CY1115209T1 - Αποδοτικη διαδικασια για προκληση εναντιοεκλεκτικοτητας στις ενωσεις προκαρβονυλιου - Google Patents

Αποδοτικη διαδικασια για προκληση εναντιοεκλεκτικοτητας στις ενωσεις προκαρβονυλιου

Info

Publication number
CY1115209T1
CY1115209T1 CY20141100196T CY141100196T CY1115209T1 CY 1115209 T1 CY1115209 T1 CY 1115209T1 CY 20141100196 T CY20141100196 T CY 20141100196T CY 141100196 T CY141100196 T CY 141100196T CY 1115209 T1 CY1115209 T1 CY 1115209T1
Authority
CY
Cyprus
Prior art keywords
procarbonyl
antioelectivity
challenging
units
effective procedure
Prior art date
Application number
CY20141100196T
Other languages
English (en)
Inventor
Chava Satya Narayana
Bollu Ravindra Babu
Original Assignee
Laurus Labs Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Limited filed Critical Laurus Labs Private Limited
Publication of CY1115209T1 publication Critical patent/CY1115209T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Αποδοτική μέθοδος για την επαγωγή εναντιοεκλεκτικότητας σε ενώσεις προκαρβονυλίου χρησιμοποιώντας χειρικά οργανομεταλλικά σύμπλοκα. Η παρούσα εφεύρεση περιγράφει επίσης μέθοδο για την παραγωγή οργανομεταλλικών συμπλόκων χρησιμοποιώντας βάση και αλογονίδιο μετάλλου.
CY20141100196T 2008-01-31 2014-03-11 Αποδοτικη διαδικασια για προκληση εναντιοεκλεκτικοτητας στις ενωσεις προκαρβονυλιου CY1115209T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN262CH2008 2008-01-31
EP08808147.6A EP2235023B1 (en) 2008-01-31 2008-07-30 An efficient process to induce enantioselectivity in procarbonyl compounds

Publications (1)

Publication Number Publication Date
CY1115209T1 true CY1115209T1 (el) 2017-01-04

Family

ID=40913373

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100196T CY1115209T1 (el) 2008-01-31 2014-03-11 Αποδοτικη διαδικασια για προκληση εναντιοεκλεκτικοτητας στις ενωσεις προκαρβονυλιου

Country Status (10)

Country Link
US (1) US9156756B2 (el)
EP (1) EP2235023B1 (el)
CN (1) CN101497573B (el)
CY (1) CY1115209T1 (el)
DK (1) DK2235023T3 (el)
ES (1) ES2449754T3 (el)
PL (1) PL2235023T3 (el)
SI (1) SI2235023T1 (el)
WO (1) WO2009095931A2 (el)
ZA (1) ZA200806473B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9073817B2 (en) * 2008-01-31 2015-07-07 Laurus Labs Private Limited Efficient process to induce enantioselectivity in procarbonyl compounds
WO2011000532A2 (de) 2009-07-03 2011-01-06 Archimica Gmbh Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren
CN102372533B (zh) * 2011-11-01 2014-08-13 浙江新华制药有限公司 酒石酸衍生物催化端炔锌试剂对含氟烷基芳酮的不对称加成方法
CN102617370B (zh) * 2012-03-05 2014-06-04 浙江江北药业有限公司 (S)-5-氯-α-(环丙乙炔基)-2-(((4-甲氧基苯基)甲基)氨基)-α-(三氟甲基)苯甲醇的制备方法
CN103833560B (zh) * 2013-03-25 2016-05-25 安徽贝克联合制药有限公司 (S)-5-氯-α-环丙炔基-2-氨基-α-三氟甲基苯甲醇的制备方法
CN105330554B (zh) 2015-02-15 2017-07-11 上海迪赛诺药业股份有限公司 手性环丙基乙炔基叔醇类化合物的合成方法
CN111548317A (zh) * 2020-04-28 2020-08-18 苏州纪元康生物科技有限公司 一种依法韦伦合成方法及制备其中间体方法
CN113968791A (zh) * 2021-11-18 2022-01-25 盐城迪赛诺制药有限公司 一种依非韦伦关键中间体的制备方法
CN115010682A (zh) * 2022-06-24 2022-09-06 盐城迪赛诺制药有限公司 依非韦伦关键中间体酸化过程无机酸替代有机酸的方法
CN115073310A (zh) * 2022-07-05 2022-09-20 盐城迪赛诺制药有限公司 一种降低依非韦伦关键中间体母液中特定杂质的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519021A (en) * 1992-08-07 1996-05-21 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
US6015926A (en) * 1997-05-16 2000-01-18 Merck & Co., Inc. Efficient enantioselective addition reaction using an organozinc reagent
DE19812480A1 (de) * 1998-03-21 1999-09-23 E B S Gmbh Tintenstrahldrucker für die Beschriftung von Waren
US6586644B2 (en) * 2001-10-05 2003-07-01 Erick M. Carreira Process for producing optically active propargyl alcohols
EP1614672B1 (en) 2003-04-04 2010-09-22 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences An amino alcohol ligand and its use in preparation of chiral proparglic tertiary alkohols and tertiary amines via enantioselective additon reaction
WO2011000532A2 (de) 2009-07-03 2011-01-06 Archimica Gmbh Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren

Also Published As

Publication number Publication date
US9156756B2 (en) 2015-10-13
WO2009095931A2 (en) 2009-08-06
US20100286408A1 (en) 2010-11-11
SI2235023T1 (sl) 2014-04-30
ZA200806473B (en) 2009-04-29
EP2235023A4 (en) 2011-09-07
EP2235023A2 (en) 2010-10-06
WO2009095931A3 (en) 2010-09-30
EP2235023B1 (en) 2013-12-11
ES2449754T3 (es) 2014-03-21
DK2235023T3 (en) 2014-03-10
CN101497573A (zh) 2009-08-05
PL2235023T3 (pl) 2014-07-31
CN101497573B (zh) 2013-09-18

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