CY1113331T1 - Μεθοδος για την παραγωγη 2-(ν,ν-διμεθυλαμινο)-προπιονικου δωδεκυλεστερα - Google Patents

Μεθοδος για την παραγωγη 2-(ν,ν-διμεθυλαμινο)-προπιονικου δωδεκυλεστερα

Info

Publication number
CY1113331T1
CY1113331T1 CY20121101103T CY121101103T CY1113331T1 CY 1113331 T1 CY1113331 T1 CY 1113331T1 CY 20121101103 T CY20121101103 T CY 20121101103T CY 121101103 T CY121101103 T CY 121101103T CY 1113331 T1 CY1113331 T1 CY 1113331T1
Authority
CY
Cyprus
Prior art keywords
dimethylamine
propionic
production
dimethylamino
propionate
Prior art date
Application number
CY20121101103T
Other languages
English (en)
Inventor
Servet Buyuktimkin
Nadir Buyuktimkin
Original Assignee
Nexmed Holdings, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings, Inc. filed Critical Nexmed Holdings, Inc.
Publication of CY1113331T1 publication Critical patent/CY1113331T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Peptides Or Proteins (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Holo Graphy (AREA)
  • Paper (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

Ο 2-(Ν,Ν-διμεθυλαμινο)-προπιονικός δωδεκυλεστέρας (DDAIP) παρασκευάζεται διά διεστεροποιήσεως του 2-(Ν,Ν-διμεθυλαμινο)-προπιονικού αιθυλεστέρος.
CY20121101103T 1999-05-19 2012-11-15 Μεθοδος για την παραγωγη 2-(ν,ν-διμεθυλαμινο)-προπιονικου δωδεκυλεστερα CY1113331T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/314,571 US6118020A (en) 1999-05-19 1999-05-19 Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate
EP04006144A EP1428816B1 (en) 1999-05-19 2000-05-18 Method for the manufacture of dodecyl 2-(n,n-dimethylamino)-propionate

Publications (1)

Publication Number Publication Date
CY1113331T1 true CY1113331T1 (el) 2016-06-22

Family

ID=23220476

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101103T CY1113331T1 (el) 1999-05-19 2012-11-15 Μεθοδος για την παραγωγη 2-(ν,ν-διμεθυλαμινο)-προπιονικου δωδεκυλεστερα

Country Status (22)

Country Link
US (1) US6118020A (el)
EP (2) EP1097126B1 (el)
JP (1) JP4864208B2 (el)
KR (1) KR100688920B1 (el)
CN (3) CN1837187A (el)
AT (1) ATE272607T1 (el)
AU (1) AU781427B2 (el)
BR (1) BR0006133A (el)
CA (2) CA2338139C (el)
CY (1) CY1113331T1 (el)
DE (1) DE60012656T2 (el)
DK (2) DK1428816T3 (el)
ES (2) ES2390952T3 (el)
HK (2) HK1088592A1 (el)
HU (1) HU230508B1 (el)
IL (1) IL140569A (el)
MX (1) MXPA01000669A (el)
PT (2) PT1428816E (el)
SI (1) SI1097126T1 (el)
TW (1) TWI256949B (el)
WO (1) WO2000069809A1 (el)
ZA (1) ZA200100142B (el)

