CY1112386T1 - Παραγωγα ισοκινολινης και βενζο[η]ισοκινολινης, η παρασκευη τους και η χρηση τους στη θεραπευτικη αγωγη ως ανταγωνιστες του υποδοχεα της ισταμινης η3 - Google Patents
Παραγωγα ισοκινολινης και βενζο[η]ισοκινολινης, η παρασκευη τους και η χρηση τους στη θεραπευτικη αγωγη ως ανταγωνιστες του υποδοχεα της ισταμινης η3Info
- Publication number
- CY1112386T1 CY1112386T1 CY20121100117T CY121100117T CY1112386T1 CY 1112386 T1 CY1112386 T1 CY 1112386T1 CY 20121100117 T CY20121100117 T CY 20121100117T CY 121100117 T CY121100117 T CY 121100117T CY 1112386 T1 CY1112386 T1 CY 1112386T1
- Authority
- CY
- Cyprus
- Prior art keywords
- products
- iskinolinin
- iskinolin
- venzo
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Ένωση του χημικού τύπου (Ι) στον οποίο το (Α) αντιπροσωπεύει έναν ακόρεστο καρβόκυκλο με διπλούς δεσμούς, το Ι μπορεί να ισούται με τιμές από 0 έως 4 · το m μπορεί να ισούται με τιμές από 0 έως 3 · το n μπορεί να ισούται με τιμές από 0 έως 6 · τα -(C)1-, -(C)m- και -(C)n-αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο, μια ομάδα – Xx-z- αλκυλιδεν, ενδεχομένως υποκατεστημένα από 1 έως 4 υποκατάστατες · το R1 αντιπροσωπεύει ένα άτομο υδρογόνου, μια ομάδα C1-3 αλκυλ, ένα C1-6 αλκυλκαρβονυλ, ένα C1-6 αλκοξυκαρβονυλ · το R2 αντιπροσωπεύει ένα άτομο υδρογόνου ή μια ομάδα C1-6 αλκυλ ή C3-6 κυκλοαλκυλ ενδεχομένως υποκατεστημένα. Εφαρμογή σε θεραπευτική αγωγή, για τη θεραπεία διαταραχών που βελτιώνονται με διαμόρφωση του υποδοχέα Η3 της ισταμίνης.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111248A EP1790646A1 (fr) | 2005-11-24 | 2005-11-24 | Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3. |
| EP06829734A EP1960387B1 (fr) | 2005-11-24 | 2006-11-22 | Derives de isoquinoline et benzo[h]isoquinoline, leur preparation et leur utilisation en therapeutique en tant qu antagonistes du recepteur de l histamine h3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112386T1 true CY1112386T1 (el) | 2015-12-09 |
Family
ID=36295552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100117T CY1112386T1 (el) | 2005-11-24 | 2012-02-02 | Παραγωγα ισοκινολινης και βενζο[η]ισοκινολινης, η παρασκευη τους και η χρηση τους στη θεραπευτικη αγωγη ως ανταγωνιστες του υποδοχεα της ισταμινης η3 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7678807B2 (el) |
| EP (2) | EP1790646A1 (el) |
| JP (1) | JP5165578B2 (el) |
| KR (1) | KR101386318B1 (el) |
| CN (1) | CN101312961B (el) |
| AR (1) | AR057615A1 (el) |
| AT (1) | ATE531707T1 (el) |
| AU (1) | AU2006316706B2 (el) |
| BR (1) | BRPI0618971A2 (el) |
| CA (1) | CA2630655C (el) |
| CY (1) | CY1112386T1 (el) |
| DK (1) | DK1960387T3 (el) |
| DO (1) | DOP2006000253A (el) |
| ES (1) | ES2376894T3 (el) |
| GT (1) | GT200600490A (el) |
| HK (1) | HK1126200A1 (el) |
| IL (1) | IL191214A (el) |
| PE (1) | PE20070827A1 (el) |
| PL (1) | PL1960387T3 (el) |
| PT (1) | PT1960387E (el) |
| RU (1) | RU2418794C2 (el) |
| SI (1) | SI1960387T1 (el) |
| TW (1) | TW200738681A (el) |
| UY (1) | UY29971A1 (el) |
| WO (1) | WO2007060027A1 (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2870846B1 (fr) | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
| JP5968307B2 (ja) | 2010-05-11 | 2016-08-10 | サノフイ | 置換フェニルシクロアルキルピロリジン（ピペリジン）スピロラクタム類及びアミド類、それらの製造及び治療的使用 |
| WO2011143148A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| EP2569296A1 (en) * | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| AR081382A1 (es) * | 2010-05-11 | 2012-08-29 | Sanofi Aventis | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL343424A1 (en) * | 1998-04-10 | 2001-08-13 | Japan Tobacco Inc | Amidine compounds |
| WO2000023437A1 (fr) * | 1998-10-16 | 2000-04-27 | Takeda Chemical Industries, Ltd. | Composes azotes hererocycliques condenses; procede de fabrication et agents les renfermant |
