CY1111301T1 - Πολυπεπτιδια που προερχονται απο προδρομο πεπτιδιο αμυλοειδους (αρρ) και οι χρησεις αυτων - Google Patents

Πολυπεπτιδια που προερχονται απο προδρομο πεπτιδιο αμυλοειδους (αρρ) και οι χρησεις αυτων

Info

Publication number
CY1111301T1
CY1111301T1 CY20111100074T CY111100074T CY1111301T1 CY 1111301 T1 CY1111301 T1 CY 1111301T1 CY 20111100074 T CY20111100074 T CY 20111100074T CY 111100074 T CY111100074 T CY 111100074T CY 1111301 T1 CY1111301 T1 CY 1111301T1
Authority
CY
Cyprus
Prior art keywords
arg
amino acid
xaa
derivative
acid residue
Prior art date
Application number
CY20111100074T
Other languages
English (en)
Inventor
Radmila Mileusnic
Steven Peter Russell Rose
Original Assignee
The Open University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0109558A external-priority patent/GB0109558D0/en
Priority claimed from US09/998,491 external-priority patent/US7491702B2/en
Priority claimed from GB0207387A external-priority patent/GB0207387D0/en
Priority claimed from EP02720228A external-priority patent/EP1381627B8/en
Application filed by The Open University filed Critical The Open University
Publication of CY1111301T1 publication Critical patent/CY1111301T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η εφεύρεση παρέχει μία ένωση έχοντας τον χημικό τύπο X1-Arg-Xaa-Arg-X2 στον οποίον τα Χ1 και Χ2 είναι μέχρι και 30 κατάλοιπα αμινοξέων και το Xaa είναι ένα κατάλοιπο αμινοξέως. Μία προτιμώμενη ένωση είναι το τριπεπτίδιο Arg-Glu-Arg το οποίο αντιστοιχεί στα κατάλοιπα αμινοξέων 328 έως 330 της ανθρώπινης πρόδρομης πρωτεΐνης αμυλοειδούς. Η εφεύρεση παρέχει περαιτέρω ένα παράγωγο ενός πολυπεπτιδίου έχοντας τον χημικό τύπο: X1-Arg-Xaa-Arg-X2 όπου τα Χ1 και Χ2, τα οποία μπορεί να είναι τα ίδια ή διαφορετικά, αναπαριστούν το κάθε ένα από 0 έως 30 κατάλοιπα φυσικών ή συνθετικών αμινοξέων ή παράγωγα εξ αυτών και το Xaa αναπαριστά ένα κατάλοιπο φυσικού ή συνθετικού αμινοξέως ή παράγωγο εξ αυτού, η δε μία τουλάχιστον λειτουργική ομάδα του ενός τουλάχιστον εν λόγω κατάλοιπου αμινοξέως ή παραγώγου εξ αυτού όντας προστατευμένη από μία προστατευτική ομάδα. Οι ενώσεις της εφεύρεσης πιστεύεται ότι είναι χρήσιμες στην αγωγή της πάθησης του Αλζχάϊμερ και ως ενισχυτές των γνωσιακών λειτουργιών.
CY20111100074T 2001-04-18 2011-01-24 Πολυπεπτιδια που προερχονται απο προδρομο πεπτιδιο αμυλοειδους (αρρ) και οι χρησεις αυτων CY1111301T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0109558A GB0109558D0 (en) 2001-04-18 2001-04-18 Polypeptides and their uses
GB0120084A GB0120084D0 (en) 2001-04-18 2001-08-17 Polypeptides and their uses
US09/998,491 US7491702B2 (en) 2001-04-18 2001-11-30 Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same
GB0207387A GB0207387D0 (en) 2002-03-28 2002-03-28 Polypeptide derivatives and their uses
EP02720228A EP1381627B8 (en) 2001-04-18 2002-04-17 Polypeptides derived from amyloid precursor peptide (app) and their uses

Publications (1)

Publication Number Publication Date
CY1111301T1 true CY1111301T1 (el) 2015-08-05

Family

ID=43038231

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100074T CY1111301T1 (el) 2001-04-18 2011-01-24 Πολυπεπτιδια που προερχονται απο προδρομο πεπτιδιο αμυλοειδους (αρρ) και οι χρησεις αυτων

Country Status (6)

Country Link
AT (1) ATE487734T1 (el)
CY (1) CY1111301T1 (el)
DE (1) DE60238243D1 (el)
DK (1) DK1381627T3 (el)
ES (1) ES2355808T3 (el)
PT (1) PT1381627E (el)

Also Published As

Publication number Publication date
DK1381627T3 (da) 2011-02-21
DE60238243D1 (de) 2010-12-23
PT1381627E (pt) 2011-02-15
ES2355808T3 (es) 2011-03-31
ATE487734T1 (de) 2010-11-15

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