ES2528198T3 - Nuevos polimorfos cristalinos de clopidogrel - Google Patents

Nuevos polimorfos cristalinos de clopidogrel Download PDF

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Publication number
ES2528198T3
ES2528198T3 ES06124851.4T ES06124851T ES2528198T3 ES 2528198 T3 ES2528198 T3 ES 2528198T3 ES 06124851 T ES06124851 T ES 06124851T ES 2528198 T3 ES2528198 T3 ES 2528198T3
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ES
Spain
Prior art keywords
forms
present
clopidogrel
relates
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES06124851.4T
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English (en)
Inventor
Ramakrishnan Arul
Ajay Singh Rawat
Maheshkumar Gadakar
Rajesh Rao
Abhinay Pise
Jason Gray
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Generics UK Ltd
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Generics UK Ltd
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29226875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2528198(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Generics UK Ltd filed Critical Generics UK Ltd
Application granted granted Critical
Publication of ES2528198T3 publication Critical patent/ES2528198T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un proceso para preparación de anhidrato de hidrobromuro de clopidogrel, que comprende el paso de recristalizar hidrobromuro de clopidogrel a partir de una mezcla de metanol o etanol con agua.

Description

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Claims (1)

  1. imagen1
ES06124851.4T 2003-09-11 2004-09-09 Nuevos polimorfos cristalinos de clopidogrel Expired - Lifetime ES2528198T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0321256 2003-09-11
GBGB0321256.0A GB0321256D0 (en) 2003-09-11 2003-09-11 Novel crystalline compounds

Publications (1)

Publication Number Publication Date
ES2528198T3 true ES2528198T3 (es) 2015-02-05

Family

ID=29226875

Family Applications (2)

Application Number Title Priority Date Filing Date
ES04768414T Expired - Lifetime ES2355729T3 (es) 2003-09-11 2004-09-09 Nuevos polimorfos cristalinos del clopidogrel.
ES06124851.4T Expired - Lifetime ES2528198T3 (es) 2003-09-11 2004-09-09 Nuevos polimorfos cristalinos de clopidogrel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES04768414T Expired - Lifetime ES2355729T3 (es) 2003-09-11 2004-09-09 Nuevos polimorfos cristalinos del clopidogrel.

Country Status (15)

Country Link
US (1) US7897613B2 (es)
EP (4) EP1618113B1 (es)
AT (1) ATE487725T1 (es)
AU (1) AU2004272337B2 (es)
CA (3) CA2536052C (es)
CY (1) CY1115917T1 (es)
DE (1) DE602004029999D1 (es)
DK (2) DK1772456T3 (es)
ES (2) ES2355729T3 (es)
GB (1) GB0321256D0 (es)
HU (1) HUE029256T2 (es)
PL (2) PL1837337T3 (es)
PT (1) PT1772456E (es)
SI (1) SI1772456T1 (es)
WO (1) WO2005026174A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068471A1 (en) * 2004-01-13 2005-07-28 Zentiva, A.S. New crystalline forms of clopidogrel hydrobromide and methods of their preparation
ZA200608569B (en) * 2004-04-20 2007-12-27 Sanofi Aventis Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
ZA200608035B (en) 2004-04-20 2008-07-30 Sanofi Aventis Clopidogrel salt and polymorphic forms thereof
WO2006018853A2 (en) 2004-08-19 2006-02-23 Hetero Drugs Limited Novel polymorphs of efavirenz
US20060154957A1 (en) 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide
CN100417653C (zh) * 2005-09-08 2008-09-10 浙江华海药业股份有限公司 噻吩并四氢吡啶乙酸及其盐的制备方法
WO2007028337A1 (en) * 2005-09-08 2007-03-15 Zhejiang Huahai Pharmaceutical Co., Ltd. Preparation of clopidogrel and its analogues methyl tetrahydrothienopyridine acetate compounds
HUE028908T2 (en) * 2006-04-05 2017-01-30 Opko Health Inc The hydrochloride salt of 8 - [{1- (3,5-bis (trifluoromethyl) phenyl) ethoxy} methyl] -8-phenyl-1,7-diazaspiro [4.5] decan-2-one, and process
ITMI20062449A1 (it) * 2006-12-19 2008-06-20 Dipharma Spa Forma cristallina di rabeprazolo sodico
WO2008081473A2 (en) * 2006-12-29 2008-07-10 Cadila Healthcare Limited Process for preparing clopidogrel
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
SG10201407538WA (en) * 2009-08-14 2015-01-29 Opko Health Inc Intravenous formulations of neurokinin-1 antagonists
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
US9233103B2 (en) 2011-03-25 2016-01-12 Takeda Pharmaceuticals U.S.A., Inc. Methods for treating heartburn, gastric bleeding or hemorrhage in patients receiving clopidogrel therapy
TWI461215B (zh) * 2011-06-24 2014-11-21 Acenda Pharma Inc 用以改善酯類前驅藥吸收率的方法與改良之藥學組合物
CA2844367C (en) * 2011-06-24 2016-02-16 Acenda Pharma, Inc. Method and improved pharmaceutical composition for improving the absorption of an ester prodrug
BR112015018144B1 (pt) * 2013-02-06 2021-03-09 Jingjun Huang composição de emulsão água/óleo farmacêutica estável com gotículas de óleo manométricas, método para fazer a mesma e alta dose única de clopidogrel usada para tratar um paciente

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
HU225504B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
HU222283B1 (hu) 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225503B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
WO2005068471A1 (en) 2004-01-13 2005-07-28 Zentiva, A.S. New crystalline forms of clopidogrel hydrobromide and methods of their preparation
ZA200608569B (en) 2004-04-20 2007-12-27 Sanofi Aventis Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide

Also Published As

Publication number Publication date
GB0321256D0 (en) 2003-10-08
SI1772456T1 (sl) 2015-03-31
US7897613B2 (en) 2011-03-01
US20070281964A1 (en) 2007-12-06
ATE487725T1 (de) 2010-11-15
DE602004029999D1 (de) 2010-12-23
DK1772456T3 (en) 2015-01-19
EP1618113B1 (en) 2010-11-10
EP1837337B1 (en) 2016-04-06
AU2004272337A1 (en) 2005-03-24
CA2810312A1 (en) 2005-03-24
PL1772456T3 (pl) 2015-03-31
CA2536052A1 (en) 2005-03-24
CY1115917T1 (el) 2017-01-25
ES2355729T3 (es) 2011-03-30
CA2809750A1 (en) 2005-03-24
DK1618113T3 (da) 2011-02-07
EP1618113A1 (en) 2006-01-25
PT1772456E (pt) 2015-02-06
EP1772456B1 (en) 2014-10-29
WO2005026174A1 (en) 2005-03-24
HUE029256T2 (en) 2017-02-28
CA2536052C (en) 2013-06-25
AU2004272337B2 (en) 2008-02-14
EP2149578A1 (en) 2010-02-03
EP1772456A1 (en) 2007-04-11
PL1837337T3 (pl) 2017-02-28
EP1837337A1 (en) 2007-09-26

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