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US6414028B1 (en) * 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
IL142536A0 (en) * 2001-04-11 2002-03-10 Yeda Res & Dev Carriers for therapeutic preparations for treatment of t-cell mediated diseases
IL142535A0 (en) * 2001-04-11 2002-03-10 Yeda Res & Dev Pharmaceutical compositions for the treatment of inflammation
CN100582085C (zh) 2002-10-10 2010-01-20 耶达研究及发展有限公司 脂肪醇的碱性酯及它们作为抗炎药或免疫调节剂的用途
US20040241243A1 (en) * 2003-03-21 2004-12-02 Nexmed (Holdings) Inc. Angiogenesis promotion by prostaglandin compositions and methods
SG152065A1 (en) 2003-03-21 2009-05-29 Nexmed Holdings Inc Antifungal nail coat and method of use
MXPA05010069A (es) * 2003-03-21 2005-11-23 Nexmed Holdings Inc Composiciones de prostaglandina para el tratamiento de la disfuncion erectil.
KR20050119187A (ko) * 2003-04-02 2005-12-20 넥스메드 홀딩스 인코포레이티드 프로스타글란딘 조성물 및 이의 혈관연축 치료용 용도
WO2008106091A1 (en) * 2007-02-26 2008-09-04 Yeda Research And Development Co. Ltd. Use of long-chain alcohol derivatives for the treatment of alopecia areata
WO2008106092A1 (en) * 2007-02-26 2008-09-04 Yeda Research And Development Co. Ltd. Enantiomers of amino-phenyl-acetic acid octadec- 9- (z) enyl ester, their salts and their uses
JP6205133B2 (ja) 2009-07-10 2017-09-27 プレジデント アンド フェローズ オブ ハーバード カレッジ 抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
EP2512240B1 (en) * 2009-12-18 2018-04-11 Achelios Therapeutics, Inc. Methods and compositions for treating and preventing trigeminal autonomic cephalgias, migraine, and vascular conditions
RU2012153177A (ru) * 2010-05-04 2014-06-20 Нексмед Холдингс, Инк. Композиции низкомолекулярных терапевтических средств
AU2011249040B2 (en) * 2010-05-04 2014-05-15 Nexmed Holdings, Inc. Therapeutic peptide composition and method
SG188612A1 (en) * 2010-09-24 2013-04-30 Nexmed Holdings Inc Enhanced transbuccal drug delivery system and compositions
ES2801999T3 (es) * 2010-12-02 2021-01-15 Ferring Int Center Sa Enantiómero activo de 2-(N,N-dimetilamino)-propionato de dodecilo
WO2012097160A1 (en) * 2011-01-14 2012-07-19 Nexmed Holdings, Inc. Rectal delivery method for therapeutic peptides
CA2838109C (en) 2011-04-07 2020-06-09 Nexmed Holdings, Inc. Topical semisolid prostaglandin e1 composition for treating raynaud's disease
US8900625B2 (en) 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use
TW201431572A (zh) 2012-12-21 2014-08-16 Teikoku Pharma Usa Inc 荷爾蒙及其它醫藥劑之經皮傳遞的組成物及方法
EP3226972A4 (en) 2014-12-01 2018-08-08 Achelios Therapeutics, Inc. Methods and compositions for treating migraine and conditions associated with pain
CN108348774A (zh) 2015-08-03 2018-07-31 哈佛大学校长及研究员协会 带电离子通道阻断剂及其应用
WO2018035380A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
WO2019006455A1 (en) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
MX2021010870A (es) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueadores de canales ionicos cargados y metodos de uso.
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN113811305A (zh) 2019-03-11 2021-12-17 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
MA55320A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques substitués par un ester et méthodes d'utilisation
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2023500890A (ja) 2019-11-06 2023-01-11 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
WO2021091585A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2023517604A (ja) 2020-03-11 2023-04-26 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法

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US5082866A (en) * 1988-06-01 1992-01-21 Odontex, Inc. Biodegradable absorption enhancers
US4980378A (en) * 1988-06-01 1990-12-25 Odontex, Inc. Biodegradable absorption enhancers
JPH08311210A (ja) * 1995-05-24 1996-11-26 Dai Ichi Kogyo Seiyaku Co Ltd 樹脂成形体の導電性改良方法および静電塗装方法

Also Published As

Publication number Publication date
TWI256949B (en) 2006-06-21
EP1428816A1 (en) 2004-06-16
AU5023200A (en) 2000-12-05
ES2223524T3 (es) 2005-03-01
CA2338139C (en) 2010-08-31
EP1428816B1 (en) 2012-09-05
SI1097126T1 (en) 2004-10-31
PT1097126E (pt) 2004-11-30
CN1315783C (zh) 2007-05-16
EP1097126A1 (en) 2001-05-09
PT1428816E (pt) 2012-09-27
HUP0202090A2 (en) 2002-10-28
DE60012656T2 (de) 2005-08-11
HK1088592A1 (en) 2006-11-10
IL140569A0 (en) 2002-02-10
CN1244546C (zh) 2006-03-08
BR0006133A (pt) 2001-04-03
CN1837187A (zh) 2006-09-27
CN1733706A (zh) 2006-02-15
CA2338139A1 (en) 2000-11-23
ES2390952T3 (es) 2012-11-20
KR100688920B1 (ko) 2007-03-09
KR20010071969A (ko) 2001-07-31
CN1306502A (zh) 2001-08-01
WO2000069809A1 (en) 2000-11-23
ATE272607T1 (de) 2004-08-15
HUP0202090A3 (en) 2002-11-28
JP4864208B2 (ja) 2012-02-01
HK1037607A1 (en) 2002-02-15
DE60012656D1 (de) 2004-09-09
AU781427B2 (en) 2005-05-26
JP2002544253A (ja) 2002-12-24
ZA200100142B (en) 2002-01-07
CA2706680A1 (en) 2000-11-23
IL140569A (en) 2006-07-05
US6118020A (en) 2000-09-12
MXPA01000669A (es) 2002-07-02
DK1097126T3 (da) 2004-11-01
CA2706680C (en) 2012-11-27
EP1097126A4 (en) 2002-08-28
DK1428816T3 (da) 2012-10-01
HU230508B1 (hu) 2016-09-28
EP1097126B1 (en) 2004-08-04

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