AR057615A1 - Derivados de isoquinolina y benzo (h) isoquinolina su preparcion y su utilizacion en terapeutica - Google Patents
Derivados de isoquinolina y benzo (h) isoquinolina su preparcion y su utilizacion en terapeuticaInfo
- Publication number
- AR057615A1 AR057615A1 ARP060105107A ARP060105107A AR057615A1 AR 057615 A1 AR057615 A1 AR 057615A1 AR P060105107 A ARP060105107 A AR P060105107A AR P060105107 A ARP060105107 A AR P060105107A AR 057615 A1 AR057615 A1 AR 057615A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- cyano
- nitro
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Compuesto de formula (1) en la que: el anillo A representa un carbociclo insaturado con dobles enlaces, opcionalmente sustituido con uno o dos sustituyentes elegidos independientemente uno del otro, entre un átomo de halogeno, un hidroxi, un grupo nitro, ciano, perhalogenoalquilo C1-2, alquilo C1-3 o un fenilo; l puede tomar un valor de 0 a 4; m puede tomar un valor de 0 a 3; n puede tomar un valor de 0 a 6; -(C)l-, -(C)m- y -(C)n-representan, independientemente uno del otro, un grupo alquilideno -Cx-z-, opcionalmente sustituido con 1 a 4 sustituyentes elegidos entre un átomo de halogeno, un grupo hidroxi, nitro, ciano, amino, perhalogenoalquilo C1-2, alquilo C1-3 o un fenilo; y además cuando l, m y/o n toman el valor 0, -(C)0- representa un enlace; R1 representa H, alquilo C1-3, alquilcarbonilo C1-6, alcoxicarbonilo 1-6, pueden estar cada uno sustituido con un átomo de halogeno, un grupo hidroxi, alcoxi C1-3, nitro, ciano, amino, un arilo, alquil C1-3- arilo, un heteroarilo monocíclico, un arilo; estando los grupos arilo y heteroarilo opcionalmente sustituidos con 1 a 4 sustituyentes elegidos entre un átomo de halogeno, un grupo hidroxi, nitro, ciano, amino, halogenoalquilo C1-3, alcoxi C1-3 o un grupo alquilidendioxi C1-3; R2 representa H o un grupo alquilo C1-6 o un grupo cicloalquilo C3-6 estando cada uno opcionalmente sustituidos con 1 a 4 sustituyentes elegidos entre un átomo de halogeno, un grupo hidroxi, nitro, ciano, amino, monoalquilamino C1-3, dialquilamino C2-6, perhalogenoalquilo C1-2, halogenoalquilo C1-3, alcoxi C1-3, cicloalquilo C3-6, un heteroarilo monocíclico, un heteroarilo bicíclico, un grupo arilo, él mismo opcionalmente sustituido con 1 a 4 sustituyentes elegidos entre un átomo de halogeno, un grupo hidroxi, nitro, ciano, amino, monoalquilamino C1-3, dialquilamino C2-6, alquilo C1-3, perhalogenoalquilo C1-2, halogenoalquilo C1-3, alcoxi C1-3 o un grupo alquilidendioxi C1-3, en el estado de base o de sal de adicion de ácido, así como en el estado de hidrato o de solvato.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111248A EP1790646A1 (fr) | 2005-11-24 | 2005-11-24 | Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057615A1 true AR057615A1 (es) | 2007-12-05 |
Family
ID=36295552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105107A AR057615A1 (es) | 2005-11-24 | 2006-11-22 | Derivados de isoquinolina y benzo (h) isoquinolina su preparcion y su utilizacion en terapeutica |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7678807B2 (es) |
| EP (2) | EP1790646A1 (es) |
| JP (1) | JP5165578B2 (es) |
| KR (1) | KR101386318B1 (es) |
| CN (1) | CN101312961B (es) |
| AR (1) | AR057615A1 (es) |
| AT (1) | ATE531707T1 (es) |
| AU (1) | AU2006316706B2 (es) |
| BR (1) | BRPI0618971A2 (es) |
| CA (1) | CA2630655C (es) |
| CY (1) | CY1112386T1 (es) |
| DK (1) | DK1960387T3 (es) |
| DO (1) | DOP2006000253A (es) |
| ES (1) | ES2376894T3 (es) |
| GT (1) | GT200600490A (es) |
| HK (1) | HK1126200A1 (es) |
| IL (1) | IL191214A (es) |
| PE (1) | PE20070827A1 (es) |
| PL (1) | PL1960387T3 (es) |
| PT (1) | PT1960387E (es) |
| RU (1) | RU2418794C2 (es) |
| SI (1) | SI1960387T1 (es) |
| TW (1) | TW200738681A (es) |
| UY (1) | UY29971A1 (es) |
| WO (1) | WO2007060027A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2870846B1 (fr) * | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
