |
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
HUP0200438A3 (en) * | 2002-02-06 | 2003-10-28 | Egis Gyogyszergyar Nyilvanosan | Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them |
WO2005068471A1 (en) | 2004-01-13 | 2005-07-28 | Zentiva, A.S. | New crystalline forms of clopidogrel hydrobromide and methods of their preparation |
EP1756116A1 (en) | 2004-04-20 | 2007-02-28 | Sanofi-Aventis | Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide |
-
2003
- 2003-09-11 GB GBGB0321256.0A patent/GB0321256D0/en not_active Ceased
-
2004
- 2004-09-09 EP EP04768414A patent/EP1618113B1/en not_active Not-in-force
- 2004-09-09 US US10/571,419 patent/US7897613B2/en not_active Expired - Fee Related
- 2004-09-09 CA CA2536052A patent/CA2536052C/en not_active Expired - Fee Related
- 2004-09-09 EP EP09159491A patent/EP2149578A1/en not_active Withdrawn
- 2004-09-09 CA CA2809750A patent/CA2809750A1/en not_active Abandoned
- 2004-09-09 DE DE602004029999T patent/DE602004029999D1/de active Active
- 2004-09-09 AU AU2004272337A patent/AU2004272337B2/en not_active Ceased
- 2004-09-09 PT PT61248514T patent/PT1772456E/pt unknown
- 2004-09-09 EP EP06124851.4A patent/EP1772456B1/en active Active
- 2004-09-09 SI SI200432211T patent/SI1772456T1/sl unknown
- 2004-09-09 PL PL06124847T patent/PL1837337T3/pl unknown
- 2004-09-09 DK DK04768414.7T patent/DK1618113T3/da active
- 2004-09-09 HU HUE06124847A patent/HUE029256T2/en unknown
- 2004-09-09 EP EP06124847.2A patent/EP1837337B1/en not_active Not-in-force
- 2004-09-09 ES ES06124851.4T patent/ES2528198T3/es active Active
- 2004-09-09 CA CA2810312A patent/CA2810312A1/en not_active Abandoned
- 2004-09-09 PL PL06124851T patent/PL1772456T3/pl unknown
- 2004-09-09 AT AT04768414T patent/ATE487725T1/de active
- 2004-09-09 WO PCT/GB2004/003867 patent/WO2005026174A1/en active Application Filing
- 2004-09-09 DK DK06124851.4T patent/DK1772456T3/en active
- 2004-09-09 ES ES04768414T patent/ES2355729T3/es active Active
-
2015
- 2015-01-12 CY CY20151100024T patent/CY1115917T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2536052A1 (en) | 2005-03-24 |
HUE029256T2 (en) | 2017-02-28 |
US7897613B2 (en) | 2011-03-01 |
EP1618113B1 (en) | 2010-11-10 |
AU2004272337A1 (en) | 2005-03-24 |
ES2355729T3 (es) | 2011-03-30 |
EP1772456B1 (en) | 2014-10-29 |
PL1772456T3 (pl) | 2015-03-31 |
EP1837337B1 (en) | 2016-04-06 |
DK1772456T3 (en) | 2015-01-19 |
DK1618113T3 (da) | 2011-02-07 |
US20070281964A1 (en) | 2007-12-06 |
CA2809750A1 (en) | 2005-03-24 |
ATE487725T1 (de) | 2010-11-15 |
EP1618113A1 (en) | 2006-01-25 |
WO2005026174A1 (en) | 2005-03-24 |
GB0321256D0 (en) | 2003-10-08 |
DE602004029999D1 (de) | 2010-12-23 |
EP2149578A1 (en) | 2010-02-03 |
PL1837337T3 (pl) | 2017-02-28 |
CA2810312A1 (en) | 2005-03-24 |
ES2528198T3 (es) | 2015-02-05 |
CA2536052C (en) | 2013-06-25 |
AU2004272337B2 (en) | 2008-02-14 |
EP1837337A1 (en) | 2007-09-26 |
PT1772456E (pt) | 2015-02-06 |
EP1772456A1 (en) | 2007-04-11 |
SI1772456T1 (sl) | 2015-03-31 |
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