| WO2002076925A2 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| NL1020155C2 (nl) * | 2002-03-11 | 2003-09-17 | Bernardus Johannes Jos Bekkers | Inrichting voor het dragen van een golftas alsmede werkwijze voor het vervaardigen ervan. |
| GB0206033D0 (en) * | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| US20060089347A1 (en) * | 2002-08-20 | 2006-04-27 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| GB0408083D0 (en) * | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| FR2870846B1 (fr) * | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
-
2005
- 2005-11-24 EP EP05111248A patent/EP1790646A1/fr not_active Withdrawn
-
2006
- 2006-11-15 DO DO2006000253A patent/DOP2006000253A/es unknown
- 2006-11-20 GT GT200600490A patent/GT200600490A/es unknown
- 2006-11-20 TW TW095142885A patent/TW200738681A/zh unknown
- 2006-11-20 PE PE2006001478A patent/PE20070827A1/es not_active Application Discontinuation
- 2006-11-22 WO PCT/EP2006/012246 patent/WO2007060027A1/fr active Application Filing
- 2006-11-22 AU AU2006316706A patent/AU2006316706B2/en not_active Ceased
- 2006-11-22 AT AT06829734T patent/ATE531707T1/de active
- 2006-11-22 CN CN2006800440166A patent/CN101312961B/zh not_active Expired - Fee Related
- 2006-11-22 SI SI200631253T patent/SI1960387T1/sl unknown
- 2006-11-22 RU RU2008125136/04A patent/RU2418794C2/ru not_active IP Right Cessation
- 2006-11-22 AR ARP060105107A patent/AR057615A1/es not_active Application Discontinuation
- 2006-11-22 KR KR1020087012407A patent/KR101386318B1/ko not_active IP Right Cessation
- 2006-11-22 PL PL06829734T patent/PL1960387T3/pl unknown
- 2006-11-22 CA CA2630655A patent/CA2630655C/fr not_active Expired - Fee Related
- 2006-11-22 BR BRPI0618971-7A patent/BRPI0618971A2/pt not_active IP Right Cessation
- 2006-11-22 JP JP2008541661A patent/JP5165578B2/ja not_active Expired - Fee Related
- 2006-11-22 EP EP06829734A patent/EP1960387B1/fr active Active
- 2006-11-22 ES ES06829734T patent/ES2376894T3/es active Active
- 2006-11-22 PT PT06829734T patent/PT1960387E/pt unknown
- 2006-11-22 DK DK06829734.0T patent/DK1960387T3/da active
- 2006-11-24 UY UY29971A patent/UY29971A1/es unknown
-
2008
- 2008-05-01 IL IL191214A patent/IL191214A/en not_active IP Right Cessation
- 2008-05-19 US US12/122,795 patent/US7678807B2/en not_active Expired - Fee Related
-
2009
- 2009-05-20 HK HK09104609.6A patent/HK1126200A1/xx not_active IP Right Cessation
-
2012
- 2012-02-02 CY CY20121100117T patent/CY1112386T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2418794C2 (ru) | 2011-05-20 |
| BRPI0618971A2 (pt) | 2011-09-20 |
| EP1790646A1 (fr) | 2007-05-30 |
| US20080269199A1 (en) | 2008-10-30 |
| PT1960387E (pt) | 2012-02-09 |
| PE20070827A1 (es) | 2007-08-17 |
| JP5165578B2 (ja) | 2013-03-21 |
| RU2008125136A (ru) | 2009-12-27 |
| AU2006316706A1 (en) | 2007-05-31 |
| CA2630655A1 (fr) | 2007-05-31 |
| SI1960387T1 (sl) | 2012-03-30 |
| KR101386318B1 (ko) | 2014-04-17 |
| HK1126200A1 (en) | 2009-08-28 |
| AU2006316706B2 (en) | 2012-05-03 |
| JP2009517357A (ja) | 2009-04-30 |
| ATE531707T1 (de) | 2011-11-15 |
| PL1960387T3 (pl) | 2012-03-30 |
| UY29971A1 (es) | 2007-06-29 |
| DK1960387T3 (da) | 2012-02-27 |
| EP1960387A1 (fr) | 2008-08-27 |
| CA2630655C (fr) | 2014-08-26 |
| DOP2006000253A (es) | 2007-07-15 |
| ES2376894T3 (es) | 2012-03-20 |
| CN101312961A (zh) | 2008-11-26 |
| GT200600490A (es) | 2007-07-06 |
| AR057615A1 (es) | 2007-12-05 |
| CN101312961B (zh) | 2012-04-11 |
| KR20080076910A (ko) | 2008-08-20 |
| US7678807B2 (en) | 2010-03-16 |
| TW200738681A (en) | 2007-10-16 |
| WO2007060027A1 (fr) | 2007-05-31 |
| EP1960387B1 (fr) | 2011-11-02 |
| IL191214A (en) | 2012-07-31 |
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