| TW201206910A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| WO2011143150A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| AR081384A1 (es) * | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N- fenil espirolactama bipirrolidinas sustituidas, preparacion y uso terapeutico de las mismas |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562828B1 (en) * | 1998-04-10 | 2003-05-13 | Japan Tobacco Inc. | Amidine compounds |
| WO2000023437A1 (fr) * | 1998-10-16 | 2000-04-27 | Takeda Chemical Industries, Ltd. | Composes azotes hererocycliques condenses; procede de fabrication et agents les renfermant |
| AU2002254114A1 (en) * | 2001-03-23 | 2002-10-08 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| NL1020155C2 (nl) * | 2002-03-11 | 2003-09-17 | Bernardus Johannes Jos Bekkers | Inrichting voor het dragen van een golftas alsmede werkwijze voor het vervaardigen ervan. |
| GB0206033D0 (en) * | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| AU2003256793A1 (en) * | 2002-08-20 | 2004-03-11 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| GB0408083D0 (en) * | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| FR2870846B1 (fr) * | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
-
2005
- 2005-11-24 EP EP05111248A patent/EP1790646A1/fr not_active Withdrawn
-
2006
- 2006-11-15 DO DO2006000253A patent/DOP2006000253A/es unknown
- 2006-11-20 TW TW095142885A patent/TW200738681A/zh unknown
- 2006-11-20 GT GT200600490A patent/GT200600490A/es unknown
- 2006-11-20 PE PE2006001478A patent/PE20070827A1/es not_active Application Discontinuation
- 2006-11-22 ES ES06829734T patent/ES2376894T3/es active Active
- 2006-11-22 DK DK06829734.0T patent/DK1960387T3/da active
- 2006-11-22 WO PCT/EP2006/012246 patent/WO2007060027A1/fr active Application Filing
- 2006-11-22 CA CA2630655A patent/CA2630655C/fr not_active Expired - Fee Related
- 2006-11-22 PL PL06829734T patent/PL1960387T3/pl unknown
- 2006-11-22 RU RU2008125136/04A patent/RU2418794C2/ru not_active IP Right Cessation
- 2006-11-22 AT AT06829734T patent/ATE531707T1/de active
- 2006-11-22 SI SI200631253T patent/SI1960387T1/sl unknown
- 2006-11-22 CN CN2006800440166A patent/CN101312961B/zh not_active Expired - Fee Related
- 2006-11-22 PT PT06829734T patent/PT1960387E/pt unknown
- 2006-11-22 BR BRPI0618971-7A patent/BRPI0618971A2/pt not_active IP Right Cessation
- 2006-11-22 JP JP2008541661A patent/JP5165578B2/ja not_active Expired - Fee Related
- 2006-11-22 EP EP06829734A patent/EP1960387B1/fr active Active
- 2006-11-22 AR ARP060105107A patent/AR057615A1/es not_active Application Discontinuation
- 2006-11-22 KR KR1020087012407A patent/KR101386318B1/ko not_active IP Right Cessation
- 2006-11-22 AU AU2006316706A patent/AU2006316706B2/en not_active Ceased
- 2006-11-24 UY UY29971A patent/UY29971A1/es unknown
-
2008
- 2008-05-01 IL IL191214A patent/IL191214A/en not_active IP Right Cessation
- 2008-05-19 US US12/122,795 patent/US7678807B2/en not_active Expired - Fee Related
-
2009
- 2009-05-20 HK HK09104609.6A patent/HK1126200A1/xx not_active IP Right Cessation
-
2012
- 2012-02-02 CY CY20121100117T patent/CY1112386T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101312961A (zh) | 2008-11-26 |
| RU2008125136A (ru) | 2009-12-27 |
| AU2006316706A1 (en) | 2007-05-31 |
| KR101386318B1 (ko) | 2014-04-17 |
| ES2376894T3 (es) | 2012-03-20 |
| DOP2006000253A (es) | 2007-07-15 |
| AU2006316706B2 (en) | 2012-05-03 |
| JP5165578B2 (ja) | 2013-03-21 |
| TW200738681A (en) | 2007-10-16 |
| PT1960387E (pt) | 2012-02-09 |
| DK1960387T3 (da) | 2012-02-27 |
| CA2630655C (fr) | 2014-08-26 |
| KR20080076910A (ko) | 2008-08-20 |
| IL191214A (en) | 2012-07-31 |
| US20080269199A1 (en) | 2008-10-30 |
| CA2630655A1 (fr) | 2007-05-31 |
| HK1126200A1 (en) | 2009-08-28 |
| PE20070827A1 (es) | 2007-08-17 |
| PL1960387T3 (pl) | 2012-03-30 |
| GT200600490A (es) | 2007-07-06 |
| EP1790646A1 (fr) | 2007-05-30 |
| WO2007060027A1 (fr) | 2007-05-31 |
| CY1112386T1 (el) | 2015-12-09 |
| ATE531707T1 (de) | 2011-11-15 |
| SI1960387T1 (sl) | 2012-03-30 |
| US7678807B2 (en) | 2010-03-16 |
| EP1960387A1 (fr) | 2008-08-27 |
| EP1960387B1 (fr) | 2011-11-02 |
| RU2418794C2 (ru) | 2011-05-20 |
| CN101312961B (zh) | 2012-04-11 |
| UY29971A1 (es) | 2007-06-29 |
| BRPI0618971A2 (pt) | 2011-09-20 |
| JP2009517357A (ja) | 2009-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |