CY1111429T1 - 1,3-διυποκατεστημενα αμιδια 4-μεθυλο-1η-πυρρολο-2-καρβονικου οξεος και η χρησιμοποιηση τους για την παρασκευη φαρμακων - Google Patents

1,3-διυποκατεστημενα αμιδια 4-μεθυλο-1η-πυρρολο-2-καρβονικου οξεος και η χρησιμοποιηση τους για την παρασκευη φαρμακων

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Publication number
CY1111429T1
CY1111429T1 CY20111100145T CY111100145T CY1111429T1 CY 1111429 T1 CY1111429 T1 CY 1111429T1 CY 20111100145 T CY20111100145 T CY 20111100145T CY 111100145 T CY111100145 T CY 111100145T CY 1111429 T1 CY1111429 T1 CY 1111429T1
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CY
Cyprus
Prior art keywords
methyl
differental
pyrrolo
medicines
amides
Prior art date
Application number
CY20111100145T
Other languages
English (en)
Inventor
Stefan Oberbörsch
Bernd Dr Sundermann
Corinna Sundermann
Edward Bijsterveld
Hagen-Heinrich Hennies
Original Assignee
Grünenthal GmbH
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Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1111429T1 publication Critical patent/CY1111429T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά 1,3-διυποκατεστημένα αμίδια 4-μεθυλο-1Η-πυρρολο-2-καρβονικού οξέος του γενικού τύπου I, μεθόδους για την παρασκευή τους, φάρμακα που περιέχουν τις ενώσεις αυτές καθώς και τη χρησιμοποίηση τους για την παρασκευή φαρμάκων.
CY20111100145T 2006-06-09 2011-02-08 1,3-διυποκατεστημενα αμιδια 4-μεθυλο-1η-πυρρολο-2-καρβονικου οξεος και η χρησιμοποιηση τους για την παρασκευη φαρμακων CY1111429T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006027229A DE102006027229A1 (de) 2006-06-09 2006-06-09 1,3-Disubstituierte 4-Methyl-1H-pyrrol-2-carbonsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
EP07725929A EP2035375B1 (de) 2006-06-09 2007-06-08 1,3-disubstituierte 4-methyl-1 h-pyrrol-2-carbonsäureamide und ihre verwendung zur herstellung von arzneimitteln

Publications (1)

Publication Number Publication Date
CY1111429T1 true CY1111429T1 (el) 2015-08-05

Family

ID=38564355

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100145T CY1111429T1 (el) 2006-06-09 2011-02-08 1,3-διυποκατεστημενα αμιδια 4-μεθυλο-1η-πυρρολο-2-καρβονικου οξεος και η χρησιμοποιηση τους για την παρασκευη φαρμακων

Country Status (26)

Country Link
US (1) US7968591B2 (el)
EP (1) EP2035375B1 (el)
JP (1) JP5156011B2 (el)
KR (1) KR20090016016A (el)
CN (1) CN101500994B (el)
AT (1) ATE496026T1 (el)
AU (1) AU2007256373B2 (el)
BR (1) BRPI0712918A2 (el)
CA (1) CA2653526A1 (el)
CY (1) CY1111429T1 (el)
DE (2) DE102006027229A1 (el)
DK (1) DK2035375T3 (el)
EC (1) ECSP088948A (el)
ES (1) ES2355766T3 (el)
HK (1) HK1129226A1 (el)
HR (1) HRP20110065T1 (el)
IL (1) IL195409A (el)
MX (1) MX2008015185A (el)
NO (1) NO20090073L (el)
NZ (1) NZ573289A (el)
PL (1) PL2035375T3 (el)
PT (1) PT2035375E (el)
RU (1) RU2463294C2 (el)
SI (1) SI2035375T1 (el)
WO (1) WO2007141039A1 (el)
ZA (1) ZA200810031B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299115B2 (en) * 2007-06-08 2012-10-30 Debnath Bhuniya Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application
CN101597278B (zh) 2008-06-04 2013-04-17 中国中化股份有限公司 酰胺类化合物及其制备与应用
MX2011003191A (es) * 2008-10-14 2011-04-27 Actelion Pharmaceuticals Ltd Derivados de fenetilamida y sus analogos heterociclicos.
TW201416348A (zh) * 2012-08-29 2014-05-01 Gruenenthal Chemie 以氟甲基取代之吡咯甲醯胺
CA2934327A1 (en) 2013-12-19 2015-06-25 Grunenthal Gmbh Fluoromethyl-substituted pyrrole carboxamides as cav2.2 calcium channel blockers
MX2016007955A (es) * 2013-12-19 2016-09-09 Gruenenthal Gmbh Pirrol carboxamidas iii fluorometil-sustituidas.
MX2016007951A (es) 2013-12-19 2016-09-09 Gruenenthal Gmbh Pirrol carboxamidas iv fluorometil-sustituidas.
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
WO2023115002A1 (en) * 2021-12-16 2023-06-22 Terran Biosciences Inc. Analogs of 4-bromo-2,5-dimethoxyphenethylamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636063B1 (fr) * 1988-09-05 1993-04-30 Centre Nat Rech Scient Composes phenylpyrroliques utiles en tant que medicaments, leur preparation et leur application
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2188095T3 (es) * 1998-04-15 2003-06-16 Pfizer Prod Inc Carboxamidas heterociclicas.
JP4316232B2 (ja) * 2001-12-28 2009-08-19 武田薬品工業株式会社 アンドロゲン受容体拮抗剤
DE60333762D1 (de) * 2002-08-23 2010-09-23 Novartis Vaccines & Diagnostic Pyrrolverbindungen als glykogen synthase kinase 3 inhibitoren
AR044586A1 (es) * 2003-06-04 2005-09-21 Aventis Pharma Sa Productos aril - heteroaromaticos, composiciones que los contienen y su utilizacion
DE102004024772A1 (de) * 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide

Also Published As

Publication number Publication date
AU2007256373A1 (en) 2007-12-13
JP2010509187A (ja) 2010-03-25
AU2007256373B2 (en) 2012-04-19
ES2355766T3 (es) 2011-03-30
DK2035375T3 (da) 2011-02-21
WO2007141039A1 (de) 2007-12-13
EP2035375B1 (de) 2011-01-19
PT2035375E (pt) 2011-04-06
US20090137573A1 (en) 2009-05-28
IL195409A (en) 2013-06-27
NZ573289A (en) 2010-07-30
JP5156011B2 (ja) 2013-03-06
ATE496026T1 (de) 2011-02-15
IL195409A0 (en) 2009-08-03
SI2035375T1 (sl) 2011-05-31
NO20090073L (no) 2009-03-06
HRP20110065T1 (hr) 2011-03-31
DE502007006315D1 (de) 2011-03-03
KR20090016016A (ko) 2009-02-12
BRPI0712918A2 (pt) 2012-10-02
MX2008015185A (es) 2008-12-09
CN101500994B (zh) 2012-12-12
PL2035375T3 (pl) 2011-06-30
HK1129226A1 (el) 2009-11-20
ECSP088948A (es) 2009-01-30
RU2463294C2 (ru) 2012-10-10
RU2008151722A (ru) 2010-07-20
US7968591B2 (en) 2011-06-28
EP2035375A1 (de) 2009-03-18
ZA200810031B (en) 2009-08-26
CN101500994A (zh) 2009-08-05
DE102006027229A1 (de) 2007-12-20
CA2653526A1 (en) 2007-12-13

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